Papers by pranit saraswat
Journal of applied pharmaceutical research, Dec 20, 2015
Gastrointestinal diseases refer to ulcerative disorders of the upper gastrointestinal tract. Stom... more Gastrointestinal diseases refer to ulcerative disorders of the upper gastrointestinal tract. Stomach acids and some enzymes can damage the lining of the G.I. tract if natural protective factors are not functioning normally. Causes of gastrointestinal diseases are use of aspirin, alcohol and tobacco, poor diet (too many fried, fatty foods, sugar and refined foods), poor food combining, drinking with meals. Various diagnostic tests that can be performed for gastrointestinal diseases are Colonoscopy, ERCP, Flexible Sigmoidoscopy, Lower GI Series, Liver Biopsy, Upper GI Series, Upper Endoscopy.
Histone Deacetylase (HDAC) inhibitors are an exciting new class of drugs that are targeted as ant... more Histone Deacetylase (HDAC) inhibitors are an exciting new class of drugs that are targeted as anticancer agents. These compounds can induce growth arrest, apoptosis and/ or terminal differentiation in a variety of solid and hematological neoplasms in patients with advanced disease. Accumulation of acetylated histones in both normal and tumour cells can be used as a marker of biological activity. Hydroxamic acid based compounds are among the most promising HDAC inhibitors as potential anti-cancer drugs. There is still much to be understood about the family of HDACs, including the varying functions of different HDACs and the range of HDAC substrates. The development of selective HDAC inhibitors might be important in defining their biological role and potential as therapeutic agents. Clinically, the optimal dose, timing and duration of therapy, as well as the most appropriate agents to combine with HDAC inhibitors, are still to be defined.
The goal of any ideal drug delivery system is to provide a therapeutic amount of drug to the prop... more The goal of any ideal drug delivery system is to provide a therapeutic amount of drug to the proper site in the body to achieve prompt response, and thus maintain the desired drug concentration. Such a conceptualized ideal drug delivery can be possible with intravenous infusion of drug at the site of action over a desired period of time. The aim of this study to different marketed product which is use in various drug delivery systems like Controlled release drug delivery and Transdermal drug delivery, the colon is a site where both local and systemic delivery of drugs can take place. Local delivery allows topical treatment of inflammatory bowel disease. However, treatment can be made effective if the drugs can be targeted directly into the colon, thereby reducing the systemic side effects. Controlled release dosage forms cover a wide range of prolonged action formulations, which provide continuous release of their active ingredients at a predetermined rate and time. The majority of ...
The increasing frequency of drugs which have poor aqueous solubility, manufacturability and stabi... more The increasing frequency of drugs which have poor aqueous solubility, manufacturability and stability in development offers risk of new drug products with low and variable bioavailability particularly for those drugs administrated by the oral route, with consequences for safety and efficacy. Although number of strategies exists for enhancing the bioavailability of these drugs, newer strategies, dependent on the physical and chemical nature of the molecules are being developed. Crystal engineering approach presents a number of routes such as co-crystallization, polymorphism and salt formation to improve physicochemical properties of drugs, which can be implemented through a detailed knowledge of crystallization processes and the molecular properties of drugs. Pharmaceutical co-crystals are emerging as a new class of solid drugs with improved physicochemical properties, which has attracted increased interests from both industrial and academic researchers. In the present review, the co...
Histone Deacetylase (HDAC) inhibitors are an exciting new class of drugs that are targeted as ant... more Histone Deacetylase (HDAC) inhibitors are an exciting new class of drugs that are targeted as anti- cancer agents. These compounds can induce growth arrest, apoptosis and/ or terminal differentiation in a variety of solid and hematological neoplasms in patients with advanced disease. Accumulation of acetylated histones in both normal and tumour cells can be used as a marker of biological activity. Hydroxamic acid based compounds are among the most promising HDAC inhibitors as potential anti-cancer drugs. There is still much to be understood about the family of HDACs, including the varying functions of different HDACs and the range of HDAC substrates. The development of selective HDAC inhibitors might be important in defining their biological role and potential as therapeutic agents. Clinically, the optimal dose, timing and duration of therapy, as well as the most appropriate agents to combine with HDAC inhibitors, are still to be defined.
Gastrointestinal diseases refer to ulcerative disorders of the upper gastrointestinal tract. Stom... more Gastrointestinal diseases refer to ulcerative disorders of the upper gastrointestinal tract. Stomach acids and some enzymes can damage the lining of the G.I. tract if natural protective factors are not functioning normally. Causes of gastrointestinal diseases are use of aspirin, alcohol and tobacco, poor diet (too many fried, fatty foods, sugar and refined foods), poor food combining, drinking with meals. Various diagnostic tests that can be performed for gastrointestinal diseases are Colonoscopy, ERCP, Flexible Sigmoidoscopy, Lower GI Series, Liver Biopsy, Upper GI Series, Upper Endoscopy.
Objective: The objective of this study is to investigate the antiurolithiatic potential of ethano... more Objective: The objective of this study is to investigate the antiurolithiatic potential of ethanolic Dolichos biflorus L. leaf extract in swiss albino mice. Methods: The antiurolithiatic potential of Dolichos biflorus L. ethanolic leaf extract was investigated by using Zinc disc foreign body insertion technique model. Antiurolithiatic activity of the leaves was evaluated on the basis of decrease in the weight of stones. 36 swiss albino mice of either sex weighing between 25-30gm were randomly selected and divided into 6 equal groups. Group-I received Prophylactic control (1% ethylene glycol for 4 weeks), Group-II received Prophylactic treatment (1% ethylene glycol + ethanolic extract of leaves of Dolichos biflorus 400 mg/kg orally for 4 weeks), Group-III received Prophylactic treatment (1% ethylene glycol + ethanolic extract of leaves of Dolichos biflorus 800 mg/ kg orally for 4 weeks), Group IV received Curative control (1% ethylene glycol for 4 weeks followed by water for 4 weeks)...
Piracetam, a derivative of the neurotransmitter gamma-aminobutyric acid (GABA), is responsible fo... more Piracetam, a derivative of the neurotransmitter gamma-aminobutyric acid (GABA), is responsible for the restoration of cell membrane fluidity. Piracetam modifies neurotransmission in a range of transmitter systems (including cholinergic and glutamatergic), has neuroprotective and anticonvulsant properties and improves neuroplasticity. At a vascular level, it appears to reduce erythrocyte adhesion to vascular endothelium, hinder vasospasm and facilitate microcirculation. It is useful in the treatment of cognitive disorders, dementia, vertigo, cortical myoclonus, dyslexia, sickle cell anemia. It improves learning, memory, brain metabolism and capacity. Piracetam acts by protecting the cell against hypoxia. Piracetam is an agent with antithrombotic, neuroprotective and rheological properties. Nowadays, there is increased use of nootropic drugs for the treatment of CNSdisorders.
Uploads
Papers by pranit saraswat