Walter Ryd

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Natalia Égüez

Universidad de La Laguna

Årstein Justnes

University of Agder

Ndubuisi Machebe

University of Nigeria, Nsukka

Fernando Oliva

Universidad Nacional de Rosario (UNR) Argentina

aaron lerner

Technion Israel Institute of Technology

Adp cn

Central Washington University

International Journal of Celiac Disease

Independent Researcher

Dr. Rohan Malik MD, PDCC, DM

All India Institute of Medical Sciences, New Delhi

Fariba Mirzaei Bavil

Tabriz University Of Medical Sciences

Chandni Patel Valodkar

Maharaja Sayajirao University of Baroda

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Cytological aspects on experimental tumor dissemination

Prognostic factors in chordoma of the sacrum and mobile spine

Cancer, 2000

The prognosis of patients with chordoma of the sacrum and mobile spine has been reported to be di... more The prognosis of patients with chordoma of the sacrum and mobile spine has been reported to be dismal and attributable in the majority of cases to intralesional surgery. The purpose of this study was to evaluate the clinical outcome of these patients using modern surgical principles aimed at complete resection and to identify prognostic factors. The clinical and morphologic features, type of surgery, and follow-up of 39 consecutive patients with chordoma were reviewed and analyzed statistically. Thirty sacral and 9 mobile spine chordomas (size range, 3-20 cm; mean, 8 cm) occurring in 22 women and 17 men (median age, 55 years) were analyzed. The preoperative morphologic diagnosis was based on fine-needle aspiration (FNA) biopsy, core needle biopsy, or incisional biopsy. The final surgical margins were wide in 23 patients and marginal or intralesional in 16. The mean follow-up was 8.1 years (range, 0.1-23 years). Seventeen patients (44%) developed local recurrences and 11 patients (28%) developed metastases. The estimated 5-, 10-, 15-, and 20-year survival rates were 84%, 64%, 52%, and 52%, respectively. Local recurrence was associated significantly with an increased risk of metastasis and tumor-related death (P &lt; 0.001). New surgical techniques have improved local control and survival of patients with sacral or spinal chordoma significantly and have decreased progressive neurologic deterioration. Larger tumor size, performance of an invasive morphologic diagnostic procedure outside of the tumor center, inadequate surgical margins, microscopic tumor necrosis, Ki-67 &gt; 5%, and local recurrence were found to be adverse prognostic factors. FNA is the preferred method for establishing the preoperative morphologic diagnosis of chordoma.

Cytological aspects on experimental tumor dissemination

Real-time Taqman PCR targeting 14 human papilloma virus types

Journal of Clinical Virology, 2007

Background: Subtyping of human papilloma virus (HPV) may enhance the precision of vaginal cytolog... more Background: Subtyping of human papilloma virus (HPV) may enhance the precision of vaginal cytological assessments and will be important for investigating the effect of the recently introduced vaccine against types 16 and 18. Objectives and study design: To evaluate an in-house real-time PCR targeting HPV types 16-18-31-33-35-39-45-51-52-56-58-59-6-11, by analysing 107 liquid-based cytology specimens representing various degrees of dysplasia. Results: In all, 71 samples were HPV positive, with multiple types present in 37 (52%). Comparison with Roche Linear Array on a subset of 24 of these 71 samples showed a good agreement. One or several types were detected in 17/17 (100%) samples with cervical intraepithelial neoplasia grade 2-3 (CIN 2-3), 16/19 (84%) with CIN 1, 32/43 (74%) with Atypical Squamous Cells of Undetermined Significance (ASCUS), and in 6/28 (21%) with benign cytology. Estimates of mean viral load were lower in CIN 1-3 than in ASCUS (≈4000 vs. ≈25,000 copies/1000 cells), and clearly lower in samples with benign cytology (≈50 copies/1000 cells). Conclusion: The HPV rates in groups with different degrees of dysplasia agrees with previous reports and support a strong link between types 16/18 and severe dysplasia. The high rate of multiple type infection might influence the outcome of HPV vaccination. The possible importance of viral load should be further studied.

Walter Ryd

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