... 1-[2-(Dimethylamino)ethyl]-3,8-dimethoxy[1]benzopyrano[5,4,3-cde][1]benzopyran-5,10-dione (Ta... more ... 1-[2-(Dimethylamino)ethyl]-3,8-dimethoxy[1]benzopyrano[5,4,3-cde][1]benzopyran-5,10-dione (Taspine, 1). Aldehyde 15 (45.0 mg, 0.132 mmol) was suspended in 40 mL of freshly distilled DCE in a 100 mL round ... [CrossRef]. (b) For related applications, see: Kelly, TR; Jagoe, CT ...
ABSTRACT ChemInform is a weekly Abstracting Service, delivering concise information at a glance t... more ABSTRACT ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
An attempt to synthesize isoquinolin-9(1H)-one, 3) gave the tautomer 3-methylpyrazolo[1,5-b]isoqu... more An attempt to synthesize isoquinolin-9(1H)-one, 3) gave the tautomer 3-methylpyrazolo[1,5-b]isoquinolin-9(4H)-one (9) instead, and led to a reconsideration of the structures assigned to the APHEs. The structures of the APHEs have now been reformulated as 15-18, known natural products, whose spectra are in close agreement with those reported for the APHEs.
The investigation of palladium-catalyzed alkoxyallylation of activated olefins, followed by ring-... more The investigation of palladium-catalyzed alkoxyallylation of activated olefins, followed by ring-closing metathesis to synthesize functionalized seven-membered ring allyl ethers is described. The influence of the olefin substituents on the diastereoselectivity of the alkoxyallylation has also been examined.
... 1-[2-(Dimethylamino)ethyl]-3,8-dimethoxy[1]benzopyrano[5,4,3-cde][1]benzopyran-5,10-dione (Ta... more ... 1-[2-(Dimethylamino)ethyl]-3,8-dimethoxy[1]benzopyrano[5,4,3-cde][1]benzopyran-5,10-dione (Taspine, 1). Aldehyde 15 (45.0 mg, 0.132 mmol) was suspended in 40 mL of freshly distilled DCE in a 100 mL round ... [CrossRef]. (b) For related applications, see: Kelly, TR; Jagoe, CT ...
a b s t r a c t SIRT1 is an NAD + -dependent protein deacetylase that appears to produce benefici... more a b s t r a c t SIRT1 is an NAD + -dependent protein deacetylase that appears to produce beneficial effects on metabolic parameters such as glucose and insulin homeostasis. Activation of SIRT1 by resveratrol (1) has been shown to modulate insulin resistance, increase mitochondrial content and prolong survival in lower organisms and in mice on a high fat diet. Herein, we describe the identification and SAR of a series of oxazolo [4,5-b]pyridines as novel small molecule activators of SIRT1 which are structurally unrelated to and more potent than resveratrol.
... 1-[2-(Dimethylamino)ethyl]-3,8-dimethoxy[1]benzopyrano[5,4,3-cde][1]benzopyran-5,10-dione (Ta... more ... 1-[2-(Dimethylamino)ethyl]-3,8-dimethoxy[1]benzopyrano[5,4,3-cde][1]benzopyran-5,10-dione (Taspine, 1). Aldehyde 15 (45.0 mg, 0.132 mmol) was suspended in 40 mL of freshly distilled DCE in a 100 mL round ... [CrossRef]. (b) For related applications, see: Kelly, TR; Jagoe, CT ...
ABSTRACT ChemInform is a weekly Abstracting Service, delivering concise information at a glance t... more ABSTRACT ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
An attempt to synthesize isoquinolin-9(1H)-one, 3) gave the tautomer 3-methylpyrazolo[1,5-b]isoqu... more An attempt to synthesize isoquinolin-9(1H)-one, 3) gave the tautomer 3-methylpyrazolo[1,5-b]isoquinolin-9(4H)-one (9) instead, and led to a reconsideration of the structures assigned to the APHEs. The structures of the APHEs have now been reformulated as 15-18, known natural products, whose spectra are in close agreement with those reported for the APHEs.
The investigation of palladium-catalyzed alkoxyallylation of activated olefins, followed by ring-... more The investigation of palladium-catalyzed alkoxyallylation of activated olefins, followed by ring-closing metathesis to synthesize functionalized seven-membered ring allyl ethers is described. The influence of the olefin substituents on the diastereoselectivity of the alkoxyallylation has also been examined.
... 1-[2-(Dimethylamino)ethyl]-3,8-dimethoxy[1]benzopyrano[5,4,3-cde][1]benzopyran-5,10-dione (Ta... more ... 1-[2-(Dimethylamino)ethyl]-3,8-dimethoxy[1]benzopyrano[5,4,3-cde][1]benzopyran-5,10-dione (Taspine, 1). Aldehyde 15 (45.0 mg, 0.132 mmol) was suspended in 40 mL of freshly distilled DCE in a 100 mL round ... [CrossRef]. (b) For related applications, see: Kelly, TR; Jagoe, CT ...
a b s t r a c t SIRT1 is an NAD + -dependent protein deacetylase that appears to produce benefici... more a b s t r a c t SIRT1 is an NAD + -dependent protein deacetylase that appears to produce beneficial effects on metabolic parameters such as glucose and insulin homeostasis. Activation of SIRT1 by resveratrol (1) has been shown to modulate insulin resistance, increase mitochondrial content and prolong survival in lower organisms and in mice on a high fat diet. Herein, we describe the identification and SAR of a series of oxazolo [4,5-b]pyridines as novel small molecule activators of SIRT1 which are structurally unrelated to and more potent than resveratrol.
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