Doug Yeager

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Natalie Baddour

University of Ottawa | Université d'Ottawa

Amir Manbachi

Johns Hopkins University

Richard Dewhurst

The University of Manchester

Leonardo Iheme

Mayo Clinic

Aida Khairuddin

Universiti Teknologi Malaysia - UTM

Mohammad Mehrmohammadi

Wayne State University

Henk Postma

California State University, Northridge

Irraivan Elamvazuthi

Universiti Teknologi PETRONAS

klaus Hans

University College London

Zeljka Krpetic

University College Dublin

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Papers by Doug Yeager

System and integrated catheter for real-time intravascular ultrasound and photoacoustic imaging

2014 IEEE International Ultrasonics Symposium, 2014

Intravascular photoacoustics for image-guidance and temperature monitoring during plasmonic photothermal therapy of atherosclerotic plaques: a feasibility study

Theranostics, 2013

Recently, combined intravascular ultrasound and photoacoustic (IVUS/IVPA) imaging has been demons... more Recently, combined intravascular ultrasound and photoacoustic (IVUS/IVPA) imaging has been demonstrated as a novel imaging modality capable of visualizing both morphology (via IVUS) and cellular/molecular composition (via IVPA) of atherosclerotic plaques, using both endogenous tissue absorbers and exogenous contrast agents. Plasmonic gold nanoparticles were previously utilized as IVPA contrast agents which co-localize with atherosclerotic plaques, particularly phagocytically active macrophages. The present work demonstrates the use of IVUS/IVPA imaging as a tool for localized temperature monitoring during laser heating. The temperature dependent change in IVPA signal intensity of silica-coated gold nanorod contrast agents absorbing within the near-infrared optical wavelength range is evaluated and shown to have a linear relationship, with a slope greater than that of endogenous tissue. A continuous wave laser was subsequently incorporated into the IVUS/IVPA integrated catheter and u...

Akcros extends partnership with Dow on biocides for polymers

Intravascular photoacoustic imaging of exogenously labeled atherosclerotic plaque through luminal blood

Journal of biomedical optics, 2012

Combined intravascular ultrasound and intravascular photoacoustic (IVUS/IVPA) imaging has been pr... more Combined intravascular ultrasound and intravascular photoacoustic (IVUS/IVPA) imaging has been previously established as a viable means for assessing atherosclerotic plaque morphological and compositional characteristics using both endogenous and exogenous contrast. In this study, IVUS/IVPA imaging of atherosclerotic rabbit aortas following systemic injection of gold nanorods (AUNRs) with peak absorbance within the tissue optical window is performed. Ex vivo imaging results reveal a high photoacoustic signal from localized AUNRs in regions with atherosclerotic plaques. Corresponding histological staining further confirms the preferential extravasation of AUNRs in atherosclerotic regions with compromised luminal endothelium and acute inflammation. The ability to detect AUNRs using combined IVUS and photoacoustic imaging in the presence of luminal saline and luminal blood is evaluated using both spectroscopic and single wavelength IVPA imaging techniques. Results demonstrate that AUNR...

Intravascular photoacoustic imaging of lipid in atherosclerotic plaques in the presence of luminal blood

Optics letters, 2012

Intravascular photoacoustic (IVPA) imaging can characterize atherosclerotic plaque composition on... more Intravascular photoacoustic (IVPA) imaging can characterize atherosclerotic plaque composition on the basis of the optical absorption contrast between different tissue types. Given the high optical absorption of lipid at 1720 nm wavelength, an atherosclerotic rabbit aorta was imaged at this wavelength ex vivo using an integrated intravascular ultrasound (IVUS) and IVPA imaging catheter in the presence of luminal blood. Strong optical absorption of lipid combined with low background signal from other tissues provides a high-contrast, depth-resolved IVPA image of lipid. The ability to image lipid at a single wavelength without removing luminal blood suggests that in vivo detection of lipid in atherosclerotic plaques using combined IVUS/IVPA imaging is possible.

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TCT-637 Intravascular Ultrasound and Photoacoustic Imaging of Plasmonic Nanoparticles for Combined Diagnosis and Image-Guided Therapy of Atherosclerotic Plaques

Intravascular Ultrasound-Guided Photoacoustic Imaging: From Visualization of Tissue Morphology to Cellular/Molecular Imaging of Atherosclerotic Plaque Composition

<title>Methodical study on plaque characterization using integrated vascular ultrasound, strain and spectroscopic photoacoustic imaging</title>

Photons Plus Ultrasound: Imaging and Sensing 2011, 2011

Carotid atherosclerosis has been identified as a potential risk factor for cerebrovascular events... more Carotid atherosclerosis has been identified as a potential risk factor for cerebrovascular events, but information about its direct effect on the risk of recurrent stroke is limited due to incomplete diagnosis. The combination of vascular ultrasound, strain rate and spectroscopic photoacoustics could improve the timely diagnosis of plaque status and risk of rupturing. Current ultrasound techniques can noninvasively image the

Photoacoustic Imaging for Cancer Diagnosis and Therapy Guidance

Cancer Theranostics, 2014

Photoacoustic Imaging for Cancer Detection and Staging

by Doug Yeager, Mohammad Mehrmohammadi, and Soon Yoon

Current Molecular Imaging, 2013

Cancer is one of the leading causes of death in the world. Diagnosing a cancer at its early stage... more Cancer is one of the leading causes of death in the world. Diagnosing a cancer at its early stages of development can decrease the mortality rate significantly and reduce healthcare costs. Over the past two decades, photoacoustic imaging has seen steady growth and has demonstrated notable capabilities to detect cancerous cells and stage cancer. Furthermore, photoacoustic imaging combined with ultrasound imaging and augmented with molecular targeted contrast agents is capable of imaging cancer at the cellular and molecular level, thus opening diverse opportunities to improve diagnosis of tumors, detect circulating tumor cells and identify metastatic lymph nodes. In this paper we introduce the principles of photoacoustic imaging, and review recent developments in photoacoustic imagingas an emerging imaging modality for cancer diagnosis and staging.

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Intravascular Photoacoustic and Ultrasound Imaging: From Tissue Characterization to Molecular Imaging to Image-Guided Therapy

Atherosclerosis Disease Management, 2010

... 26 Intravascular Photoacoustic and Ultrasound Imaging structure of the phantom. However, due ... more

Intravascular photoacoustic imaging of gold nanorod-labeled atherosclerotic plaques

Photons Plus Ultrasound: Imaging and Sensing 2012, 2012

ABSTRACT Combined intravascular photoacoustic (IVPA) and intravascular ultrasound (IVUS) imaging ... more ABSTRACT Combined intravascular photoacoustic (IVPA) and intravascular ultrasound (IVUS) imaging has been previously established as a viable means for imaging atherosclerotic plaques using both endogenous and exogenous contrast. In this study, IVUS/IVPA imaging of an atherosclerotic rabbit aorta following injection of gold nanorods (AuNR) with peak absorbance within the tissue optical window was performed. Ex-vivo imaging results revealed high photoacoustic signal from localized AuNR. Corresponding histological cross-sections and digital photographs of the artery lumen confirmed the presence of AuNR preferentially located at atherosclerotic regions and in agreement with IVPA signal. Furthermore, an integrated IVUS/IVPA imaging catheter was used to image the AuNR in the presence of luminal blood. The results suggest that AuNR allow for IVPA imaging of exogenously labeled atherosclerotic plaques with a comparatively low background signal and without the need for arterial flushing.

Intravascular photoacoustic imaging of lipid in atherosclerotic plaques in the presence of luminal blood

Optics Letters, 2012

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CATHETER FOR INTRAVASCULAR ULTRASOUND AND PHOTOACOUSTIC IMAGING

< i> In vivo</i> Intravascular Ultrasound-guided Photoacoustic Imaging of Lipid in Plaques Using an Animal Model of Atherosclerosis

Biomedical Applications of Photoacoustic Imaging with Exogenous Contrast Agents

by Geoffrey Luke and Doug Yeager

Annals of Biomedical Engineering, 2012

Photoacoustic imaging is a biomedical imaging modality that provides functional information, and,... more Photoacoustic imaging is a biomedical imaging modality that provides functional information, and, with the help of exogenous contrast agents, cellular and molecular signatures of tissue. In this article, we review the biomedical applications of photoacoustic imaging assisted with exogenous contrast agents. Dyes, noble metal nanoparticles, and other constructs are contrast agents which absorb strongly in the near-infrared band of the optical spectrum and generate strong photoacoustic response. These contrast agents, which can be specifically targeted to molecules or cells, have been coupled with photoacoustic imaging for preclinical and clinical applications ranging from detection of cancer cells, sentinel lymph nodes, and micrometastasis to angiogenesis to characterization of atherosclerotic plaques. Multi-functional agents have also been developed, which can carry drugs or simultaneously provide contrast in multiple imaging modalities. Furthermore, contrast agents were used to guide and monitor the therapeutic procedures. Overall, photoacoustic imaging shows significant promise in its ability to assist in diagnosis, therapy planning, and monitoring of treatment outcome for cancer, cardiovascular disease, and other pathologies.

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System and integrated catheter for real-time intravascular ultrasound and photoacoustic imaging

2014 IEEE International Ultrasonics Symposium, 2014

Intravascular photoacoustics for image-guidance and temperature monitoring during plasmonic photothermal therapy of atherosclerotic plaques: a feasibility study

Theranostics, 2013

Akcros extends partnership with Dow on biocides for polymers

Intravascular photoacoustic imaging of exogenously labeled atherosclerotic plaque through luminal blood

Journal of biomedical optics, 2012

Intravascular photoacoustic imaging of lipid in atherosclerotic plaques in the presence of luminal blood

Optics letters, 2012

Download

TCT-637 Intravascular Ultrasound and Photoacoustic Imaging of Plasmonic Nanoparticles for Combined Diagnosis and Image-Guided Therapy of Atherosclerotic Plaques

Intravascular Ultrasound-Guided Photoacoustic Imaging: From Visualization of Tissue Morphology to Cellular/Molecular Imaging of Atherosclerotic Plaque Composition

<title>Methodical study on plaque characterization using integrated vascular ultrasound, strain and spectroscopic photoacoustic imaging</title>

Photons Plus Ultrasound: Imaging and Sensing 2011, 2011

Photoacoustic Imaging for Cancer Diagnosis and Therapy Guidance

Cancer Theranostics, 2014

Photoacoustic Imaging for Cancer Detection and Staging

by Doug Yeager, Mohammad Mehrmohammadi, and Soon Yoon

Current Molecular Imaging, 2013

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Intravascular Photoacoustic and Ultrasound Imaging: From Tissue Characterization to Molecular Imaging to Image-Guided Therapy

Atherosclerosis Disease Management, 2010

... 26 Intravascular Photoacoustic and Ultrasound Imaging structure of the phantom. However, due ... more

Intravascular photoacoustic imaging of gold nanorod-labeled atherosclerotic plaques

Photons Plus Ultrasound: Imaging and Sensing 2012, 2012

Intravascular photoacoustic imaging of lipid in atherosclerotic plaques in the presence of luminal blood

Optics Letters, 2012

Download

CATHETER FOR INTRAVASCULAR ULTRASOUND AND PHOTOACOUSTIC IMAGING

< i> In vivo</i> Intravascular Ultrasound-guided Photoacoustic Imaging of Lipid in Plaques Using an Animal Model of Atherosclerosis

Biomedical Applications of Photoacoustic Imaging with Exogenous Contrast Agents

by Geoffrey Luke and Doug Yeager

Annals of Biomedical Engineering, 2012

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