Papers by shabir ahmad lone
Mycoses, 2019
With ever increasing microbial drug resistance and emergence of new multidrug-resistant (MDR) spe... more With ever increasing microbial drug resistance and emergence of new multidrug-resistant (MDR) species, clinicians and microbiologists are battling to control the associated morbidity and mortality rates. Among new MDR species, C. auris is an emerging fungal pathogen that causes severe invasive infections, with a crude mortality ranging from 30% to 72%. 1-5 C. auris is first isolated and described from an ear canal discharge of a patient in Japan in year 2009 6 , and since then it was isolated from the 6 continents of the world. 7 After its description in 2009, first associated invasive infection was recognised from three patients in South Korea in 2011. 8 In comparison with other Candida species, which are thought to cause sporadic infection, C. auris exhibit a capability for nosocomial transmission. 9 As a result, significant clonal hospital outbreaks were reported from
Medicinal plants discovered by traditional societies are proving to be an important source of pot... more Medicinal plants discovered by traditional societies are proving to be an important source of potentially therapeutic drugs and antimicrobial agents. Due to increasing drug resistance, there is need to search new infection-fighting strategies to control microbial infections. Plants represent the richest resource of drugs of traditional systems of medicine, modern medicines, nutraceuticals, food supplements, folk medicines, pharmaceutical intermediates and chemical entities for synthetic drugs. In the present paper, we present a picture of the potential of medicinal plants as source of natural phytochemicals that act as new antimicrobial agents. Plant extracts possess an antimicrobial activity due to presence of various phytochemicals like essential oils or isolated compounds such as alkaloids, trepenoids, lignans and flavonoids, tannins, glycosides, phenolics, sesquiterpene lactones, diterpenes, triterpenes or naphtoquinones, aliphatic compounds, steroids etc. Antimicrobial activity...
Animal Reproduction Science, 2020
Greater than optimal diluting of semen for producing a large number of doses containing relativel... more Greater than optimal diluting of semen for producing a large number of doses containing relatively small numbers of sperm can lead to compromised quality of sperm, post-thawing. In the present study the French mini-straw plug position was modified and the effect of re-positioning was evaluated on the quality of sperm after thawing subsequent to cryopreservation of small doses of sperm. Four types of mini-straws were used based on the position of cotton plug including no plug displacement (Type 1; Manufacturers location for plug-placement in 0.25 mL French mini-straws), and Type II, III, and IV with re-positioning the cotton plug being 2.5, 5, and 7.5 cm, respectively, further from the manufacturer's placement location. Each ejaculate was proportioned into four Aliquots (I, II, III, and IV) and diluted to 80, 60, 40, and 20, million sperm/mL, respectively. Aliquot I was placed in all types of straws, while Aliquots II, III, IV were placed only in Type I straws. Semen straws were equilibrated, cryopreserved and sperm kinetic and functional variables were evaluated post-thawing. The results indicate that in Aliquots III and IV there were lesser (P < 0.05) values for sperm kinetic and function variables compared with sperm from Aliquot I (i.e., unmodified mini-straw). In conclusion, cryopreservation of small doses of sperm in modified French mini-straws resulted in acceptable values for kinetic and function variables, post-thawing.
Buffalo Bulletin, 2020
The cryopreservation induced sperm damage in buffalo is one of the hurdles responsible for its po... more The cryopreservation induced sperm damage in buffalo is one of the hurdles responsible for its poor freezability and fertility. Therefore, the Present study was planned to understand the role of antioxidant additives on freezability of buffalo spermatozoa. Twenty four ejaculates were collected having mass motility ≥ +3 from 4 Murrah bulls (6 from each bull). Each ejaculate was divided into four groups viz., Group 1 as Control containing Tris-egg yolk-glycerol extender, Group 2 containing Pentoxiphylline 3.6 mM, Group 3 containing Theophylline 10 mM, Group 4 containing Theobromine 10 mM, Group 5 containing N-propyl gallate 15 µM and finally diluted upto 80×106 sperm/ml. Ejaculates were evaluated after freezing for seminal attribute viz., individual motility, live sperm, acrosomal integrity (AI) and hypo-osmotic swelling test (HOST). One way ANOVA was used to analyse the data. Significantly (P<0.05) higher sperm motility was observed in semen samples treated with pentoxiphylline in...
SpringerBriefs in Pharmacology and Toxicology, 2015
Dedico este trabalho aos meus filhos Michel e Juliano, os maiores amores da minha vida.
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Papers by shabir ahmad lone