Yoram Harth MD

Followers

Following

Co-authors

Public Views

World renown Dermatologist, serial entrepreneur, former research fellow at the department of Dermatology Columbia Presbyterian in New York, winner of the world street journal Europe and Edison product innovation awards.

less

Anna M. Czarnecka

Medical University of Warsaw

David Seamon

Kansas State University

Giridhara R Babu

Indian Institute of Public Health

Bora Gurel

Kocaeli University

Marcin Miłkowski

Polish Academy of Sciences

Alexander Fantalkin

Tel Aviv University

Michael J. Gonzalez

Universidad de Puerto Rico Rio

Dr. Gary Kao

University of Pennsylvania

Hillel Cohen

The Hebrew University of Jerusalem

Daniele Chiffi

Politecnico di Milano

Interests

Uploads

Papers by Yoram Harth MD

Is Telehealth A Real Alternative to In-Office Physician Consultations? (Preprint)

UNSTRUCTURED The high cost and scarcity of physicians results in lack of proper service to the ma... more UNSTRUCTURED The high cost and scarcity of physicians results in lack of proper service to the majority of the population in the US and more so in the rest of the world. Telehealth, based on remote physicians does not seem to be the solution due to less than optimal cost/benefit ratio offered to the human provider. Recent developments in mobile processing power, mobile camera resolution, and deep learning technology present an opportunity to build solutions to specific diseases that are comparable in accuracy to a human in-person service for a fraction of the cost democratizing the availability of health services.

Photosensitivity to Systemic Agents

American Journal of Contact Dermatitis, Dec 1, 1993

Eradication of<i>Propionibacterium acnes</i>by its endogenic porphyrins after illumination with high intensity blue light

Fems Immunology and Medical Microbiology, 2003

Propionibacterium acnes is a Gram-positive, microaerophilic bacterium that causes skin wounds. It... more Propionibacterium acnes is a Gram-positive, microaerophilic bacterium that causes skin wounds. It is known to naturally produce high amounts of intracellular porphyrins. The results of the present study confirm that the investigated strain of P. acnes is capable of producing endogenic porphyrins with no need for any trigger molecules. Extracts from growing cultures have demonstrated emission peaks around 612 nm when excited at 405 nm, which are characteristic for porphyrins. Endogenic porphyrins were determined and quantified after their extraction from the bacterial cells by fluorescence intensity and by elution retention time on high-performance liquid chromatography (HPLC). The porphyrins produced by P. acnes are mostly coproporphyrin, as shown by the HPLC elution patterns. Addition of N-aminolevulinic acid (ALA) enhanced intracellular porphyrin synthesis and higher amounts of coproporphyrin have been found. Eradication of P. acnes by its endogenic porphyrins was examined after illumination with intense blue light at 407^420 nm. The viability of 24 h cultures grown anaerobically in liquid medium was reduced by less than two orders of magnitude when illuminated once with a light dose of 75 J cm 32. Better photodynamic effects were obtained when cultures were illuminated twice or three times consecutively with a light dose of 75 J cm 32 and an interval of 24 h between illuminations. The viability of the culture under these conditions decreased by four orders of magnitude after two illuminations and by five orders of magnitude after three illuminations. When ALA-triggered cultures were illuminated with intense blue light at a light dose of 75 J cm 32 the viability of the treated cultures decreased by seven orders of magnitude. This decrease in viability can occur even after a single exposure of illumination for the indicated light intensity. X-ray microanalysis and transmission electron microscopy revealed structural damages to membranes in the illuminated P. acnes. Illumination of the endogenous coproporphyrin with blue light (407^420 nm) apparently plays a major role in P. acnes photoinactivation. A treatment protocol with a series of several illuminations or illumination after application of ALA may be suitable for curing acne. Treatment by both pathways may overcome the resistance of P. acnes to antibiotic treatment.

Download

Patentpraxis in der Industrie. W. Krumme. Beispiele zur Einführung in das patentrechtliche Denken. 95 S. mit 52 Abb. und 2 Tafeln. Carl Hanser Verlag München, 1963. Kartoniert DM 9,80

Materials and Corrosion-werkstoffe Und Korrosion, Aug 1, 1963

Oberflachenschutz von Gegcnstandcn aus Eisen, die in Beton ein,gebettet werden.

Download

Patent- und Gebrauchsmusterrecht. H. Geigel. Einf�hrung und Praxis. Dritte, neubearbeitete Auflage der ?Patentfibel?. 407 Seiten. Verlag Chemie, GmbH., Weinheim/Bergstr. 1962. Gln. DM 28,?

Materials and Corrosion-werkstoffe Und Korrosion, Aug 1, 1963

Oberflachenschutz von Gegcnstandcn aus Eisen, die in Beton ein,gebettet werden.

Download

Deep Learning-Based Acne Apps Can Solve the Problem of Ineffective Office Consultations

Biomedical Journal of Scientific & Technical Research, 2018

Monitoring Acne Quality of Life Questionnaire: The app: easy. Do you know any doctors that do tha... more Monitoring Acne Quality of Life Questionnaire: The app: easy. Do you know any doctors that do that? Patient education: Tell the patient what acne is. Tell the patient how the treatment works. Let the patient know that no treatments work instantly and indicate when the patient may expect to see an improvement. Provide a detailed explanation of how to use the recommended treatment regimen. The app: wins. It provides dozens of video tutorials, guides and tips to educate the acne patient. The doctor: it is hard to educate the patient in a 5-minute visit.

Download

ISID0199 - Computer vision AI-based androgenetic alopecia analysis using a novel mobile web app

Successful Treatment of Localized Leukoderma With the MultiClear™ - a Computerized Tunable UVB/UVA-1 Targeted High Intensity Light System

Background : Effective treatment solutions for leukoderma such as stretch marks and vitiligo have... more Background : Effective treatment solutions for leukoderma such as stretch marks and vitiligo have been the subject of intensive research in the past few years. Initial results obtained with pure UVB pulsed Excimer lasers on localized leukoderma have demonstrated the effectiveness of high intensity pulsed systems. However, Excimer lasers lack the additional UVA-1 component necessary for the fast and efficient treatment of leukoderma, are cumbersome to operate and hard to maintain. Objectives: To study the effectiveness of a novel fiber-based tunable UVB / UVA-1 localized leukoderma treatment system with computerized MED capabilities on stretch marks and vitiligo. Methods : We have utilized a high intensity pulsed tunable UVB ( 304- 313 nm) / UVA-1 (360-370 nm) system to treat stretch marks and localized vitiligo on various body sites. Spot size was 23X23 mm. Results were assessed by baseline and post- therapy photography. Results: Stretch marks were rapidly repigmented within 1 – 8 t...

Photosensitivity to Systemic Agents

Dermatitis, 1993

加大污水治理力度促进纺织产业升级——高阳县污水处理厂建设经验

高阳县污水处理厂位于县城东纺织印染循环经济园区内，占地213亩，配套管网20公里，一期日处理印染废水和城区生活污水6万吨，总投资18602万元，其中厂区建设投资14602万元，污水管网投资400... more 高阳县污水处理厂位于县城东纺织印染循环经济园区内，占地213亩，配套管网20公里，一期日处理印染废水和城区生活污水6万吨，总投资18602万元，其中厂区建设投资14602万元，污水管网投资4000万元。2006年8月开工建设，2008年4月进行闭水试验和菌种培养，5月投入试运行，8月通过省环保专家的验收，9月正式运行，已收入三利等30家印染企业废水，出水水质初步达到国家二级排放标准。

Regional distribution of melanocytic naevi in relation to sun exposure

“Death is not allowed”—an ancient concept of healing by suggestion

Psychosomatic Medicine, 1991

My honeymoon journey brought me to the Asklepion of Pergamon; an old health resort on the Aegean ... more My honeymoon journey brought me to the Asklepion of Pergamon; an old health resort on the Aegean coast of Asia minor founded in the 4th century B.C. The writing over the main entrance was prominent: "Death is not allowed" (1). The patients coming for treatment were examined at the gate and were not let in if there was no known cure for their illnesses (1). Criteria for patients' eligibility were reassured by fitness tests conducted outside the Asklepion. Pregnant women, patients appearing too sick and terminally ill persons were not admitted. At the first sign of approaching death patients were cast out (2), lest their death would suggest that the healing god and its priests were fallible. The consequence was that not one of the thousands of patients treated in these popular centers died there; in modern terms an unusually low mortality rate.

Novel Multi-Source Phase-Controlled Radiofrequency Technology for Non-Ablative and Micro-Ablative Treatment of Wrinkles, Lax Skin and Acne Scars

LASER THERAPY, 2011

Patient demand for a non-invasive and long-lasting treatment to reduce wrinkles has grown dramati... more Patient demand for a non-invasive and long-lasting treatment to reduce wrinkles has grown dramatically over the past decade as new treatments and technologies have been introduced. A major cause of skin wrinkles, skin laxity and cellulite is the reduction in the quantity and quality of collagen fibers in the dermis and hypodermis. It is well documented that one of the effects of dermal heating is an immediate change in collagen structure followed by a longer term stimulation of neocollagenesis starting at 4-6 weeks after therapy .1) These changes can help reduce the appearance of wrinkles and lax and improve contours on both the face and body. Lasers and pulsed light technologies are very effective in the treatment of colored skin lesions such as lentigines and vascular lesions and in hair removal. Nevertheless, due to the limited penetration of optical energy into tissue, lasers and light are less useful for

Download

The effective treatment of acne vulgaris by a high‐intensity, narrow band 405–420 nm light source

Journal of Cosmetic and Laser Therapy, 2003

Available topical treatments are slow and frequently irritating. Oral therapies may be associated... more Available topical treatments are slow and frequently irritating. Oral therapies may be associated with increased bacterial resistance (antibiotics) or possible severe side effects (oral isotretinoin). In vitro and in vivo exposure of acne bacteria to 405-420 nm ultraviolet (UV) free blue light results in the photo-destruction of these bacteria through the effects on the porphyrins produced naturally by Propionibacterium acnes. A novel, high-intensity, narrow band 420 nm UV free blue light has been shown to decrease inflammatory acne lesions after eight bi-weekly treatments. To examine the effects of high-intensity, narrow band 420 nm UV free blue light (ClearLight) on inflammatory acne lesions. Three studies were carried out to examine the clinical effects of high-intensity, narrow band blue light on papulo-pustular acne: the split-face dose-response study, the full-face open trial and the split-face, double-blind controlled study. The studies enrolled 10, 13 and 23 patients respectively. The data show more than an 80% response to 420 nm acne phototherapy with a significant reduction of 59-67% of inflammatory acne lesions after only eight treatments of 8-15 minutes. The reduction in lesions was steady in the follow-ups at 2, 4 and 8 weeks after the end of therapy. Prolonged remission was evident in the 8 weeks after the end of therapy. No adverse effects or patient discomfort were noted in any of the patients. Acne phototherapy by high intensity, narrow band 405-420 nm light is proven to be an attractive, fast, effective, non-invasive alternative to current topical and parenteral anti-acne remedies.

[Topical photodynamic therapy in basal and squamous cell carcinoma and penile Bowen's disease with 20% aminolevulinic acid, and exposure to red light and infrared light]

Harefuah, Jan 15, 1998

Photodynamic therapy (PDT) is a noninvasive selective therapy for a specific group of skin tumors... more Photodynamic therapy (PDT) is a noninvasive selective therapy for a specific group of skin tumors. 5-aminolevulinic acid 20% in a water-in-oil cream base was applied to the tumors as a photosensitizer and was followed after 12 hours by exposure to a high output light source emitting red (585-720 nm; 150 mW/cm2) and near infrared irradiation (1.25-1.6 mm; 50 mW/cm2) for 10-15 minutes (VersaLight, incoherent filtered light source). Complete responses were achieved after 1-3 treatments in 26/31 lesions of superficial or small nodular basal cell carcinoma (BCC) and 4/5 in superficial, squamous cell carcinoma (SCC) lesions. There was a patient with Bowen's disease of the penis. Follow-up was for 12-24 months. This noninvasive, nearly painless treatment gives excellent therapeutic and cosmetic results. Our data show its efficacy for certain subtypes of BCC, SCC and Bowen's disease. Further studies will determine the exact cure and recurrence rates with this modality and compare it...

Anti photoaging effects of carrot oil and multivitamin cream in the hairless mouse model: A blinded morphological and histopathological controlled study

Journal of the European Academy of Dermatology and Venereology, 1998

Influence of cumulative sun exposure on the prevalence of common acquired nevi

Journal of the American Academy of Dermatology, 1992

Download

‘Hairy sunscreen’ for the prevention of recurrent herpes simplex labialis

Journal of Dermatological Treatment, 1992

Seborrheic Skin and Acne vulgaris as Protective Factors against the Development of Basal Cell Epithelioma

Dermatology, 1991

This study was conducted in order to evaluate a possible protective role of seborrheic complexion... more This study was conducted in order to evaluate a possible protective role of seborrheic complexion and a history of acne on the development of basal cell epithelioma (BCE). For this purpose, 77 patients with this tumor were examined and asked to fill out a questionnaire. The questionnaire included demographic data and questions about skin type, eye and hair colors, sun exposure habits and a past history of acne. The nature, number and location of tumors, the texture of skin and acne scars were noted by a physician. A group of 93 age-, sex- and skin-color-matched patients served as controls. The results show a clear relationship between seborrheic features and a lower risk of developing BCE, after controlling for solar exposure using the Mantel-Haenszel summary measure. The same trend was found in patients with a history of acne. Whether ultraviolet light absorption by sebum, an anticancer activity of Propionibacterium acnes or other factors play a protective role against the developm...

Painless, safe, and efficacious noninvasive skin tightening, body contouring, and cellulite reduction using multisource 3DEEP radiofrequency

Journal of Cosmetic Dermatology, 2015

In the last decade, Radiofrequency (RF) energy has proven to be safe and highly efficacious for f... more In the last decade, Radiofrequency (RF) energy has proven to be safe and highly efficacious for face and neck skin tightening, body contouring, and cellulite reduction. In contrast to first-generation Monopolar/Bipolar and "X -Polar" RF systems which use one RF generator connected to one or more skin electrodes, multisource radiofrequency devices use six independent RF generators allowing efficient dermal heating to 52-55 °C, with no pain or risk of other side effects. In this review, the basic science and clinical results of body contouring and cellulite treatment using multisource radiofrequency system (Endymed PRO, Endymed, Cesarea, Israel) will be discussed and analyzed.

Download

Is Telehealth A Real Alternative to In-Office Physician Consultations? (Preprint)