Dizziness and vertigo are symptoms related to peripheral vestibular disorders. These are among th... more Dizziness and vertigo are symptoms related to peripheral vestibular disorders. These are among the most common complaints in medical offices, and knowledge of the major diseases affecting this system is of fundamental importance to the specialist in otolaryngology. In recent years, great advances have been made in otoneurology, which, coupled with increasing knowledge in the field of neurosciences, have substantially modified the approach of the patient with balance complaints. This book studies the most polemic of these vestibular diseases, the Meniere's disease
Amac: Ulkemizde uzmanlik egitimini tamamlamak icin tez yazmak zorunludur, ancak tezin bir makale ... more Amac: Ulkemizde uzmanlik egitimini tamamlamak icin tez yazmak zorunludur, ancak tezin bir makale olarak yayinlanmasi zorunlu degildir. Bu nedenle, degerli bilimsel gercekleri iceren bircok tez maalesef makaleye donusturulmemektedir. Calismanin amaci, KBB hastaliklari tezlerinin bilimsel makalelere donusum oranlarini ve nitel bir analizini belirlemektir. Materyal – Metod: 2010-2015 yillari arasinda KBB ile ilgili tezleri arastirmak icin Yuksekogretim Kurulu Ulusal Tez Merkezi web veritabani kullanilmistir. Her bir tez icin yayin yili, danisman ve yazarin adi, derginin adi, egitim kurumu ve tezin ozeti bilgileri kaydedilmistir: Tezin yayinlanma durumu Google Akademik, Pubmed, WoS ve ULAKBIM platformlarinda arastirilmistir. Bulgular: Calisma kapsaminda 517 teze ulasildi. En sik arastirma yontemi olarak prospektif (314; %61) kullanildigi gozlemlendi. Arastirmacilar otoloji (%40) ve rinolojinin (%29) kulak burun bogazinin en cok tercih edilen alt dali oldugunu bulmuslardir. Yayina donusturulen tezlerin 154'unun (%67,5) SCI ve SCI-E dergilerinde yayinlandigi; en cok makalenin European Archives Of Oto-Rhino-Laryngology (%16,7) dergisinde yayinlandigi bulundu. Sonuc: KBB alanlarinda tezle ilgili makale yazma orani ulkemizde ve dunyadaki diger dallardan daha yuksektir, ancak yeterli degildir. Uzmanlik tezlerinin makale haline getirilip yayinlanmasi hem bilimin gelismesi hem de ulkemizin bilim camiasindaki yeri acisindan oldukca degerlidir. Bu nedenle danisman egitimciler arastirmacilari hazirladiklari tezleri makaleye donusturmeleri icin tesvik etmelidir.
Purpose Tonsillectomy is still one of the most common surgical procedures worldwide performed by ... more Purpose Tonsillectomy is still one of the most common surgical procedures worldwide performed by otorhinolaryngologists. This single-blind randomized study aimed to compare cold dissection tonsillectomy, coblation tonsillectomy, and harmonic scalpel tonsillectomy in pediatric patients in respect of intraoperative blood loss, operating time, and postoperative pain and bleeding. Methods This single-blind randomized clinical trial evaluated 82 pediatric patients aged 3-16 years (mean age: 7.23 ± 3.26 years) applied with tonsillectomy between April 2017 and March 2020. Harmonic scalpel tonsillectomy was applied to 33 (40.2%) patients, the cold knife technique to 25 (30.5%), and coblation tonsillectomy to 24 (29.3%). Results There was no statistically significant difference between the three techniques in respect of postoperative pain levels and post-tonsillectomy bleeding rates. The intraoperative bleeding rate and mean operating time were determined to be significantly lower in the harmonic scalpel group (p < 0.05). Conclusion Harmonic scalpel tonsillectomy is associated with a shorter operating time and lower intraoperative bleeding rates and similar postoperative pain score and postoperative bleeding rates compared with coblation tonsillectomy and cold dissection tonsillectomy. Harmonic scalpel tonsillectomy is a fast, safe, and effective method for tonsillectomy in children.
A 13-year-old female patient was admitted to our clinic with complaints of a gradually growing sw... more A 13-year-old female patient was admitted to our clinic with complaints of a gradually growing swelling in cervical region leading to diffi culty to chew and swallow which was noticed approximately one year ago. A mass lesion measuring approximately 5x5 cm, fi lling mouth fl oor and could be observed on mid-cervical line on inspection, which is smooth,
The aim of this experimental study was to investigate the cytotoxic effects of intranasal midazol... more The aim of this experimental study was to investigate the cytotoxic effects of intranasal midazolam on nasal mucosal tissue in rats. Forty healthy rats were randomly divided into 5 groups. Group 1 (n ¼ 8) was the control group, group 2 (n ¼ 8) received intranasal saline, group 3 (n ¼ 8) received intranasal midazolam, group 4 (n ¼ 8) received intraperitoneal saline, and group 5 received intraperitoneal midazolam (n ¼ 8). Midazolam and saline were administered via intraperitoneal and intranasal routes at doses of 200 mg/kg. Nasal septal mucosal stripe tissues were removed at the 6th hour. All materials were evaluated according to Ki67 and p53 staining to evaluate proliferation and apoptosis, respectively, and hemotoxylin and eosin staining was performed for histopathology evaluation. Ki67 values and inflammation in group 3 were statistically higher compared to group 1, group 2, and group 4. P53 values in group 3 were statistically higher compared to group 1. Assessment of subepithelial edema between group 3 and the other groups revealed no statistically significant differences. Assessment of cilia loss between group 3 and group 1, group 2, and group 4 revealed no statistically significant difference. The evaluation of goblet cell loss between group 3 and group 1 revealed a statistically significant difference. Intranasal midazolam had adverse effects on nasal mucosa. However, intranasal midazolam is as safe as systemic midazolam administration with respect to nasal mucosa.
We aimed to determine whether advanced oxidation protein product (AOPP) levels can serve as a mar... more We aimed to determine whether advanced oxidation protein product (AOPP) levels can serve as a marker of oxidative stress in paediatric patients with chronic tonsillitis. Thirty children with chronic tonsillitis and 30 healthy children (control group) were recruited from the Otorhinolaryngology (ORL) and Paediatric Surgery departments, respectively, of Dumlupinar University Hospital. In the patient group, blood samples were collected before tonsillectomy, and tonsil tissue was sampled during the operation. Blood samples were also obtained from the control subjects. AOPP levels in the serum and tonsil tissue were measured by the spectrophotometric method. Serum AOPP levels were significantly higher in the patient group (13.1 ± 3.3 ng/ml) than in the control group (11.6 ± 2.3 ng/ml; P < 0.05). In addition, the mean AOPP level (41.9 ± 13.5 ng/mg protein) in the tonsil tissue in the patient group was significantly higher than the mean serum AOPP levels in the control and patient groups (P < 0.05). AOPP levels are elevated in the tonsil tissue and serum of patients with chronic tonsillitis compared to the serum AOPP levels in healthy controls. AOPPs may represent a novel class of pro-inflammatory molecules that are involved in oxidative stress in chronic tonsillitis. AOPPs may be used as a marker of oxidative stress in paediatric patients with chronic tonsillitis. KEY WORDS: Chronic tonsillitis • Advanced oxidation protein products (AOPPs) • Oxidative stress RIASSUNTO L'obiettivo del presente studio è stato determinare se i livelli plasmatici dei prodotti avanzati di ossidazione proteica (AOPP) rappresentino dei marker di stress ossidativo nei pazienti pediatrici affetti da tonsillite cronica. Per lo studio sono stati arruolati, presso i Dipartimenti di Otorinolaringoiatria e Chirurgia pediatrica dell'Ospedale Universitario di Dumlupinar, trenta bambini sani e trenta affetti da tonsillite cronica. Il gruppo dei pazienti affetti da malattia è stato sottoposto a un prelievo ematico preoperatorio e ad una biopsia intraoperatoria del tessuto tonsillare. Il gruppo dei pazienti sani è stato sottoposto unicamente al prelievo ematico. I livelli plasmatici e tissutali degli AOPP sono quindi stati misurati mediante spettrofotometria. I livelli sierici degli AOPP sono risultati essere più elevati nel gruppo dei pazienti affetti da tonsillite cronica (13,1 ± 3,3 ng/ml) rispetto al gruppo di controllo (11,6 ± 2,3 ng/ml; P < 0,05). Il livello tissutale medio degli AOPP nei pazienti malati è risultato essere superiore a quello plasmatico medio sia nel gruppo dei pazienti sani che in quello dei pazienti malati (41,9 ± 13,5 ng/mg; P < 0,05). I livelli plasmatici e tissutali degli AOPP sono risultati quindi essere più elevati nei pazienti malati rispetto al gruppo di controllo. Gli AOPP potrebbero quindi rappresentare una nuova classe di molecole pro-infiammatorie coinvolte nello stress ossidativo nella tonsillite cronica e potrebbero avere un ruolo come marker di stress ossidativo nei pazienti pediatrici affetti da tale patologia.
Larenks kanserlerini % 85-95 skuamöz hücreli karsinom oluşturur. Skuamoz hücreli karsinomların va... more Larenks kanserlerini % 85-95 skuamöz hücreli karsinom oluşturur. Skuamoz hücreli karsinomların varyantları bulunmaktadır. Bu varyantlardan biride sarkomatoid skuamoz hücreli karsinomdur. Sarkomatoid skuamoz hücreli karsinom tüm skuamoz hücreli karsinomların %3'nü oluşturmaktadır. Bu tümörler daha çok düzgün şekilli, polipoid kitleler şeklinde anterior vokal kordda görülürler. Genellikle glottik yerleşimlidirler. Sunduğumuzda olguda; 69 yaşında erkek hastada ileri evrede sarkomatoid karsinom ses kısıklığı ve solunum sıkıntısı ile prezentasyon göstermiştir. Hasta metabolik alkoloz tablosunda iken acil servise başvurmuş ve acil trakeotomi açılmak zorunda kalınmıştır. Sonrasında yapılan biyopsi sonucu ile bilateral fonsiyonel boyun diseksiyonu, total larenjektomi, sağ tiroid lobektomi ve sağ submandibular gland eksizyonu yapıldı. Nihai patoloji rapor sonucu sarkomatoid skuamöz hücreli karsinom olarak geldi.
The Journal of Maternal-Fetal & Neonatal Medicine, 2021
BACKGROUND New generation Doppler ultrasonography (DUSG) application effects on cochlea and cochl... more BACKGROUND New generation Doppler ultrasonography (DUSG) application effects on cochlea and cochlear nucleus (CN) are unclear. We aimed to investigate the effects of new generation DUSG application at different frequencies in prenatal period on cochlea and CN in rats. OBJECTIVE Twenty-four pregnant female rats were divided into three groups (n = 8). Group 1 was the control group and was not subjected to any treatment. Group 2 was determined as the USG every day (USGED) treatment group. Group 2 has received DUSG application every day from the 4th to 18th day (20 min/15 per day). Group 3 has received DUSG application as "2 days/one dose as every other day application" (USG2D1) from the 4th to 18th day (20 min/8 every other day). Twenty-four female rats were sacrificed in 21 days. Also, 24 pups were sacrificed after two days. First day after born, the cochlear activities of the right ears of all pups were examined using DPOAEs. Second day, neural tissues from CN were evaluated histopathologically and immunohistochemically. RESULTS There was no any statistical difference between the groups in respect of histopathologically. USGED group showed mild caspase-3 positive neurons and glial cells. However, there was no significant difference between the USGED and other groups (p>.05). Similarly, the rats applied with USG2D1 had mild caspase-3 expression, but no significant difference between the USG2D1 and other groups (p>.05). Differences in DPOAE amplitudes, and therefore in cochlear activity, between the groups were revealed. The decrease in cochlear activity between the groups involved frequencies at 2, 8, 16, and 32 kHz (p<.05). CONCLUSIONS Multiple administration of new generation DUSG to pregnant rats has not shown harmful effects on the cochlear neural tissue. High frequencies are more sensitive in cochlea to apply DUSG.
Objective: This study aimed to determine how prevalent allergic rhinitis (AR) is in Turkey and to... more Objective: This study aimed to determine how prevalent allergic rhinitis (AR) is in Turkey and to compare the current prevalence with the figures obtained 10 years earlier. Methods: This study included 9,017 participants. The minimum number of participants required from each center was determined via a stratified sampling technique according to regional demographic characteristics as ascertained from the last census. For each region, both men and women were administered the score for allergic rhinitis (SFAR) questionnaire and a score for each participant was calculated based on the responses supplied. Results: A total of 9,017 individuals (55.3% men and 44.7% women) took part in this study. Of these, 94.4% were urban residents and 5.6% lived in a rural setting. Of the men, 38.5% self-reported as suffering from AR. The corresponding figure in women was 40.5%. The overall prevalence of AR, as deduced on the basis of the SFAR, was found to be 36.7%. Comparing the prevalence in different regions, we found that AR was the least prevalent in the Black Sea region with a frequency of 35.8%. The highest prevalence was in the Mediterranean region, where the prevalence was 37.7%. There was no statistical significance in the apparent differences in prevalence between different geographical regions. Despite this, however, there was a clear increase in the frequency of AR over the preceding decade. This increase was most pronounced in the SouthEastern Anatolian region, where the frequency rose from 21.0% to 36.9%. Conclusion: Our results indicate that there has been a marked increase in the prevalence of AR in every region in Turkey over the last 10 years. This could be related to living conditions in urban environments. Alterations in lifestyle, urban living, air pollution causing impairments in immune defense mechanisms, and other aspects of modern lifestyles may account for the increase in AR in Turkey.
Allergic respiratory diseases are common public health problem. Although several treatment option... more Allergic respiratory diseases are common public health problem. Although several treatment options, some of patients cannot manage to get satisfactory recovery. High altitude (HA) is shown as a natural additive and/or salvage therapy option for this patient group. We aimed to present the effect of HA on allergic rhinitis and bronchial hyperreactivity in company with literature.
Is blood type really a riskfactorfor epistaxis? OBJECTIVES To determine the association between A... more Is blood type really a riskfactorfor epistaxis? OBJECTIVES To determine the association between ABO blood type and epistaxis. METHODS This retrospective study involved 359 patients with idiopathic epistaxis. Patients with risk factors for bleeding, including anticoagulant use, thrombocytopenia, hypertension, liver diseases, elevated bleeding time, low coagulation factor levels, or any benign/malignant tumor, were excluded from the study. Thus, only patients with idiopathic epistaxis were included in this study. For the control group, blood-type information was retrieved from the database of the Turkish Red Crescent, the largest blood bank in Turkey. RESULTS The distributions of blood types A, B, AB, and 0 were compared between the epistaxis and control groups. The distribution of blood types A and AB did not significantly differ between the epistaxis and control groups (P>0.05). Blood type B occurred significantly less frequently (P<0.05) and blood type 0 occurred significantl...
Osteomlar, yavas buyuyen matur kemik dokusundan olusmus benign tumorlerdir. Osteomlar, en sik man... more Osteomlar, yavas buyuyen matur kemik dokusundan olusmus benign tumorlerdir. Osteomlar, en sik mandibulada yerlesir. Paranazal sinusler icerisinde en sik frontal sinusu takiben etmoidal ve maksillar sinusu tutar. Osteomlarin tedavisinde endonazal ve eksternal yaklasimlar uygulanmaktadir. Bu vakada, eksternal yaklasimla eksize edilen frontal sinusten kaynaklanip ethmoid sinuse uzanan osteom olgusunu sunuyoruz. Altmis yedi yasinda erkek hasta 1 yildir devam eden sag yuz yariminda agri ve sislik sikâyeti ile poliklinigimize basvurdu. Paranazal sinus bilgisayarli tomografi incelemesinde sag frontal sinusten kaynaklanip ethmoid sinuse uzanan osteom ile uyumlu kitle gorunumu izlendi. Osteoplastik flep yaklasimiyla kitle salim sinirlarla eksize edildi. Abdomenden alinan yag dokusu ile frontal sinus oblitere edildi. Postoperatif 6 aylik takibinde nukse rastlanmadi. Osteomlarin buyuk cogunlugu asemptomatiktir. Cerrahi endikasyonlar dikkatle degerlendirilmelidir. Cerrahi yaklasim ise kitlenin ...
Purpose We aimed to evaluate oxidative stress in patients with peripheral vertigo by measuring se... more Purpose We aimed to evaluate oxidative stress in patients with peripheral vertigo by measuring serum prolidase, malondialdehyde (MDA) and catalase levels. Methods A total of 30 patients (age: 60 <) with peripheral vertigo and 30 healthy subjects were recruited. Blood samples were collected from both groups and serum prolidase levels were measured using enzyme-linked immunosorbent assay (ELISA). MDA and catalase levels were measured by the spectrophotometric method. Results The most common cause of vertigo was BPPV (53.3%), followed by Ménière's disease (16.6%), vestibular neuritis (13.3%), lateral semicircular canal fistula (3.3%), and idiopathic vertigo (13.3%). Mean serum prolidase activity and MDA levels were significantly higher in the vertigo patients than in the control subjects (P < 0.05); however, there was no statistically significant difference in mean serum catalase levels between the groups (P > 0.05). Conclusion We concluded that serum prolidase and MDA levels may be used as markers of oxidative stress in patients with peripheral vertigo.
Objective:To investigate nasal mucociliary clearance in patients with Behçet's disease.Method... more Objective:To investigate nasal mucociliary clearance in patients with Behçet's disease.Methods:Thirty patients with Behçet's disease, diagnosed on the basis of criteria defined by the International Study Group for Behçet's Disease, and 30 healthy individuals were recruited. In both groups, individuals with conditions that could affect nasal mucociliary clearance were excluded. Nasal mucociliary clearance time was evaluated using saccharin tests. The time between placement of a saccharin tablet and the tasting of the saccharin was measured and recorded as the saccharin clearance time.Results:The mean nasal mucociliary clearance time was significantly longer in the Behçet's disease patients than in the control subjects (p < 0.001). Furthermore, there was a positive correlation between Behçet's disease duration and nasal mucociliary clearance time (p < 0.001, r = 0.882).Conclusion:The results suggest that nasal mucociliary clearance time is longer in Behçet...
To investigate the relationship between body dysmorphic syndrome and self-esteem in rhinoplasty c... more To investigate the relationship between body dysmorphic syndrome and self-esteem in rhinoplasty candidates. A negative statistical correlation was evident between Rosenberg Self-Esteem Scale (RSES) and Body Dysmorphic Disorder Examination-Self Report (BDDE-SR) scores. In terms of responses to the first Body Dysmorphic Disorder Questionnaire (BDDQ) question, which focuses on general attitude toward body dysmorphic syndrome, the average RSES "YES" score was significantly less than the "NO" score. No significant differences appeared between RSES scores and scores for the 4th subgroup of BDDQ questions (subgroups A, B, and C; these questions explore how much time is spent daily on maintenance of bodily appearance). However, significant differences appeared between scores for the 4th subgroup of BDDQ questions and BDDE-SR scores. The average BDD-SR score of subgroup A (less than 1 hour spent on bodily maintenance) was significantly lower than those of group B (1-3 hou...
The authors aimed to evaluate the effects of obstructive sleep apnea in children as a result of a... more The authors aimed to evaluate the effects of obstructive sleep apnea in children as a result of adenoid and/or adenotonsillar hypertrophy on maternal psychologic status. The study sample comprised the mothers of 66 children aged 3 to 15 years (mean age: 7.55 AE 2.94 years) who were scheduled to undergo curette adenoidectomy or adenotonsillectomy because of airway obstruction. The mothers completed the 14-item Hospital Anxiety and Depression Scale (HADS), 20-item State-Trait Anxiety Inventory-1 (STAI-1), and 20-item State-Trait Anxiety Inventory-2 (STAI-2) questionnaires before the operation and 10 days afterwards. Mothers who were under psychiatric treatment or declined to fill the questionnaires were excluded from the study. The results obtained postoperatively by day 10, when all the children had considerable improvement in their breathing, were analyzed as control data. The mean postoperative HAD-A and HAD-D scores of the mothers were significantly lower than the mean preoperative scores (P < 0.001). Mothers' mean STAI-1 and STAI-2 scores were also significantly lower postoperatively (P < 0.001). Pediatric adenoidectomy or adenotonsillectomy to relieve airway obstruction has a beneficial effect not only on the health of pediatric patients but also on the psychologic status of their mothers.
Dizziness and vertigo are symptoms related to peripheral vestibular disorders. These are among th... more Dizziness and vertigo are symptoms related to peripheral vestibular disorders. These are among the most common complaints in medical offices, and knowledge of the major diseases affecting this system is of fundamental importance to the specialist in otolaryngology. In recent years, great advances have been made in otoneurology, which, coupled with increasing knowledge in the field of neurosciences, have substantially modified the approach of the patient with balance complaints. This book studies the most polemic of these vestibular diseases, the Meniere's disease
Amac: Ulkemizde uzmanlik egitimini tamamlamak icin tez yazmak zorunludur, ancak tezin bir makale ... more Amac: Ulkemizde uzmanlik egitimini tamamlamak icin tez yazmak zorunludur, ancak tezin bir makale olarak yayinlanmasi zorunlu degildir. Bu nedenle, degerli bilimsel gercekleri iceren bircok tez maalesef makaleye donusturulmemektedir. Calismanin amaci, KBB hastaliklari tezlerinin bilimsel makalelere donusum oranlarini ve nitel bir analizini belirlemektir. Materyal – Metod: 2010-2015 yillari arasinda KBB ile ilgili tezleri arastirmak icin Yuksekogretim Kurulu Ulusal Tez Merkezi web veritabani kullanilmistir. Her bir tez icin yayin yili, danisman ve yazarin adi, derginin adi, egitim kurumu ve tezin ozeti bilgileri kaydedilmistir: Tezin yayinlanma durumu Google Akademik, Pubmed, WoS ve ULAKBIM platformlarinda arastirilmistir. Bulgular: Calisma kapsaminda 517 teze ulasildi. En sik arastirma yontemi olarak prospektif (314; %61) kullanildigi gozlemlendi. Arastirmacilar otoloji (%40) ve rinolojinin (%29) kulak burun bogazinin en cok tercih edilen alt dali oldugunu bulmuslardir. Yayina donusturulen tezlerin 154'unun (%67,5) SCI ve SCI-E dergilerinde yayinlandigi; en cok makalenin European Archives Of Oto-Rhino-Laryngology (%16,7) dergisinde yayinlandigi bulundu. Sonuc: KBB alanlarinda tezle ilgili makale yazma orani ulkemizde ve dunyadaki diger dallardan daha yuksektir, ancak yeterli degildir. Uzmanlik tezlerinin makale haline getirilip yayinlanmasi hem bilimin gelismesi hem de ulkemizin bilim camiasindaki yeri acisindan oldukca degerlidir. Bu nedenle danisman egitimciler arastirmacilari hazirladiklari tezleri makaleye donusturmeleri icin tesvik etmelidir.
Purpose Tonsillectomy is still one of the most common surgical procedures worldwide performed by ... more Purpose Tonsillectomy is still one of the most common surgical procedures worldwide performed by otorhinolaryngologists. This single-blind randomized study aimed to compare cold dissection tonsillectomy, coblation tonsillectomy, and harmonic scalpel tonsillectomy in pediatric patients in respect of intraoperative blood loss, operating time, and postoperative pain and bleeding. Methods This single-blind randomized clinical trial evaluated 82 pediatric patients aged 3-16 years (mean age: 7.23 ± 3.26 years) applied with tonsillectomy between April 2017 and March 2020. Harmonic scalpel tonsillectomy was applied to 33 (40.2%) patients, the cold knife technique to 25 (30.5%), and coblation tonsillectomy to 24 (29.3%). Results There was no statistically significant difference between the three techniques in respect of postoperative pain levels and post-tonsillectomy bleeding rates. The intraoperative bleeding rate and mean operating time were determined to be significantly lower in the harmonic scalpel group (p < 0.05). Conclusion Harmonic scalpel tonsillectomy is associated with a shorter operating time and lower intraoperative bleeding rates and similar postoperative pain score and postoperative bleeding rates compared with coblation tonsillectomy and cold dissection tonsillectomy. Harmonic scalpel tonsillectomy is a fast, safe, and effective method for tonsillectomy in children.
A 13-year-old female patient was admitted to our clinic with complaints of a gradually growing sw... more A 13-year-old female patient was admitted to our clinic with complaints of a gradually growing swelling in cervical region leading to diffi culty to chew and swallow which was noticed approximately one year ago. A mass lesion measuring approximately 5x5 cm, fi lling mouth fl oor and could be observed on mid-cervical line on inspection, which is smooth,
The aim of this experimental study was to investigate the cytotoxic effects of intranasal midazol... more The aim of this experimental study was to investigate the cytotoxic effects of intranasal midazolam on nasal mucosal tissue in rats. Forty healthy rats were randomly divided into 5 groups. Group 1 (n ¼ 8) was the control group, group 2 (n ¼ 8) received intranasal saline, group 3 (n ¼ 8) received intranasal midazolam, group 4 (n ¼ 8) received intraperitoneal saline, and group 5 received intraperitoneal midazolam (n ¼ 8). Midazolam and saline were administered via intraperitoneal and intranasal routes at doses of 200 mg/kg. Nasal septal mucosal stripe tissues were removed at the 6th hour. All materials were evaluated according to Ki67 and p53 staining to evaluate proliferation and apoptosis, respectively, and hemotoxylin and eosin staining was performed for histopathology evaluation. Ki67 values and inflammation in group 3 were statistically higher compared to group 1, group 2, and group 4. P53 values in group 3 were statistically higher compared to group 1. Assessment of subepithelial edema between group 3 and the other groups revealed no statistically significant differences. Assessment of cilia loss between group 3 and group 1, group 2, and group 4 revealed no statistically significant difference. The evaluation of goblet cell loss between group 3 and group 1 revealed a statistically significant difference. Intranasal midazolam had adverse effects on nasal mucosa. However, intranasal midazolam is as safe as systemic midazolam administration with respect to nasal mucosa.
We aimed to determine whether advanced oxidation protein product (AOPP) levels can serve as a mar... more We aimed to determine whether advanced oxidation protein product (AOPP) levels can serve as a marker of oxidative stress in paediatric patients with chronic tonsillitis. Thirty children with chronic tonsillitis and 30 healthy children (control group) were recruited from the Otorhinolaryngology (ORL) and Paediatric Surgery departments, respectively, of Dumlupinar University Hospital. In the patient group, blood samples were collected before tonsillectomy, and tonsil tissue was sampled during the operation. Blood samples were also obtained from the control subjects. AOPP levels in the serum and tonsil tissue were measured by the spectrophotometric method. Serum AOPP levels were significantly higher in the patient group (13.1 ± 3.3 ng/ml) than in the control group (11.6 ± 2.3 ng/ml; P < 0.05). In addition, the mean AOPP level (41.9 ± 13.5 ng/mg protein) in the tonsil tissue in the patient group was significantly higher than the mean serum AOPP levels in the control and patient groups (P < 0.05). AOPP levels are elevated in the tonsil tissue and serum of patients with chronic tonsillitis compared to the serum AOPP levels in healthy controls. AOPPs may represent a novel class of pro-inflammatory molecules that are involved in oxidative stress in chronic tonsillitis. AOPPs may be used as a marker of oxidative stress in paediatric patients with chronic tonsillitis. KEY WORDS: Chronic tonsillitis • Advanced oxidation protein products (AOPPs) • Oxidative stress RIASSUNTO L'obiettivo del presente studio è stato determinare se i livelli plasmatici dei prodotti avanzati di ossidazione proteica (AOPP) rappresentino dei marker di stress ossidativo nei pazienti pediatrici affetti da tonsillite cronica. Per lo studio sono stati arruolati, presso i Dipartimenti di Otorinolaringoiatria e Chirurgia pediatrica dell'Ospedale Universitario di Dumlupinar, trenta bambini sani e trenta affetti da tonsillite cronica. Il gruppo dei pazienti affetti da malattia è stato sottoposto a un prelievo ematico preoperatorio e ad una biopsia intraoperatoria del tessuto tonsillare. Il gruppo dei pazienti sani è stato sottoposto unicamente al prelievo ematico. I livelli plasmatici e tissutali degli AOPP sono quindi stati misurati mediante spettrofotometria. I livelli sierici degli AOPP sono risultati essere più elevati nel gruppo dei pazienti affetti da tonsillite cronica (13,1 ± 3,3 ng/ml) rispetto al gruppo di controllo (11,6 ± 2,3 ng/ml; P < 0,05). Il livello tissutale medio degli AOPP nei pazienti malati è risultato essere superiore a quello plasmatico medio sia nel gruppo dei pazienti sani che in quello dei pazienti malati (41,9 ± 13,5 ng/mg; P < 0,05). I livelli plasmatici e tissutali degli AOPP sono risultati quindi essere più elevati nei pazienti malati rispetto al gruppo di controllo. Gli AOPP potrebbero quindi rappresentare una nuova classe di molecole pro-infiammatorie coinvolte nello stress ossidativo nella tonsillite cronica e potrebbero avere un ruolo come marker di stress ossidativo nei pazienti pediatrici affetti da tale patologia.
Larenks kanserlerini % 85-95 skuamöz hücreli karsinom oluşturur. Skuamoz hücreli karsinomların va... more Larenks kanserlerini % 85-95 skuamöz hücreli karsinom oluşturur. Skuamoz hücreli karsinomların varyantları bulunmaktadır. Bu varyantlardan biride sarkomatoid skuamoz hücreli karsinomdur. Sarkomatoid skuamoz hücreli karsinom tüm skuamoz hücreli karsinomların %3'nü oluşturmaktadır. Bu tümörler daha çok düzgün şekilli, polipoid kitleler şeklinde anterior vokal kordda görülürler. Genellikle glottik yerleşimlidirler. Sunduğumuzda olguda; 69 yaşında erkek hastada ileri evrede sarkomatoid karsinom ses kısıklığı ve solunum sıkıntısı ile prezentasyon göstermiştir. Hasta metabolik alkoloz tablosunda iken acil servise başvurmuş ve acil trakeotomi açılmak zorunda kalınmıştır. Sonrasında yapılan biyopsi sonucu ile bilateral fonsiyonel boyun diseksiyonu, total larenjektomi, sağ tiroid lobektomi ve sağ submandibular gland eksizyonu yapıldı. Nihai patoloji rapor sonucu sarkomatoid skuamöz hücreli karsinom olarak geldi.
The Journal of Maternal-Fetal & Neonatal Medicine, 2021
BACKGROUND New generation Doppler ultrasonography (DUSG) application effects on cochlea and cochl... more BACKGROUND New generation Doppler ultrasonography (DUSG) application effects on cochlea and cochlear nucleus (CN) are unclear. We aimed to investigate the effects of new generation DUSG application at different frequencies in prenatal period on cochlea and CN in rats. OBJECTIVE Twenty-four pregnant female rats were divided into three groups (n = 8). Group 1 was the control group and was not subjected to any treatment. Group 2 was determined as the USG every day (USGED) treatment group. Group 2 has received DUSG application every day from the 4th to 18th day (20 min/15 per day). Group 3 has received DUSG application as "2 days/one dose as every other day application" (USG2D1) from the 4th to 18th day (20 min/8 every other day). Twenty-four female rats were sacrificed in 21 days. Also, 24 pups were sacrificed after two days. First day after born, the cochlear activities of the right ears of all pups were examined using DPOAEs. Second day, neural tissues from CN were evaluated histopathologically and immunohistochemically. RESULTS There was no any statistical difference between the groups in respect of histopathologically. USGED group showed mild caspase-3 positive neurons and glial cells. However, there was no significant difference between the USGED and other groups (p>.05). Similarly, the rats applied with USG2D1 had mild caspase-3 expression, but no significant difference between the USG2D1 and other groups (p>.05). Differences in DPOAE amplitudes, and therefore in cochlear activity, between the groups were revealed. The decrease in cochlear activity between the groups involved frequencies at 2, 8, 16, and 32 kHz (p<.05). CONCLUSIONS Multiple administration of new generation DUSG to pregnant rats has not shown harmful effects on the cochlear neural tissue. High frequencies are more sensitive in cochlea to apply DUSG.
Objective: This study aimed to determine how prevalent allergic rhinitis (AR) is in Turkey and to... more Objective: This study aimed to determine how prevalent allergic rhinitis (AR) is in Turkey and to compare the current prevalence with the figures obtained 10 years earlier. Methods: This study included 9,017 participants. The minimum number of participants required from each center was determined via a stratified sampling technique according to regional demographic characteristics as ascertained from the last census. For each region, both men and women were administered the score for allergic rhinitis (SFAR) questionnaire and a score for each participant was calculated based on the responses supplied. Results: A total of 9,017 individuals (55.3% men and 44.7% women) took part in this study. Of these, 94.4% were urban residents and 5.6% lived in a rural setting. Of the men, 38.5% self-reported as suffering from AR. The corresponding figure in women was 40.5%. The overall prevalence of AR, as deduced on the basis of the SFAR, was found to be 36.7%. Comparing the prevalence in different regions, we found that AR was the least prevalent in the Black Sea region with a frequency of 35.8%. The highest prevalence was in the Mediterranean region, where the prevalence was 37.7%. There was no statistical significance in the apparent differences in prevalence between different geographical regions. Despite this, however, there was a clear increase in the frequency of AR over the preceding decade. This increase was most pronounced in the SouthEastern Anatolian region, where the frequency rose from 21.0% to 36.9%. Conclusion: Our results indicate that there has been a marked increase in the prevalence of AR in every region in Turkey over the last 10 years. This could be related to living conditions in urban environments. Alterations in lifestyle, urban living, air pollution causing impairments in immune defense mechanisms, and other aspects of modern lifestyles may account for the increase in AR in Turkey.
Allergic respiratory diseases are common public health problem. Although several treatment option... more Allergic respiratory diseases are common public health problem. Although several treatment options, some of patients cannot manage to get satisfactory recovery. High altitude (HA) is shown as a natural additive and/or salvage therapy option for this patient group. We aimed to present the effect of HA on allergic rhinitis and bronchial hyperreactivity in company with literature.
Is blood type really a riskfactorfor epistaxis? OBJECTIVES To determine the association between A... more Is blood type really a riskfactorfor epistaxis? OBJECTIVES To determine the association between ABO blood type and epistaxis. METHODS This retrospective study involved 359 patients with idiopathic epistaxis. Patients with risk factors for bleeding, including anticoagulant use, thrombocytopenia, hypertension, liver diseases, elevated bleeding time, low coagulation factor levels, or any benign/malignant tumor, were excluded from the study. Thus, only patients with idiopathic epistaxis were included in this study. For the control group, blood-type information was retrieved from the database of the Turkish Red Crescent, the largest blood bank in Turkey. RESULTS The distributions of blood types A, B, AB, and 0 were compared between the epistaxis and control groups. The distribution of blood types A and AB did not significantly differ between the epistaxis and control groups (P>0.05). Blood type B occurred significantly less frequently (P<0.05) and blood type 0 occurred significantl...
Osteomlar, yavas buyuyen matur kemik dokusundan olusmus benign tumorlerdir. Osteomlar, en sik man... more Osteomlar, yavas buyuyen matur kemik dokusundan olusmus benign tumorlerdir. Osteomlar, en sik mandibulada yerlesir. Paranazal sinusler icerisinde en sik frontal sinusu takiben etmoidal ve maksillar sinusu tutar. Osteomlarin tedavisinde endonazal ve eksternal yaklasimlar uygulanmaktadir. Bu vakada, eksternal yaklasimla eksize edilen frontal sinusten kaynaklanip ethmoid sinuse uzanan osteom olgusunu sunuyoruz. Altmis yedi yasinda erkek hasta 1 yildir devam eden sag yuz yariminda agri ve sislik sikâyeti ile poliklinigimize basvurdu. Paranazal sinus bilgisayarli tomografi incelemesinde sag frontal sinusten kaynaklanip ethmoid sinuse uzanan osteom ile uyumlu kitle gorunumu izlendi. Osteoplastik flep yaklasimiyla kitle salim sinirlarla eksize edildi. Abdomenden alinan yag dokusu ile frontal sinus oblitere edildi. Postoperatif 6 aylik takibinde nukse rastlanmadi. Osteomlarin buyuk cogunlugu asemptomatiktir. Cerrahi endikasyonlar dikkatle degerlendirilmelidir. Cerrahi yaklasim ise kitlenin ...
Purpose We aimed to evaluate oxidative stress in patients with peripheral vertigo by measuring se... more Purpose We aimed to evaluate oxidative stress in patients with peripheral vertigo by measuring serum prolidase, malondialdehyde (MDA) and catalase levels. Methods A total of 30 patients (age: 60 <) with peripheral vertigo and 30 healthy subjects were recruited. Blood samples were collected from both groups and serum prolidase levels were measured using enzyme-linked immunosorbent assay (ELISA). MDA and catalase levels were measured by the spectrophotometric method. Results The most common cause of vertigo was BPPV (53.3%), followed by Ménière's disease (16.6%), vestibular neuritis (13.3%), lateral semicircular canal fistula (3.3%), and idiopathic vertigo (13.3%). Mean serum prolidase activity and MDA levels were significantly higher in the vertigo patients than in the control subjects (P < 0.05); however, there was no statistically significant difference in mean serum catalase levels between the groups (P > 0.05). Conclusion We concluded that serum prolidase and MDA levels may be used as markers of oxidative stress in patients with peripheral vertigo.
Objective:To investigate nasal mucociliary clearance in patients with Behçet's disease.Method... more Objective:To investigate nasal mucociliary clearance in patients with Behçet's disease.Methods:Thirty patients with Behçet's disease, diagnosed on the basis of criteria defined by the International Study Group for Behçet's Disease, and 30 healthy individuals were recruited. In both groups, individuals with conditions that could affect nasal mucociliary clearance were excluded. Nasal mucociliary clearance time was evaluated using saccharin tests. The time between placement of a saccharin tablet and the tasting of the saccharin was measured and recorded as the saccharin clearance time.Results:The mean nasal mucociliary clearance time was significantly longer in the Behçet's disease patients than in the control subjects (p < 0.001). Furthermore, there was a positive correlation between Behçet's disease duration and nasal mucociliary clearance time (p < 0.001, r = 0.882).Conclusion:The results suggest that nasal mucociliary clearance time is longer in Behçet...
To investigate the relationship between body dysmorphic syndrome and self-esteem in rhinoplasty c... more To investigate the relationship between body dysmorphic syndrome and self-esteem in rhinoplasty candidates. A negative statistical correlation was evident between Rosenberg Self-Esteem Scale (RSES) and Body Dysmorphic Disorder Examination-Self Report (BDDE-SR) scores. In terms of responses to the first Body Dysmorphic Disorder Questionnaire (BDDQ) question, which focuses on general attitude toward body dysmorphic syndrome, the average RSES "YES" score was significantly less than the "NO" score. No significant differences appeared between RSES scores and scores for the 4th subgroup of BDDQ questions (subgroups A, B, and C; these questions explore how much time is spent daily on maintenance of bodily appearance). However, significant differences appeared between scores for the 4th subgroup of BDDQ questions and BDDE-SR scores. The average BDD-SR score of subgroup A (less than 1 hour spent on bodily maintenance) was significantly lower than those of group B (1-3 hou...
The authors aimed to evaluate the effects of obstructive sleep apnea in children as a result of a... more The authors aimed to evaluate the effects of obstructive sleep apnea in children as a result of adenoid and/or adenotonsillar hypertrophy on maternal psychologic status. The study sample comprised the mothers of 66 children aged 3 to 15 years (mean age: 7.55 AE 2.94 years) who were scheduled to undergo curette adenoidectomy or adenotonsillectomy because of airway obstruction. The mothers completed the 14-item Hospital Anxiety and Depression Scale (HADS), 20-item State-Trait Anxiety Inventory-1 (STAI-1), and 20-item State-Trait Anxiety Inventory-2 (STAI-2) questionnaires before the operation and 10 days afterwards. Mothers who were under psychiatric treatment or declined to fill the questionnaires were excluded from the study. The results obtained postoperatively by day 10, when all the children had considerable improvement in their breathing, were analyzed as control data. The mean postoperative HAD-A and HAD-D scores of the mothers were significantly lower than the mean preoperative scores (P < 0.001). Mothers' mean STAI-1 and STAI-2 scores were also significantly lower postoperatively (P < 0.001). Pediatric adenoidectomy or adenotonsillectomy to relieve airway obstruction has a beneficial effect not only on the health of pediatric patients but also on the psychologic status of their mothers.
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