Papers by Tina Ann Varghese
Letters in applied microbiology, Jan 16, 2015
In light of important detrimental role of aberrant HDAC production during various clinical compli... more In light of important detrimental role of aberrant HDAC production during various clinical complications, development of therapeutically effective and specific inhibitors of HDAC is critically important. This study deals with screening for HDAC inhibitors from marine actinomycetes. The isolation of actinomycetes from 22 sediment samples along the Southern Coast of India yielded 186 strains including Streptomyces, Nocardipsis, evaluated for HDAC inhibition using HeLa cells. Among the 186 isolates, 10 strains have shown moderate to strong inhibition. The maximum inhibition (61%) was seen with strain VITKSM06 and least inhibition (31%) was seen with strain VITSJT03. The MTT cell proliferation assay using HeLa cell line showed significant cytotoxicity with an IC50 of 5.9 μg ml(-1) by VITKSM06 derived metabolite and 26.2 μg ml(-1) by VITSJT03. The compound treated HeLa cells displayed an altered morphology and condensed chromatin which may be due to HDAC inhibition. Based on the phylogen...
The Canadian journal of cardiology, 2018
Atherosclerotic cardiovascular disease (ASCVD) and its associated economic burden are increasing ... more Atherosclerotic cardiovascular disease (ASCVD) and its associated economic burden are increasing globally. Although cardiac rehabilitation is a vital component of secondary prevention with proven benefits, it is underutilized due to numerous barriers, especially in resource-limited settings. New care models for delivery of comprehensive prevention programs such as community-based, home-based, and "hybrid" models implementing m-health, e-health, and telemedicine need to be adopted. Such new care models should be offered to all patients with established ASCVD (coronary, cerebral, and peripheral) and additionally to those at high risk of developing ASCVD with multiple risk factors for panvascular prevention.
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Papers by Tina Ann Varghese