Papers by monica fernandez
PanVascular Medicine, 2015
PanVascular Medicine, 2015
PanVascular Medicine, 2013
PanVascular Medicine, 2013
ABSTRACT
Psychopharmacology, 1988
The effects of the dopamine (DA) receptor agonists apomorphine, bromocriptine and pergolide were ... more The effects of the dopamine (DA) receptor agonists apomorphine, bromocriptine and pergolide were compared with those produced by a DA receptor antagonist, haloperidol, in rats implanted with electrodes for chronic sleep recordings. Apomorphine (0.025–2.0 mg/kg) and bromocriptine (0.25–6.0 mg/kg) induced biphasic effects such that low doses decreased wakefulness (W) and increased slow wave sleep (SWS) and REM sleep (REMS), while large doses induced opposite effects. The effects of pergolide (0.05–0.5 mg/kg) on W and SWS were also biphasic, while REMS was suppressed over the range of dosages given. At 0.040 mg/kg, haloperidol increased W, while at 0.160 mg/kg it produced the opposite effect. Pretreatment with haloperidol (0.020 mg/kg) in a dose which preferentially acts at presynaptic sites reversed the effects of low doses of apomorphine, bromocriptine or pergolide on sleep and W. However, the compound differed substantially in its ability to block agonist effects. The increase in sleep after low doses of apomorphine, bromocriptine or pergolide could be related to activation of presynaptic D-2 receptors located on DA axons of mesolimbic and mesocortical systems. In addition, inhibition of norepinephrine and acetylcholine neurons having inhabitory D-2 receptors could contribute to the increase of sleep after small doses of the DA agonists.
Resources, Conservation and Recycling, 2010
Organic fraction (OF) from municipal solid waste (MSW) was sampled from several Spanish compostin... more Organic fraction (OF) from municipal solid waste (MSW) was sampled from several Spanish composting facilities just before the composting process began, considering the two groups of OF treated at the current time: OF from source sorted collection (SC) and OF from non-source sorted collection but selected in the plant by mechanical devices (MS). Moisture content (MC), pH, electric conductivity (EC), total organic matter (TOM), resistant organic matter (ROM), organic nitrogen (org-N), resistant organic nitrogen (nh-N), and soluble inorganic nitrogen (NH 4 + -N) were analysed from both samples. These parameters are significant in the composting process and have environmental implications. Most of the Spanish composting facilities treat MS from the MSW collected in mass. This study was carried out to assess and underline the variation in the composition of OF depending on the sorting system. Significant differences were detected between the two groups. SC showed higher values for MC, TOM, org-N than MS which resulted in the highest pH and EC values. No differences were detected for ROM and nh-N, indicating a similar degradable potential. Based on the results of this study, it is recommended that the composting process be carried out in a way that reflects the category of OF treated as well as considering the addition of yard trimmings to avoid leachates formation, balance the C/N ratio and improve aeration.
Journal of Environmental Chemical Engineering, 2014
2011 Baltic Congress on Future Internet and Communications, 2011
... Monica Fernandez, Jose Manuel Palacios Valverde, Miguel Angel Carnero Fernandez Home Network ... more ... Monica Fernandez, Jose Manuel Palacios Valverde, Miguel Angel Carnero Fernandez Home Network Architecture Telefonica I+D Madrid, Spain mfp ... and Protocols for Advanced Networking (TISPAN); NGN Functional Architecture Release 2 [4] J. López, A. Fandiño, A. García ...
MedEdPORTAL Publications, 2012
European Journal of Immunology, 1992
Intracellular replication of the protozoan parasite Trypanosoma cruzi inside macrophages is essen... more Intracellular replication of the protozoan parasite Trypanosoma cruzi inside macrophages is essential for the production of the disease and the development of the parasite. Two CD4+ T cell lines, A10 and A28, were established from T. cruzi-infected BALB/c mice which specifically proliferated to parasite antigens. The trypanocidal activity of BALB/c macrophages was induced upon culture with the A10, but not with the A28 T cell line. The cell-free supernatant from this A10 line, as well as from immune spleen cells stimulated with specific antigen or concanavalin A, but not from the A28 T cell line also activated the trypanocidal activity of peritoneal macrophages or of the J774 macrophage-like cell line. When the lymphokine content of the supernatants from both cell lines was analyzed, it was found that the A10 T cell line secreted interferon (IFN)-γ, tumor necrosis factor (TNF)-α and interleukin 2, whereas the A28 line did not secrete IFN-γ upon stimulation. Furthermore, the trypanocidal-inducing ability of A10 supernatant was completely abrogated by neutralizing anti-IFN-γ antibodies and partially abrogated by neutralizing anti-TNF-α antibodies. When recombinant cytokines were added to J774 cells, IFN-γ was able to induce significant trypanocidal activity whereas TNF-α was almost ineffective. However, TNF-α or lipopolysaccharide (LPS) showed a synergistic effect with IFN-γ on macrophage activation. IFN-γ triggered nitric oxide (NO) synthesis by J774 cells whereas TNF-α was almost ineffective. TNF-α and LPS were also synergistic with IFN-γ in the NO production. Both the NO production and the trypanocidal activity in J774 cells induced by T cell supernatants or lymphokine combinations were inhibited by N-monomethyl-L-arginine, a competitive inhibitor of NO synthase activity. A good correlation between the levels of NO production and trypanocidal activity induced by different lymphokine preparations was found. Those results suggest that IFN-γ and TNF-α, secreted by T. cruzi-immune T cells, are involved in the activation of the trypanocidal activity of mouse macrophages through an NO-dependent mechanism.
Arthritis and Rheumatism, 2007
ObjectiveTo examine health disparities as a function of ethnicity using data from LUpus in MInori... more ObjectiveTo examine health disparities as a function of ethnicity using data from LUpus in MInorities, NAture versus nurture (LUMINA), a longitudinal study of patients with systemic lupus erythematosus (SLE); to build an explanatory model of how ethnic disparities occur in this setting; and to suggest appropriate interventions.To examine health disparities as a function of ethnicity using data from LUpus in MInorities, NAture versus nurture (LUMINA), a longitudinal study of patients with systemic lupus erythematosus (SLE); to build an explanatory model of how ethnic disparities occur in this setting; and to suggest appropriate interventions.MethodsLUMINA patients (meeting American College of Rheumatology criteria for SLE) ages ≥16 years of African American, Hispanic (from Texas), Hispanic (from Puerto Rico), or Caucasian ethnicity were studied. In addition to examining the basic features of the cohort, we examined, by univariable and multivariable analyses, the factors associated with disease activity, damage accrual, lupus nephritis, and mortality. An empiric model based on the data presented (and the literature reviewed) was derived to explain the disparities observed.LUMINA patients (meeting American College of Rheumatology criteria for SLE) ages ≥16 years of African American, Hispanic (from Texas), Hispanic (from Puerto Rico), or Caucasian ethnicity were studied. In addition to examining the basic features of the cohort, we examined, by univariable and multivariable analyses, the factors associated with disease activity, damage accrual, lupus nephritis, and mortality. An empiric model based on the data presented (and the literature reviewed) was derived to explain the disparities observed.ResultsThere were substantial differences in the socioeconomic/demographic, clinical, and genetic features among patients from the different ethnic groups, with Texan Hispanic and African American patients exhibiting overall a lower socioeconomic status, different genetic associations, more serious disease at a younger age, and worse intermediate and final outcomes than the Caucasian and Puerto Rican Hispanic patients. A model of disease outcome as a function of the disparities observed was created.There were substantial differences in the socioeconomic/demographic, clinical, and genetic features among patients from the different ethnic groups, with Texan Hispanic and African American patients exhibiting overall a lower socioeconomic status, different genetic associations, more serious disease at a younger age, and worse intermediate and final outcomes than the Caucasian and Puerto Rican Hispanic patients. A model of disease outcome as a function of the disparities observed was created.ConclusionEthnic disparities occur in SLE. Environmental, socioeconomic/demographic, psychosocial, genetic, and clinical factors play an important role as determinants of the ethnic differences observed. Measures aimed at eliminating these disparities are suggested while further research is conducted to elucidate the basis of these disparities and their changes at the societal level and to eliminate the gap between the rich and the poor.Ethnic disparities occur in SLE. Environmental, socioeconomic/demographic, psychosocial, genetic, and clinical factors play an important role as determinants of the ethnic differences observed. Measures aimed at eliminating these disparities are suggested while further research is conducted to elucidate the basis of these disparities and their changes at the societal level and to eliminate the gap between the rich and the poor.
Clinical and Translational Oncology, 2011
In breast cancer, the metastatic process may involve the dissemination of circulating tumour cell... more In breast cancer, the metastatic process may involve the dissemination of circulating tumour cells (CTCs) through the blood and lymphatic system prior to the colonisation of distant organs. Here we demonstrate the predictive capacity of CTCs for detecting risk of death in breast cancer patients during established time intervals. CTCs were identified by immunocytochemical methods following isolation by selective immunomagnetic cell separation of cytokeratin-positive cells. Serial blood samples from 65 patients were collected at roughly monthly intervals for up to 50 months. Follow-up was conducted at different intervals: 1-5, >5-12, >12-24 and >24-50 months. Both presence and number of CTCs were correlated to risk of death: patients with CTCs at any time during follow-up had a higher risk of death (p=0.035) than patients without CTCs. Furthermore, during the first 5 months of therapy, patients with…
Arthritis & Rheumatism, 2007
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Papers by monica fernandez