In this paper, a series of semi-interpenetrating polymer network (semi-IPN) hydrogels based on po... more In this paper, a series of semi-interpenetrating polymer network (semi-IPN) hydrogels based on poly((2-dimethylamino)ethyl methacrylate)/poly (N,N-diethylacrylamide) (PDMAEMA/PDEA) were synthesized by changing the initial PDMAEMA/DEA molar ratio at room temperature. The influence of this additive on the property of resulting PDEA hydrogels was investigated and characterized. The interior morphology by scanning electron microscopy (SEM) revealed that the semi-IPN hydrogels have interconnected porous network structures. The glass transition temperature (T g) of the semi-IPN hydrogels was observed by differential scanning calorimetry (DSC). Equilibrium swelling ratio (ESR), swelling and deswelling dynamics of the hydrogels responding to temperature and pH were investigated in detail. Compared to PDEA, the semi-IPN hydrogels exhibited excellent mutative values in response to an alternation of the temperature and pH, and showed fast swelling and deswelling rates in response to temperature and pH change. The release behaviors of the model drug, aminophylline, were found dependent on hydrogel compositions and environmental temperature. These results suggest that the stimuli semi-IPN hydrogel have potential application as intelligent drug carriers.
Mutation Research-fundamental and Molecular Mechanisms of Mutagenesis, 1997
Effects or citrus fruits on the mutagenic_ Ity of I-methyl-l,2,3.4-tetrahydro-ll-carbollne-3_ ,ca... more Effects or citrus fruits on the mutagenic_ Ity of I-methyl-l,2,3.4-tetrahydro-ll-carbollne-3_ ,carboxylic acid treated with nitrite In the presence of ethanol Keyword(s): Citrus fruits; Nitrite treatment; Antimutagenicity It has been shown that the mutagenicity of l-methyl-I,2,3,4-tetrahyd* carboline-3-carboxylic acid (MTCCA), a mutagen precursor in soy sauce treated with nitrite, was strongly increased when it was treated with nitrite in the presence of alcohols. We found that the mutagenicity of MTCCA treated with 50 mM nitrite at pH 3, 37"C for 60 min in the presence of 7.5% ethanol was reduced by the addition of citrus fruits such as sudachi (Citrus sudachi), lemon (c. limon) and yuzu (c. junos) to the reaction mixture. The mutagenicity-reducing activity per weight of flavedo of the citrus fruits was considerably higher than that of their juices. The jUices of other oranges commercially available in Japan also had mutagenicity_ reducing activity against the nitrite-treated MTCCA. Among the components in the juice and the flavedo of their citrus fruits, lignin, d-limonene, quercetin, naringin, hesperidin, ascorbic acid, pectin and citric acid showed antimuta_ genic activity in the reaction mixture, suggesting that the mixed fractions of these compounds reduce the production of mutagens in the reaction mixture containing nitrite and ethanol. CItruses sudachi and lemon strongly redUced the mutagenicity of MTCCA treated with nitrite both in the absence and presence ofethanol. In addition, their citrus samples considerably reduced the mutagenicity of nitrite-treated soy sauce in the presence of ethanol. However, the mutagenicity of nitrite-treated tyramine, another mutagen precursor in soy sauce, both in the presence and absence of ethanol was not reduced by the addition of their Citrus samples.
Dalam Arsitektur, Romantik sering dianggap sebagai gaya nostalgia pada masa lampau, contohnya gay... more Dalam Arsitektur, Romantik sering dianggap sebagai gaya nostalgia pada masa lampau, contohnya gaya Gotik. Romantik juga dapat dianggap sebagai kombinasi dari berbagai gaya. Rijksmuseum adalah salah satu bangunan bergaya Romantik di Belanda. Rijksmuseum dibangun pada 1876 dan didesain oleh seorang arsitek Belanda, P.J.H Cuypers. Cuypers menggunakan dua gaya yang berbeda. Tujuan dari artikel ini untuk mengetahui jenis gaya Romantik apa yang diterapkan pada Rijksmuseum. Hasil artikel ini dapat terlihat bahwa desain yang diterapkan pada Rijksmuseum merupakan gabungan dari gaya Gotik dan Renaissance.
In this paper, a series of semi-interpenetrating polymer network (semi-IPN) hydrogels based on po... more In this paper, a series of semi-interpenetrating polymer network (semi-IPN) hydrogels based on poly((2-dimethylamino)ethyl methacrylate)/poly (N,N-diethylacrylamide) (PDMAEMA/PDEA) were synthesized by changing the initial PDMAEMA/DEA molar ratio at room temperature. The influence of this additive on the property of resulting PDEA hydrogels was investigated and characterized. The interior morphology by scanning electron microscopy (SEM) revealed that the semi-IPN hydrogels have interconnected porous network structures. The glass transition temperature (T g) of the semi-IPN hydrogels was observed by differential scanning calorimetry (DSC). Equilibrium swelling ratio (ESR), swelling and deswelling dynamics of the hydrogels responding to temperature and pH were investigated in detail. Compared to PDEA, the semi-IPN hydrogels exhibited excellent mutative values in response to an alternation of the temperature and pH, and showed fast swelling and deswelling rates in response to temperature and pH change. The release behaviors of the model drug, aminophylline, were found dependent on hydrogel compositions and environmental temperature. These results suggest that the stimuli semi-IPN hydrogel have potential application as intelligent drug carriers.
Mutation Research-fundamental and Molecular Mechanisms of Mutagenesis, 1997
Effects or citrus fruits on the mutagenic_ Ity of I-methyl-l,2,3.4-tetrahydro-ll-carbollne-3_ ,ca... more Effects or citrus fruits on the mutagenic_ Ity of I-methyl-l,2,3.4-tetrahydro-ll-carbollne-3_ ,carboxylic acid treated with nitrite In the presence of ethanol Keyword(s): Citrus fruits; Nitrite treatment; Antimutagenicity It has been shown that the mutagenicity of l-methyl-I,2,3,4-tetrahyd* carboline-3-carboxylic acid (MTCCA), a mutagen precursor in soy sauce treated with nitrite, was strongly increased when it was treated with nitrite in the presence of alcohols. We found that the mutagenicity of MTCCA treated with 50 mM nitrite at pH 3, 37"C for 60 min in the presence of 7.5% ethanol was reduced by the addition of citrus fruits such as sudachi (Citrus sudachi), lemon (c. limon) and yuzu (c. junos) to the reaction mixture. The mutagenicity-reducing activity per weight of flavedo of the citrus fruits was considerably higher than that of their juices. The jUices of other oranges commercially available in Japan also had mutagenicity_ reducing activity against the nitrite-treated MTCCA. Among the components in the juice and the flavedo of their citrus fruits, lignin, d-limonene, quercetin, naringin, hesperidin, ascorbic acid, pectin and citric acid showed antimuta_ genic activity in the reaction mixture, suggesting that the mixed fractions of these compounds reduce the production of mutagens in the reaction mixture containing nitrite and ethanol. CItruses sudachi and lemon strongly redUced the mutagenicity of MTCCA treated with nitrite both in the absence and presence ofethanol. In addition, their citrus samples considerably reduced the mutagenicity of nitrite-treated soy sauce in the presence of ethanol. However, the mutagenicity of nitrite-treated tyramine, another mutagen precursor in soy sauce, both in the presence and absence of ethanol was not reduced by the addition of their Citrus samples.
Dalam Arsitektur, Romantik sering dianggap sebagai gaya nostalgia pada masa lampau, contohnya gay... more Dalam Arsitektur, Romantik sering dianggap sebagai gaya nostalgia pada masa lampau, contohnya gaya Gotik. Romantik juga dapat dianggap sebagai kombinasi dari berbagai gaya. Rijksmuseum adalah salah satu bangunan bergaya Romantik di Belanda. Rijksmuseum dibangun pada 1876 dan didesain oleh seorang arsitek Belanda, P.J.H Cuypers. Cuypers menggunakan dua gaya yang berbeda. Tujuan dari artikel ini untuk mengetahui jenis gaya Romantik apa yang diterapkan pada Rijksmuseum. Hasil artikel ini dapat terlihat bahwa desain yang diterapkan pada Rijksmuseum merupakan gabungan dari gaya Gotik dan Renaissance.
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