The aim of our study is to establish an animal model of olfactory hypersensitivity to volatile or... more The aim of our study is to establish an animal model of olfactory hypersensitivity to volatile organic compounds (VOCs) and to apply the model for pathological understanding of VOC-related human disorders such as sick house syndrome. We developed a system for evaluating olfactory detection of VOCs in mice, which is composed of a standard operant chamber, an odor-sniffing glassy port, solenoid valves, diaphragm pumps, two polyethylene gas bags, and a personal computer. Male mice were trained for an operant learning task of pressing the levers coresponding to sniffed gas, and then they performed a session of tasks to discriminate between VOC gas with various concentrations and pure nitrogen gas. We found that the detection thresholds of the two VOC gas (toluene and dichloromethane (DCM)) in mice were below the limit of finding with our system but that the accuracy for detecting DCM with fixed concentration (100 ppb) may be a useful index in mice for monitoring olfactory sensitivity within or after the period with repeated exposure to VOC gas.
La información presentada en esta publicación ha sido preparada de acuerdo con principios de inge... more La información presentada en esta publicación ha sido preparada de acuerdo con principios de ingeniería reconocidos y es solamente para información general. Mientras que se considera exacta, esta información no debe ser usada o tenida en cuenta para un uso determinado sin el examen profesional competente y verificación de su exactitud, adecuación y aplicabilidad por parte de un profesional ingeniero, diseñador o arquitecto debidamente certificado.
The aim of our study is to establish an animal model of olfactory hypersensitivity to volatile or... more The aim of our study is to establish an animal model of olfactory hypersensitivity to volatile organic compounds (VOCs) and to apply the model for pathological understanding of VOC-related human disorders such as sick house syndrome. We developed a system for evaluating olfactory detection of VOCs in mice, which is composed of a standard operant chamber, an odor-sniffing glassy port, solenoid valves, diaphragm pumps, two polyethylene gas bags, and a personal computer. Male mice were trained for an operant learning task of pressing the levers coresponding to sniffed gas, and then they performed a session of tasks to discriminate between VOC gas with various concentrations and pure nitrogen gas. We found that the detection thresholds of the two VOC gas (toluene and dichloromethane (DCM)) in mice were below the limit of finding with our system but that the accuracy for detecting DCM with fixed concentration (100 ppb) may be a useful index in mice for monitoring olfactory sensitivity within or after the period with repeated exposure to VOC gas.
La información presentada en esta publicación ha sido preparada de acuerdo con principios de inge... more La información presentada en esta publicación ha sido preparada de acuerdo con principios de ingeniería reconocidos y es solamente para información general. Mientras que se considera exacta, esta información no debe ser usada o tenida en cuenta para un uso determinado sin el examen profesional competente y verificación de su exactitud, adecuación y aplicabilidad por parte de un profesional ingeniero, diseñador o arquitecto debidamente certificado.
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Papers by Jorge Zavaleta