Several psychopharmacological agents induce weight gain. Recent studies have suggested that the t... more Several psychopharmacological agents induce weight gain. Recent studies have suggested that the tumor necrosis factor-α (TNF-α) cytokine system is pathophysiologically involved. To assess whether carbamazepine and lithium, which have been reported to lead to weight gain, have effects on the circulating levels of cytokines, we measured plasma levels of TNF-α, its soluble receptors sTNF-R p55 and p75, and leptin, as well as weight in 25 inpatients receiving lithium (n=10) or carbamazepine (n=15) weekly during the first 4 weeks of treatment. We found an increase in the body mass index and in TNF-α and its soluble receptor levels, but not in leptin levels over the 4 weeks of treatment. These changes did not differ between treatment groups. Changes of weight during the first week of treatment, but no other parameter, strongly predicted weight change until endpoint. We conclude that the mood stabilizers carbamazepine and lithium have similar effects on the TNF-α system and do not affect leptin levels.
In this paper, the filter technique of Fletcher and Leyffer (1997) is used to globalize the prima... more In this paper, the filter technique of Fletcher and Leyffer (1997) is used to globalize the primal-dual interior-point algorithm for nonlinear programming, avoiding the use of merit functions and the updating of penalty parameters. The new algorithm decomposes the primal-dual step obtained from the perturbed first-order necessary conditions into a normal and a tangential step, whose sizes are controlled by a trust-region type parameter. Each entry in the filter is a pair of coordinates: one resulting from feasibility and centrality, and associated with the normal step; the other resulting from optimality (complementarity and duality), and related with the tangential step. Global convergence to first-order critical points is proved for the new primal-dual interior-point filter algorithm.
Background: Geobacter species are δ-Proteobacteria and are often the predominant species in a var... more Background: Geobacter species are δ-Proteobacteria and are often the predominant species in a variety of sedimentary environments where Fe(III) reduction is important. Their ability to remediate contaminated environments and produce electricity makes them attractive for further study. Cell motility, biofilm formation, and type IV pili all appear important for the growth of Geobacter in changing environments and for electricity production. Recent studies in other bacteria have demonstrated that signaling pathways homologous to the paradigm established for Escherichia coli chemotaxis can regulate type IV pili-dependent motility, the synthesis of flagella and type IV pili, the production of extracellular matrix material, and biofilm formation. The classification of these pathways by comparative genomics improves the ability to understand how Geobacter thrives in natural environments and better their use in microbial fuel cells.
Canadian Journal of Botany-revue Canadienne De Botanique, 2001
Infraspecific variation and phylogenetic relationships of Canadian Arctic species of the genus Po... more Infraspecific variation and phylogenetic relationships of Canadian Arctic species of the genus Poa were stud- ied based on chloroplast DNA (cpDNA) variation. Restriction site analysis of polymerase chain reaction amplified cpDNA was used to reexamine the status of infraspecific taxa, reconstruct phylogenetic relationships, and reexamine previous classification systems and hypotheses of relationships. Infraspecific variation was detected in three species, but
Durante as últimas semanas, foi chamada minha atenção que, por vezes, as mulheres realmente gosta... more Durante as últimas semanas, foi chamada minha atenção que, por vezes, as mulheres realmente gostam de chorar. Eles choram sobre livros, programas de TV, aqueles terríveis comerciais abusado de animais, e filmes, especialmente filmes. Sentar para assistir propositadamente algo que você sabe que vai fazer você infeliz? Não faz sentido maldito.
Several psychopharmacological agents induce weight gain. Recent studies have suggested that the t... more Several psychopharmacological agents induce weight gain. Recent studies have suggested that the tumor necrosis factor-α (TNF-α) cytokine system is pathophysiologically involved. To assess whether carbamazepine and lithium, which have been reported to lead to weight gain, have effects on the circulating levels of cytokines, we measured plasma levels of TNF-α, its soluble receptors sTNF-R p55 and p75, and leptin, as well as weight in 25 inpatients receiving lithium (n=10) or carbamazepine (n=15) weekly during the first 4 weeks of treatment. We found an increase in the body mass index and in TNF-α and its soluble receptor levels, but not in leptin levels over the 4 weeks of treatment. These changes did not differ between treatment groups. Changes of weight during the first week of treatment, but no other parameter, strongly predicted weight change until endpoint. We conclude that the mood stabilizers carbamazepine and lithium have similar effects on the TNF-α system and do not affect leptin levels.
In this paper, the filter technique of Fletcher and Leyffer (1997) is used to globalize the prima... more In this paper, the filter technique of Fletcher and Leyffer (1997) is used to globalize the primal-dual interior-point algorithm for nonlinear programming, avoiding the use of merit functions and the updating of penalty parameters. The new algorithm decomposes the primal-dual step obtained from the perturbed first-order necessary conditions into a normal and a tangential step, whose sizes are controlled by a trust-region type parameter. Each entry in the filter is a pair of coordinates: one resulting from feasibility and centrality, and associated with the normal step; the other resulting from optimality (complementarity and duality), and related with the tangential step. Global convergence to first-order critical points is proved for the new primal-dual interior-point filter algorithm.
Background: Geobacter species are δ-Proteobacteria and are often the predominant species in a var... more Background: Geobacter species are δ-Proteobacteria and are often the predominant species in a variety of sedimentary environments where Fe(III) reduction is important. Their ability to remediate contaminated environments and produce electricity makes them attractive for further study. Cell motility, biofilm formation, and type IV pili all appear important for the growth of Geobacter in changing environments and for electricity production. Recent studies in other bacteria have demonstrated that signaling pathways homologous to the paradigm established for Escherichia coli chemotaxis can regulate type IV pili-dependent motility, the synthesis of flagella and type IV pili, the production of extracellular matrix material, and biofilm formation. The classification of these pathways by comparative genomics improves the ability to understand how Geobacter thrives in natural environments and better their use in microbial fuel cells.
Canadian Journal of Botany-revue Canadienne De Botanique, 2001
Infraspecific variation and phylogenetic relationships of Canadian Arctic species of the genus Po... more Infraspecific variation and phylogenetic relationships of Canadian Arctic species of the genus Poa were stud- ied based on chloroplast DNA (cpDNA) variation. Restriction site analysis of polymerase chain reaction amplified cpDNA was used to reexamine the status of infraspecific taxa, reconstruct phylogenetic relationships, and reexamine previous classification systems and hypotheses of relationships. Infraspecific variation was detected in three species, but
Durante as últimas semanas, foi chamada minha atenção que, por vezes, as mulheres realmente gosta... more Durante as últimas semanas, foi chamada minha atenção que, por vezes, as mulheres realmente gostam de chorar. Eles choram sobre livros, programas de TV, aqueles terríveis comerciais abusado de animais, e filmes, especialmente filmes. Sentar para assistir propositadamente algo que você sabe que vai fazer você infeliz? Não faz sentido maldito.
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