Papers by Vuslat Yurut-caloglu
International braz j urol : official journal of the Brazilian Society of Urology, 2016
Clear cell renal cell cancers frequently harbor Von Hippel-Lindau gene mutations, leading to stab... more Clear cell renal cell cancers frequently harbor Von Hippel-Lindau gene mutations, leading to stabilization of the hypoxia-inducible factors (HIFs) and their target genes. In this study, we investigated the relationship between vascular endotelial growth factor (VEGF), HIF-1α, HIF-2α, p53 positivity, microvessel density, and Ki-67 rates with prognostic histopathologic factors (Fuhrman nuclear grade, stage, and sarcomatoid differentiation) and survival in clear cell renal cell carcinomas. Seventy-two nephrectomy specimens diagnosed as clear cell renal cell carcinoma between 2000 and 2012 were reevaluated. Immunohistochemically VEGF, HIF-1α, HIF-2α, p53, CD34 (for microvessel density evaluation), and Ki-67 antibodies were applied to the tumor areas. The relationships of these antibodies with prognostic factors and survival rates were evaluated with statistical analyses. Mean survival time was 105.6 months in patients with ccRCC. Patients with high expression of VEGF, HIF-1α and HIF-2α ...
Iranian Journal of Radiation Research, Oct 10, 2015
Background: The aim of the study was to compare the radioprotec ve efficacy in the kidney of L-ca... more Background: The aim of the study was to compare the radioprotec ve efficacy in the kidney of L-carni ne to that of amifos ne. Materials and Methods: Thirty three-month-old Wistar albino rats were randomly assigned to four groups: Group 1 (Control); Group 2 (Irradia on alone); Group 3 (amifos ne plus irradia on); and Group 4 (L-carni ne before irradia on). The rats in Groups 2, 3, and 4 were irradiated individually with a single dose of 20 Gy to whole abdomen. L-carni ne (300 mg/kg) or amifos ne (200 mg/kg) was administered 30 minutes before irradia on. Euthanasia was performed 5 days a/er irradia on, and kidneys were evaluated histopathologically. Results: Dilata on of Bowman's capsule, conges on of blood vessels, and tubular epithelial degenera on were significantly different among the groups (p < 0.05). Pretreatment with both L-carni ne and amifos ne reduced the radia on-induced dilata on of Bowman's capsule (p < 0.05), conges on of blood vessels (p < 0.05), and tubular epithelial degenera on (p < 0.05). L-carni ne and amifos ne were similar in protec ve effect. Conclusion: L-carni ne was equally effec ve as amifos ne in protec ng the kidney against acute irradia on damage.
Evaluation of swallowing function with clinical and dosimetric parameters in head and neck cancer patients receiving radio (chemo)therapy
Iranian Journal of Radiation Research, Oct 10, 2019
Oncocytic Carcinoma of the Parotid Gland
Oncology Research and Treatment, 2006
Oncocytic carcinoma is a rare tumor of major salivary glands. Despite being described 5 decades a... more Oncocytic carcinoma is a rare tumor of major salivary glands. Despite being described 5 decades ago, not much is known about these rare tumors. Histochemical or electron microscopic confirmation of the oncocytic nature of the tumor cell is needed for differential diagnosis. The main treatment modality is surgery with or without adjuvant radiotherapy. Malignant oncocytomas have the potential risk of developing distant metastases and demand long term follow-up after therapy. A 58-year old man presented with a recurrent mass in the left parotid gland with a prior diagnosis of monomorphic adenoma in the same localization which had been treated by tumor excision in July 2002. Left superficial parotidectomy followed by radiotherapy into tumor bed and upper neck were carried out in September 2004. To date, he has had no evidence of recurrence for 14 months. For an accurate approach in the management of patients, oncocytic adenocarcinoma should be considered in the differential diagnosis of lesions of the parotid gland, most of which are benign.
Radiotherapy and Oncology, 2012
2010 15th National Biomedical Engineering Meeting, 2010
Bu deneysel çalışma düşük doz radyasyonun kırık iyileşmesini ve mineralleşmesini arttırabilme hip... more Bu deneysel çalışma düşük doz radyasyonun kırık iyileşmesini ve mineralleşmesini arttırabilme hipotezini araştırmıştır. Kırk Sprague-Dawley genç erkek rat standart açık yöntemle transvers femur kırığı ve K-teli ile intramedüller çivileme uygulandıktan sonra RT (1 Gy radyoterapi) ve C (kontrol, sham radyoterapi) gruplarına ayrıldı. Kırık sonrası üçüncü ve altıncı haftalarda yüksek çözünürlüklü kemik mineral yoğunluğu (KMY), kemik sintigrafisi ve mammografi cihazı ile radyolojik incelemeler sonrası histopatoloji için sakrifikasyon uygulandı. İstatistiksel olarak anlamlı sonuçlar, sadece altıncı haftada görüldü; KMY indeksinde ışınlanan alanlarda kontrole göre yükseklik (p=0.006) ve ışınlanmış kemiğin kırık olmayan bölgesinde KMY düşüklüğü (p=0.005) saptandı. Diğer parametrelerde anlamlı fark yoktu. Sonuçlar, düşük doz radyasyonun sadece ışınlanmış komşu kemik ile karşılaştırıldığında kırık bölgesinde mineralizasyon artışına neden olabildiğini göstermiştir. Bu durum klinik uygulamalara temel oluşturabilecek yönde değildir. Ancak heterotopik ossifikasyon profilaksisi gibi ilgili uygulamalar dikkate alınınca konunun moleküler açıdan, 1-5 Gy aralığında incelenmesinde yarar görülmektedir.
EP-1576 Can Radiation-Induced Chronic-Oxidative Stress in Kidney and Liver Be Prevented by Dimethyl Sulfoxide?
Radiotherapy and Oncology, 2012
Pre-treatment hemoglobin levels are important for bladder carcinoma patients with extravesical extension undergoing definitive radiotherapy
PubMed, 2009
Purpose: To evaluate prognostic factors affecting local control (LC), distant metastases-free sur... more Purpose: To evaluate prognostic factors affecting local control (LC), distant metastases-free survival (DMFS) and overall survival (OS) in bladder carcinoma patients undergoing extravesical extension. Patients and methods: We retrospectively reviewed the charts of 61 consecutive patients with T3 or T4 bladder carcinoma, treated with definitive radiotherapy from 1999 through 2007. Results: Median age was 69 years and follow-up was 29 months. The LC rate was 33% at 4 years and was increased in patients with a Hb< 12 g/dl (p= 0.003) or a LDH< 180 U/L (p= 0.021) and in those who received concurrent chemotherapy (p= 0.022) on univariate analysis. DMFS was affected by anemia (Hb< 12 g/dl) (p= 0.039), the absence of chemotherapy (p= 0.034) and the presence of newly-diagnosed disease (p= 0.01). The OS rate was 19% at 4 years. Non-pure transitional cell carcinoma histological type (p= 0.024), anemia (p= 0.004), elevated LDH (p= 0.003), and newly diagnosed disease (p= 0.011) were poor prognostic factors on univariate analyses for OS. Anemia was the only negative prognostic factor for LC (p= 0.03), DMFS (p= 0.002) and OS (p< 0.0001) on multivariate analysis. Conclusion: Pre-treatment Hb level is the most important prognostic factor in patients treated with definitive radiotherapy, so that anemia may act as a surrogate biological marker for aggressive disease.
An Ambiguous Phenomenon of Radiation and Drugs: Recall Reactions
Oncology Research and Treatment, 2007
The term &amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp... more The term &amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;#39;radiation recall&amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;#39; describes an acute inflammatory reaction in previously irradiated areas after the administration of certain inciting systemic agents. It was first described in 1959 by D&amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;#39;Angio that dermatitis is related to the application of actinomycin D on the skin. Though this reaction occurs frequently on the skin, it may also be seen in the oral mucosa, the larynx, esophagus, small intestine, lungs, muscle tissue, and brain. Most drugs associated with recall reactions are cytotoxics, however, several other drugs may also elicit the phenomenon. Although this phenomenon is well known, its etiology is not understood. Radiation recall reactions are generally associated with megavoltage radiotherapy. The time interval between the completion of radiotherapy and the recall reaction ranges from days to years. The recall reaction occurs on average 8 days (3 days to 2 months) after the application of the promoting agent. Although no standard treatment exists, some authors suggest discontinuation of the inciting drug and the use of corticosteroids or nonsteroidal anti-inflammatory agents.
TheRelationshipofFuhrmanNuclearGrade,TumorStageand SarcomatoidDifferentiationwithSurvivalinRenalCellCarcinomas
Objective: Renal cell carcinoma derived from tubular epithelium is one of the malignant tumors of... more Objective: Renal cell carcinoma derived from tubular epithelium is one of the malignant tumors of the kidney. We have investigated the histological features, pathological stage, nuclear grade and sarcomatoid differentiation of these tumors. Material and Methods: Histological slides from seventy-eight nephrectomy specimens diagnosed as renal cell carcinoma between 2000 and 2008 were reevaluated according to the 2004 World Health Organization classification system of kidney tumors. Reclassified cases were collected in five groups and were scored for Fuhrman nuclear grading, stage, sarcomatoid differentiation and survival rate. Results: In our study, cases with high nuclear grade, advanced stage and sarcomatoid differentiation revealed poor survival rates (p<0.05). In conclusion, the correlation between prognostic histopathological parameters and survival rates was consistent with literature findings. Conclusion: Fuhrman nuclear grading, stage and sarcomatoid differentiation are imp...
The Medical Journal of Okmeydani Training and Research Hospital, 2017
Lokalize prostat kanseri tedavisinde brakiterapi uygulaması doz hızına göre düşük doz hızlı (Low ... more Lokalize prostat kanseri tedavisinde brakiterapi uygulaması doz hızına göre düşük doz hızlı (Low Dose Rate; LDR) ve yüksek doz hızlı (High Dose Rate; HDR) olmak üzere ikiye ayrılır. Prostat kanseri için α/β oranı tartışmalı olmakla birlikte, invivo ve invitro deney sonuçları α/β oranının ≤3 olduğunu göstermektedir. Bu faktör prostat kanseri tedavisinde HDR brakiterapi lehine teorik bir avantaj sağlamaktadır. Klinik deneyimin daha eskiye dayandığı LDR monoterapisinde ise kaynakların düşük radyoaktiviteleri nedeni ile toplam tedavi dozuna ulaşma süresinin 1-4 ay gibi bir süre alması, ortalama foton enerjilerinin düşük olması ve prostat kanserinin düşük proliferasyon kapasitesi tedavinin radyobiyolojik etkinliğini azaltmaktadır. HDR brakiterapisi genelde daha yüksek riskli hastalarda eksternal radyoterapi üstüne boost dozu şeklinde uygulanmaktadır. Ancak, HDR monoterapisinin de LDR brakiterapiden farklı olarak birden fazla implant gerektirmesi ve toplam dozun daha düşük olmasına rağmen, fraksiyon dozunun yüksek olması, sağlam doku koruması açısından bir dezavantaj oluşturmaktadır. HDR monoterapisi kısıtlı klinik deneyim nedeniyle kontrollü çalışmalar dışında kullanılmamaktadır. Bu derleme ile prostat kanseri tedavisinde brakiterapi uygulamalarının radyobiyolojik temellerinin özetlenmesi amaçlanmaktadır.
The Importance of Self-Care Rehabilitation in Irradiated Head and Neck Cancer Patients
International Journal of Radiation Oncology*Biology*Physics, 2015
MON-PP092: The Importance of Weight Loss in Head and Neck Cancer Patients During Radiochemotherapy
Clinical Nutrition, 2015
Erythropoietin and radiotherapy in lung cancer patients
Journal of B.U.ON. : official journal of the Balkan Union of Oncology
To evaluate the effectiveness of recombinant human erythropoietin (rhEPO) in relation to low hemo... more To evaluate the effectiveness of recombinant human erythropoietin (rhEPO) in relation to low hemoglobin (Hb) level, overall tumor response rates, and rhEPO adverse events in patients with lung cancer undergoing radiotherapy (RT). Thirteen consecutive patients were included. All of them had measurable tumor before RT. 150 IU/kg of rhEPO-alpha or -beta were administered 3 times per week, 7-10 days before RT. The target Hb value was 13 g/dl. Tumor response was assessed 6 weeks after completion of RT. Response to rhEPO was seen 62% (n=8) of the patients. Weekly mean Hb increment was 0.69 g/dl (range 0.42-1). The mean Hb value during RT was 13.2 g/dl (range 9-14.7) in responding patients, and 10.7 g/dl (range 9.7-11.8) in non-responding patients (p=0.005). Overall response rates to RT were significantly higher in responding than in non-responding patients (p=0.034). rhEPO increased Hb levels in lung cancer patients undergoing RT. However, safety, and more importantly, indications need fu...
The Relationship of Fuhrman Nuclear Grade, Tumor Stage and Sarcomatoid Differentiation with Survive in Renal Cell Carcinomas
Balkan Medical Journal, 2012
Oncocytic Carcinoma of the Parotid Gland
Acta Cytologica, 2003
BACKGROUND Oncocytic carcinoma is a rare malignant tumor of the salivary gland. Abundant, granula... more BACKGROUND Oncocytic carcinoma is a rare malignant tumor of the salivary gland. Abundant, granular, eosinophilic cytoplasm is recognized as an oncocytic feature that reflects an accumulation of mitochondria. Ultrastructural study or immunohistochemical staining using antimitochondrial antibody can confirm the oncocytic nature of the tumor. However, there have been no data on whether immunocytochemical staining for human mitochondria aids in the confirmation of the oncocytic nature of oncocytic carcinoma. CASE A 61-year-old man presented with a swelling in the left lower cheek. Computed tomography demonstrated a solid, isodense tumor in the parotid gland. An excisional biopsy of the tumor was performed, and an enlarged regional lymph node was removed. Imprint cytology of the lymph node showed cohesive cell clusters with lymphocytes. The clusters were composed of tumor cells that had characteristic abundant, granular cytoplasm and round to oval, centrally or eccentrically located nuclei with increased, fine chromatin and distinct nucleoli. Immunocytochemical staining revealed granular immunoreactivity of the cytoplasm for human mitochondria. Histology demonstrated tumor invasion in the normal gland and adjacent skeletal muscles. All tumor cells showed positive cytoplasm with antimitochondrial antibody by immunohistochemistry. Ultrastructural studies demonstrated packed mitochondria in the cytoplasm of the tumor. CONCLUSION Immunocytochemical staining for human mitochondria help confirm the oncocytic nature of oncocytic carcinoma in cytologic specimens.
PO-089: The Self-Care Rehabilitation in the Patients with Head and Neck Cancer Treated with Definitive Radiotherapy
Radiotherapy and Oncology, 2013
Evaluation of Nutritional Status and Anxiety Levels in Patients Applying to the Radiation Oncology Outpatient Clinic during the COVID-19 Pandemic: Turkish Society for Radiation Oncology Group Study (TROD 12:02)
Nutrition and Cancer
The importance of weight loss during definitive radiotherapy in patients with laryngeal carcinoma
Journal of Cancer Research and Therapeutics, 2021
Evaluation of swallowing function with clinical and dosimetric parameters in head and neck cancer patients receiving radio (chemo)therapy
Iranian Journal of Radiation Research, 2019
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Papers by Vuslat Yurut-caloglu