HAL is a multidisciplinary open access archive for the deposit and dissemination of scientific re... more HAL is a multidisciplinary open access archive for the deposit and dissemination of scientific research documents, whether they are published or not. The documents may come from teaching and research institutions in France or abroad, or from public or private research centers. L'archive ouverte pluridisciplinaire HAL, est destinée au dépôt et à la diffusion de documents scientifiques de niveau recherche, publiés ou non, émanant des établissements d'enseignement et de recherche français ou étrangers, des laboratoires publics ou privés.
In this study, a surface acoustic wave (SAW) biosensor has been investigated to quantify the affi... more In this study, a surface acoustic wave (SAW) biosensor has been investigated to quantify the affinity and to estimate the binding kinetic between tumor necrosis factor α (TNF-α) and its inhibitor: SPD-304. To the best of our knowledge this is first ever report on real time and label free monitoring of TNF-α/ SPD-304 affinity. Effects of the SPD-304 solvent and DMSO cosolvent on TNFα/SPD-304 interaction have been investigated. Gravimetric results indicate that the limit of detection (LOD) of the developed biosensor was of order of 10 nM and that DMSO cosolvent influences the kinetic of interaction, the saturation value, and thus the value of the dissociation constant (Kd) of the TNF-α / SPD-304 system.
ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was e... more ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
The "Swedish slow motion theory" [Nilsson and Kowalewski, J. Magn. Reson. 146, 345 (2000)] applie... more The "Swedish slow motion theory" [Nilsson and Kowalewski, J. Magn. Reson. 146, 345 (2000)] applied so far to Nuclear Magnetic Relaxation Dispersion (NMRD) profiles for solutions of transition metal ion complexes has been extended to ESR spectral analysis, including in addition g-tensor anisotropy effects. The extended theory has been applied to interpret in a consistent way (within one set of parameters) NMRD profiles and ESR spectra at 95 and 237 GHz for two Gd(III) complexes denoted as P760 and P792 (hydrophilic derivatives of DOTA-Gd, with molecular masses of 5.6 and 6.5 kDa, respectively). The goal is to verify the applicability of the commonly used pseudorotational model of the transient zero field splitting (ZFS). According to this model the transient ZFS is described by a tensor of a constant amplitude, defined in its own principal axes system, which changes its orientation with respect to the laboratory frame according to the isotropic diffusion equation with a characteristic time constant (correlation time) reflecting the time scale of the distortional motion. This unified interpretation of the ESR and NMRD leads to reasonable agreement with the experimental data, indicating that the pseudorotational model indeed captures the essential features of the electron spin dynamics.
HAL (Le Centre pour la Communication Scientifique Directe), Nov 24, 2022
HAL is a multidisciplinary open access archive for the deposit and dissemination of scientific re... more HAL is a multidisciplinary open access archive for the deposit and dissemination of scientific research documents, whether they are published or not. The documents may come from teaching and research institutions in France or abroad, or from public or private research centers. L'archive ouverte pluridisciplinaire HAL, est destinée au dépôt et à la diffusion de documents scientifiques de niveau recherche, publiés ou non, émanant des établissements d'enseignement et de recherche français ou étrangers, des laboratoires publics ou privés.
HAL (Le Centre pour la Communication Scientifique Directe), 2018
Abstract Numerous studies are published on the synthesis and characterization of bismuth oxide or... more Abstract Numerous studies are published on the synthesis and characterization of bismuth oxide or bismuth sulfide nanoparticles. Only a few works are dealing with the synthesis and applications of spherical bismuth metallic nanoparticles. However, this field of research is emerging and so in this chapter, different strategies to synthesize spherical metallic bismuth nanoparticles are reviewed. Two pathways are referenced: the top-down and, more described, bottom-up approaches. All procedures are critically compared to show how they could be improved and directed towards greener strategies. The different capping agents (polymers, hydrophilic or hydrophobic monomers) used to control size, morphology, and stability of these nanoparticles are discussed, as well as the choice of solvent. The relevance of heating techniques (classical heating or irradiation under microwaves) and purification are compared to green processes. Finally, bismuth metallic nanoparticles are discussed in different medical applications, such as theranostic applications as X-ray contrast agent, or X-ray radiosensitizers.
HAL (Le Centre pour la Communication Scientifique Directe), Feb 11, 2021
HAL is a multidisciplinary open access archive for the deposit and dissemination of scientific re... more HAL is a multidisciplinary open access archive for the deposit and dissemination of scientific research documents, whether they are published or not. The documents may come from teaching and research institutions in France or abroad, or from public or private research centers. L'archive ouverte pluridisciplinaire HAL, est destinée au dépôt et à la diffusion de documents scientifiques de niveau recherche, publiés ou non, émanant des établissements d'enseignement et de recherche français ou étrangers, des laboratoires publics ou privés.
HAL is a multidisciplinary open access archive for the deposit and dissemination of scientific re... more HAL is a multidisciplinary open access archive for the deposit and dissemination of scientific research documents, whether they are published or not. The documents may come from teaching and research institutions in France or abroad, or from public or private research centers. L'archive ouverte pluridisciplinaire HAL, est destinée au dépôt et à la diffusion de documents scientifiques de niveau recherche, publiés ou non, émanant des établissements d'enseignement et de recherche français ou étrangers, des laboratoires publics ou privés.
In this study, a surface acoustic wave (SAW) biosensor has been investigated to quantify the affi... more In this study, a surface acoustic wave (SAW) biosensor has been investigated to quantify the affinity and to estimate the binding kinetic between tumor necrosis factor α (TNF-α) and its inhibitor: SPD-304. To the best of our knowledge this is first ever report on real time and label free monitoring of TNF-α/ SPD-304 affinity. Effects of the SPD-304 solvent and DMSO cosolvent on TNFα/SPD-304 interaction have been investigated. Gravimetric results indicate that the limit of detection (LOD) of the developed biosensor was of order of 10 nM and that DMSO cosolvent influences the kinetic of interaction, the saturation value, and thus the value of the dissociation constant (Kd) of the TNF-α / SPD-304 system.
ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was e... more ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
The "Swedish slow motion theory" [Nilsson and Kowalewski, J. Magn. Reson. 146, 345 (2000)] applie... more The "Swedish slow motion theory" [Nilsson and Kowalewski, J. Magn. Reson. 146, 345 (2000)] applied so far to Nuclear Magnetic Relaxation Dispersion (NMRD) profiles for solutions of transition metal ion complexes has been extended to ESR spectral analysis, including in addition g-tensor anisotropy effects. The extended theory has been applied to interpret in a consistent way (within one set of parameters) NMRD profiles and ESR spectra at 95 and 237 GHz for two Gd(III) complexes denoted as P760 and P792 (hydrophilic derivatives of DOTA-Gd, with molecular masses of 5.6 and 6.5 kDa, respectively). The goal is to verify the applicability of the commonly used pseudorotational model of the transient zero field splitting (ZFS). According to this model the transient ZFS is described by a tensor of a constant amplitude, defined in its own principal axes system, which changes its orientation with respect to the laboratory frame according to the isotropic diffusion equation with a characteristic time constant (correlation time) reflecting the time scale of the distortional motion. This unified interpretation of the ESR and NMRD leads to reasonable agreement with the experimental data, indicating that the pseudorotational model indeed captures the essential features of the electron spin dynamics.
HAL (Le Centre pour la Communication Scientifique Directe), Nov 24, 2022
HAL is a multidisciplinary open access archive for the deposit and dissemination of scientific re... more HAL is a multidisciplinary open access archive for the deposit and dissemination of scientific research documents, whether they are published or not. The documents may come from teaching and research institutions in France or abroad, or from public or private research centers. L'archive ouverte pluridisciplinaire HAL, est destinée au dépôt et à la diffusion de documents scientifiques de niveau recherche, publiés ou non, émanant des établissements d'enseignement et de recherche français ou étrangers, des laboratoires publics ou privés.
HAL (Le Centre pour la Communication Scientifique Directe), 2018
Abstract Numerous studies are published on the synthesis and characterization of bismuth oxide or... more Abstract Numerous studies are published on the synthesis and characterization of bismuth oxide or bismuth sulfide nanoparticles. Only a few works are dealing with the synthesis and applications of spherical bismuth metallic nanoparticles. However, this field of research is emerging and so in this chapter, different strategies to synthesize spherical metallic bismuth nanoparticles are reviewed. Two pathways are referenced: the top-down and, more described, bottom-up approaches. All procedures are critically compared to show how they could be improved and directed towards greener strategies. The different capping agents (polymers, hydrophilic or hydrophobic monomers) used to control size, morphology, and stability of these nanoparticles are discussed, as well as the choice of solvent. The relevance of heating techniques (classical heating or irradiation under microwaves) and purification are compared to green processes. Finally, bismuth metallic nanoparticles are discussed in different medical applications, such as theranostic applications as X-ray contrast agent, or X-ray radiosensitizers.
HAL (Le Centre pour la Communication Scientifique Directe), Feb 11, 2021
HAL is a multidisciplinary open access archive for the deposit and dissemination of scientific re... more HAL is a multidisciplinary open access archive for the deposit and dissemination of scientific research documents, whether they are published or not. The documents may come from teaching and research institutions in France or abroad, or from public or private research centers. L'archive ouverte pluridisciplinaire HAL, est destinée au dépôt et à la diffusion de documents scientifiques de niveau recherche, publiés ou non, émanant des établissements d'enseignement et de recherche français ou étrangers, des laboratoires publics ou privés.
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