Papers by mahboobeh mahmoodi
International Journal of Biological Macromolecules
Complexes of Co (II) and Ni (II) with dipicolinic acid, 2,6-pyridine dicarboxylic acid (PydcH2) h... more Complexes of Co (II) and Ni (II) with dipicolinic acid, 2,6-pyridine dicarboxylic acid (PydcH2) have been synthesized in the NaX (zeolite-X) nanopores. The formation of zeolite X encapsulated Co(II) and Ni(II) complexes ([M(pydcH)2]-NaX, where M = Co(II) and Ni(II]) were confirmed using spectroscopic methods of FT-IR, elemental analysis, XRD, FE-SEM, and TEM. It was affirmed that the encapsulation of complexes in NaX pores was performed without changes in the structure and shape of the zeolite. The oxidative degradation reaction of atenolol with hydrogen peroxide as an oxidant was performed in the presence of synthesized [M(pydcH)2]-NaX nanocomposites to study their catalytic activity. Therefore, oxidation of atenolol was performed under different conditions of catalyst, temperature, and time. Under optimal conditions, catalysts [Co(pydcH)2]-NaX and [Ni(pydcH)2]-NaX showed 82.3% and 71.1% activity of atenolol oxidation, respectively. These catalysts were stable after recovery and we...
The purpose of this study is to prepare cationic nanoparticles (NPs) by coating chitosan (CS) on ... more The purpose of this study is to prepare cationic nanoparticles (NPs) by coating chitosan (CS) on the surface of PLGA NPs and evaluated laser thrombolysis capabilities and photomechanical drug delivery in a blood clot. The tPA encapsulated PLGA and PLGA/ CS nanoparticles were fabricated via the W/O/W double emulsion solvent evaporation surface coating method. The characteristics of NPs are determined by laser light scattering and zeta potential measurement. The CS coating was confirmed by zeta potential and fourier transform infrared spectroscopy. The surface morphology of NPs was also studied by transmition scanning microscopy (TEM). Differential scanning calorimetry was used for thermal analysis. In vitro drug release experiments of tPA encapsulated PLGA and PLGA/CS are determined by HPLC and showed a sustained release profile for three days with little initial burst release for PLGA/CS NPs. The mean particle size and encapsulation efficiency of tPA NPs were in the range of 280-360...
Journal of Materials Engineering and Performance, 2022
In this research, keratin (Kr)/ poly caprolactone (PCL)/ hydroxyapatite (HA) scaffold was made by... more In this research, keratin (Kr)/ poly caprolactone (PCL)/ hydroxyapatite (HA) scaffold was made by electrospinning method. Then, the effect of HA nanoparticles on properties of scaffold B (Kr 33%, PCL 50% and HA 17%) and scaffold A (Kr 40% and PCL 60%) were studied. The surface morphology, functional groups on the surface of samples, porosity, and specific surface area were evaluated by Scanning Electron Microscopy (SEM), Fourier Transform Infrared Spectrophotometer (FTIR), liquid displacement method, and BET test, respectively. The mean diameter of fibers in samples A and B was measured 184 nm and 108 nm, respectively. Results showed that the specific surface area in scaffolds with HA nanoparticles was almost 2 times higher than that of the scaffold without HA. The biodegradability of scaffolds was examined in * :یکینورتکلا تسپ ،تابتاکم لوئسم : [email protected] D ow nl oa de d fr om ja m e. iu t.a c. ir at 5 :0 8 IR S T o n S un da y D ec em be r 30 th 2 01 8 [ D O I: 10 .2 ...
The effect of a Nd: YAG laser (1064 nm) has been studied on Ti6Al4V alloy in terms of optical and... more The effect of a Nd: YAG laser (1064 nm) has been studied on Ti6Al4V alloy in terms of optical and physical parameters for biomedical applications. The superior surface microhardness hardness (i.e. 377 VHN) is attributed to grain refinement associated with laser melting and rapid solidification. The electrochemical property, mainly pitting corrosion resistance, has been carried out in Hanks salt balanced physiological solution using standard potentiodynamic polarization testing. At the optimium laser treating fluence (140 Jcm -2 ), the EDX spectroscopy showed a decrease of about 30 % in the vanadium and the contact angle measurements also indicated an improved surface wettability seen in the characteristics with a contact angle of 35°. Finally, Cell spreading on the implanted specimens was analyzed by SEM and their condition in a specific area was studied for 10 cells for three separate regions on the same specimen using Image J Program software. The in vivo tests provided some usefu...
Biofabrication
Droplet-based microfluidic systems have been employed to manipulate discrete fluid volumes with i... more Droplet-based microfluidic systems have been employed to manipulate discrete fluid volumes with immiscible phases. Creating the fluid droplets at microscale has led to a paradigm shift in mixing, sorting, encapsulation, sensing, and designing high throughput devices for biomedical applications. Droplet microfluidics has opened many opportunities in microparticle synthesis, molecular detection, diagnostics, drug delivery, and cell biology. In the present review, we first introduce standard methods for droplet generation (i.e., passive and active methods) and discuss the latest examples of emulsification and particle synthesis approaches enabled by microfluidic platforms. Then, the applications of droplet-based microfluidics in different biomedical applications are detailed. Finally, a general overview of the latest trends along with the perspectives and future potentials in the field are provided.
Materials Today Communications
Materials Science in Semiconductor Processing
Ternary mesoporous nanocomposites of RGO/Fe 3 O 4-ZnO were prepared successfully via hydrothermal... more Ternary mesoporous nanocomposites of RGO/Fe 3 O 4-ZnO were prepared successfully via hydrothermal technique. Fe 3 O 4-ZnO core/shell nanoparticles were decorated on the surface of reduced graphene oxide platelet to improve charge separation efficiency and magnetic properties. The phase, microstructure and specific surface area of the prepared samples were determined via X-ray diffraction (XRD), field emission scanning electron microscopy (FESEM), transmission electron microscopy/selected area electron diffraction (TEM/SAED) and Brunauer-Emmett-Teller (BET) techniques. A vibrating sample magnetometer (VSM) was used for recording the magnetization hysteresis curves. The methylene blue (MB) degradation and photocatalytic activities of prepared catalysts were examined under natural daylight irradiation. The magnetic properties of the RFZ photocatalyst increased compared with the FZ from 12.45 emu g −1 to 20.18 emu g −1. The specific surface area (a s , BET) for the RFZ compared to the FZ increased from 31.56 m 2 g −1 to 36.05 m 2 g −1. The RFZ photocatalyst, as a result of synergistic effects, indicated an excellent performance for treatment of MB dye. The photocatalytic reactions obeyed pseudo-first-order kinetics and apparent rate constant (k ap) of RFZ photocatalyst increased compared to FZ. Furthermore, the RFZ photocatalyst could be recycling using a common magnet besides to the high efficiency of degradation. The repeatability of the photocatalytic activity after 10 cycles was additionally tested and revealed that the RFZ photocatalyst up to 8 cycles showed a small drop in catalysis efficiency. Thus, it was concluded that the RFZ ternary photocatalyst can be an economical multifunctional photocatalyst for the degradation of unsafe compounds in wastewater.
The purpose of this study is to prepare cationic nanoparticles (NPs) by coating chitosan (CS) on ... more The purpose of this study is to prepare cationic nanoparticles (NPs) by coating chitosan (CS) on the surface of PLGA NPs and evaluated laser thrombolysis capabilities and photomechanical drug delivery in a blood clot. The tPA encapsulated PLGA and PLGA/ CS nanoparticles were fabricated via the W/O/W double emulsion solvent evaporation surface coating method. The characteristics of NPs are determined by laser light scattering and zeta potential measurement. The CS coating was confirmed by zeta potential and fourier transform infrared spectroscopy. The surface morphology of NPs was also studied by transmition scanning microscopy. Differential scanning calorimetry was used for thermal analysis. In vitro drug release experiments of tPA encapsulated PLGA and PLGA/CS are determined by HPLC and showed a sustained release profile for three days with little initial burst release for PLGA/CS NPs. The mean particle size and encapsulation efficiency of tPA NPs were in the range of 280-360 nm and 46.7%±1.56, 50.8%±1.09, respectively. The encapsulation efficiency and the particles size were increased as a result of coating with CS. The release kinetics was evaluated by fitting the experimental data to standard release equations (Higuchie equation). This model was used to find the best fit for NPs. The results showed that the NPs for the highest weight percentages of digested clot is PLGA/CS NPs. Compared with tPA, the NPs significantly increased the weight of digested clots in the following order, PLGA/CS NPs (21.6%) > PLGA NPs (15.54%) > tPA (8.05%). Also, the thrombolysis process can be enhanced by delivering tPA into clot during laser ablation based on the photomechanical effect due to optical cavitation bubbles. Photomechanical drug delivery and the NPs used in this experiment showed that they can significantly thrombolysis in vitro in this model, and may be useful for acute myocardial infarction (AMI).
Journal of Laser Applications, 2008
ABSTRACT The effect of Nd:yttrium-aluminum-garnet laser on the microtopography and physicochemica... more ABSTRACT The effect of Nd:yttrium-aluminum-garnet laser on the microtopography and physicochemical properties of Ti6Al4V alloy are investigated in the view of biomedical applications. The surface roughness and hardness for laser treated samples (LTS) at 140 J cm−2 were measured 7±0.02 and 825 vickers hardness number, respectively. This superior microhardness value is attributed to grain refinement associated with laser melting and rapid solidification. The electrochemical property, mainly pitting corrosion resistance, has been carried out in Hanks salt balanced physiological solution using standard potentiodynamic polarization testing. A higher corrosion potential of −0.21 V was achieved for LTS. At the optimium treating value of laser fluence (140 J cm−2), the energy dispersive x-ray analysis showed about a 30% decrease of vanadium. The contact angle measurements also indicated an improved surface wettability (i.e., hydrophilicity) characteristic at 35°. Finally, the cell culture studies provided a useful tool to investigate the morphology and cell cytotoxicity.
Lab on a Chip
A critical review of healthy and diseased in vitro models of the vascular system and in particula... more A critical review of healthy and diseased in vitro models of the vascular system and in particular for atherosclerosis, aneurysm, and thrombosis.
Surface and Coatings Technology
Surface Engineering
ABSTRACT The effect of Nd:YAG laser surface modification on the microtopography and physicochemic... more ABSTRACT The effect of Nd:YAG laser surface modification on the microtopography and physicochemical properties of Ti–6Al–4V alloy has been investigated with a view of biomedical applications. The surface roughness and hardness of laser treated samples at 140 J cm?2 were found to be 7±0·02 and 825 VHN respectively. The superior microhardness value can be attributed to grain refinement associated with laser melting and rapid solidification. The electrochemical property, mainly pitting corrosion resistance, has been carried out in Hank's salt balanced physiological solution using standard potentiodynamic polarisation testing. A higher corrosion potential of ?0·21 V was achieved for laser treated samples. At the optimum of laser fluence (140 J cm?2), energy dispersive X-ray analysis showed about a 30% decrease in vanadium content. Contact angle measurements also indicated improved surface wettability (i.e. hydrophilicity) characteristics at 35°. Finally, cell culture studies provided a useful tool to investigate the morphology and cell cytotoxicity of the laser treated surfaces.
Uploads
Papers by mahboobeh mahmoodi