This article is an open access article distributed under the terms and conditions of the Creative... more This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY
Anales del Instituto de Estudios Madrileños publica ininterrumpidamente desde 1966 un volumen anu... more Anales del Instituto de Estudios Madrileños publica ininterrumpidamente desde 1966 un volumen anual dedicado a temas de investigación relacionados con Madrid y su provincia. Arte, Arqueología, Geografía, Historia, Urbanismo, Lingüística, Literatura, Economía, sociedad y biografías de madrileños ilustres y personajes relacionados con Madrid son sus temas preferentes. Los autores o editores de trabajos relacionados con Madrid que deseen dar a conocer sus obras en Anales del Instituto de Estudios Madrileños deberán remitirlas a la Secretaría del Instituto, calle de Albasanz, 26-28, despacho 2F10, 28037-Madrid, ajustándose a las normas para autores publicadas en el presente número de la revista. Los originales recibidos son sometidos a informe y evaluación por el Consejo de Redacción, contando con el concurso de especialistas externos.
Congenital malformations are important not only because of their prevalence, but for the infantil... more Congenital malformations are important not only because of their prevalence, but for the infantile mortality and the disability that most of them cause. The study of the temporary evolution of mortality and prevalence in Spain shows a decrease of these facts; however, we should consider the possible influence that the prevailing law 9/1985 about the voluntary interruption of the pregnancy may have caused on these figures . When studying the risk factors of congenital malformations, four etiological groups are usually taken into consideration: unknown cause, genetic cause, environmental cause and multifactorial cause (in which there is an interaction between genetic and environmental factors). On the other hand, the most frequent embryopathies in Spain are caused by the alcohol, the chronic diabetes and anticonvulsant drugs. These factors facilitate a preventive action against these diseases. This review talks about the different risk factors related to these processes. Finally, the text deals with the primary prevention of the neural tube defects by the folic acid supplementation, previous to the conception, and the controversy generated by this fact.
Using standard search engines PubMed, Scopus, Scielo, Cochrane, Science Direct and Medline, 433 a... more Using standard search engines PubMed, Scopus, Scielo, Cochrane, Science Direct and Medline, 433 articles were found to evaluate the information about sutural bones. Thirty-six articles that match our stated objectives about sutural bones were analyzed. Data were evaluated in the current medical literature for their historical aspects, anatomical classification, development, clinically significance and their presence in some bone dysplasias. There is still dispute on whether sutural bone development is influenced by genetic or external factors. Sutural bones are a known sporadic occurrence in the human cranium and do not predispose a person to any particular disease. Their presence, however, is commonly used as a useful marker of some underlying genetic disorders.
The aim of this study was to determine the main stages of submandibular salivary gland developmen... more The aim of this study was to determine the main stages of submandibular salivary gland development during the embryonic period in humans. In addition, we studied submandibular salivary gland development in rats on embryonic days 14-16 and expression in the submandibular salivary gland region with the monoclonal antibody HNK-1. Serial sections from 25 human embryos with a greatest length ranging from 10 to 31 mm (Carnegie stages 16-23; weeks 5.5-8 of development) and Wistar rats of embryonic days (E) 14-16 were analysed with light microscopy. Five stages of submandibular salivary gland development were identified. The prospective stage (1), between weeks 5.5 and early week 6, is characterized by a thickening of the epithelium of the medial paralingual groove in the floor of the mouth corresponding to the primordium of the submandibular salivary gland parenchyma. At this stage, the primordium of the parasympathetic ganglion lies below the lingual nerve. The primordium of the submandibular salivary gland parenchyma is observed in rats on E14 in the medial paralingual groove with mesenchymal cells, underlying the lingual nerve. These cells are HNK-1-positive, corresponding to the primordium of the parasympathetic ganglion. The bud stage (2), at the end of week 6 in humans and on E15 in rats, is characterized by the proliferation and invagination of the epithelial condensation, surrounded by an important condensation of the mesenchyme. The pseudoglandular stage (3) at week 6.5 is characterized by the beginning of the formation of lobes in the condensed mesenchyme. The canalicular stage (4), between week 7 and 7.5, is characterized by the appearance of a lumen in the proximal part of the submandibular duct. The innervation stage (5) occurs during week 8, with the innervation of the submandibular and interlobular ducts. Nervous branches arriving from the parasympathetic ganglion innervate the glandular parenchyma. Numerous blood vessels are observed nearby. Our results suggest that submandibular salivary gland development requires interactions among epithelium, mesenchyme, parasympathetic ganglion and blood vessels.
Revista Complutense de Ciencias Veterinarias, Feb 3, 2017
La Osteogénesis imperfecta, es una enfermedad hereditaria que causa un déficit en la formación de... more La Osteogénesis imperfecta, es una enfermedad hereditaria que causa un déficit en la formación de colágeno tipo I. El manejo de la osteogénesis imperfecta debe ser multidisciplinar, se utilizan tratamientos y terapias farmacológicas, físicas, quirúrgicas y psicológicas. Palabras Clave: osteogenesis imperfecta; osteogenesis imperfecta & occupational therapy; osteogenesis imperfecta heart; osteogenesis imperfecta ribs; osteogenesis imperfecta diagnosis. SUMARY Imperfect osteogenesis is a hereditary disease that causes a deficit in the formation of type I collagen. The management of osteogenesis imperfecta must be multidisciplinary, pharmacological, physical, surgical and psychological treatments and therapies are used.
Since it was first described by the German anatomist and histologist, Joseph Hugo Vincenz Disse, ... more Since it was first described by the German anatomist and histologist, Joseph Hugo Vincenz Disse, the structure and functions of the space of Disse, a thin perisinusoidal area between the endothelial cells and hepatocytes filled with blood plasma, have acquired great importance in liver disease. The space of Disse is home for the hepatic stellate cells (HSCs), the major fibrogenic players in the liver. Quiescent HSCs (qHSCs) store vitamin A, and upon activation they lose their retinol reservoir and become activated. Activated HSCs (aHSCs) are responsible for secretion of extracellular matrix (ECM) into the space of Disse. This early event in hepatic injury is accompanied by loss of the pores-known as fenestrations-of the endothelial cells, triggering loss of balance between the blood flow and the hepatocyte, and underlies the link between fibrosis and organ dysfunction. If the imbalance persists, the expansion of the fibrotic scar followed by the vascularized septae leads to cirrhosis and/or end-stage hepatocellular carcinoma (HCC). Thus, researchers have been focused on finding therapeutic targets that reduce fibrosis. The space of Disse provides the perfect microenvironment for the stem cells niche in the liver and the interchange of nutrients between cells. In the present review article, we focused on the space of Disse, its components and its leading role in liver disease development.
Revista Espanola De Enfermedades Digestivas, May 1, 2009
With a prevalence of 0.3-0.5/1000 births, congenital diaphragmatic hernia (CDH) remains a serious... more With a prevalence of 0.3-0.5/1000 births, congenital diaphragmatic hernia (CDH) remains a serious, poorly understood abnormality with a high mortality rate that cannot always be effectively managed. Its reported frequency in Spain is 0.69%00 with a yearly decreasing trend of 0.10%00 during the period 1980-2006. Up to 5% of cases are incidentally identified in adults undergoing studies for other reasons. We report the case of a 74-year-old woman with vomiting for three months due to parasternal diaphragmatic hernia of Morgagni-Larrey (retrochondrosternal, retrocostoxyphoid, retrosternal, subcostal, substernal or subcostosternal hernia), which allowed us to report an update on this condition in the adult, and on thoracoabdominal diaphragm morphogenesis. It is in the embryology of the diaphragm where an explanation may be found for some morphological changes and clinical manifestations, even though a number of uncertainties remain. We also analyze the extent of controversy persisting on some aspects of surgical treatment (access routes, mesh use, hernial sac reduction). Overall, minimally invasive techniques predominate. We consider laparoscopy the approach of choice for adult patients with parasternal hernia eligible for surgery.
This article focuses on Antonio de Gimbernat y Arbós (1734-1816), with particular attention paid ... more This article focuses on Antonio de Gimbernat y Arbós (1734-1816), with particular attention paid to his famous publication ''Nuevo método de operar en la hernia crural'' (2013 marking its 220 anniversary), which was translated into English by Thomas Beddoe two years later (A new method of operating for the femoral hernia Translated from the Spanish of Don Antonio de Gimbernat, To which are added, with plates by the translator, queries respecting a safer method of performing inoculation). Antonio de Gimbernat y Arbós, a Spanish anatomist and surgeon, was one of the pioneers during the ''Age of Dissection'' (late 18th Century). He was a man of great willpower, bright, thorough, and unique. From his careful anatomical study in the inguinal region, he made a detailed description of the lacunar ligament, which John Hunter called the Gimbernat's ligament in his honor. Antonio de Gimbernat y Arbós also proposed an advanced treatment for strangulated femoral hernias. He acquired extraordinarily broad surgical skills with therapeutic orientation, conservative, not aggressive, based on the knowledge he had gained through dissection. Furthermore, though this is less well known nowadays, Antonio de Gimbernat y Arbós was also relevant organizer of education and health-services-as it was the custom of the great physician of this time. Consequently, Antonio de Gimbernat y Arbós is truly representative of the great figures of the anatomistssurgeons of the Enlightenment.
La ocupación es una actividad propositiva que desde los tiempos más remotos ha influido en la evo... more La ocupación es una actividad propositiva que desde los tiempos más remotos ha influido en la evolución humana determinando la organización de su tiempo vital. También a lo largo de la historia de la Medicina ha sido utilizada como forma de tratamiento, en la actualidad denominada Terapia Ocupacional. Desde 1917 ha desarrollado una serie de protocolos de actuación en consonancia con el paradigma predominante. Entre ellos se encuentra el Modelo Biomecánico con una vigencia de unos 50 años, aplicable en situaciones disfuncionales de origen ortopédico con integridad del SNC.
This article is an open access article distributed under the terms and conditions of the Creative... more This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY
Anales del Instituto de Estudios Madrileños publica ininterrumpidamente desde 1966 un volumen anu... more Anales del Instituto de Estudios Madrileños publica ininterrumpidamente desde 1966 un volumen anual dedicado a temas de investigación relacionados con Madrid y su provincia. Arte, Arqueología, Geografía, Historia, Urbanismo, Lingüística, Literatura, Economía, sociedad y biografías de madrileños ilustres y personajes relacionados con Madrid son sus temas preferentes. Los autores o editores de trabajos relacionados con Madrid que deseen dar a conocer sus obras en Anales del Instituto de Estudios Madrileños deberán remitirlas a la Secretaría del Instituto, calle de Albasanz, 26-28, despacho 2F10, 28037-Madrid, ajustándose a las normas para autores publicadas en el presente número de la revista. Los originales recibidos son sometidos a informe y evaluación por el Consejo de Redacción, contando con el concurso de especialistas externos.
Congenital malformations are important not only because of their prevalence, but for the infantil... more Congenital malformations are important not only because of their prevalence, but for the infantile mortality and the disability that most of them cause. The study of the temporary evolution of mortality and prevalence in Spain shows a decrease of these facts; however, we should consider the possible influence that the prevailing law 9/1985 about the voluntary interruption of the pregnancy may have caused on these figures . When studying the risk factors of congenital malformations, four etiological groups are usually taken into consideration: unknown cause, genetic cause, environmental cause and multifactorial cause (in which there is an interaction between genetic and environmental factors). On the other hand, the most frequent embryopathies in Spain are caused by the alcohol, the chronic diabetes and anticonvulsant drugs. These factors facilitate a preventive action against these diseases. This review talks about the different risk factors related to these processes. Finally, the text deals with the primary prevention of the neural tube defects by the folic acid supplementation, previous to the conception, and the controversy generated by this fact.
Using standard search engines PubMed, Scopus, Scielo, Cochrane, Science Direct and Medline, 433 a... more Using standard search engines PubMed, Scopus, Scielo, Cochrane, Science Direct and Medline, 433 articles were found to evaluate the information about sutural bones. Thirty-six articles that match our stated objectives about sutural bones were analyzed. Data were evaluated in the current medical literature for their historical aspects, anatomical classification, development, clinically significance and their presence in some bone dysplasias. There is still dispute on whether sutural bone development is influenced by genetic or external factors. Sutural bones are a known sporadic occurrence in the human cranium and do not predispose a person to any particular disease. Their presence, however, is commonly used as a useful marker of some underlying genetic disorders.
The aim of this study was to determine the main stages of submandibular salivary gland developmen... more The aim of this study was to determine the main stages of submandibular salivary gland development during the embryonic period in humans. In addition, we studied submandibular salivary gland development in rats on embryonic days 14-16 and expression in the submandibular salivary gland region with the monoclonal antibody HNK-1. Serial sections from 25 human embryos with a greatest length ranging from 10 to 31 mm (Carnegie stages 16-23; weeks 5.5-8 of development) and Wistar rats of embryonic days (E) 14-16 were analysed with light microscopy. Five stages of submandibular salivary gland development were identified. The prospective stage (1), between weeks 5.5 and early week 6, is characterized by a thickening of the epithelium of the medial paralingual groove in the floor of the mouth corresponding to the primordium of the submandibular salivary gland parenchyma. At this stage, the primordium of the parasympathetic ganglion lies below the lingual nerve. The primordium of the submandibular salivary gland parenchyma is observed in rats on E14 in the medial paralingual groove with mesenchymal cells, underlying the lingual nerve. These cells are HNK-1-positive, corresponding to the primordium of the parasympathetic ganglion. The bud stage (2), at the end of week 6 in humans and on E15 in rats, is characterized by the proliferation and invagination of the epithelial condensation, surrounded by an important condensation of the mesenchyme. The pseudoglandular stage (3) at week 6.5 is characterized by the beginning of the formation of lobes in the condensed mesenchyme. The canalicular stage (4), between week 7 and 7.5, is characterized by the appearance of a lumen in the proximal part of the submandibular duct. The innervation stage (5) occurs during week 8, with the innervation of the submandibular and interlobular ducts. Nervous branches arriving from the parasympathetic ganglion innervate the glandular parenchyma. Numerous blood vessels are observed nearby. Our results suggest that submandibular salivary gland development requires interactions among epithelium, mesenchyme, parasympathetic ganglion and blood vessels.
Revista Complutense de Ciencias Veterinarias, Feb 3, 2017
La Osteogénesis imperfecta, es una enfermedad hereditaria que causa un déficit en la formación de... more La Osteogénesis imperfecta, es una enfermedad hereditaria que causa un déficit en la formación de colágeno tipo I. El manejo de la osteogénesis imperfecta debe ser multidisciplinar, se utilizan tratamientos y terapias farmacológicas, físicas, quirúrgicas y psicológicas. Palabras Clave: osteogenesis imperfecta; osteogenesis imperfecta & occupational therapy; osteogenesis imperfecta heart; osteogenesis imperfecta ribs; osteogenesis imperfecta diagnosis. SUMARY Imperfect osteogenesis is a hereditary disease that causes a deficit in the formation of type I collagen. The management of osteogenesis imperfecta must be multidisciplinary, pharmacological, physical, surgical and psychological treatments and therapies are used.
Since it was first described by the German anatomist and histologist, Joseph Hugo Vincenz Disse, ... more Since it was first described by the German anatomist and histologist, Joseph Hugo Vincenz Disse, the structure and functions of the space of Disse, a thin perisinusoidal area between the endothelial cells and hepatocytes filled with blood plasma, have acquired great importance in liver disease. The space of Disse is home for the hepatic stellate cells (HSCs), the major fibrogenic players in the liver. Quiescent HSCs (qHSCs) store vitamin A, and upon activation they lose their retinol reservoir and become activated. Activated HSCs (aHSCs) are responsible for secretion of extracellular matrix (ECM) into the space of Disse. This early event in hepatic injury is accompanied by loss of the pores-known as fenestrations-of the endothelial cells, triggering loss of balance between the blood flow and the hepatocyte, and underlies the link between fibrosis and organ dysfunction. If the imbalance persists, the expansion of the fibrotic scar followed by the vascularized septae leads to cirrhosis and/or end-stage hepatocellular carcinoma (HCC). Thus, researchers have been focused on finding therapeutic targets that reduce fibrosis. The space of Disse provides the perfect microenvironment for the stem cells niche in the liver and the interchange of nutrients between cells. In the present review article, we focused on the space of Disse, its components and its leading role in liver disease development.
Revista Espanola De Enfermedades Digestivas, May 1, 2009
With a prevalence of 0.3-0.5/1000 births, congenital diaphragmatic hernia (CDH) remains a serious... more With a prevalence of 0.3-0.5/1000 births, congenital diaphragmatic hernia (CDH) remains a serious, poorly understood abnormality with a high mortality rate that cannot always be effectively managed. Its reported frequency in Spain is 0.69%00 with a yearly decreasing trend of 0.10%00 during the period 1980-2006. Up to 5% of cases are incidentally identified in adults undergoing studies for other reasons. We report the case of a 74-year-old woman with vomiting for three months due to parasternal diaphragmatic hernia of Morgagni-Larrey (retrochondrosternal, retrocostoxyphoid, retrosternal, subcostal, substernal or subcostosternal hernia), which allowed us to report an update on this condition in the adult, and on thoracoabdominal diaphragm morphogenesis. It is in the embryology of the diaphragm where an explanation may be found for some morphological changes and clinical manifestations, even though a number of uncertainties remain. We also analyze the extent of controversy persisting on some aspects of surgical treatment (access routes, mesh use, hernial sac reduction). Overall, minimally invasive techniques predominate. We consider laparoscopy the approach of choice for adult patients with parasternal hernia eligible for surgery.
This article focuses on Antonio de Gimbernat y Arbós (1734-1816), with particular attention paid ... more This article focuses on Antonio de Gimbernat y Arbós (1734-1816), with particular attention paid to his famous publication ''Nuevo método de operar en la hernia crural'' (2013 marking its 220 anniversary), which was translated into English by Thomas Beddoe two years later (A new method of operating for the femoral hernia Translated from the Spanish of Don Antonio de Gimbernat, To which are added, with plates by the translator, queries respecting a safer method of performing inoculation). Antonio de Gimbernat y Arbós, a Spanish anatomist and surgeon, was one of the pioneers during the ''Age of Dissection'' (late 18th Century). He was a man of great willpower, bright, thorough, and unique. From his careful anatomical study in the inguinal region, he made a detailed description of the lacunar ligament, which John Hunter called the Gimbernat's ligament in his honor. Antonio de Gimbernat y Arbós also proposed an advanced treatment for strangulated femoral hernias. He acquired extraordinarily broad surgical skills with therapeutic orientation, conservative, not aggressive, based on the knowledge he had gained through dissection. Furthermore, though this is less well known nowadays, Antonio de Gimbernat y Arbós was also relevant organizer of education and health-services-as it was the custom of the great physician of this time. Consequently, Antonio de Gimbernat y Arbós is truly representative of the great figures of the anatomistssurgeons of the Enlightenment.
La ocupación es una actividad propositiva que desde los tiempos más remotos ha influido en la evo... more La ocupación es una actividad propositiva que desde los tiempos más remotos ha influido en la evolución humana determinando la organización de su tiempo vital. También a lo largo de la historia de la Medicina ha sido utilizada como forma de tratamiento, en la actualidad denominada Terapia Ocupacional. Desde 1917 ha desarrollado una serie de protocolos de actuación en consonancia con el paradigma predominante. Entre ellos se encuentra el Modelo Biomecánico con una vigencia de unos 50 años, aplicable en situaciones disfuncionales de origen ortopédico con integridad del SNC.
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