Background: Adropin is a bioactive protein that maintains energy balance through the metabolism o... more Background: Adropin is a bioactive protein that maintains energy balance through the metabolism of glucose and lipids. Adropin is associated with blood pressure, endothelial function, and glucose metabolism, according to reported studies. High blood pressure is one of the complications of obesity. Objectives: Our study investigated the relationship between adropin levels and systolic and diastolic blood pressure in obese adolescents. Methods: The study was conducted with a total of 88 adolescents, 45 females and 43 males, aged 10-18 years. The mean age of the participants was 13.79 ± 1.98 years. Participants were divided into two groups: "obese" (n = 61) and "control" (n = 27). Adolescents with a body mass index (BMI) above the 95% percentile for age, gender, and race were defined as "obese." The control group comprised adolescents with a body mass index between the 5th and 85th percentiles. A sample was taken from the forearm pit of the subjects after fasting for at least 12 hours for the determination of glucose, insulin, urea, creatinine, aspartate aminotransferase (AST), alanine aminotransferase (ALT), gamma-glutamyl transferase (GGT), C-reactive protein (CRP), total cholesterol, low-density lipoproteincholesterol (LDL-cholesterol), high-density lipoprotein-cholesterol (HDL-cholesterol), triglyceride, thyroid-stimulating hormone (TSH), free T4 (fT4), and 25-hydroxyvitamin D3. In both groups, systolic and diastolic blood pressures were assessed using an aneroid manometer and a suitable cuff after subjects had rested for at least 10 minutes in the outpatient clinic. The following formula determined the homeostatic model of assessment for insulin resistance (HOMA-IR): fasting insulin (uIU/mL) × fasting glucose (mg/dL) /405. An enzyme-linked immunosorbent assay (ELISA) kit was used to measure adropin levels. Results: The insulin, HOMA-IR, AST, ALT, GGT, CRP, triglyceride, and LDL-cholesterol levels of adolescents in the obese group were statistically significantly higher than those in the control group (P < 0.05). HDL-cholesterol and 25-hydroxyvitamin D3 levels of adolescents in the obese group were statistically significantly lower than those of the control group (P < 0.05). There was no statistically significant difference between groups in glucose, urea, creatinine, total cholesterol, TSH, fT4, and adropin levels (P > 0.05). In the obese group, there was an inverse and statistically significant correlation between adropin level and diastolic blood pressure (P: 0.029; P < 0.05). Conclusions: We found an inverse relationship between adropin levels and DBP but no relationship between adropin levels and SBP in obese adolescents.
Doğumda genetik ve biyolojik olarak belirlenmiş cinsiyet ile cinsiyet kimliğinin uyuşmaması cinsi... more Doğumda genetik ve biyolojik olarak belirlenmiş cinsiyet ile cinsiyet kimliğinin uyuşmaması cinsiyet disforisi (cinsiyet hoşnutsuzluğu) olarak tanımlanmaktadır. Çocukluk yaşlarından itibaren görülmekle beraber sekonder seks karakterlerinin geliştiği ergenlik döneminde bu tablo ağırlaşmaktadır. Bu nedenle DSM-V tanı kriterleri ile birey değerlendirilmeli gerekli tıbbi onamlar alındıktan sonra geri dönüşümlü bir tedavi olan GnRH agonistleri ile önce puberte baskılanmalı ve tıbbi endikasyon konulan hastalarda bir sonraki aşama olan istenen cinsiyet yönünde puberte indüksiyonu uygulanmalıdır. Daha sonraki aşamada ise uygun vakalarda cinsiyet değiştirici ameliyatlar yapılmaktadır. Bu ameliyatlar tam olarak geri dönüşümsüz olup uygun endikasyonlar açısından çok titiz davranılmalı ve operasyon kararı için acele edilmemelidir. Bu konuda tam bir konsensus sağlanmalıdır. Ameliyat kararı alınan hastalar için operasyon öncesinde doğurganlık ile ilgili tüm seçenekler ayrıntıları ile sunulmalıdır. Tüm bunların yanında sağlıklı nesillerin devamı açısından cinsel disforisi olan ergenleri yaftalamaktan kaçınılmalı ve bu bireylere tedavinin her aşamasında eşlik eden psikopatolojik durumlar nedeniyle psikolojik destek sağlanmalıdır.
Bacterial infections such as erysipelas, cellulitis, furuncle, carbuncle, or folliculitis are com... more Bacterial infections such as erysipelas, cellulitis, furuncle, carbuncle, or folliculitis are common infections of the skin, which is the largest organ of the body that forms a protective layer by wrapping the body. These skin bacterial infections of the skin are very important in pediatric medicine and primary health care. These infections usually occur when skin integrity is impaired. Skin integrity should be preserved with personal hygiene measures, and a multidisciplinary approach should be given to these skin infections with appropriate antibiotic regimens and when necessary, with dermatology and pediatric infectious disease consultations.
Zenodo (CERN European Organization for Nuclear Research), Apr 24, 2023
The atherogenic index of plasma (AIP) is calculated as the logarithmic conversion of the triglyce... more The atherogenic index of plasma (AIP) is calculated as the logarithmic conversion of the triglyceride to high density lipoprotein-cholesterol ratio [log₁₀(Triglyceride/HDL-cholesterol)]. AIP values of <0.11 are considered lower risk, between 0.11 and 0.21 are considered medium risk, and >0.21 are considered higher risk. AIP produced by triglycerides and HDL-cholesterol, avoiding the inconsistent assessment of different lipid components and simplifies task of a marker in clinical application. It has been reported that AIP value is an important predictor for cardiovascular diseases and atherosclerosis. COVID-19 is a viral infection that started in 2019 and quickly caused a pandemic. And it continues to cause death, especially in people with pre-existing comorbidities. COVID-19 infection is associated with lipid levels and cardiovascular disease. Studies have shown that AIP levels are high in COVID-19 patients. In addition, studies have found that high AIP values are associated with prolonged hospital stay, poor prognosis, and increased disease severity. Reporting of AIP value in laboratory results may alarm clinicians for atherosclerosis and cardiovascular diseases.
Objective: Anemia, which is a public health problem on a global scale, continues to maintain its ... more Objective: Anemia, which is a public health problem on a global scale, continues to maintain its importance in pediatric patients. There are few studies on the prevalence of anemia in hospitalized children. This study was conducted to evaluate the prevalence and etiologies of anemia in hospitalized pediatric patients. Material and Method: This is a cross-sectional epidemiological study. The study group consists of 1000 patients between the ages of 6 months and 18 years who were hospitalized in the Department of Pediatrics of Prof. Dr. Cemil Tascioglu City Hospital. The data of the patients were reviewed retrospectively. The SPSS 22.0 program was used for statistical analyzes and calculations and p< 0.05 was accepted for significance. Results: Of the patients included in the study, 569 (56.9%) were male, and 431 (43.1%) were female. In the study, the number of patients with anemia was 276 (27.6%), and among those 151 (26.5%) were male and 125 (29.0%) were female. The highest rate ...
Internet addiction, which is one of the handicaps seen as a result of modern lifestyle and techno... more Internet addiction, which is one of the handicaps seen as a result of modern lifestyle and technological development, can be defined as the inability to prevent the desire to use the internet excessively and the need for more and more time spent on the internet. Rather than banning the internet entirely, controlling its use is a more appropriate option. As in all addictions, when the problem cannot be solved, it is important to benefit from medical and cognitive therapies and, when appropriate, child and adolescent mental health counseling.
enoch-Schönlein purpura (HSP) was first described by Heberden, in 1801, and its relationship with... more enoch-Schönlein purpura (HSP) was first described by Heberden, in 1801, and its relationship with arthritis was highlighted by Schönlein, in 1837 [1]. HSP is a leukocytoclastic vasculitis with small vessel involvement; it mainly affects the skin as well as joints, the gastrointestinal system (GIS), kidneys, and, more rarely, other organs. Its etiology is not fully known [2] and it is the most widespread reason of non-thrombocytopenic purpura in children. It is a disease that is generally seen in children between the ages of 5 and 15 years. The estimated incidence of the disease in children <17 is 13-20/100.000 [3]. Although the etiology of HSP is unknown, it has been reported that various factors such as infections, vaccines, drugs, foods, and insect bites trigger the disease [4]. The fact that two-thirds of the patients had a history of upper respiratory tract infection (URTI) and the disease was more commonly seen in winter and spring, when URTIs are very frequent, could be incidental, but it is more likely that HSP is linked to infectious diseases. The most important microorganisms are streptococci; in addition, many viral and other bacterial agents have also been reported to precipitating the disease [3]. IgA plays an important role in the pathogenesis of HSP. Studies have shown renal mesenchymal IgA accumulation, increased serum IgA, and the presence of IgAcontaining immune complexes in patients with HSP [5]. The most common and distinct sign of the disease is a skin rash in the form of non-thrombocytopenic palpable purpura that appears, especially on lower extremities. Non-thrombocytopenic purpura, arthritis, and abdominal pain in the early phase of the disease constitute the classic triad of symptoms of HSP and facilitate a clinical diagnosis [5]. The skin rash can be accompanied by soft tissue swelling, especially on the scalp, on the tibial aspect of the lower extremities, and on the back of the hands. Less frequently, localized edema on the eyelids, lips, ears, and perineum can be seen especially in younger children [6]. This edema is not associated with proteinuria, but it generally stems from angioedema and does not leave an indented mark when pressed [7]. Joint involvement in HSP manifests as arthralgia or arthritis. Knee, elbow, wrist, and ankle involvement are frequently seen. There is no intra-articular hemorrhage or effusion, nor permanent deformity [8].
Objective: Zinc is an essential trace element for the body that is involved in various significan... more Objective: Zinc is an essential trace element for the body that is involved in various significant body functions such as protein synthesis, DNA synthesis, and cellular growth. It is found in almost every cell and plays an important role in the immune system, affecting both innate and acquired immunity. Patients with beta-thalassemia major are at risk of zinc deficiency. Beta-thalassemia major is an inherited disease caused by a reduction or complete absence of beta-globin chains and the affected patients need repeated blood transfusions to survive. Accordingly, it causes oxidative stress and tissue damage, alteration of antioxidant enzymes, and changes in other essential trace element levels due to iron overload. Zinc levels in beta-thalassemia major patients were reported to be significantly reduced in most of the studies. Serum zinc levels of the patients with beta-thalassemia major should be monitored regularly and zinc supplementation should be provided to these patients.
Objective: We aimed to compare the platelet distribution width (PDW) and platelet parameters (PLT... more Objective: We aimed to compare the platelet distribution width (PDW) and platelet parameters (PLT), particularly MPV values of children who were diagnosed with adenoid hypertrophy at the pediatric clinic with those of healthy children to investigate a relationship between adenoid hypertrophy and MPV values. Material and method: This prospective, cross-sectional study was conducted at the department of pediatrics, Health Sciences University, Ministry of Health Okmeydanı Training and Research Hospital between January 2012 and December 2014. The PLT and PDW values as well as MPV of children who were diagnosed with adenoid hypertrophy were compared with those of healthy children. Results: In this study, 120 children with adenoid hypertrophy and 120 healthy children were evaluated. The age range of participants was between 3 years and 16 years, and the mean age was 9.13±2.94 years. The mean MPV value in children with adenoid hypertrophy (10.88 ± 1.15 fL) was statistically significantly higher than that in the control group (9.84 ± 1.04 fL). While the mean platelet distribution width value in the adenoid hypertrophy group was statistically significantly higher than that of the control group, there was no statistically significant difference between the mean platelet counts of both groups. Conclusion: MPV, PLT, and PDW values did not differ significantly in children with adenoid hypertrophy compared to healthy children. MPV values were determined significantly higher in children with adenoid hypertrophy when compared with healthy children. Children with adenoid hypertrophy should be followed up in terms of cardiovascular diseases on the long view.
Objective: The aim of this study was to evaluate the approach of parents to fever of children and... more Objective: The aim of this study was to evaluate the approach of parents to fever of children and related factors. Methods: In this survey study, A 26-question survey was conducted the parents whose children were under 15 years of age and admitted to the department of Emergency at Ministry of Health Okmeydan? Training and Research Hospital between November 2014 and April 2015 due to fever. The survey questions included the presence of a thermometer at home, their manner of taking temperature, mother’s knowledge level about fever, methods applied for reducing fever, antipyretic use and their concerns as well as the demographic characteristics. Results: In the study, 250 parents who were parents of 132 boys and 128 girls enrolled and the mean age of mothers, fathers and children who participated in the study were 25, 29.3 and 3.6 years, respectively. Most of the families (81.2 %) were nuclear family which consists of mother, father and children. It was recorded that 3.2% of parents ...
The concepts of games and toys have a very important role in children's lives. It contributes to ... more The concepts of games and toys have a very important role in children's lives. It contributes to the development of cognitive, motor, psychosocial, emotional, and linguistic skills. It also plays a key role in raising self-confident, creative, and happy children. Therefore, attention should be paid to the concepts of games and toys, which are so important for the child to be a part of society as a healthy individual at every stage of his development. On the other hand, providing playgrounds where children can play comfortably and safely are essential in reducing the risk of accidents related to toys. All health-care components, especially pediatricians and family physicians, should take an active role in ensuring that these play processes, which are the most beautiful parts of childhood, are healthy and safe.
Background: Glypican-4 is an adipose tissue-originated cytokine which enhances insulin signaling ... more Background: Glypican-4 is an adipose tissue-originated cytokine which enhances insulin signaling through direct interaction with the insulin receptors. Objectives: The aim of this study was to analyze the relationship between obesity and serum glipican-4 levels in adolescents. Methods: Our study was carried out on 80 volunteer adolescents, 49 were obese patients and 31 were healthy normal weight control cases. The adolescents with a body mass index (BMI) of 95% percentile and over were defined as obese in terms of age and sex. The Enzyme-Linked Immuno Sorbent Assay kit was utilized for the assessment of Glypican-4 in serum. Laboratory assays (glypican-4, glucose, urea, creatinine, AST, ALT, total cholesterol, triglyceride, HbA1c, insulin, HOMA-IR), age, sex and BMI were compared amidst the groups. Correlations between glypican-4 levels and laboratory factors were analyzed in the obese adolescent group. Results: The average age of the research participants was 13.2 ± 1.8 years. The mean BMI was 27.1 ± 5.1 kg/m 2. Of the 49 obese adolescents, 41 were insulin resistant, and 8 did not have insulin resistance. The levels of glypican-4, BMI, AST, ALT, HbA1c, triglyceride, HOMA-IR and insulin were notably higher in the obese group than the control group (P < 0.05). In obese group, no statistically remarkable relationship was found between glypican-4 levels and other parameters (P > 0.05). Conclusions: We found high serum glypican-4 levels in obese adolescents. We suggest that glypican-4 levels may be increased in order to reduce insulin resistance in obese adolescents.
Background: Febrile seizures are defined as seizures associated with a febrile illness that devel... more Background: Febrile seizures are defined as seizures associated with a febrile illness that developed without central nervous system infection or acute electrolyte imbalance, intoxication, trauma, and metabolic disorder in children aged 1 month to 5 years without previous afebrile seizures. Various studies show a relationship between zinc levels and febrile seizures. Objectives: The purpose of this study was to examine the relationship between serum zinc levels and febrile seizures. Methods: This prospective, cross-sectional, and descriptive study was conducted from 04/10/2021 to 04/02/2022. A total of 85 children aged 6 months to 5 years admitted to the pediatric emergency service of the Republic of Turkey Ministry of Health Cemil Taşcıoğlu City Hospital were included in the study. The patients who met the inclusion criteria and whose consent was obtained were included in the study. Complex and febrile status patients were not included in the study due to the small number of patien...
This study was conducted to determine mothers&amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp... more This study was conducted to determine mothers&amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;#39; knowledge about fever, and their attitudes and responses to fever in children, along with the influence of demographic characteristics on the level of knowledge, and to identify occurrences of fear of fever. The study consisted of 4500 mothers with children 0-12 years of age who were referred to the pediatric health and disease polyclinic and primary care polyclinic over a period of 24 months. Data were collected using a questionnaire containing 32 open-ended, multichoice questions, and assessed using number, percentage and χ(2) analyses. In this study, 36% of mothers regarded body temperatures lower than 37°C as fever; 83% believed that fever was harmful for their children, and 92.3% experienced fear and concern due to their child&amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;#39;s fever. The most significant reason for fear was the belief that the child may have a seizure. Moreover, 12% of mothers feared that their child would die due to fever. The level of fear triggered by fever was lower as the education level of the mothers increased. Meanwhile, when their child had a fever, 28.9% of mothers used antifebrile drugs without consulting a physician, while 19% applied cold water and 7.7% applied water with alcohol or vinegar, among other inappropriate practices. Increased information about fevers geared towards the caregivers of children, particularly mothers, would prevent the unnecessary treatment of children, as well as minimising delayed and insufficient responses to fever.
Objective: The aim of this study was to evaluate mood changes in mothers of infants diagnosed wit... more Objective: The aim of this study was to evaluate mood changes in mothers of infants diagnosed with infantile colic.Materials and Methods: In this prospective case-control study, mothers with infants who were referred to the Pediatric Clinic of Ministry of Health Okmeydani Research and Training Hospital and diagnosed with infantile colic between November 2014 and February 2015 were compared with those of infants without infantile colic using the Beck Depression Inventory and a questionnaire.Results: A total of 31 mothers with male infants (51%) and 30 mothers with female infants (49%) participated in the study. The mean Beck depression inventory scores were 18.3 (min 5-max 35 points; median score: 21) in the infantile colic group and 14.6 (min 5-max 33; median score: 12) in the control group. Beck depression inventory scores in the infantile colic group were significantly higher than those of control group. The mean Beck depression inventory scores were 17.0 (min 5-max 32 points; med...
Introduction: Obesity is a gradually more important multifactorial disease in both children and a... more Introduction: Obesity is a gradually more important multifactorial disease in both children and adults. Obese children and adolescents are at higher risk of becoming obese in adulthood, which is associated with an increased risk of mortality and morbidity. There is subclinical systemic inflammation in obesity. The study aimed to evaluate the hematological parameters as an indicator of inflammation in obese adolescents and to show the relationship of monocyte/HDL-cholesterol ratio, having a lipid component, with other inflammatory hematological parameters. Materials and methods: We retrospectively reviewed the medical files of 60 patients, 30 obese and 30 healthy controls, aged between 11 and 16 years, who applied to the pediatric outpatient clinic. Laboratory tests, hematological parameters, gender, age, and BMI were compared between the groups. Correlations between monocyte/HDL-cholesterol ratio and other laboratory parameters in the obese group were examined. Results: BMI, Alanine...
Objective: The aim of this study was to evaluate mood changes in mothers of infants diagnosed wit... more Objective: The aim of this study was to evaluate mood changes in mothers of infants diagnosed with infantile colic. Materials and Methods: In this prospective case-control study, mothers with infants who were referred to the Pediatric Clinic of Ministry of Health Okmeydanı Research and Training Hospital and diagnosed with infantile colic between November 2014 and February 2015 were compared with those of infants without infantile colic using the Beck Depression Inventory and a questionnaire. Results: A total of 31 mothers with male infants (51%) and 30 mothers with female infants (49%) participated in the study. The mean Beck depression inventory scores were 18.3 (min 5-max 35 points; median score: 21) in the infantile colic group and 14.6 (min 5-max 33; median score: 12) in the control group. Beck depression inventory scores in the infantile colic group were significantly higher than those of control group. The mean Beck depression inventory scores were 17.0 (min 5-max 32 points; m...
Background: Adropin is a bioactive protein that maintains energy balance through the metabolism o... more Background: Adropin is a bioactive protein that maintains energy balance through the metabolism of glucose and lipids. Adropin is associated with blood pressure, endothelial function, and glucose metabolism, according to reported studies. High blood pressure is one of the complications of obesity. Objectives: Our study investigated the relationship between adropin levels and systolic and diastolic blood pressure in obese adolescents. Methods: The study was conducted with a total of 88 adolescents, 45 females and 43 males, aged 10-18 years. The mean age of the participants was 13.79 ± 1.98 years. Participants were divided into two groups: "obese" (n = 61) and "control" (n = 27). Adolescents with a body mass index (BMI) above the 95% percentile for age, gender, and race were defined as "obese." The control group comprised adolescents with a body mass index between the 5th and 85th percentiles. A sample was taken from the forearm pit of the subjects after fasting for at least 12 hours for the determination of glucose, insulin, urea, creatinine, aspartate aminotransferase (AST), alanine aminotransferase (ALT), gamma-glutamyl transferase (GGT), C-reactive protein (CRP), total cholesterol, low-density lipoproteincholesterol (LDL-cholesterol), high-density lipoprotein-cholesterol (HDL-cholesterol), triglyceride, thyroid-stimulating hormone (TSH), free T4 (fT4), and 25-hydroxyvitamin D3. In both groups, systolic and diastolic blood pressures were assessed using an aneroid manometer and a suitable cuff after subjects had rested for at least 10 minutes in the outpatient clinic. The following formula determined the homeostatic model of assessment for insulin resistance (HOMA-IR): fasting insulin (uIU/mL) × fasting glucose (mg/dL) /405. An enzyme-linked immunosorbent assay (ELISA) kit was used to measure adropin levels. Results: The insulin, HOMA-IR, AST, ALT, GGT, CRP, triglyceride, and LDL-cholesterol levels of adolescents in the obese group were statistically significantly higher than those in the control group (P < 0.05). HDL-cholesterol and 25-hydroxyvitamin D3 levels of adolescents in the obese group were statistically significantly lower than those of the control group (P < 0.05). There was no statistically significant difference between groups in glucose, urea, creatinine, total cholesterol, TSH, fT4, and adropin levels (P > 0.05). In the obese group, there was an inverse and statistically significant correlation between adropin level and diastolic blood pressure (P: 0.029; P < 0.05). Conclusions: We found an inverse relationship between adropin levels and DBP but no relationship between adropin levels and SBP in obese adolescents.
Doğumda genetik ve biyolojik olarak belirlenmiş cinsiyet ile cinsiyet kimliğinin uyuşmaması cinsi... more Doğumda genetik ve biyolojik olarak belirlenmiş cinsiyet ile cinsiyet kimliğinin uyuşmaması cinsiyet disforisi (cinsiyet hoşnutsuzluğu) olarak tanımlanmaktadır. Çocukluk yaşlarından itibaren görülmekle beraber sekonder seks karakterlerinin geliştiği ergenlik döneminde bu tablo ağırlaşmaktadır. Bu nedenle DSM-V tanı kriterleri ile birey değerlendirilmeli gerekli tıbbi onamlar alındıktan sonra geri dönüşümlü bir tedavi olan GnRH agonistleri ile önce puberte baskılanmalı ve tıbbi endikasyon konulan hastalarda bir sonraki aşama olan istenen cinsiyet yönünde puberte indüksiyonu uygulanmalıdır. Daha sonraki aşamada ise uygun vakalarda cinsiyet değiştirici ameliyatlar yapılmaktadır. Bu ameliyatlar tam olarak geri dönüşümsüz olup uygun endikasyonlar açısından çok titiz davranılmalı ve operasyon kararı için acele edilmemelidir. Bu konuda tam bir konsensus sağlanmalıdır. Ameliyat kararı alınan hastalar için operasyon öncesinde doğurganlık ile ilgili tüm seçenekler ayrıntıları ile sunulmalıdır. Tüm bunların yanında sağlıklı nesillerin devamı açısından cinsel disforisi olan ergenleri yaftalamaktan kaçınılmalı ve bu bireylere tedavinin her aşamasında eşlik eden psikopatolojik durumlar nedeniyle psikolojik destek sağlanmalıdır.
Bacterial infections such as erysipelas, cellulitis, furuncle, carbuncle, or folliculitis are com... more Bacterial infections such as erysipelas, cellulitis, furuncle, carbuncle, or folliculitis are common infections of the skin, which is the largest organ of the body that forms a protective layer by wrapping the body. These skin bacterial infections of the skin are very important in pediatric medicine and primary health care. These infections usually occur when skin integrity is impaired. Skin integrity should be preserved with personal hygiene measures, and a multidisciplinary approach should be given to these skin infections with appropriate antibiotic regimens and when necessary, with dermatology and pediatric infectious disease consultations.
Zenodo (CERN European Organization for Nuclear Research), Apr 24, 2023
The atherogenic index of plasma (AIP) is calculated as the logarithmic conversion of the triglyce... more The atherogenic index of plasma (AIP) is calculated as the logarithmic conversion of the triglyceride to high density lipoprotein-cholesterol ratio [log₁₀(Triglyceride/HDL-cholesterol)]. AIP values of <0.11 are considered lower risk, between 0.11 and 0.21 are considered medium risk, and >0.21 are considered higher risk. AIP produced by triglycerides and HDL-cholesterol, avoiding the inconsistent assessment of different lipid components and simplifies task of a marker in clinical application. It has been reported that AIP value is an important predictor for cardiovascular diseases and atherosclerosis. COVID-19 is a viral infection that started in 2019 and quickly caused a pandemic. And it continues to cause death, especially in people with pre-existing comorbidities. COVID-19 infection is associated with lipid levels and cardiovascular disease. Studies have shown that AIP levels are high in COVID-19 patients. In addition, studies have found that high AIP values are associated with prolonged hospital stay, poor prognosis, and increased disease severity. Reporting of AIP value in laboratory results may alarm clinicians for atherosclerosis and cardiovascular diseases.
Objective: Anemia, which is a public health problem on a global scale, continues to maintain its ... more Objective: Anemia, which is a public health problem on a global scale, continues to maintain its importance in pediatric patients. There are few studies on the prevalence of anemia in hospitalized children. This study was conducted to evaluate the prevalence and etiologies of anemia in hospitalized pediatric patients. Material and Method: This is a cross-sectional epidemiological study. The study group consists of 1000 patients between the ages of 6 months and 18 years who were hospitalized in the Department of Pediatrics of Prof. Dr. Cemil Tascioglu City Hospital. The data of the patients were reviewed retrospectively. The SPSS 22.0 program was used for statistical analyzes and calculations and p< 0.05 was accepted for significance. Results: Of the patients included in the study, 569 (56.9%) were male, and 431 (43.1%) were female. In the study, the number of patients with anemia was 276 (27.6%), and among those 151 (26.5%) were male and 125 (29.0%) were female. The highest rate ...
Internet addiction, which is one of the handicaps seen as a result of modern lifestyle and techno... more Internet addiction, which is one of the handicaps seen as a result of modern lifestyle and technological development, can be defined as the inability to prevent the desire to use the internet excessively and the need for more and more time spent on the internet. Rather than banning the internet entirely, controlling its use is a more appropriate option. As in all addictions, when the problem cannot be solved, it is important to benefit from medical and cognitive therapies and, when appropriate, child and adolescent mental health counseling.
enoch-Schönlein purpura (HSP) was first described by Heberden, in 1801, and its relationship with... more enoch-Schönlein purpura (HSP) was first described by Heberden, in 1801, and its relationship with arthritis was highlighted by Schönlein, in 1837 [1]. HSP is a leukocytoclastic vasculitis with small vessel involvement; it mainly affects the skin as well as joints, the gastrointestinal system (GIS), kidneys, and, more rarely, other organs. Its etiology is not fully known [2] and it is the most widespread reason of non-thrombocytopenic purpura in children. It is a disease that is generally seen in children between the ages of 5 and 15 years. The estimated incidence of the disease in children <17 is 13-20/100.000 [3]. Although the etiology of HSP is unknown, it has been reported that various factors such as infections, vaccines, drugs, foods, and insect bites trigger the disease [4]. The fact that two-thirds of the patients had a history of upper respiratory tract infection (URTI) and the disease was more commonly seen in winter and spring, when URTIs are very frequent, could be incidental, but it is more likely that HSP is linked to infectious diseases. The most important microorganisms are streptococci; in addition, many viral and other bacterial agents have also been reported to precipitating the disease [3]. IgA plays an important role in the pathogenesis of HSP. Studies have shown renal mesenchymal IgA accumulation, increased serum IgA, and the presence of IgAcontaining immune complexes in patients with HSP [5]. The most common and distinct sign of the disease is a skin rash in the form of non-thrombocytopenic palpable purpura that appears, especially on lower extremities. Non-thrombocytopenic purpura, arthritis, and abdominal pain in the early phase of the disease constitute the classic triad of symptoms of HSP and facilitate a clinical diagnosis [5]. The skin rash can be accompanied by soft tissue swelling, especially on the scalp, on the tibial aspect of the lower extremities, and on the back of the hands. Less frequently, localized edema on the eyelids, lips, ears, and perineum can be seen especially in younger children [6]. This edema is not associated with proteinuria, but it generally stems from angioedema and does not leave an indented mark when pressed [7]. Joint involvement in HSP manifests as arthralgia or arthritis. Knee, elbow, wrist, and ankle involvement are frequently seen. There is no intra-articular hemorrhage or effusion, nor permanent deformity [8].
Objective: Zinc is an essential trace element for the body that is involved in various significan... more Objective: Zinc is an essential trace element for the body that is involved in various significant body functions such as protein synthesis, DNA synthesis, and cellular growth. It is found in almost every cell and plays an important role in the immune system, affecting both innate and acquired immunity. Patients with beta-thalassemia major are at risk of zinc deficiency. Beta-thalassemia major is an inherited disease caused by a reduction or complete absence of beta-globin chains and the affected patients need repeated blood transfusions to survive. Accordingly, it causes oxidative stress and tissue damage, alteration of antioxidant enzymes, and changes in other essential trace element levels due to iron overload. Zinc levels in beta-thalassemia major patients were reported to be significantly reduced in most of the studies. Serum zinc levels of the patients with beta-thalassemia major should be monitored regularly and zinc supplementation should be provided to these patients.
Objective: We aimed to compare the platelet distribution width (PDW) and platelet parameters (PLT... more Objective: We aimed to compare the platelet distribution width (PDW) and platelet parameters (PLT), particularly MPV values of children who were diagnosed with adenoid hypertrophy at the pediatric clinic with those of healthy children to investigate a relationship between adenoid hypertrophy and MPV values. Material and method: This prospective, cross-sectional study was conducted at the department of pediatrics, Health Sciences University, Ministry of Health Okmeydanı Training and Research Hospital between January 2012 and December 2014. The PLT and PDW values as well as MPV of children who were diagnosed with adenoid hypertrophy were compared with those of healthy children. Results: In this study, 120 children with adenoid hypertrophy and 120 healthy children were evaluated. The age range of participants was between 3 years and 16 years, and the mean age was 9.13±2.94 years. The mean MPV value in children with adenoid hypertrophy (10.88 ± 1.15 fL) was statistically significantly higher than that in the control group (9.84 ± 1.04 fL). While the mean platelet distribution width value in the adenoid hypertrophy group was statistically significantly higher than that of the control group, there was no statistically significant difference between the mean platelet counts of both groups. Conclusion: MPV, PLT, and PDW values did not differ significantly in children with adenoid hypertrophy compared to healthy children. MPV values were determined significantly higher in children with adenoid hypertrophy when compared with healthy children. Children with adenoid hypertrophy should be followed up in terms of cardiovascular diseases on the long view.
Objective: The aim of this study was to evaluate the approach of parents to fever of children and... more Objective: The aim of this study was to evaluate the approach of parents to fever of children and related factors. Methods: In this survey study, A 26-question survey was conducted the parents whose children were under 15 years of age and admitted to the department of Emergency at Ministry of Health Okmeydan? Training and Research Hospital between November 2014 and April 2015 due to fever. The survey questions included the presence of a thermometer at home, their manner of taking temperature, mother’s knowledge level about fever, methods applied for reducing fever, antipyretic use and their concerns as well as the demographic characteristics. Results: In the study, 250 parents who were parents of 132 boys and 128 girls enrolled and the mean age of mothers, fathers and children who participated in the study were 25, 29.3 and 3.6 years, respectively. Most of the families (81.2 %) were nuclear family which consists of mother, father and children. It was recorded that 3.2% of parents ...
The concepts of games and toys have a very important role in children's lives. It contributes to ... more The concepts of games and toys have a very important role in children's lives. It contributes to the development of cognitive, motor, psychosocial, emotional, and linguistic skills. It also plays a key role in raising self-confident, creative, and happy children. Therefore, attention should be paid to the concepts of games and toys, which are so important for the child to be a part of society as a healthy individual at every stage of his development. On the other hand, providing playgrounds where children can play comfortably and safely are essential in reducing the risk of accidents related to toys. All health-care components, especially pediatricians and family physicians, should take an active role in ensuring that these play processes, which are the most beautiful parts of childhood, are healthy and safe.
Background: Glypican-4 is an adipose tissue-originated cytokine which enhances insulin signaling ... more Background: Glypican-4 is an adipose tissue-originated cytokine which enhances insulin signaling through direct interaction with the insulin receptors. Objectives: The aim of this study was to analyze the relationship between obesity and serum glipican-4 levels in adolescents. Methods: Our study was carried out on 80 volunteer adolescents, 49 were obese patients and 31 were healthy normal weight control cases. The adolescents with a body mass index (BMI) of 95% percentile and over were defined as obese in terms of age and sex. The Enzyme-Linked Immuno Sorbent Assay kit was utilized for the assessment of Glypican-4 in serum. Laboratory assays (glypican-4, glucose, urea, creatinine, AST, ALT, total cholesterol, triglyceride, HbA1c, insulin, HOMA-IR), age, sex and BMI were compared amidst the groups. Correlations between glypican-4 levels and laboratory factors were analyzed in the obese adolescent group. Results: The average age of the research participants was 13.2 ± 1.8 years. The mean BMI was 27.1 ± 5.1 kg/m 2. Of the 49 obese adolescents, 41 were insulin resistant, and 8 did not have insulin resistance. The levels of glypican-4, BMI, AST, ALT, HbA1c, triglyceride, HOMA-IR and insulin were notably higher in the obese group than the control group (P < 0.05). In obese group, no statistically remarkable relationship was found between glypican-4 levels and other parameters (P > 0.05). Conclusions: We found high serum glypican-4 levels in obese adolescents. We suggest that glypican-4 levels may be increased in order to reduce insulin resistance in obese adolescents.
Background: Febrile seizures are defined as seizures associated with a febrile illness that devel... more Background: Febrile seizures are defined as seizures associated with a febrile illness that developed without central nervous system infection or acute electrolyte imbalance, intoxication, trauma, and metabolic disorder in children aged 1 month to 5 years without previous afebrile seizures. Various studies show a relationship between zinc levels and febrile seizures. Objectives: The purpose of this study was to examine the relationship between serum zinc levels and febrile seizures. Methods: This prospective, cross-sectional, and descriptive study was conducted from 04/10/2021 to 04/02/2022. A total of 85 children aged 6 months to 5 years admitted to the pediatric emergency service of the Republic of Turkey Ministry of Health Cemil Taşcıoğlu City Hospital were included in the study. The patients who met the inclusion criteria and whose consent was obtained were included in the study. Complex and febrile status patients were not included in the study due to the small number of patien...
This study was conducted to determine mothers&amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp... more This study was conducted to determine mothers&amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;#39; knowledge about fever, and their attitudes and responses to fever in children, along with the influence of demographic characteristics on the level of knowledge, and to identify occurrences of fear of fever. The study consisted of 4500 mothers with children 0-12 years of age who were referred to the pediatric health and disease polyclinic and primary care polyclinic over a period of 24 months. Data were collected using a questionnaire containing 32 open-ended, multichoice questions, and assessed using number, percentage and χ(2) analyses. In this study, 36% of mothers regarded body temperatures lower than 37°C as fever; 83% believed that fever was harmful for their children, and 92.3% experienced fear and concern due to their child&amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;#39;s fever. The most significant reason for fear was the belief that the child may have a seizure. Moreover, 12% of mothers feared that their child would die due to fever. The level of fear triggered by fever was lower as the education level of the mothers increased. Meanwhile, when their child had a fever, 28.9% of mothers used antifebrile drugs without consulting a physician, while 19% applied cold water and 7.7% applied water with alcohol or vinegar, among other inappropriate practices. Increased information about fevers geared towards the caregivers of children, particularly mothers, would prevent the unnecessary treatment of children, as well as minimising delayed and insufficient responses to fever.
Objective: The aim of this study was to evaluate mood changes in mothers of infants diagnosed wit... more Objective: The aim of this study was to evaluate mood changes in mothers of infants diagnosed with infantile colic.Materials and Methods: In this prospective case-control study, mothers with infants who were referred to the Pediatric Clinic of Ministry of Health Okmeydani Research and Training Hospital and diagnosed with infantile colic between November 2014 and February 2015 were compared with those of infants without infantile colic using the Beck Depression Inventory and a questionnaire.Results: A total of 31 mothers with male infants (51%) and 30 mothers with female infants (49%) participated in the study. The mean Beck depression inventory scores were 18.3 (min 5-max 35 points; median score: 21) in the infantile colic group and 14.6 (min 5-max 33; median score: 12) in the control group. Beck depression inventory scores in the infantile colic group were significantly higher than those of control group. The mean Beck depression inventory scores were 17.0 (min 5-max 32 points; med...
Introduction: Obesity is a gradually more important multifactorial disease in both children and a... more Introduction: Obesity is a gradually more important multifactorial disease in both children and adults. Obese children and adolescents are at higher risk of becoming obese in adulthood, which is associated with an increased risk of mortality and morbidity. There is subclinical systemic inflammation in obesity. The study aimed to evaluate the hematological parameters as an indicator of inflammation in obese adolescents and to show the relationship of monocyte/HDL-cholesterol ratio, having a lipid component, with other inflammatory hematological parameters. Materials and methods: We retrospectively reviewed the medical files of 60 patients, 30 obese and 30 healthy controls, aged between 11 and 16 years, who applied to the pediatric outpatient clinic. Laboratory tests, hematological parameters, gender, age, and BMI were compared between the groups. Correlations between monocyte/HDL-cholesterol ratio and other laboratory parameters in the obese group were examined. Results: BMI, Alanine...
Objective: The aim of this study was to evaluate mood changes in mothers of infants diagnosed wit... more Objective: The aim of this study was to evaluate mood changes in mothers of infants diagnosed with infantile colic. Materials and Methods: In this prospective case-control study, mothers with infants who were referred to the Pediatric Clinic of Ministry of Health Okmeydanı Research and Training Hospital and diagnosed with infantile colic between November 2014 and February 2015 were compared with those of infants without infantile colic using the Beck Depression Inventory and a questionnaire. Results: A total of 31 mothers with male infants (51%) and 30 mothers with female infants (49%) participated in the study. The mean Beck depression inventory scores were 18.3 (min 5-max 35 points; median score: 21) in the infantile colic group and 14.6 (min 5-max 33; median score: 12) in the control group. Beck depression inventory scores in the infantile colic group were significantly higher than those of control group. The mean Beck depression inventory scores were 17.0 (min 5-max 32 points; m...
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