Papers by Vidosava Radonjic
PubMed, Sep 1, 2016
Background: Maternal deprivation (MD) in rodents is an important neurodevelopmental model for stu... more Background: Maternal deprivation (MD) in rodents is an important neurodevelopmental model for studying a variety of behavioral changes which closely resemble the symptoms of schizophrenia in humans. Subjects and methods: To determine whether early-life stress leads to changes in the limbic system structures: the amygdala and the nucleus accumbens, 9-day-old Wistar rats were exposed to 24 hour MD. On P60 the rats were sacrificed for morphometric analysis and their brains were compared to the control group. Results: Results show that MD affected important limbic system structures: the amygdala and the nucleus accumbens, whose volume was decreased (17% of the control value for the amygdala and 9% of the control value for the nucleus accumbens ), as well as the number of neurons (41% of the control value for the amygdala and 43% of the control value for the nucleus accumbens ) and the size of their cells soma (12% of the control value for the amygdala and 33% of the control value for the nucleus accumbens ). Conclusion: This study indicates that early stress in life leads to changes in the morphology of the limbic areas of the brain, most probably due to the loss of neurons during postnatal development, and it further contributes to our understanding of the effects of maternal deprivation on brain development.
Oxidative medicine and cellular longevity, 2017
Maternal deprivation (MD) causes perinatal stress, with subsequent behavioral changes which resem... more Maternal deprivation (MD) causes perinatal stress, with subsequent behavioral changes which resemble the symptoms of schizophrenia. The NADPH oxidase is one of the major generators of reactive oxygen species, known to play a role in stress response in different tissues. The aim of this study was to elucidate the long-term effects of MD on the expression of NADPH oxidase subunits (gp91(phox), p22(phox), p67(phox), p47(phox), and p40(phox)). Activities of cytochrome C oxidase and respiratory chain Complex I, as well as the oxidative stress parameters using appropriate spectrophotometric techniques were analyzed. Nine-day-old Wistar rats were exposed to a 24 h maternal deprivation and sacrificed at young adult age. The structures affected by perinatal stress, cortex, hippocampus, thalamus, and caudate nuclei were investigated. The most prominent findings were increased expressions of gp91(phox) in the cortex and hippocampus, increased expression of p22(phox) and p40(phox), and decrease...
Vojnotehnicki glasnik, 2015
U radu su sprovedena istraživanja načina poboljšanja tehnologije srednjeg nivoa održavanja radio-... more U radu su sprovedena istraživanja načina poboljšanja tehnologije srednjeg nivoa održavanja radio-relejnih uređaja. Poboljšani model tehnologije održavanja biće primenjen u praksi tokom korektivnog održavanja radio-relejnih uređaja. Rezultati dobijeni tokom primene predloženog modela poslužiće za donošenje zaključaka o uspešnosti primene definisanog modela tehnologije održavanja.
Vojnotehnicki glasnik, 2015
U radu će biti izvršena analiza i poređenje pokazatelja pouzdanosti dve vrste uređaja specijalne ... more U radu će biti izvršena analiza i poređenje pokazatelja pouzdanosti dve vrste uređaja specijalne namene koji se koriste u radio-relejnim sistemima. Na osnovu rezultata sprovedene analize, stečenog iskustva iz domena najvišeg nivoa održavanja uređaja, predložiće se modernizacija postojećeg analognog radio-frekventnog filtera sa odgovarajućim digitalnim filterom. Predložena modernizacija unapređuje tehnološki proces održavanja uređaja, poboljšava karakteristike pogodnosti za održavanjem, povećava pouzdanost u radu uređaja uz znatno smanjenje troškova održavanja uređaja.
Vojnotehnicki glasnik, 2014
U radu su realizovana istraživanja i prikazani rezultati primene optimalnog modela koncepta održa... more U radu su realizovana istraživanja i prikazani rezultati primene optimalnog modela koncepta održavanja savremenih radio-relejnih uređaja. Model se zasniva na preventivnom održavanju prema stanju sa kontrolom nivoa pouzdanosti, pri čemu se koriste mnogobrojne pozitivne konstrukciono-tehnološke mogućnosti uređaja, radi sveobuhvatnog smanjenja troškova održavanja, uz postignuti nivo zadate vrednosti pouzdanosti uređaja.
Psychiatria Danubina, 2015
Studies imposing rigorous control over lifetime alcohol intake usually have not found smaller hip... more Studies imposing rigorous control over lifetime alcohol intake usually have not found smaller hippocampal volumes in persons with posttraumatic stress disorder (PTSD). Since the majority of negative studies have used adolescent samples, it has been suggested that chronicity is a necessary condition for such findings. We have hypothesized that the volumes of hippocampus, amygdale, prefrontal cortex and the intracranial volume are reduced in the patients with PTSD and excessive alcohol intake. Study has been carried out on 54 therapy naive PTSD suffering subjects and healthy controls, divided in two groups: 29 with PTSD and consequent alcoholism, 25 with PTSD but without problems of excessive alcohol intake, and 25 healthy volunteers. All of the patients underwent same magnetic resonance imaging (MRI) protocol and volumetric evaluation of the region of interest. Only hippocampal volume appeared to be significantly reduced in patients with PTSD and alcoholism. Other differences in the ...
Serbian Journal of Electrical Engineering, 2014
This paper is a result of a broader study, oriented to optimization of maintenance process for sp... more This paper is a result of a broader study, oriented to optimization of maintenance process for special purpose devices and presents the selection of optimal maintenance variant for selected specific purposes device, using the method of analytic hierarchy process, with assumed model of device usage. This paper formalizes the decision process, decision-makers subjectivism boils down to an acceptable level, impruves optimization approach for solving the problems in hierarchical systems, and encourages training in the improvement of decision makers in solving problems of multi character.
Objective. In our study we have hypothesized that volume changes of amygdala, hippocampus, and pr... more Objective. In our study we have hypothesized that volume changes of amygdala, hippocampus, and prefrontal cortex are more pronounced in male posttraumatic stress disorder participants. Material and Methods. We have conducted a study of 79 male participants who underwent MRI brain scanning. PTSD diagnosis was confirmed in 49 participants. After MRI was taken all scans were software based volume computed and statistically processed. Results. We found that left amygdala is the most significant parameter for distinction between PTSD participants and participants without PTSD. There were no significant differences in volumes of hippocampi and prefrontal cortices. Roc curve method outlined left amygdala AUC = 0.898 (95% CI = 0.830-0.967) and right amygdala AUC = 0.882 (95% CI = 0.810-0.954) in the group of PTSD participants which makes both variables highly statistically significant. Conclusion. The present investigation revealed significant volume decrease of left amygdala in PTSD patients. Concerning important functions of the amygdala and her neuroanatomical connections with other brain structures, we need to increase number of participants to clarify the correlation between impared amygdala and possible other different brain structures in participants with PTSD.
Vojnotehnicki glasnik, 2014
Uvod loženi tehnički sistemi predstavljaju skup većeg broja modularnih celina (sistema, podsistem... more Uvod loženi tehnički sistemi predstavljaju skup većeg broja modularnih celina (sistema, podsistema, sklopova), povezanih u celinu, gde su svi elementi u međusobnoj interakciji, radi izvršavanja određenih funkcija. Za sistem odbrane posebno su važni STS pomoću kojih se ostvaruju ciljevi oružane borbe (Petković, Kokanović, Ćirović, 1988). Od ostalih TS razlikuju se po složenosti konstrukcije i nameni. Njihova namena može biti S
BioMed research international, 2014
Early separation of rat pups from their mothers (separatio a matrem) is considered and accepted a... more Early separation of rat pups from their mothers (separatio a matrem) is considered and accepted as an animal model of perinatal stress. Adult rats, separated early postnatally from their mothers, are developing long-lasting changes in the brain and neuroendocrine system, corresponding to the findings observed in schizophrenia and affective disorders. With the aim to investigate the morphological changes in this animal model we exposed 9-day-old (P9) Wistar rats to a 24 h maternal deprivation (MD). At young adult age rats were sacrificed for morphometric analysis and their brains were compared with the control group bred under the same conditions, but without MD. Rats exposed to MD had a 28% smaller cell soma area in the prefrontal cortex (PFCX), 30% in retrosplenial cortex (RSCX), and 15% in motor cortex (MCX) compared to the controls. No difference was observed in the expression of glial fibrillary acidic protein in the neocortex of MD rats compared to the control group. The result...
Vojnosanitetski pregled, 2014
Knee surgery, sports traumatology, arthroscopy : official journal of the ESSKA, Jan 8, 2014
The anterolateral ligament, a structure that has been known for 130 years, has again attracted th... more The anterolateral ligament, a structure that has been known for 130 years, has again attracted the attention both of orthopaedic doctors and anatomists. Since its initial description until now, this structure has had different names. Whether labelled as the mid-third lateral capsular ligament, the anterior oblique band of the fibular collateral ligament or the anterolateral ligament of the knee, this structure has been responsible for the so-called Segond avulsion fractures. The aim of this study was to determine the precise position and layer of the lateral knee compartment within which the anterolateral ligament is located, as well as its type. In this study, the anatomical dissection of the lateral segment of 14 cadaveric knees (six male, eight female; seven right, seven left; average age of subjects: 78 years) was performed. The dissection was carried out in keeping with Seebacher, layer by layer. The anterolateral ligament was identified in seven out of 14 cadaveric knee joints...
Knee Surgery, Sports Traumatology, Arthroscopy, 2014
and the control group consisting of patients without ACL rupture. After this, the patients from t... more and the control group consisting of patients without ACL rupture. After this, the patients from these two groups were paired off on the basis of three factors, level of professional involvement in sports (including the type of sports activity), left or right side of the body and the age of the subjects. In the end, there were 29 pairs (58 subjects). The concentration of sex hormones was determined from saliva specimens with the aid of the Salimetrics enzyme immunoassay. The testing of generalized joint laxity was performed with the aid of the "laxity score" according to Beighton et al. Results Subjects with ACL rupture have highly statistically significantly greater concentrations of testosterone (p < 0.01), statistically significantly greater concentrations of 17-β estradiol (p < 0.05), and a highly statistically significantly greater generalized joint laxity score than subjects with an intact ACL (p < 0.01). Conclusion Increased concentrations of testosterone or 17-β estradiol may be a risk factor leading to ACL rupture. Also, generalized joint laxity may be a factor leading to ACL rupture, but none of the monitored hormones can be set down as the cause of its existence. Young male athletes with higher concentrations of testosterone and greater hyperelasticity should plan preventive programs of physiotherapy for ACL preservation since they present a vulnerable group susceptible to ACL rupture. Level of evidence Diagnostic study, Level II.
Medical review, 2007
Introduction Morphological features and morphometric parameters of galanin (GAL) and vasoactive i... more Introduction Morphological features and morphometric parameters of galanin (GAL) and vasoactive intestinal peptide (VIP) immunoreactive neurons and neuronal fibres were studied in all nuclei of adult male rat amygdala. Material and methods After perfusion and fixation, rat brains were immunohistochemically stained with antibodies against GAL and VIP and then visualized by avidin-biotin-peroxidase complex. Results and Discussion The greatest number of galanin-immunoreactive neurons were identified in the medial part of the central nucleus and in the dorsal part of the medial nucleus. In the first case, most neurons were bipolar (37%), and in the second, they were ovoid (45%). GAL-immunoreactive fibers were identified in the medial nucleus, "bed nucleus" of the accessory olfactory tract, frontal cortical nucleus, amygdalo-hippocampal area and basolateral nucleus. VIP-immunoreactive neurons were diffusely distributed in more nuclei than the previous, mostly in the lateral, ba...
Co-Occurrence of Large Cavum Septum Pellucidum and the Absence of the Adhesio Interthalamica in Patients with Schizophrenia: A Post Mortem Study
Current Psychopharmacology, 2013
Vojnosanitetski pregled, 2014
Background/Aim. The tibial slope is one of the most frequently cited anatomical causes of anterio... more Background/Aim. The tibial slope is one of the most frequently cited anatomical causes of anterior cruciate ligament trauma. The aim of this study was to determine the possibility of direct measuring of the tibial slope of the knee without prior soft tissue dissection in cadavers. Methods. Measurement was performed on the two groups of samples: osteological and cadaveric. The osteological group consisted of 102 matured tibiae and measurement was performed: indirectly by sagittal photographing of the tibia, and directly by a set of parallel bars. The cadaveric group consisted of 50 cadaveric knees and measurement was performed directly by a set of parallel bars. The difference and correlation between indirect and the direct measurements were observed, which included also measuring of the difference and correlation of the tibial slope on the medial and lateral condyles. Results. A statistically significant difference between the direct and indirect method of measuring (p < 0.01) of...
Vojnotehni?ki glasnik, 2012
Uvođenjem savremenih radio-relejnih uređaja na upotrebu u sistem veza Vojske Srbije od njih se za... more Uvođenjem savremenih radio-relejnih uređaja na upotrebu u sistem veza Vojske Srbije od njih se zahteva maksimalna efektivnost, raspoloživost i gotovost. Doprinos tome daje nov pristup i način realizacije tehnologija održavanja radio-relejnih uređaja primenom metode tehničke dijagnostike. Tehnička dijagnostika je naučno-tehnička disciplina koja prepoznaje tehničko stanje ispravnosti uređaja i može se efikasno koristiti u funkciji održavanja. U radu će biti prikazana primena metode tehničke dijagnostike kroz primenu merenja test-stanicom grupe A, koja omogućava automatizovan način dobijanja svih relevantnih podataka o tehničkoj ispravnosti uređaja. Na osnovu rezultata merenja dalje se realizuje tehnologija održavanja radio-relejnih uređaja. Ključne reči: tehnička dijagnostika, održavanje radio-relejnih uređaja, testiranje ispravnosti, test-stanica. Uvod adio-relejni uređaji familije GRC 408E su savremeni digitalni telekomunikacioni uređaji. Koncepcija proizvodnje ove vrste uređaja je moderna i složena, te je za njihovo održavanje potreban visokoobrazovan i stručan kadar. Za utvrđivanje tehničke ispravnosti uređaja potrebno je poznavanje dosta mernih parametara koji karakterišu isprav-R
Significance of Proto-Oncogene Bcl-XS/LExpression in Wilms Tumor
Renal Failure, 2005
The rate of apoptosis varies in malignant tumors, and it can be involved in diminishing tumor siz... more The rate of apoptosis varies in malignant tumors, and it can be involved in diminishing tumor size. Different protein-regulators of apoptosis, such as Bcl-2, BclX, and Bax have an influence on the rate of apoptosis in various tumors. In human renal diseases, such as the experimental model of acute renal failure, and many tumors, including Wilms&amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;#39; tumor, the expression of antiapoptotic members of Bcl-2 family is increased, while the expression of proapoptotic members is low. The aim of our study was to investigate Bcl-X(S/L) protein expression in Wilms&amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;#39; tumor, to compare it with the expression in normal renal tissue, as well as to see if there is a correlation between Bcl-X(S/L) expression in Wilms&amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;#39; tumor with tumor stage, histological type, prognostic group, or response to preoperative chemotherapy. Twenty-eight cases of Wilms&amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;#39; tumor (two cases with metastasis) and two samples of normal kidney tissue were studied using streptavidin-biotin-complex technique. Bcl-X(S/L) expression levels were semiquantitatively scored. The expression of Bcl-X(S/L) was observed in the majority of cases (60.7%), more often in the blastemal than in the epithelial component of Wilms&amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;#39; tumor: 60.7% and 28.6%, respectively (p=0.02). There was a statistically significant inverse relationship between Bcl-X(S/L) expression and tumor stage (p=0.015). Bcl-X(S/L) was found less frequently in high-risk tumors then in tumors with good prognosis (p=0.02). Treated Wilms&amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;#39; tumors showed Bcl-X(S/L) expression more often than nontreated tumors, but the relationship was not statistically significant (p=0.08). Expression of Bcl-X(S/L) was detected in various histological types of Wilms&amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;#39; tumor, but there was no statistically significant association (p=0.82) except in cases with diffuse anaplasia (p=0.012), which were always negative. No Bcl-X(S/L) immunostaining was observed in two cases of metastasis or in one case of bilateral Wilms&amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;#39; tumor. Our results suggest that the expression of Bcl-X(S/L) protein is associated with prognostic group, tumor stage, and presence of anaplasia.
Correlation between the morphometric parameters of the anterior cruciate ligament and the intercondylar width: gender and age differences
Knee Surgery, Sports Traumatology, Arthroscopy, 2009
The study was conducted on 50 cadavers (32 male and 18 female, aged 15-53 years; mean 34; SD 11) ... more The study was conducted on 50 cadavers (32 male and 18 female, aged 15-53 years; mean 34; SD 11) with intact anterior cruciate ligament (ACL), without diagnosed gonarthrosis of the knee joint. The following anatomical parameters of the ACL were measured: the length of anteromedial and posterolateral bundle, the mean length and the width of the ligament, the length and width of tibial insertion, the length and width of femoral insertion. The intercondylar width was measured at the level of popliteal groove. The width of male intercondylar notch (22 mm) was statistically significantly greater (P &amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;lt; 0.05) than the width of female intercondylar notch (18 mm). The width of the male ACL (12 mm) was significantly greater (P &amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;lt; 0.05) than the width of the female ACL (10 mm). The length of the male ACL femoral insertion (14 mm) was statistically significantly greater (P &amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;lt; 0.05) than in the female ACL femoral insertion (12 mm). Accordingly, with greater width of intercondylar notch, men have wider ACL than women. ACL width is in positive correlation with the male intercondylar notch width but it is not in correlation with the female intercondylar notch width. The width of male intercondylar notch correlates with the length and width of ACL femoral insertion. Taking into account the length and width of femoral insertion in examined cadaver knees, double bundle reconstruction would theoretically be possible in 76% of cases.
Acta veterinaria, 2011
Having in mind the former results which confirmed the functional relationship between the thyroid... more Having in mind the former results which confirmed the functional relationship between the thyroid and the immune system, and the administration of potassium iodide (KI) in the therapy of auto-immune diseases, we considered it of interest to investigate the pathogenesis of KI induced experimental thyroiditis, by studying the morphology of thymus, thyroid gland and spleen, as well as the phenotype of lymphocytes in the thymus and peripheral blood in relation to the expression of CD4 and CD8 molecules. The experiments have been carried out on 30 male Wistar rats, divided in 3 groups. The first group (n=10) received KI (225 mg/g, i.p.), the second group (n=10) received KI (675 mg/g, i.p.), while the third group (n=10) received sodium chloride (0.9%, i.p.). The intensity of histological lesions in the thyroid gland, was statistically significant (p<0.01) in KI treated groups, compared to the controls. KI also significantly decreased rat body mass, and increased masses of thymus and thyroid gland (p<0.05). No statistically significant difference was found in thymocyte and peripheral blood CD4+ and CD8+ subpopulation numbers between the groups. Our experiments suggest that KI, at least in some doses could induce mild lymphocytic thyroiditis in rats, and that this simple, practical and non-expensive model of experimental thyroiditis could be of importance for further research.
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Papers by Vidosava Radonjic