c-Jun N-terminal kinases (JNKs) participate in cellular responses to mitogenic stimuli, environme... more c-Jun N-terminal kinases (JNKs) participate in cellular responses to mitogenic stimuli, environmental stresses, and apoptotic agents. The mechanisms by which JNK integrates with other signaling pathways and regulates the diverse cellular events are unclear. We found JNK, but not p38-mitogen-activated protein kinase (MAPK) or extracellular signal-regulated kinase 2, to be persistently activated in apoptosis induced by ␥ radiation, UV-C, and anti-Fas treatment. Direct correlation was found between JNK activation and apoptosis induced by UV-C and ␥ radiation; however, JNK induction and apoptosis induced by Fas signaling were not well correlated.
There are now more than a thousand Web Services offering access to disparate biological resources... more There are now more than a thousand Web Services offering access to disparate biological resources namely data and computational tools. It is extremely difficult for biological researchers to search in a Web Services (WS) registry for a relevant WS using the standard (primarily computational) descriptions used to describe it. Semantic Biological Web Services Registry (SemBOWSER) is an ontology-based implementation of the UDDI specification, which enables, at present, glycoproteomics researchers to publish, search and discover WS using semantic, service-level, descriptive domain keywords . SemBOWSER classifies a WS along two dimensions--the task they implement and the domain they are associated with. Each published WS is associated with the relevant ProPreO (comprehensive process ontology for glycoproteomics experimental lifecycle) ontology-based keywords (implemented as part of the registry). A researcher, in turn, can search for relevant WS using only the descriptive keywords, part of their everyday working lexicon. This intuitive search is underpinned by the ProPreO ontology, thereby making use of the inherent advantages of a semantic search, as compared to a purely syntactic search, namely disambiguation and use of named relationships between concepts. SemBOWSER is part of the glycoproteomics web portal 'Stargate'.
c-Jun N-terminal kinases (JNKs) participate in cellular responses to mitogenic stimuli, environme... more c-Jun N-terminal kinases (JNKs) participate in cellular responses to mitogenic stimuli, environmental stresses, and apoptotic agents. The mechanisms by which JNK integrates with other signaling pathways and regulates the diverse cellular events are unclear. We found JNK, but not p38-mitogen-activated protein kinase (MAPK) or extracellular signal-regulated kinase 2, to be persistently activated in apoptosis induced by ␥ radiation, UV-C, and anti-Fas treatment. Direct correlation was found between JNK activation and apoptosis induced by UV-C and ␥ radiation; however, JNK induction and apoptosis induced by Fas signaling were not well correlated.
There are now more than a thousand Web Services offering access to disparate biological resources... more There are now more than a thousand Web Services offering access to disparate biological resources namely data and computational tools. It is extremely difficult for biological researchers to search in a Web Services (WS) registry for a relevant WS using the standard (primarily computational) descriptions used to describe it. Semantic Biological Web Services Registry (SemBOWSER) is an ontology-based implementation of the UDDI specification, which enables, at present, glycoproteomics researchers to publish, search and discover WS using semantic, service-level, descriptive domain keywords . SemBOWSER classifies a WS along two dimensions--the task they implement and the domain they are associated with. Each published WS is associated with the relevant ProPreO (comprehensive process ontology for glycoproteomics experimental lifecycle) ontology-based keywords (implemented as part of the registry). A researcher, in turn, can search for relevant WS using only the descriptive keywords, part of their everyday working lexicon. This intuitive search is underpinned by the ProPreO ontology, thereby making use of the inherent advantages of a semantic search, as compared to a purely syntactic search, namely disambiguation and use of named relationships between concepts. SemBOWSER is part of the glycoproteomics web portal 'Stargate'.
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