pablo perez

Followers

Following

Co-author

Public Views

Daniel M. Knight

University of St Andrews

Lasantha Meegahapola

RMIT University

Ismael De la Rosa

Universidad Autónoma de Zacatecas

Francisco J. García Tartera

Universidad Complutense de Madrid

Marciano Alves Carneiro

UFF - Universidade Federal Fluminense

Jose A. Aguado

Universidad de Málaga

Manuel Joaquín Morocoima

Universidad de Los Andes (Venezuela)

Héctor Mauricio Martínez Camargo

Universidad Nacional de Colombia (National University of Colombia)

Carmen María Abreu Fernández

Universidade de Vigo

Enrique Rodriguez-Colina

Universidad Autónoma Metropolitana

Interests

Uploads

Papers by pablo perez

Acute Nicotine Administration Increases BOLD fMRI Signal in Brain Regions Involved in Reward Signaling and Compulsive Drug Intake in Rats

The international journal of neuropsychopharmacology / official scientific journal of the Collegium Internationale Neuropsychopharmacologicum (CINP), 2014

Acute nicotine administration potentiates brain reward function and enhances motor and cognitive ... more Acute nicotine administration potentiates brain reward function and enhances motor and cognitive function. These studies investigated which brain areas are being activated by a wide range of doses of nicotine, and if this is diminished by pretreatment with the nonselective nicotinic receptor antagonist mecamylamine. Drug-induced changes in brain activity were assessed by measuring changes in the blood oxygen level dependent (BOLD) signal using an 11.1-Tesla magnetic resonance scanner. In the first experiment, nicotine naïve rats were mildly anesthetized and the effect of nicotine (0.03-0.6mg/kg) on the BOLD signal was investigated for 10min. In the second experiment, the effect of mecamylamine on nicotine-induced brain activity was investigated. A high dose of nicotine increased the BOLD signal in brain areas implicated in reward signaling, such as the nucleus accumbens shell and the prelimbic area. Nicotine also induced a dose-dependent increase in the BOLD signal in the striato-th...

Gene expression of adipose tissue, endothelial cells and platelets in subjects with metabolic syndrome (Review)

Molecular medicine reports, 2012

Metabolic syndrome is a combination of medical disorders including hypertension, dyslipidemia, hy... more Metabolic syndrome is a combination of medical disorders including hypertension, dyslipidemia, hyperglycemia, insulin resistance and increased waist circumference, and is associated with a higher risk of cardiovascular disease. An increase in adipose tissue mass is associated with the augmented secretion of certain adipokines, such as interleukin-6, tumor necrosis factor-α and resistin, which cause endothelial dysfunction (an increase in vasoconstrictor molecules and in the expression of adhesion molecules as well as a decrease of vasodilator molecules, amongst other features) and hemostasis alterations that also favor a prothrombotic state (increased fibrinogen and plasminogen activator inhibitor-1 concentrations and platelet activation/aggregation). This interaction between adipose tissue, endothelial cells and platelets is associated with an increase or decrease in the expression of several transcription factors (peroxisome proliferator-activated receptors, CCAAT-enhancer-binding...

pablo perez

Uploads

Papers by pablo perez

Log In