Rapamycin is an immunosuppressant compound with a broad spectrum of pharmaco-logical activities. ... more Rapamycin is an immunosuppressant compound with a broad spectrum of pharmaco-logical activities. In recent years, it has been used successfully to decrease ischemia-reperfusion injury in several organ systems. The purpose of the present study was to examine the effect of rapamycin on testicular ischemia-reperfusion injury. Seventy-two adult male Wistar rats were divided into six groups: control (group1), sham-operated (Group2), T/D + DMSO as vehicle group (group3), and groups 4-6; respectively received 0.5, 1, and 1.5 mgkgof rapamycin, IP 30 min before detorsion. Ischemia was achieved by twisting the right testis 720° clockwise for 1 hr. The right testis of 6 animals from each group were excised 4 hr after detorsion for the measurement of lipid peroxidation, caspase-3, and antioxidant enzyme activities. Histopathological changes and germ cell apoptosis were determined by measuring mean of seminiferous tubules diameters (MSTD) and TUNEL test in right testis of 6 animals per group, 24...
Environmental pollution is a worldwide problem, heavy metals belonging to the most important poll... more Environmental pollution is a worldwide problem, heavy metals belonging to the most important pollutants. The progress of industries has led to increased emission of pollutants into ecosystems. Southern Caspian Sea coast is one of the most important aquasystems at the eastern south of Caspian Sea, which receives effluents discharges from heavily industrialized and highly populated settlements. Metals tend to accumulate in water and move up through the food chain. So, studies to ascertain the level of heavy metals in environment and determine potentially hazardous levels for human are necessary. In this investigation, concentration of four heavy metals (zinc [Zn], chromium (Cr), cadmium, [Cd] and lead [Pb]) in three species of most-consumed fishes, water and sediments have been determined. Samples were collected from 10 stations along the Southern coast of Caspian Sea, in spring 2008. Heavy metal concentrations were measured by graphite furnace atomic absorption spectrometry. Then, th...
Rapamycin is an immunosuppressant compound with a broad spectrum of pharmaco-logical activities. ... more Rapamycin is an immunosuppressant compound with a broad spectrum of pharmaco-logical activities. In recent years, it has been used successfully to decrease ischemia-reperfusion injury in several organ systems. The purpose of the present study was to examine the effect of rapamycin on testicular ischemia-reperfusion injury. Seventy-two adult male Wistar rats were divided into six groups: control (group1), sham-operated (Group2), T/D + DMSO as vehicle group (group3), and groups 4-6; respectively received 0.5, 1, and 1.5 mgkgof rapamycin, IP 30 min before detorsion. Ischemia was achieved by twisting the right testis 720° clockwise for 1 hr. The right testis of 6 animals from each group were excised 4 hr after detorsion for the measurement of lipid peroxidation, caspase-3, and antioxidant enzyme activities. Histopathological changes and germ cell apoptosis were determined by measuring mean of seminiferous tubules diameters (MSTD) and TUNEL test in right testis of 6 animals per group, 24...
Environmental pollution is a worldwide problem, heavy metals belonging to the most important poll... more Environmental pollution is a worldwide problem, heavy metals belonging to the most important pollutants. The progress of industries has led to increased emission of pollutants into ecosystems. Southern Caspian Sea coast is one of the most important aquasystems at the eastern south of Caspian Sea, which receives effluents discharges from heavily industrialized and highly populated settlements. Metals tend to accumulate in water and move up through the food chain. So, studies to ascertain the level of heavy metals in environment and determine potentially hazardous levels for human are necessary. In this investigation, concentration of four heavy metals (zinc [Zn], chromium (Cr), cadmium, [Cd] and lead [Pb]) in three species of most-consumed fishes, water and sediments have been determined. Samples were collected from 10 stations along the Southern coast of Caspian Sea, in spring 2008. Heavy metal concentrations were measured by graphite furnace atomic absorption spectrometry. Then, th...
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