Wet cupping therapy (WCT) is increasingly practiced worldwide, especially in hospitals of China a... more Wet cupping therapy (WCT) is increasingly practiced worldwide, especially in hospitals of China and Germany. Al-hijamah is WCT of prophetic medicine. Al-hijamah was recently reported to be more effective than Chinese WCT. Al-hijamah filters and clears blood and interstitial fluids from causative pathological substances (CPS) including disease-causing substances (DCS) and disease-related substances (DRS) according to the evidence-based Taibah theory. This occurs via a percutaneous pressure-dependent and size-dependent filtration of capillary blood of skin circulation. This explains why Al-hijamah treats diseases with different pathogeneses e.g. headache and rheumatoid arthritis. Hijamatology is a novel term describing the science of education, qualification, practice and research related to Al-hijamah. Al-hijamah was described by Prophet Mohammad (Muhammad) peace be upon him as one of the best remedies: "The best among what you use in therapy is Al-Hijamah and Al-Qust Al-Bahri (white roots of saussurealappa)". No published research studies are there to guide researchers, physicians and practitioners to the best anatomical sites for practicing Al-hijamah for treating different diseases as this science is still in its beginning and may benefit from future research. Based on our background in prophetic medicine, anatomy, medicine and our practice, we review here prophetic medicine, its remedies, cupping therapy of prophetic medicine (Al-hijamah), indications and anatomical sites that may be suitable for practicing Al-hijamah. Suitable anatomical sites for practicing Al-hijamah differ from disease to disease. In prophetic medicine, Al-hijamah was practiced at skin overlying and near sites of pathology e.g. skin overlying skull vertex, dorsal surface of the foot, thigh region and at general sites e.g. kahel region (mainly skin overlying 7 th cervical vertebra) and akhdayin (both sides of the neck posterior and inferior to ears and close to jugular veins. We report here a novel technique (Salah's technique) for practicing Al-hijamah safely at some special anatomical sites. In conclusion, Al-hijamah is better to be practiced at sites of pathology (for local clearance), at back region and back of neck (for general blood clearance).
Background: Cardiac remodeling is an important issue after surgical closure of ventricular septal... more Background: Cardiac remodeling is an important issue after surgical closure of ventricular septal defect (VSD). Objective: The purpose of the present study was to evaluate cardiac remodeling by echocardiography by measuring the ejection fraction, fractional shortening, left ventricular internal diameter in diastole (LVIDd) and left ventricular internal diameter in systole (LVIDs) after surgical closure of VSD defect in patients less than 1 year. Methodology: This study was conducted in the department of pediatric cardiology, Maternity and Children Hospital (MCH), El Madina El Menwara, Saudi Arebia. Patients were divided into 3 groups according to the age. All patients presented with isolated perimembreanous VSD (PM-VSD) who were surgically treated at the age less than1 year. This study population was divided into 3 groups as group A from (0- 3) months, group B from (3- 6) months and group C from 6 months to 1 year. Echocardiographic variables such as ejection fraction, fractional sh...
Many cases with congenital heart disease are presented by intracardiac thrombosis. Most common si... more Many cases with congenital heart disease are presented by intracardiac thrombosis. Most common site of is the right atrium. Insertion of a venous catheter in the inferior vena cava is one of the risk factor for thrombus in the right atrium. There are many causes that affect the occurrence of intracardiac thrombosis. There are genetic, mechanical or infectious causes. The association between the abnormal development of blood vessel and the thrombus formation was studied. In this article, the prothrombin G20210A mutation is responsible for thrombus.
Background: Studies regarding treatment of acute toxicity with diclofenac (ATD) are quite few. Di... more Background: Studies regarding treatment of acute toxicity with diclofenac (ATD) are quite few. Diclofenac is commonly prescribed in neurology, psychiatry, and general medicine practice. This study investigated possible colon-protective effects exerted by Ajwa date fruit extract (ADFE), a prophetic medicine remedy native to Al-Madinah, Saudi Arabia against ATD. Phytochemicals in ADFE as gallic acid and quercetin have reported protective effects against ATD. Methods: Total phenols and flavonoids in ADFE were estimated as equivalents to gallic acid and quercetin. Four experimental groups were allocated each of six rats: control group, ATD group received a single dose of 150 mg diclofenac intraperitoneally, toxicity prevention group received a single dose of ADFE orally followed 4 hours later by diclofenac injection, and toxicity treatment group received a similar diclofenac dose followed 4 hours later by a single dose of ADFE. Four days later, animals were sacrificed. Histological and biochemical examinations were done. Results: ADFE has a total phenolic content of 331.7 gallic acid equivalent/gram extract and a total flavonoid content of 70.23 quercetin equivalent/gram. ATD significantly increased oxidative stress markers as serum malondialdehyde (MDA) and hydrogen peroxide (H 2 O 2). Serum MDA and H 2 O 2 were significantly scavenged by ADFE. ATD significantly (p<0.001) decreased antioxidant power as serum total antioxidant capacity and catalase activity. That was reversed by ADFE in both prevention and treatment groups. Histologically, ATD caused complete destruction of colonic crypts architecture, patchy loss of the crypts, loss of the surface epithelium, absent goblet cells and submucosal exudate, heavy infiltration of the lamina propria and submucosa with inflammatory cells, mainly lymphocytes and eosinophils. There were mucosal haemorrhages and submucosal dilated congested blood vessels. All that was prevented and treated using ADFE.
Thalassemia is a major health problem in affected children due to iron overload, increased oxidat... more Thalassemia is a major health problem in affected children due to iron overload, increased oxidative stress, atherogenic lipid profile and tissue-damage. This study aims at investigating the cardioprotective and tissue-protective benefits of Al-hijamah and their impact on cell-mediated immunity for treating thalassemic children. This study aimed also at investigating the tissue-clearance principle of Taibah mechanism: whenever pathological substances are to be cleared from the human body, Al-hijamah is indicated. Al-hijamah was done to thalassemic children (15 males and 5 females having a mean age of 9.07 ± 4.26 years) using sterile disposable sets in a complete aseptic hospital environment. Prior ethical committee agreement (in addition to written patient's consents) was obtained from Tanta Faculty of Medicine, Egypt. Twenty thalassemic children received iron chelation therapy plus Al-hijamah for one session (30-60 minutes) versus an age and sex-matched thalassemic control grou...
Zamzam water is the most frequently used drinking water by millions of people in Saudi Arabia. It... more Zamzam water is the most frequently used drinking water by millions of people in Saudi Arabia. It is carried all the time by millions of pilgrims to their home countries as gifts to close and near relatives and friends. Safety of constituents of Zamzam water is a vital health topic. British Broadcasting Corporation (BBC) raised many health concerns regarding the high serum arsenic and nitrate contents in Zamzam water that may cause cancer. It is role of scientific research to present scientific facts to relieve such concerns. Arsenic is a carcinogen while nitrate causes methemogloinemia that affect oxygen carriage by haemoglobin. An ethical committee approval was obtained. Eighteen white albino mice (40-45 g) were used in this study. Three experimental groups were allocated (six mice per group): tap water group, distilled water group and Zamzam water group. Our data revealed that Zamzam water exerts tissue-protective effects that contradict malignancy. Our data proved that Zamzam wa...
Beta-ketothiolase deficiency (BKTD) is an inborn error of ketone bodies and isoleucine metabolism... more Beta-ketothiolase deficiency (BKTD) is an inborn error of ketone bodies and isoleucine metabolism. Patients with BKTD manifest during late infancy and early childhood with recurrent episodes of ketoacidosis (accumulated acetoacetate and β-hydroxybutyrate) that may be refractory to treatment and life-threatening. BKTD is exaggerated by fasting, starvation and catabolic conditions. Dichloroacetate (DCA) is a safe effective treatment for both lactic acidosis and non-Hodgkin’s lymphoma. DCA is non-toxic and non-carcinogenic at therapeutic doses. DCA toxic doses are hundred times (12- gram/l) more than the therapeutic doses. In experimental models of ketosis, DCA reduces ketonemia and ketonuria while significantly lowering blood glucose. Importantly, DCA was reported to divert pyruvate (amino group acceptor to form alanine in transamination reactions to regenerate α-ketoglutarate from glutamate) to oxidative pathways to form acetyl CoA that is oxidized in Krebs cycle. That inhibits first...
Public prophylaxis to decrease the emergence of new daily COVID-19 cases is vital. Adjuvant TaibU... more Public prophylaxis to decrease the emergence of new daily COVID-19 cases is vital. Adjuvant TaibUVID nutritional supplements are promising home-made or hospital-made supplements suggested for rapidly preventing and treating COVID-19 pandemic. We report here a 44 years old male physician who caught COVID-19 infection at hospital in Egypt with confirmed positive nasopharyngeal swab PCR. Ethical committee approval and informed patient's consent were gained before performing this study. Chest X-ray revealed increased bronchovascular markings. Close follow-up was done with no treatment given and he was sent for home isolation. Few days later, he developed progressive non-productive cough and a sense of difficult breathing with no associated fever or chest pain. An antitussive drug was given to him. The patient read about TaibUVID supplements from social media and started to feel improvement after TaibUVID inhalation therapy (using the heated solution of nigella sativa and chamomile f...
With the continuously expanding terrible pandemic of COVID-19 infection, globally increasing numb... more With the continuously expanding terrible pandemic of COVID-19 infection, globally increasing numbers of COVID-19 patients and contacts progressively jump to heavy burdens beyond capabilities. Developing and poor countries may face humanity disasters in the next few days unless urgent measures are rapidly performed. Standard anti-COVID-19 treatment should inhibit COVID-19 replication, repair virus-induced tissue damage and enhance patients' immunity. Unfortunately, such criteria are still lacking in current treatments resulting in relatively high viral infectivity, morbidity and mortality. Based on previous prophetic medicine research experience and the modern literature, we introduce TaibUVID therapy as a novel evidence-based medicinal nutritional treatment for eradicating COVID-19 pandemic. TaibUVID stands for Taibah University anti-COVID-19 treatment as a novel evidence-based approach (using natural products) for treating COVID-19 patients. A single TaibUVID dose includes: 1 s...
Sex hormones might be viewed as biomarkers for cardiovascular health status, as well as protectiv... more Sex hormones might be viewed as biomarkers for cardiovascular health status, as well as protective agents against heart diseases. Coronary artery disease (CAD) is the most common disease in humans and has a complex etiology. In this study, we aimed to investigate the association of CAD with ESR1 PvuII and XbaI gene mutation frequencies and to see if it's important as a genetic risk factor and the susceptibility for CAD in Tanta region, Egypt. By polymerase chain reaction with restriction fragment length polymorphism (PCR- RFLP), we determined the frequency of the ESR1 gene polymorphisms in 110 healthy and 100 CAD sample. Results revealed that there were no significant differences between CAD patients and the control group as regard the frequency AA, AG and GG of XbaI genotype. PvuII genotype frequencies were TT, TC and CC with no significant value. Regarding allele frequencies of PvuII and XbaI polymorphism, they were not statistically important. There was no significant differe...
Adjuvant nutritional treatment is a commonly overlooked topic when treating lethal viral diseases... more Adjuvant nutritional treatment is a commonly overlooked topic when treating lethal viral diseases as COVID-19 pandemic. We recently introduced TaibUVID nutritional supplements (nigella sativa, chamomile and natural honey) as adjuvants for COVID-19 contacts, patients and public prophylaxis. TaibUVID Forte adds costus, senna and fennel to TaibUVID. Meta-analyses and systematic reviews confirmed evidence-based therapeutic benefits of TaibUVID components in treating many human diseases e.g. diabetes mellitus and hypertension, common co-morbidities in COVID-19 patients. Double-blind clinical trials for treating COVID-19 patients with TaibUVID supplements were inapplicable. In this retrospective study in Egypt, COVID-19 patients and contacts knew TaibUVID via social media and voluntarily used them. 65% of COVID-19 patients (n = 13) received both pharmacological treatments and adjuvant TaibUVID nutritional supplements. 35% (n = 7) received TaibUVID only. Lymphopenia rapidly improved to lym...
Gliomas and glioblastomas are space-occupying brain tumors with variable aggressive behaviour. Gl... more Gliomas and glioblastomas are space-occupying brain tumors with variable aggressive behaviour. Glioblastomas are the most lethal brain tumors and are not responsive to current chemotherapy and radiotherapy. To date, no satisfactory curative treatment exists. 3-bromopyruvate (3BP) is a promising chemotherapeutic that proved effective in treating gliomas and other malignancies in so many reported studies. 3BP is both an alkylating agent and antimetabolite (pharmacological antagonist of lactate, the Warburg effect). Our previous publications proved effectiveness of 3BP in treating glioma cell lines (2D models) and early glioma spheroids (3D models) where 3BP was added early after culturing glioma cells. No report is there regarding treating well-established glioma spheroids (well-established avascular 3D tumor models) using 3BP that we report here. In this study, our data revealed that 3BP effectively and maximally killed cultured glioma cells causing cellular fragmentation that correl...
Assessing nutritional status using body mass index (BMI) measurements and body compositions evalu... more Assessing nutritional status using body mass index (BMI) measurements and body compositions evaluation could be simple clinical reliable tools and indicators of adolescent health. On the other hand, hypertension becomes a serious public health problem affecting both children and adolescents. This study aimed at evaluating the association of body composition alterations and development of blood pressure changes among adolescents in Taif governorate, Saudi Arabia. A cross sectional survey design was adopted in which 701 children (aged 12-15) years in Taif city were drawn and randomly selected from the preparatory schools. Measurement of systolic/diastolic blood pressure and comprehensive assessment of anthropometric parameters were done for all participants including weight, height, waist and hip circumferences in addition to triceps, biceps, subscapular and supra-iliac skinfold thickness. Body mass index (BMI), percentage body fat, waist: hip, total body fat and lean body mass were a...
Dichloroacetate (DCA) is an acetate analog that was reported to improve the hemodynamic functions... more Dichloroacetate (DCA) is an acetate analog that was reported to improve the hemodynamic functions and mechanical efficiency in patients with congestive heart failure. DCA is also known for decades as an activator of pyruvate dehydrogenase (stimulates oxidation of pyruvate to acetyl CoA). This prevents lactate accumulation (stimulating conversion of lactate to form pyruvate then acetyl CoA). Currently, DCA is an effective and safe drug for treating lactic acidosis, a clinical condition due to the accumulation of hydrogen (H+) ions from lactic acid, characterized by blood lactate levels > 5 mM and arterial pH < 7.25. Interestingly, DCA was reported to cause a significant decrease in serum lactate that was accompanied by an increase in arterial blood pH. Moreover, DCA decreases blood lactate levels under various conditions in both man and laboratory animals via diverting pyruvate metabolism (source of lactate) towards oxidation through activating the target enzyme pyruvate dehydr...
Background: Thalassemia is a major health problem due to iron overload, iron deposition and oxida... more Background: Thalassemia is a major health problem due to iron overload, iron deposition and oxidative stress-induced tissue damage. Here, we introduce Al-hijamah (a minor surgical excretory procedure) as a novel percutaneous iron excretion therapy. Al-hijamah is a wet cupping therapy of prophetic medicine, and prophet Muhammad, peace be upon him, strongly recommended Al-hijamah, saying: "The best of your treatment is Al-hijamah". Aim of the study: Our study aimed at investigating the safety, iron chelation, pharmacological potentiation and oxidant clearance effects exerted by Al-hijamah to thalassemic children. Patients and methods: Ethical committee's approval and patients' written agreement consents were obtained. We treated 20 thalassemic children (15 males and five females aged 9.07±4.26 years) with iron chelation therapy (ICT) plus Al-hijamah (using sterile disposable sets and in a complete aseptic environment) vs a control group treated with ICT only. This clinical trial was registered in the ClinicalTrial.gov registry under the name "Study of the Therapeutic Benefits of Al-hijamah in Children with Beta Thalassemia Major" (identifier no NCT 02761395) on 30 January 2016. Results: Al-hijamah was quite simple, safe, effective, tolerable (with no side effects) and time-saving procedure (30-60 minutes). A single session of Al-hijamah significantly reduced iron overload (P<0.001) in all thalassemic children. Al-hijamah significantly decreased serum ferritin by 25.22% (from 3,778.350±551.633 ng/mL to 2,825.300±558.94 ng/mL), significantly decreased oxidative stress by 68.69% (P<0.05; serum malondialdehyde dropped from 42.155±12.42 to 13.195±0.68 nmol/L), exerted pharmacological potentiation to ICT and significantly increased total antioxidant capacity (P<0.001) by 260.95% (from 13.195±0.68 nmol/L to 42.86±12.40 nmol/L through excreting reactive oxygen species). Moreover, therapeutic indices for evaluating Al-hijamah were promising. Conclusion: Al-hijamah is a novel, safe, effective percutaneous iron excretion therapy through percutaneous iron excretion with minimal blood loss in agreement with the evidence-based Taibah mechanism. Al-hijamah is an effective outpatient hematological procedure that is safer than many pediatric procedures such as catheterization, hemofiltration and dialysis. Increasing the number of cups during Al-hijamah session or the number of sessions reduces iron overload more strongly. Medical practice of Al-hijamah is strongly recommended in hospitals.
Nigella sativa improves anemia, enhances immunity and relieves iron overload-induced oxidative st... more Nigella sativa improves anemia, enhances immunity and relieves iron overload-induced oxidative stress as a novel promising treatment in children having beta-thalassemia major
This virus was transmitted to human through infected fruit bats, monkeys, apes, and pigs. Animals... more This virus was transmitted to human through infected fruit bats, monkeys, apes, and pigs. Animals got the infection mostly through contact with bat saliva or feces. [1-4] Due to urgency, the WHO allowed the use of experimental treatments. [5] This review aims to elucidate the health efforts exerted to combat Ebola virus and update the diagnostic and treatment lines to fight this lethal health problem. In this article, we review the
Autoimmune diseases have common properties characterized by abnormal blood chemistry with high se... more Autoimmune diseases have common properties characterized by abnormal blood chemistry with high serum autoimmune antibodies, and inflammatory mediators. Those causative pathological substances (CPS) cannot be excreted by physiological mechanisms. Current treatments for autoimmune diseases involve steroids, cytotoxic drugs, plasmapheresis and monoclonal antibodies. Wet cupping therapy (WCT) of prophetic medicine is called Al-hijamah that treats numerous diseases having different etiology and pathogenesis via a pressure-dependent and size-dependent non-specific filtration then excretion of CPS causing clearance of blood and interstitial fluids. Al-hijamah clears blood passing through the fenestrated skin capillaries. Medical bases of Al-hijamah were reported in the evidence-based Taibah mechanism (Taibah theory). Al-hijamah was reported to be an excellent treatment for rheumatoid arthritis that improved patients' blood chemistry and induced significant clinical improvement and pharmacological potentiation. Al-hijamah improved the natural immunity and suppressed the pathological immunity through decreasing the serum level of autoantibodies, inflammatory mediators, and serum ferritin (a key player in autoimmunity). Al-hijamah reduced significantly pain severity, number of swollen joints and disease activity with no significant side effects. Main steps of Al-hijamah are skin suction (cupping), scarification (sharatmihjam in Arabic) and second suction (triple S technique) that is better therapeutically than the traditional WCT (double S technique). Whenever an excess noxious substance is to be removed from patients' blood and interstitial fluids, Al-hijamah is indicated.Shartatmihjam is a curative treatment in prophetic teachings according to the prophetic hadeeth: "Cure is in three: in shartatmihjam, oral honey and cauterization. I do not recommend my nation to cauterize".Al-hijamah may have better therapeutic benefits than plasmapheresis. Al-hijamah may be promising in treating autoimmune diseases as a sole treatment or adjuvant treatment.
Wet cupping therapy (WCT) is increasingly practiced worldwide, especially in hospitals of China a... more Wet cupping therapy (WCT) is increasingly practiced worldwide, especially in hospitals of China and Germany. Al-hijamah is WCT of prophetic medicine. Al-hijamah was recently reported to be more effective than Chinese WCT. Al-hijamah filters and clears blood and interstitial fluids from causative pathological substances (CPS) including disease-causing substances (DCS) and disease-related substances (DRS) according to the evidence-based Taibah theory. This occurs via a percutaneous pressure-dependent and size-dependent filtration of capillary blood of skin circulation. This explains why Al-hijamah treats diseases with different pathogeneses e.g. headache and rheumatoid arthritis. Hijamatology is a novel term describing the science of education, qualification, practice and research related to Al-hijamah. Al-hijamah was described by Prophet Mohammad (Muhammad) peace be upon him as one of the best remedies: "The best among what you use in therapy is Al-Hijamah and Al-Qust Al-Bahri (white roots of saussurealappa)". No published research studies are there to guide researchers, physicians and practitioners to the best anatomical sites for practicing Al-hijamah for treating different diseases as this science is still in its beginning and may benefit from future research. Based on our background in prophetic medicine, anatomy, medicine and our practice, we review here prophetic medicine, its remedies, cupping therapy of prophetic medicine (Al-hijamah), indications and anatomical sites that may be suitable for practicing Al-hijamah. Suitable anatomical sites for practicing Al-hijamah differ from disease to disease. In prophetic medicine, Al-hijamah was practiced at skin overlying and near sites of pathology e.g. skin overlying skull vertex, dorsal surface of the foot, thigh region and at general sites e.g. kahel region (mainly skin overlying 7 th cervical vertebra) and akhdayin (both sides of the neck posterior and inferior to ears and close to jugular veins. We report here a novel technique (Salah's technique) for practicing Al-hijamah safely at some special anatomical sites. In conclusion, Al-hijamah is better to be practiced at sites of pathology (for local clearance), at back region and back of neck (for general blood clearance).
Background: Cardiac remodeling is an important issue after surgical closure of ventricular septal... more Background: Cardiac remodeling is an important issue after surgical closure of ventricular septal defect (VSD). Objective: The purpose of the present study was to evaluate cardiac remodeling by echocardiography by measuring the ejection fraction, fractional shortening, left ventricular internal diameter in diastole (LVIDd) and left ventricular internal diameter in systole (LVIDs) after surgical closure of VSD defect in patients less than 1 year. Methodology: This study was conducted in the department of pediatric cardiology, Maternity and Children Hospital (MCH), El Madina El Menwara, Saudi Arebia. Patients were divided into 3 groups according to the age. All patients presented with isolated perimembreanous VSD (PM-VSD) who were surgically treated at the age less than1 year. This study population was divided into 3 groups as group A from (0- 3) months, group B from (3- 6) months and group C from 6 months to 1 year. Echocardiographic variables such as ejection fraction, fractional sh...
Many cases with congenital heart disease are presented by intracardiac thrombosis. Most common si... more Many cases with congenital heart disease are presented by intracardiac thrombosis. Most common site of is the right atrium. Insertion of a venous catheter in the inferior vena cava is one of the risk factor for thrombus in the right atrium. There are many causes that affect the occurrence of intracardiac thrombosis. There are genetic, mechanical or infectious causes. The association between the abnormal development of blood vessel and the thrombus formation was studied. In this article, the prothrombin G20210A mutation is responsible for thrombus.
Background: Studies regarding treatment of acute toxicity with diclofenac (ATD) are quite few. Di... more Background: Studies regarding treatment of acute toxicity with diclofenac (ATD) are quite few. Diclofenac is commonly prescribed in neurology, psychiatry, and general medicine practice. This study investigated possible colon-protective effects exerted by Ajwa date fruit extract (ADFE), a prophetic medicine remedy native to Al-Madinah, Saudi Arabia against ATD. Phytochemicals in ADFE as gallic acid and quercetin have reported protective effects against ATD. Methods: Total phenols and flavonoids in ADFE were estimated as equivalents to gallic acid and quercetin. Four experimental groups were allocated each of six rats: control group, ATD group received a single dose of 150 mg diclofenac intraperitoneally, toxicity prevention group received a single dose of ADFE orally followed 4 hours later by diclofenac injection, and toxicity treatment group received a similar diclofenac dose followed 4 hours later by a single dose of ADFE. Four days later, animals were sacrificed. Histological and biochemical examinations were done. Results: ADFE has a total phenolic content of 331.7 gallic acid equivalent/gram extract and a total flavonoid content of 70.23 quercetin equivalent/gram. ATD significantly increased oxidative stress markers as serum malondialdehyde (MDA) and hydrogen peroxide (H 2 O 2). Serum MDA and H 2 O 2 were significantly scavenged by ADFE. ATD significantly (p<0.001) decreased antioxidant power as serum total antioxidant capacity and catalase activity. That was reversed by ADFE in both prevention and treatment groups. Histologically, ATD caused complete destruction of colonic crypts architecture, patchy loss of the crypts, loss of the surface epithelium, absent goblet cells and submucosal exudate, heavy infiltration of the lamina propria and submucosa with inflammatory cells, mainly lymphocytes and eosinophils. There were mucosal haemorrhages and submucosal dilated congested blood vessels. All that was prevented and treated using ADFE.
Thalassemia is a major health problem in affected children due to iron overload, increased oxidat... more Thalassemia is a major health problem in affected children due to iron overload, increased oxidative stress, atherogenic lipid profile and tissue-damage. This study aims at investigating the cardioprotective and tissue-protective benefits of Al-hijamah and their impact on cell-mediated immunity for treating thalassemic children. This study aimed also at investigating the tissue-clearance principle of Taibah mechanism: whenever pathological substances are to be cleared from the human body, Al-hijamah is indicated. Al-hijamah was done to thalassemic children (15 males and 5 females having a mean age of 9.07 ± 4.26 years) using sterile disposable sets in a complete aseptic hospital environment. Prior ethical committee agreement (in addition to written patient's consents) was obtained from Tanta Faculty of Medicine, Egypt. Twenty thalassemic children received iron chelation therapy plus Al-hijamah for one session (30-60 minutes) versus an age and sex-matched thalassemic control grou...
Zamzam water is the most frequently used drinking water by millions of people in Saudi Arabia. It... more Zamzam water is the most frequently used drinking water by millions of people in Saudi Arabia. It is carried all the time by millions of pilgrims to their home countries as gifts to close and near relatives and friends. Safety of constituents of Zamzam water is a vital health topic. British Broadcasting Corporation (BBC) raised many health concerns regarding the high serum arsenic and nitrate contents in Zamzam water that may cause cancer. It is role of scientific research to present scientific facts to relieve such concerns. Arsenic is a carcinogen while nitrate causes methemogloinemia that affect oxygen carriage by haemoglobin. An ethical committee approval was obtained. Eighteen white albino mice (40-45 g) were used in this study. Three experimental groups were allocated (six mice per group): tap water group, distilled water group and Zamzam water group. Our data revealed that Zamzam water exerts tissue-protective effects that contradict malignancy. Our data proved that Zamzam wa...
Beta-ketothiolase deficiency (BKTD) is an inborn error of ketone bodies and isoleucine metabolism... more Beta-ketothiolase deficiency (BKTD) is an inborn error of ketone bodies and isoleucine metabolism. Patients with BKTD manifest during late infancy and early childhood with recurrent episodes of ketoacidosis (accumulated acetoacetate and β-hydroxybutyrate) that may be refractory to treatment and life-threatening. BKTD is exaggerated by fasting, starvation and catabolic conditions. Dichloroacetate (DCA) is a safe effective treatment for both lactic acidosis and non-Hodgkin’s lymphoma. DCA is non-toxic and non-carcinogenic at therapeutic doses. DCA toxic doses are hundred times (12- gram/l) more than the therapeutic doses. In experimental models of ketosis, DCA reduces ketonemia and ketonuria while significantly lowering blood glucose. Importantly, DCA was reported to divert pyruvate (amino group acceptor to form alanine in transamination reactions to regenerate α-ketoglutarate from glutamate) to oxidative pathways to form acetyl CoA that is oxidized in Krebs cycle. That inhibits first...
Public prophylaxis to decrease the emergence of new daily COVID-19 cases is vital. Adjuvant TaibU... more Public prophylaxis to decrease the emergence of new daily COVID-19 cases is vital. Adjuvant TaibUVID nutritional supplements are promising home-made or hospital-made supplements suggested for rapidly preventing and treating COVID-19 pandemic. We report here a 44 years old male physician who caught COVID-19 infection at hospital in Egypt with confirmed positive nasopharyngeal swab PCR. Ethical committee approval and informed patient's consent were gained before performing this study. Chest X-ray revealed increased bronchovascular markings. Close follow-up was done with no treatment given and he was sent for home isolation. Few days later, he developed progressive non-productive cough and a sense of difficult breathing with no associated fever or chest pain. An antitussive drug was given to him. The patient read about TaibUVID supplements from social media and started to feel improvement after TaibUVID inhalation therapy (using the heated solution of nigella sativa and chamomile f...
With the continuously expanding terrible pandemic of COVID-19 infection, globally increasing numb... more With the continuously expanding terrible pandemic of COVID-19 infection, globally increasing numbers of COVID-19 patients and contacts progressively jump to heavy burdens beyond capabilities. Developing and poor countries may face humanity disasters in the next few days unless urgent measures are rapidly performed. Standard anti-COVID-19 treatment should inhibit COVID-19 replication, repair virus-induced tissue damage and enhance patients' immunity. Unfortunately, such criteria are still lacking in current treatments resulting in relatively high viral infectivity, morbidity and mortality. Based on previous prophetic medicine research experience and the modern literature, we introduce TaibUVID therapy as a novel evidence-based medicinal nutritional treatment for eradicating COVID-19 pandemic. TaibUVID stands for Taibah University anti-COVID-19 treatment as a novel evidence-based approach (using natural products) for treating COVID-19 patients. A single TaibUVID dose includes: 1 s...
Sex hormones might be viewed as biomarkers for cardiovascular health status, as well as protectiv... more Sex hormones might be viewed as biomarkers for cardiovascular health status, as well as protective agents against heart diseases. Coronary artery disease (CAD) is the most common disease in humans and has a complex etiology. In this study, we aimed to investigate the association of CAD with ESR1 PvuII and XbaI gene mutation frequencies and to see if it's important as a genetic risk factor and the susceptibility for CAD in Tanta region, Egypt. By polymerase chain reaction with restriction fragment length polymorphism (PCR- RFLP), we determined the frequency of the ESR1 gene polymorphisms in 110 healthy and 100 CAD sample. Results revealed that there were no significant differences between CAD patients and the control group as regard the frequency AA, AG and GG of XbaI genotype. PvuII genotype frequencies were TT, TC and CC with no significant value. Regarding allele frequencies of PvuII and XbaI polymorphism, they were not statistically important. There was no significant differe...
Adjuvant nutritional treatment is a commonly overlooked topic when treating lethal viral diseases... more Adjuvant nutritional treatment is a commonly overlooked topic when treating lethal viral diseases as COVID-19 pandemic. We recently introduced TaibUVID nutritional supplements (nigella sativa, chamomile and natural honey) as adjuvants for COVID-19 contacts, patients and public prophylaxis. TaibUVID Forte adds costus, senna and fennel to TaibUVID. Meta-analyses and systematic reviews confirmed evidence-based therapeutic benefits of TaibUVID components in treating many human diseases e.g. diabetes mellitus and hypertension, common co-morbidities in COVID-19 patients. Double-blind clinical trials for treating COVID-19 patients with TaibUVID supplements were inapplicable. In this retrospective study in Egypt, COVID-19 patients and contacts knew TaibUVID via social media and voluntarily used them. 65% of COVID-19 patients (n = 13) received both pharmacological treatments and adjuvant TaibUVID nutritional supplements. 35% (n = 7) received TaibUVID only. Lymphopenia rapidly improved to lym...
Gliomas and glioblastomas are space-occupying brain tumors with variable aggressive behaviour. Gl... more Gliomas and glioblastomas are space-occupying brain tumors with variable aggressive behaviour. Glioblastomas are the most lethal brain tumors and are not responsive to current chemotherapy and radiotherapy. To date, no satisfactory curative treatment exists. 3-bromopyruvate (3BP) is a promising chemotherapeutic that proved effective in treating gliomas and other malignancies in so many reported studies. 3BP is both an alkylating agent and antimetabolite (pharmacological antagonist of lactate, the Warburg effect). Our previous publications proved effectiveness of 3BP in treating glioma cell lines (2D models) and early glioma spheroids (3D models) where 3BP was added early after culturing glioma cells. No report is there regarding treating well-established glioma spheroids (well-established avascular 3D tumor models) using 3BP that we report here. In this study, our data revealed that 3BP effectively and maximally killed cultured glioma cells causing cellular fragmentation that correl...
Assessing nutritional status using body mass index (BMI) measurements and body compositions evalu... more Assessing nutritional status using body mass index (BMI) measurements and body compositions evaluation could be simple clinical reliable tools and indicators of adolescent health. On the other hand, hypertension becomes a serious public health problem affecting both children and adolescents. This study aimed at evaluating the association of body composition alterations and development of blood pressure changes among adolescents in Taif governorate, Saudi Arabia. A cross sectional survey design was adopted in which 701 children (aged 12-15) years in Taif city were drawn and randomly selected from the preparatory schools. Measurement of systolic/diastolic blood pressure and comprehensive assessment of anthropometric parameters were done for all participants including weight, height, waist and hip circumferences in addition to triceps, biceps, subscapular and supra-iliac skinfold thickness. Body mass index (BMI), percentage body fat, waist: hip, total body fat and lean body mass were a...
Dichloroacetate (DCA) is an acetate analog that was reported to improve the hemodynamic functions... more Dichloroacetate (DCA) is an acetate analog that was reported to improve the hemodynamic functions and mechanical efficiency in patients with congestive heart failure. DCA is also known for decades as an activator of pyruvate dehydrogenase (stimulates oxidation of pyruvate to acetyl CoA). This prevents lactate accumulation (stimulating conversion of lactate to form pyruvate then acetyl CoA). Currently, DCA is an effective and safe drug for treating lactic acidosis, a clinical condition due to the accumulation of hydrogen (H+) ions from lactic acid, characterized by blood lactate levels > 5 mM and arterial pH < 7.25. Interestingly, DCA was reported to cause a significant decrease in serum lactate that was accompanied by an increase in arterial blood pH. Moreover, DCA decreases blood lactate levels under various conditions in both man and laboratory animals via diverting pyruvate metabolism (source of lactate) towards oxidation through activating the target enzyme pyruvate dehydr...
Background: Thalassemia is a major health problem due to iron overload, iron deposition and oxida... more Background: Thalassemia is a major health problem due to iron overload, iron deposition and oxidative stress-induced tissue damage. Here, we introduce Al-hijamah (a minor surgical excretory procedure) as a novel percutaneous iron excretion therapy. Al-hijamah is a wet cupping therapy of prophetic medicine, and prophet Muhammad, peace be upon him, strongly recommended Al-hijamah, saying: "The best of your treatment is Al-hijamah". Aim of the study: Our study aimed at investigating the safety, iron chelation, pharmacological potentiation and oxidant clearance effects exerted by Al-hijamah to thalassemic children. Patients and methods: Ethical committee's approval and patients' written agreement consents were obtained. We treated 20 thalassemic children (15 males and five females aged 9.07±4.26 years) with iron chelation therapy (ICT) plus Al-hijamah (using sterile disposable sets and in a complete aseptic environment) vs a control group treated with ICT only. This clinical trial was registered in the ClinicalTrial.gov registry under the name "Study of the Therapeutic Benefits of Al-hijamah in Children with Beta Thalassemia Major" (identifier no NCT 02761395) on 30 January 2016. Results: Al-hijamah was quite simple, safe, effective, tolerable (with no side effects) and time-saving procedure (30-60 minutes). A single session of Al-hijamah significantly reduced iron overload (P<0.001) in all thalassemic children. Al-hijamah significantly decreased serum ferritin by 25.22% (from 3,778.350±551.633 ng/mL to 2,825.300±558.94 ng/mL), significantly decreased oxidative stress by 68.69% (P<0.05; serum malondialdehyde dropped from 42.155±12.42 to 13.195±0.68 nmol/L), exerted pharmacological potentiation to ICT and significantly increased total antioxidant capacity (P<0.001) by 260.95% (from 13.195±0.68 nmol/L to 42.86±12.40 nmol/L through excreting reactive oxygen species). Moreover, therapeutic indices for evaluating Al-hijamah were promising. Conclusion: Al-hijamah is a novel, safe, effective percutaneous iron excretion therapy through percutaneous iron excretion with minimal blood loss in agreement with the evidence-based Taibah mechanism. Al-hijamah is an effective outpatient hematological procedure that is safer than many pediatric procedures such as catheterization, hemofiltration and dialysis. Increasing the number of cups during Al-hijamah session or the number of sessions reduces iron overload more strongly. Medical practice of Al-hijamah is strongly recommended in hospitals.
Nigella sativa improves anemia, enhances immunity and relieves iron overload-induced oxidative st... more Nigella sativa improves anemia, enhances immunity and relieves iron overload-induced oxidative stress as a novel promising treatment in children having beta-thalassemia major
This virus was transmitted to human through infected fruit bats, monkeys, apes, and pigs. Animals... more This virus was transmitted to human through infected fruit bats, monkeys, apes, and pigs. Animals got the infection mostly through contact with bat saliva or feces. [1-4] Due to urgency, the WHO allowed the use of experimental treatments. [5] This review aims to elucidate the health efforts exerted to combat Ebola virus and update the diagnostic and treatment lines to fight this lethal health problem. In this article, we review the
Autoimmune diseases have common properties characterized by abnormal blood chemistry with high se... more Autoimmune diseases have common properties characterized by abnormal blood chemistry with high serum autoimmune antibodies, and inflammatory mediators. Those causative pathological substances (CPS) cannot be excreted by physiological mechanisms. Current treatments for autoimmune diseases involve steroids, cytotoxic drugs, plasmapheresis and monoclonal antibodies. Wet cupping therapy (WCT) of prophetic medicine is called Al-hijamah that treats numerous diseases having different etiology and pathogenesis via a pressure-dependent and size-dependent non-specific filtration then excretion of CPS causing clearance of blood and interstitial fluids. Al-hijamah clears blood passing through the fenestrated skin capillaries. Medical bases of Al-hijamah were reported in the evidence-based Taibah mechanism (Taibah theory). Al-hijamah was reported to be an excellent treatment for rheumatoid arthritis that improved patients' blood chemistry and induced significant clinical improvement and pharmacological potentiation. Al-hijamah improved the natural immunity and suppressed the pathological immunity through decreasing the serum level of autoantibodies, inflammatory mediators, and serum ferritin (a key player in autoimmunity). Al-hijamah reduced significantly pain severity, number of swollen joints and disease activity with no significant side effects. Main steps of Al-hijamah are skin suction (cupping), scarification (sharatmihjam in Arabic) and second suction (triple S technique) that is better therapeutically than the traditional WCT (double S technique). Whenever an excess noxious substance is to be removed from patients' blood and interstitial fluids, Al-hijamah is indicated.Shartatmihjam is a curative treatment in prophetic teachings according to the prophetic hadeeth: "Cure is in three: in shartatmihjam, oral honey and cauterization. I do not recommend my nation to cauterize".Al-hijamah may have better therapeutic benefits than plasmapheresis. Al-hijamah may be promising in treating autoimmune diseases as a sole treatment or adjuvant treatment.
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