Papers by indu rani singh
Coir pith is a polyphenol containing agroindustrial residue which causes land and water pollution... more Coir pith is a polyphenol containing agroindustrial residue which causes land and water pollution. Research programs are advancing by utilising coir pith as a substrate for bio energy production, and oxidative delignificationwas reported as an effective pretreatmentmethod. Oxidative delignification process generates highly coloured ÂÂCoir pith Black LiquorÂÂ (CBL) as effluent and its release to open environment poses pollution risks. Evaluation of toxicity of CBL is of significance for its safe disposal plans. In the present study, we investigated the phytotoxicity of CBL to a standard test species Oryza sativa. A 96 hour bioassay was conducted. Root length, shoot length, seed germination, Germination Index (GI), Seed Vigor Index (SVI) and Shoot toRoot ratio (S:R)were the parameters studied. Data acquisition was done with the help of image analysis software ÂÂFijiÂÂ. Statistical analysis was carried out using ÂÂRÂÂ software. The EC50 (Median Effective Concentration), the conce...
The present investigation deals with solubility enhancement of Etodolac (ETD) through co-crystals... more The present investigation deals with solubility enhancement of Etodolac (ETD) through co-crystals technique utilizing various co-formers and to evaluate their therapeutic efficacy against carrageenan-induced inflammation. Co-formers citric acid anhydrous and tartaric acid were selected to formulate ETD co-crystals to improve solubility and dissolution employing neat grinding technique. The prepared co-crystals were characterized for solubility enhancement, Fourier transform infrared spectroscopy (FTIR), differential scanning calorimetry (DSC), powder X-ray diffraction (PXRD), in vitro dissolution and stability studies. The co-crystals were further investigated for in vivo studies to assess their potential to cure paw edema in mice. The outcome of the study illustrated significantly improved solubility and dissolution of ETD up to 6.15 folds using citric acid. Approximately a two-fold reduction in nitric oxide and cytokines levels was observed with optimized formulation. Also, substa...
Global education requires collaborative, standardized and flexible teaching pedagogies which are ... more Global education requires collaborative, standardized and flexible teaching pedagogies which are fit for purpose to each local community and diverse range of changing student population across institutions. Educational initiatives and use of technology are essential to train self-directed lifelong learners with transferrable skills preparing graduates for technical, professional, entrepreneurial and multinational leadership roles in future. The emerging economies are based on knowledge as a key factor of production, and industries demand highly trained employees in the fast changing health industry. To address diverse needs of students, mixed mode innovative strategies need to be used to train globally work ready allied health care graduates with modern day employability attributes including good soft and human skills by incorporating flexible learning tools and technology. Our teaching strategies, resulting in very high employment rate before graduation with global employers and low attrition rate, include work integrated learning, problem based learning, inter professional learning, team work with group discussions leading to peer review, reflective practice, self-directed learning and various means of formative and summative assessment items. This is incorporated within horizontal and vertical scaffolding of teaching material across courses and subjects to prepare interdisciplinary graduates for very liquid workplace of the world today. This article will introduce some of the above mentioned strategies employed and successfully achieved by our degree programs across allied health. However, our challenges remain in evaluation of effectiveness and incorporation of entrepreneurship for increasing healthcare students aspiring to be self-employed innovators in the international healthcare industry.
Five promising lines of faba bean, which includes two line i.e. 2011215 and 2011410 for grain pur... more Five promising lines of faba bean, which includes two line i.e. 2011215 and 2011410 for grain purpose with yield potential of >5.0t/ha and three promising lines viz., VFBP201302, VFBP201304 and VFBP201306 were identified for vegetablepurposes with green pod yield potential of 21.51 to 23.54 t/ha, suitable for Eastern Parts of India.These developed lines were evaluated along with national check varieties viz., Vikrant and Pusa Sumeet for its nutritional and antinutritional quality.Developed lines containmore dietary fiber, total soluble sugar, total starch, phosphorus, iron manganese and zinc. Less phytate was found in the developed lines as compare to checks varieties. Maximum (1.56%) fat was reported in VFBP 201304 (IC No IC No. 0595988), Maximum dietary fiber (13.49%) was obtained inthe 2011410 line (IC No.0595986), however, minimum dietary fiber was found in check variety Vikrant (11.94). Similarly, minimum (0.10%) phytate was noticedin the line 2011215(IC No. 0595985).
Journal of entomology and zoology studies, 2017
The present study was carried out on 24 birds of different age groups of Uttara fowl and elucidat... more The present study was carried out on 24 birds of different age groups of Uttara fowl and elucidates the age-related changes in the heart through gross morphological and gross morphometrical studies. The birds were reared and procured from the Instructional Livestock Farm (ILF), GBPUA&T, Pantnagar and were divided into four age groups viz. day old, 7, 28 and 112 days old. The present research study was undertaken for a period of four months from January, 2017 to April, 2017. Gross morphological studies revealed that the heart of Uttara fowl was located in the cranial part of thoracoabdominal cavity was enclosed by semi-transparent pericardial sac. The shape of the heart of Uttara fowl was like a cone with pointed apex and wide base. As the age advanced this cone becomes less pointed towards the apex. The colour of heart was brownish red which become darken with increase in age. Gross morphometrical studies revealed that there was a gradual increase in body weight of bird which was 37...
A series of 7-un/substituted-2-spiro-[5-((1-acetyl-5-(substitutedphenyl)amino)-3-(1-acetyl-5-(sub... more A series of 7-un/substituted-2-spiro-[5-((1-acetyl-5-(substitutedphenyl)amino)-3-(1-acetyl-5-(substitutedphenyl)) pyazolin-3-yl)-1,3,4-oxadiazol-2-yl]coumarins (4a-4h) and 7-un/substituted-2-spiro-2-[(-5(substitutedphenyl)amino-4-(5-(substitutedphenyl))pyazolin-3-yl)-1,3,4-oxadiazol-2-yl]coumarins (5a-5h) by the reaction of 7-un/substituted-2-spiro-(3-substitutedarylidinyl chalconyl)-5-(substitutedarylidinylaminochalconyl)oxadiazol-2-yl)coumarins (3a-3h) with hydrazine hydrate and hydroxyl amine respectively. All the newly synthesized compounds were screened for their antibacterial activity against K. pneumoniae, S. aureus, E. coli and B. sublitis and were compared with the standard drug ciprofloxacin. The most potent antibacterial compound of this series was 4g. Structure of all the compounds were established by the elemental (C, H, N) and spectral (IR,
Red mud a real solid waste\by product produced from the digestion of bauxite ore with caustic sod... more Red mud a real solid waste\by product produced from the digestion of bauxite ore with caustic soda for the production of alumina. During the past decadal comprehensive work has been carried out by lot of researcher to develop various ways for the utilization of red mud. This paper deals with the basic and engineering property of red mud it's neutralization and disposal methods as enormous quantity in generation of red mud is creating threatening environmental issues .It also account for production and depiction of red mud in concern with the world and Indian context. The chemical and mineralogical composition of red mud are also resumed up.
Scientific Reports, 2021
Elevated blood serotonin levels have been observed in patients with heart failure and serotonin h... more Elevated blood serotonin levels have been observed in patients with heart failure and serotonin has a role in pathological cardiac function. The serotonin receptor system was examined in adult rat isolated cardiac fibroblast and myofibroblast cells. This is one of the first studies that has investigated serotonin receptors and other proteins involved in the serotonin receptor system in rat cardiac fibroblast and myofibroblast cells. Rat primary cardiac fibroblasts were isolated and transformed into myofibroblasts using 5 ng/ml TGF-β1. Transformation of cells to myofibroblasts was confirmed with the presence of α-smooth muscle actin using Western blot. Serotonin metabolism and receptor protein expression was assessed using Western blot techniques and serotonin levels measured using ELISA. The 5-HT1A, 5-HT2A and 5-HT2B receptors were found to be present in both rat cardiac fibroblasts and myofibroblast cells, however no significance in protein expression between the two cell types was...
Recent Advances in Computer Science and Communications, 2021
Background: Breast cancer is the development of a malignant tumor in the breast of human beings (... more Background: Breast cancer is the development of a malignant tumor in the breast of human beings (especially females). If not detected at the initial stages, it can substantially lead to an inoperable construct. It is a reason for majority of cancer-related deaths throughout the world. Objectives: The main aim of our study is to diagnose the breast cancer at early stage so that required treatment can be provided for survival. The tumor is classified as malignant or benign accurately at early stage using a novel approach that includes an ensemble of Genetic Algorithm for feature selection and kernel selection for SVM-Classifier. Methods: The proposed GA-SVM (Genetic Algorithm – Support Vector Machine) algorithm in this paper optimally selects the most appropriate features for training with the SVM classifier. Genetic Programming is used to select the features and the kernel for the SVM classifier. Genetic Algorithm operates by exploring the optimal layout of features for breast cancer...
Ingénierie des systèmes d information, 2020
Breast cancer causes a high percentage of mortality among women throughout the world. For improvi... more Breast cancer causes a high percentage of mortality among women throughout the world. For improving breast cancer survival and results, early detection is important. The primary aim of the given study is to enhance the results of automated expert system (ES) in the field of medical diagnosis and come up with more accurate diagnosis system for breast cancer detection at early stage. This research introduces a new ensemble approach that accurately diagnose the breast cancer at a pre-developed stage. The recognized Wisconsin Diagnosis Breast Cancer (WDBC) dataset is used to provide raw breast cancer data in our study. Our proposed model rGWO-KSE (revised Grey Wolf Optimized SVM KNN Ensemble) implements an SVM-KNN ensemble and optimizes it with our newly introduced rGWO (revised Grey Wolf Optimization) technique. The performance of the proposed algorithm is evaluated based on several measures, e.g. accuracy, sensitivity, specificity, f-score and precision. Our model achieves 98.83 % accuracy in detection of breast cancer on WDBC dataset. The comparison with the previous studies for breast cancer detection proves that the proposed study provides better values for performance measures.
Diabetes & metabolic syndrome, Jan 30, 2017
Type-2 Diabetes Mellitus (T2DM) is one of the most prevalent and progressive metabolic conditions... more Type-2 Diabetes Mellitus (T2DM) is one of the most prevalent and progressive metabolic conditions affecting approximately 8.5% of the global population. Individuals with T2DM have a significantly increased risk of developing chronic conditions such as cardiovascular disease (CVD) and its associated complications, therefore, it is of great importance to establish strategies for combatting T2DM and its associated chronic conditions. Current literature has identified several biomarkers that are known to play a key role in the pathogenesis of CVD. Many of these biomarkers affecting CVD are influenced by an increase in oxidative stress as seen in T2DM. The purpose of this review is to analyse and correlate the oxidative stress-related biomarkers that have been identified in the literature to provide an updated summary of their significance in CVD risk factors. This review has analysed current research on T2DM, CVD, and oxidative stress. Four key cardiovascular risk factors: thrombosis, i...
Canadian Journal of Communication, 1980
The last few years have witnessed an unprecedented turn of events in the socio-political climate ... more The last few years have witnessed an unprecedented turn of events in the socio-political climate of India. These socio-political changes have brought about corresponding changes in the character of the Indian mass media system, especially in the freedom and independence of the Indian press. In June, 1975, Indira Gandhi's government declared a state of emergency and suspended civil liberties. Immediately after this declaration, the government tightened its controls on the Indian mass media, especially on the newspapers which had reputations of being free and lively.
Chemical Sciences Journal, 2016
In this study, Coconut Coir Pith was used to prepare a low cost bio adsorbent through chemical mo... more In this study, Coconut Coir Pith was used to prepare a low cost bio adsorbent through chemical modification. The effect of adsorbent dosage, contact time, initial metal-ion concentration, pH and temperature on the adsorption of nickel onto chemically modified coconut coir pith was investigated. The maximum removal was observed at pH 6.0 and adsorbent dose 2.0 g/L for initial metal-ions concentration 50 mg/L. Study of temperature effect proved that the process is endothermic. Langmuir and Freundlich isotherm models were used for equilibrium adsorption data. Langmuir isotherm proved to be a better fit. Pseudo first order and pseudo second order kinetic models were applied to analyze the kinetic mechanism of adsorption. The values of Gibbs free energy ΔG°, Enthalpy ΔH° and Entropy ΔS° was calculated by the thermodynamic studies.
PLOS ONE, 2016
HFE-HH impairs the haemorheological properties of blood; however, RBC aggregability was similar b... more HFE-HH impairs the haemorheological properties of blood; however, RBC aggregability was similar between HFE-HH and controls when cells were suspended in a plasma-free medium, indicating that plasma factor(s) may explain the altered haemorheology in HFE-HH patients. Acute exposure to elevated iron levels does not appear (in isolation) to account for these differences. Further consideration is required prior to utilising routine venesection blood for harvesting RBC concentrates due to the potential risk of microvascular disorders arising from impaired haemorheology.
Improving Health Management through Clinical Decision Support Systems
Hereditary Hemochromatosis (HH) is a disorder where iron and ferritin concentrations in a patient... more Hereditary Hemochromatosis (HH) is a disorder where iron and ferritin concentrations in a patient's blood are much higher than normal healthy levels. The main therapeutic intervention for individuals with HH is removing 300-500 mL of blood every few months to maintain ferritin concentration within acceptable ranges. The blood collected during these venesections is usually discarded as there is a belief that blood with high levels of ferritin are not suitable for blood transfusion purposes. Australian Red Cross Blood Services voluntarily collects blood from donors for subsequent use in blood transfusion. Annually more than 700 thousand units are transfused within Australia and there is a constant need for new donors given the significant imbalance between supply and demand of blood products. Besides red cell transfusions, the Red Cross also issues donor blood for development of many other blood products essential for patient health care. The HH blood can currently be used for oth...
Herbicides - Properties, Synthesis and Control of Weeds, 2012
Polymer Journal, 2012
The processing parameters, namely, clay loading, magnetic stirring time and sonication time, were... more The processing parameters, namely, clay loading, magnetic stirring time and sonication time, were optimized for the dispersion of two types of clay into an epoxy and into chopped strand mat (CSM) glass fiber-based epoxy nanocomposite laminates. A vacuum-assisted resin transfer molding setup was used to fabricate these laminates. Optimizations were performed based on improvements in Young's modulus. The intercalated and exfoliated distributions of clay in the composites were confirmed using X-ray diffraction and transmission electron microscopy. The transmission electron micrographs of optimized specimens showed a well-ordered intercalated structure within the epoxy. Using optimized processing conditions, three layered laminates of CSM, woven roving glass fibers or both were prepared with epoxy and clay for the preparation of new lightweight hybrid epoxy nanocomposites. The tensile, flexural and impact properties of these hybrid nanocomposites were investigated. A combination of the two types of glass fibers produced promising results.
Fertility and Sterility, 2002
Objective: Insulin resistance, and its compensatory hyperinsulinemia, plays a key role in the pat... more Objective: Insulin resistance, and its compensatory hyperinsulinemia, plays a key role in the pathogenesis of infertility in women with PCOS. Metformin is an insulin-sensitizing agent, which appear to ameliorate the biochemical profile and improve reproductive function in obese patients with PCOS. The objective of this study was to examine the effects of combined metformin and CC treatment on endocrine function and pregnancy rates in nonobese infertile women with PCOS. Design: Prospective study in a private practice. Materials/Methods: Our study included 102 non-obese (BMI <25 Kg/m2) women with PCOS. Blood samples were obtained in the early follicular phase of the cycle. Basal blood estradiol, follicle stimulating hormone (FSH), luteinizing hormone (LH), insulin, thyroid stimulating hormone (TSH) and prolactin were determined using commercially available kits. Diagnosis of PCOS was based on a history of oligohypomenorrhea, and/or anovulation, pelvic ultrasound and reversed LH/FSH ratio (>2). The patients received no treatment for at least 3 months prior to recruitment. Patients were categorized into 2 groups: group I received CC 50 mg/day from day 3 to day 7 of the cycle and metformin 1000 mg/day (n = 51). Group II received CC 50 mg/day from day 3 to day 7 of the cycle and a placebo (n = 51). A second hormonal profile was performed in non-pregnant women after 6 months of treatment. The mean (± SD) age of patients was 28 ± 6 in group I and was 31 ± 7 in group II. The 2 groups were comparable regarding basal levels of insulin, estradiol, LH, FSH and LH/FSH ratio. Levels of TSH and prolactin were normal for all patients. A clinical pregnancy was found in 24/51 (47%) patients in group I within 6 months of treatment (per cycle pregnancy rate = 9.8%) compared to 13/53 (25.5%) in group II (per cycle pregnancy rate = 4.8%) (P = 0.023). Basal LH/FSH ratio in pregnant women from group I (n = 24) was significantly lower than the basal ratio in non-pregnant women from the same group (n = 27) (P = 0.026). However, LH/FSH ratio of nonpregnant women in group I at 6 months following treatment was not significantly different from the basal ratio of pregnant women in the same group (P = 0.651). LH and LH/FSH ratio of non-pregnant women, at 6 months, were significantly lower than basal values only in group I (P = 0.008 & 0.019; respectively). Our data indicate that co-administration of metformin with CC results in a significant increase in pregnancy rates than CC alone. Such improvement in pregnancy rates may be related, at least in part, to reduction of LH level and LH/FSH ratio. The lack of significant difference between basal LH/FSH ratio in pregnant women and that of non-pregnant women after 6 months of treatment, suggests that the later group may benefit from longer duration of therapy.
Canadian Journal of Anesthesia/Journal canadien d'anesthésie, 2007
PURPOSE: Ornithine Transcarbamylase Deficency (OTCD) is a rare genetic condition that predisposes... more PURPOSE: Ornithine Transcarbamylase Deficency (OTCD) is a rare genetic condition that predisposes the patient to acute states of hyperammonemia. Acute decompensation, including increased intracranial pressure (ICP) has been documented in patients with late onset OTCD (1). Precipitating events in these patients include stressful circumstances such as surgery and the peripartum period (2,3). We discuss the anesthetic management of a parturient with known late onset OTCD. CLINICAL FEATURES: Consent was obtained from the patient for publication of this report. A 30 year-old primigravida with OTCD presented to our institution at 40 weeks with spontaneous rupture of membranes. Recent diagnosis of late onset OTCD had been made through family history and molecular analysis. Previous consultation at our institution's Metabolic Disease Clinic revealed normal ranges of serum ammonia, plasma amino acids and urine orotic acid. After clinical signs of increased ICP were ruled out, epidural analgesia was provided to decrease the stress of labour. A continuous infusion of Bupivicaine 0.125% and Fentanyl 2 ug/ml provided satisfactory labour analgesia. Serial laboratory investigations including serum ammonia, blood gases and electrolytes were gathered during admission. Ammonia levels ranged from <9 to 25 umol/L. Other laboratory data were within normal limits. Infusions of sodium benzoate and sodium phenylacetate were available in case of hyperammonemia. A 10% dextrose intravenous solution was infused to decrease catabolism and ammonia production. On the second day of admission the patient required Caesarian delivery secondary to poor progression of labour. This was performed successfully under epidural anesthesia with 2% lidocaine with epinephrine and preservative free morphine. A healthy male baby was born without incident. The patient progressed through an uneventful course in hospital. After a 48-hour observation period, the patient and child were discharged from hospital with scheduled follow-up in the Metabolic disease clinic. CONCLUSIONS: This is the first English language report in adult anesthesia literature on the management of a parturient with OTCD. Collaboration is required between Anesthesia, Obstetrical and Metabolic Disease teams in the peripartum period. Epidural anesthesia may be desirable in these patients to blunt the stress response to labour. A cautious approach to neuraxial blockade is advised in patients with suspected hyperammonemia, as increased ICP may be present. Treatment of symptomatic patients ranges from ammonia scavengers to haemodialysis. Other goals of care include avoidance of ammonia-producing medications such as
Brazilian Journal of Plant Physiology, 2006
Various lipid classes and compounds were monitored during the period of leaf emergence to leaf dr... more Various lipid classes and compounds were monitored during the period of leaf emergence to leaf drop of Catharanthus roseus. The expansion to early maturation phase was accompanied by cellular build-up of all major lipid classes, whilst aging and senescence were characterized by their substantial decline, except for the neutral lipids; the leaf monogalactosyl diglyceride/digalactosyl diglyceride ratio decreased from 4.3 (complete maturity) to 2.1 (abscised stage). The early maturation stage was the earliest stage when appreciable amounts of free sterols and fatty acids could be observed. Sterol/phospholipids ratios increased by 68-fold in the abscised leaf as compared to that at full maturity. The unsaturated/saturated fatty acid ratio was far lower in the senescent leaf as compared to that of the fully expanded leaf. The spatial alterations in lipid profiles may be suggestive of concomitant changes in membrane ultrastructure and functions, putatively leading to perturbation of indol...
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Papers by indu rani singh