Papers by Xochitl Ambriz-Peña
The understanding of the cytoskeleton's importance in stem cells is essential for their manipulat... more The understanding of the cytoskeleton's importance in stem cells is essential for their manipulation and further clinical application. The cytoskeleton is crucial in stem cell biology and depends on physical and chemicals signals to define its structure. Additionally, cell culture conditions will be important in the proper maintenance of stemness, lineage commitment and differentiation. This review focuses on the role of the actin cytoskeleton of stem cells during differentiation, the significance of cellular morphology, signaling pathways involved in cytoskeletal rearrangement in stem cells, the mechanobiology and mechanotransduction processes implicated in the interactions of stem cells with different surfaces of biomaterials, such as the nanotopography which is a physical cue influencing the differentiation of stem cells. Also, cancer stem cells are included since it is necessary to understand the role of their mechanical properties to develop new strategies to treat cancer. In this context, to study the stem cells requires integrated disciplines, including molecular and cellular biology, chemistry, physics, immunology, but also mechanobiology. Finally, as one of the purposes of stem cells is their application in regenerative medicine, their deepest understanding is necessary in order to establish safety protocols and effective cell-based therapies.
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Papers by Xochitl Ambriz-Peña