Atherosclerosis and vascular calcification are independent predictors of left ventricular hypertr... more Atherosclerosis and vascular calcification are independent predictors of left ventricular hypertrophy in chronic haemodialysis patients
The iron in the hemoglobin molecule is in ferrous state (Fe ++ ). The oxidation of iron from ferr... more The iron in the hemoglobin molecule is in ferrous state (Fe ++ ). The oxidation of iron from ferrous to ferric (Fe +++ ) state causes methemoglobinemia. This reaction decreases the oxygen-carrying capacity of hemoglobin leading to hypoxemia of the peripheral tissues and even to death in severe cases. Methemoglobinemia is frequently related to chemical substances. However, hereditary or idiopathic cases have also been described. Methemoglobinemia due to local anesthetic drugs may occur especially in newborn infants. Here, we presented an adult case in which methemoglobinemia developed after the administration of prilocaine prior to an epilation procedure. OZET ++ +++
The International Journal of Artificial Organs, 2018
Background:Arterial stiffness is a strong predictor of mortality in hemodialysis patients. In thi... more Background:Arterial stiffness is a strong predictor of mortality in hemodialysis patients. In this study, we aimed to investigate possible relations of arterial stiffness with volume status determined by bioimpedance analysis and aortic blood pressure parameters. Also, effects of a single hemodialysis session on these parameters were studied.Methods:A total of 75 hemodialysis patients (M/F: 43/32; mean age: 53 ± 17) were enrolled. Carotid-femoral pulse wave velocity, augmentation index, and aortic pulse pressure were measured by applanation tonometry before and after hemodialysis. Extracellular fluid and total body fluid volumes were determined by bioimpedance analysis.Results:Carotid-femoral pulse wave velocity (9.30 ± 3.30 vs 7.59 ± 2.66 m/s, p < 0.001), augmentation index (24.52 ± 9.42 vs 20.28 ± 10.19, p < 0.001), and aortic pulse pressure (38 ± 14 vs 29 ± 8 mmHg, p < 0.001) significantly decreased after hemodialysis. Pre-dialysis carotid-femoral pulse wave velocity was...
1. Am Heart J. 1999 Feb;137(2):375-6. Time-dependent changes of HRV after PTCA. Ozcan M, Kudat H,... more 1. Am Heart J. 1999 Feb;137(2):375-6. Time-dependent changes of HRV after PTCA. Ozcan M, Kudat H, Akkaya V, Sözen AB, Demirel S, Tükek T. Comment on: Am Heart J. 1998 May;135(5 Pt 1):755-61. PMID: 10049193 [PubMed - indexed for MEDLINE]. Publication Types: ...
Catheterization and Cardiovascular Diagnosis, 1998
We studied 120 patients (M:F 105:15, mean age 57.5 +/- 10.1 years) with acute myocardial infarcti... more We studied 120 patients (M:F 105:15, mean age 57.5 +/- 10.1 years) with acute myocardial infarction (MI) successfully treated with percutaneous coronary angioplasty (PTCA) to analyze the influence of the resolution of the ST segment elevation and depression after intervention to 1 month composite endpoints of reinfarction or reocclusion, development of congestive heart failure (CF) and death. Sum of preintervention and postintervention ST segment elevation and depression and the rate of resolution of these ST segment elevations and depressions were recorded for every patient. A total of 17 (14.2%) composite endpoint events (events group) were recorded (7 reocclusion or recurrent MI, 9 CF, and 1 death). On univariate analysis, events group patients were older (53.3 +/- 9.9 vs. 58.8 +/- 9.1 years, P = 0.032), had lesser resolution of ST segment elevations (85 +/- 24% vs. 44 +/- 55%, P = 0.017) and depression (72 +/- 26% vs. 52 +/- 30%, P = 0.009), had greater preintervention ST segment elevation (17.49 +/- 12.95 mm vs. 28.38 +/- 20.41 mm, P = 0.045), had lower ejection fraction (59.3 +/- 10.2% vs. 43.6 +/- 9.4%, P &lt; 0.001), and had more frequent multivessel disease (71% vs. 47%, P = 0.048) compared to the nonevents group. Time from angina to reperfusion, residual stenosis, sex, infarct location and infarct-related vessel distribution were similar. On multivariate analysis (logistic regression with backward likelihood ratio) only older age (P = 0.0752), lesser rate of resolution of ST segment depression (P = 0.0262) and lower ejection fractions (P = 0.0014) were retained as predictors of the composite endpoints. Relative risk conferred by less than 50% resolution of ST segment depressions for composite endpoints were 3.78 (95% CI 1.63-8.73). We conclude that the lack of resolution of the sum of reciprocal ST segment depressions identifies a subgroup of acute MI patients with greater morbidity after primary PTCA.
Autonomic dysfunction in hemodialysis patients is one of the components of uremic neuropathy. In ... more Autonomic dysfunction in hemodialysis patients is one of the components of uremic neuropathy. In this prospective study, we investigated the effect of renal transplantation on uremic autonomic dysfunction with long-term time-domain and frequency-domain heart rate variability. Fourteen hemodialysis patients (10 male, 4 female; mean age 33 ± 11 (range 16–50) years) were examined before and at the early after transplantation period (mean 4.6 ± 1.5 (range 3–7.5) months). The mean time spent on hemodialysis was 16.7 ± 15.6 (range 6–65) months. In time-domain analysis, significant increases in all parameters except pNN50 (SD, SDANN, SDNN, rMSSD) were observed after renal transplantation (p < 0.01). In frequency-domain analysis, low-frequency (LF) (0.04–0.15 Hz) and high-frequency (HF) (0.15–0.40 Hz) spectral power were found to be significantly increased after renal transplantation (4.54 ± 1.04 vs. 12.58 ± 8.69 for LF (p = 0.005), 2.80 ± 1.0 vs. 6.50 ± 3.55 for HF (p = 0.005)), but the...
Pulmonary complications are a major causes of morbidity and mortality for persons with spinal cor... more Pulmonary complications are a major causes of morbidity and mortality for persons with spinal cord injury (SCI). The degree of respiratory impairment resulting from SCI is dependent on the level of injury sustained. The aim of this study was to assess pulmonary function of the SCI patients with spirometry and relate the clinical complaints to vital capacity (VC). We also correlated other pulmonary function test parameters with VC. Thirty-five subjects, aged 34.5 to 15.2 years, participated in the study. Eleven patients (31.4 percent) were tetraplegic, and 24 patients (68.6 percent) were paraplegic. Paraplegic and tetraplegic groups were compared. No significant difference in the prevalance of cough, wheezing, chest pain, or sputum production was found. Dyspnea was more common in tetraplegics (p < 0.05). Chest expansion was greater in paraplegics without reaching statististical significance. Spirometric tests revealed that VC, forced vital capacity (FVC), inspiratory capacity (IC), inspiratory reserve volume (IRV), and expiratory reserve volume (ERV) were significantly smaller in the tetraplegics. Statistical relationships were determined between VC and other tests. VC was found to be significantly correlated with each of the other pulmonary function tests. VC measurements show a significant correlation with other pulmonary function measurements, but clinical complaints of patients do not appear to be related to VC.
bAsic reseArch on biocomPAtibility, immunology, inflAmmAtion And fibrosis miRNA589 Regulate Epith... more bAsic reseArch on biocomPAtibility, immunology, inflAmmAtion And fibrosis miRNA589 Regulate Epithelial-Mesenchymal Transition in Human Peritoneal Mesothelial Cells Background: microRNAs (miRNA, miR) are thought to interact with multiple mRNAs resulting in either translational repression or degradation which is involved in the EMT process. Since miRNAs distributed with tissue specificity, the role of miRNAs in peritoneal fibrosis remains unknown. Our unpressed data showed that expression of miRNA589 was notably decreased in HPMCs isolated from patients undergoing long-term continuous ambulatory peritoneal dialysis (CAPD). Objective: To determine if miRNA589 regulates the EMT induced by TGFβ1 in human peritoneal mesothelial cell line (HMrSV5 cells). Methods: HMrSV5 cells were divided into three groups: control group (only FBS-free DMEM/F12), TGF-β1 group (treated with TGF-1 5 ng/ml for 24h) and pre-miR-5891 group (pre-treated with pre-miR-589 to up-regulate the level of miR-589, and treated with TGF-1 5 ng/ml for 24h). The level of miRNA589 was determined by realtime PCR. The expressions of ZO-1, vimentin, E-cadherinin HPMCs were determined by immunofluorescence, realtime PCR, and Western blot, respectively. Result: In vitro,TGF1 led to up-regulation of vimentin and downregulation of ZO-1 as well as E-cadherin in HMrSV5 cells, which suggested EMT was induced. The changes were accompanied with notably decreased level of miRNA589 in HMrSV5 cells treated by TGF1. Over-expression of miRNA589 by transfection with pre-miRNA589 partially reversed these EMT changes. Conclusion: miRNA589 mediates TGF1-induced EMT in human peritoneal mesothelial cells.
In essential hypertension, endothelial dysfunction has been documented many times and correlates ... more In essential hypertension, endothelial dysfunction has been documented many times and correlates with prognosis. The influence of the renin–angiotensin–aldosterone system (RAAS) on endothelial dysfunction has also been studied. The present study investigated the duration of the effects of RAAS-blocking drugs on endothelial function in 44 consecutive, never-treated, outpatients with mild to moderate hypertension. Patients (11 per group) received an angiotensin receptor blocker (ARB; irbesartan 300 mg/day or valsartan 160 mg/day) or an angiotensin-converting enzyme inhibitor (ACEi; fosinopril 10 mg/day or quinapril 20 mg/day). If target blood pressure (< 140/90 mmHg) was not achieved, 12.5 mg/day hydrochlorothiazide was added. Endothelial function, assessed by measuring brachial artery diameter, did not change significantly after 6 weeks, 1 year or 3 years of treatment in any group. Across all groups, endothelium-dependent and-independent vasodilation increased significantly after ...
Background and hypothesis: Genetic influence on cardiac remodeling is uncertain. The purpose of t... more Background and hypothesis: Genetic influence on cardiac remodeling is uncertain. The purpose of this study is to determine the effects of polymorphism of the angiotensin‐converting enzyme (ACE) gene on cardiac remodeling after myocardial infarction.
Catheterization and Cardiovascular Interventions, 2002
Forty-four consecutive pregnant patients with mitral stenosis were submitted to percutaneous mitr... more Forty-four consecutive pregnant patients with mitral stenosis were submitted to percutaneous mitral valvuloplasty (PMV) over a period of 12 years. The mean age was 28 +/- 6 years and the mean gestational age was 23 +/- 6 weeks. The mean mitral valve area had a significant increase from 1.17 +/- 0.26 to 2.06 +/- 0.41 cm(2) (P = 0.0000). The mean mitral valve gradient decreased from 16.22 +/- 5.55 to 7.94 +/- 3.75 mm Hg (P = 0.0001). The procedure was performed successfully in 95% of the patients and there were no major complications. Concerning labor and delivery, we evaluated 37 patients. Thirty patients (81%) reached term and delivered normal infants. Seven patients (18.9%) delivered prematurely, resulting in two fetal death; one patient delivered a stillborn. We concluded that PMV is a safe procedure for the treatment of mitral stenosis in pregnant patients, providing significant symptomatic relief and better clinical conditions for labor and delivery.
... (12:12) Alman doktorun Türkiye aşkı. ... Due To Clopidogrel: Case Report Seyit Mehmet KAYACAN... more ... (12:12) Alman doktorun Türkiye aşkı. ... Due To Clopidogrel: Case Report Seyit Mehmet KAYACAN, MD a , Sezai VATANSEVER, MD a , Mustafa YENEREL, MD b , Vakur AKKAYA, MD a , Dilek KAYACAN, MD c , Osman ERK, MD a , Aytaç KARADAĞ, MD a , İbrahim ALTUN, MD d ...
... In McGraw-Hill (ed). Harrison's Principles of Internal Medicine 15th ed., Braunwald E, F... more ... In McGraw-Hill (ed). Harrison's Principles of Internal Medicine 15th ed., Braunwald E, Fauci AS, Kasper DL, Hauser SL, Longo DL, Jameson JL: 2001; pp 1055-1058. 10. ... 13. Watt G, Padre LP, Tuazon ML, Calubaquib C, Santiago E, Ranoa CP, Laughlin LW. ...
Kliniğimizde 16'sı erkek, 20 hastada uygulanan 30 trans venöz endomiyokardiyal biyopsi (EMB) işle... more Kliniğimizde 16'sı erkek, 20 hastada uygulanan 30 trans venöz endomiyokardiyal biyopsi (EMB) işlemi literatür bilgisi ışığı altında değerlendirildi. Onbir hastaya dilate kardiyomiyopati, 3 hastaya restriktif-konstriktif kardiyak patolojinin ayırımı için, 3'üne amiloldoz, 2'sine akut Miyokardit, Tine hipertrofik kardiyomiyopati ön tanısı ile EMB uygulandı. Kalp transplantas yonu yapılan hastaya akut transplant rejeksiyonu izlenmesi için toplam 10 kez EMB yapıldı. Femoral venöz sheath tekniği kul lanılarak sağ ventrikülden biyopsi örnekleri alındı ve ışık mikroskobunda incelendi. Tüm hastalarda yeterli doku parçası alındı. Hastaların 4'ünde tanıya yardımcı bulgu saptanmadı ve yöntemin tanı değeri %86.6 olarak bulundu. EMB'nin iskemik ol mayan kalp hastalıklarında klinik olarak faydalı bilgiler sağlayan, güvenli bir invaz/f tanı yöntemi olduğu kanısına katilindi.
Atherosclerosis and vascular calcification are independent predictors of left ventricular hypertr... more Atherosclerosis and vascular calcification are independent predictors of left ventricular hypertrophy in chronic haemodialysis patients
The iron in the hemoglobin molecule is in ferrous state (Fe ++ ). The oxidation of iron from ferr... more The iron in the hemoglobin molecule is in ferrous state (Fe ++ ). The oxidation of iron from ferrous to ferric (Fe +++ ) state causes methemoglobinemia. This reaction decreases the oxygen-carrying capacity of hemoglobin leading to hypoxemia of the peripheral tissues and even to death in severe cases. Methemoglobinemia is frequently related to chemical substances. However, hereditary or idiopathic cases have also been described. Methemoglobinemia due to local anesthetic drugs may occur especially in newborn infants. Here, we presented an adult case in which methemoglobinemia developed after the administration of prilocaine prior to an epilation procedure. OZET ++ +++
The International Journal of Artificial Organs, 2018
Background:Arterial stiffness is a strong predictor of mortality in hemodialysis patients. In thi... more Background:Arterial stiffness is a strong predictor of mortality in hemodialysis patients. In this study, we aimed to investigate possible relations of arterial stiffness with volume status determined by bioimpedance analysis and aortic blood pressure parameters. Also, effects of a single hemodialysis session on these parameters were studied.Methods:A total of 75 hemodialysis patients (M/F: 43/32; mean age: 53 ± 17) were enrolled. Carotid-femoral pulse wave velocity, augmentation index, and aortic pulse pressure were measured by applanation tonometry before and after hemodialysis. Extracellular fluid and total body fluid volumes were determined by bioimpedance analysis.Results:Carotid-femoral pulse wave velocity (9.30 ± 3.30 vs 7.59 ± 2.66 m/s, p < 0.001), augmentation index (24.52 ± 9.42 vs 20.28 ± 10.19, p < 0.001), and aortic pulse pressure (38 ± 14 vs 29 ± 8 mmHg, p < 0.001) significantly decreased after hemodialysis. Pre-dialysis carotid-femoral pulse wave velocity was...
1. Am Heart J. 1999 Feb;137(2):375-6. Time-dependent changes of HRV after PTCA. Ozcan M, Kudat H,... more 1. Am Heart J. 1999 Feb;137(2):375-6. Time-dependent changes of HRV after PTCA. Ozcan M, Kudat H, Akkaya V, Sözen AB, Demirel S, Tükek T. Comment on: Am Heart J. 1998 May;135(5 Pt 1):755-61. PMID: 10049193 [PubMed - indexed for MEDLINE]. Publication Types: ...
Catheterization and Cardiovascular Diagnosis, 1998
We studied 120 patients (M:F 105:15, mean age 57.5 +/- 10.1 years) with acute myocardial infarcti... more We studied 120 patients (M:F 105:15, mean age 57.5 +/- 10.1 years) with acute myocardial infarction (MI) successfully treated with percutaneous coronary angioplasty (PTCA) to analyze the influence of the resolution of the ST segment elevation and depression after intervention to 1 month composite endpoints of reinfarction or reocclusion, development of congestive heart failure (CF) and death. Sum of preintervention and postintervention ST segment elevation and depression and the rate of resolution of these ST segment elevations and depressions were recorded for every patient. A total of 17 (14.2%) composite endpoint events (events group) were recorded (7 reocclusion or recurrent MI, 9 CF, and 1 death). On univariate analysis, events group patients were older (53.3 +/- 9.9 vs. 58.8 +/- 9.1 years, P = 0.032), had lesser resolution of ST segment elevations (85 +/- 24% vs. 44 +/- 55%, P = 0.017) and depression (72 +/- 26% vs. 52 +/- 30%, P = 0.009), had greater preintervention ST segment elevation (17.49 +/- 12.95 mm vs. 28.38 +/- 20.41 mm, P = 0.045), had lower ejection fraction (59.3 +/- 10.2% vs. 43.6 +/- 9.4%, P &lt; 0.001), and had more frequent multivessel disease (71% vs. 47%, P = 0.048) compared to the nonevents group. Time from angina to reperfusion, residual stenosis, sex, infarct location and infarct-related vessel distribution were similar. On multivariate analysis (logistic regression with backward likelihood ratio) only older age (P = 0.0752), lesser rate of resolution of ST segment depression (P = 0.0262) and lower ejection fractions (P = 0.0014) were retained as predictors of the composite endpoints. Relative risk conferred by less than 50% resolution of ST segment depressions for composite endpoints were 3.78 (95% CI 1.63-8.73). We conclude that the lack of resolution of the sum of reciprocal ST segment depressions identifies a subgroup of acute MI patients with greater morbidity after primary PTCA.
Autonomic dysfunction in hemodialysis patients is one of the components of uremic neuropathy. In ... more Autonomic dysfunction in hemodialysis patients is one of the components of uremic neuropathy. In this prospective study, we investigated the effect of renal transplantation on uremic autonomic dysfunction with long-term time-domain and frequency-domain heart rate variability. Fourteen hemodialysis patients (10 male, 4 female; mean age 33 ± 11 (range 16–50) years) were examined before and at the early after transplantation period (mean 4.6 ± 1.5 (range 3–7.5) months). The mean time spent on hemodialysis was 16.7 ± 15.6 (range 6–65) months. In time-domain analysis, significant increases in all parameters except pNN50 (SD, SDANN, SDNN, rMSSD) were observed after renal transplantation (p < 0.01). In frequency-domain analysis, low-frequency (LF) (0.04–0.15 Hz) and high-frequency (HF) (0.15–0.40 Hz) spectral power were found to be significantly increased after renal transplantation (4.54 ± 1.04 vs. 12.58 ± 8.69 for LF (p = 0.005), 2.80 ± 1.0 vs. 6.50 ± 3.55 for HF (p = 0.005)), but the...
Pulmonary complications are a major causes of morbidity and mortality for persons with spinal cor... more Pulmonary complications are a major causes of morbidity and mortality for persons with spinal cord injury (SCI). The degree of respiratory impairment resulting from SCI is dependent on the level of injury sustained. The aim of this study was to assess pulmonary function of the SCI patients with spirometry and relate the clinical complaints to vital capacity (VC). We also correlated other pulmonary function test parameters with VC. Thirty-five subjects, aged 34.5 to 15.2 years, participated in the study. Eleven patients (31.4 percent) were tetraplegic, and 24 patients (68.6 percent) were paraplegic. Paraplegic and tetraplegic groups were compared. No significant difference in the prevalance of cough, wheezing, chest pain, or sputum production was found. Dyspnea was more common in tetraplegics (p < 0.05). Chest expansion was greater in paraplegics without reaching statististical significance. Spirometric tests revealed that VC, forced vital capacity (FVC), inspiratory capacity (IC), inspiratory reserve volume (IRV), and expiratory reserve volume (ERV) were significantly smaller in the tetraplegics. Statistical relationships were determined between VC and other tests. VC was found to be significantly correlated with each of the other pulmonary function tests. VC measurements show a significant correlation with other pulmonary function measurements, but clinical complaints of patients do not appear to be related to VC.
bAsic reseArch on biocomPAtibility, immunology, inflAmmAtion And fibrosis miRNA589 Regulate Epith... more bAsic reseArch on biocomPAtibility, immunology, inflAmmAtion And fibrosis miRNA589 Regulate Epithelial-Mesenchymal Transition in Human Peritoneal Mesothelial Cells Background: microRNAs (miRNA, miR) are thought to interact with multiple mRNAs resulting in either translational repression or degradation which is involved in the EMT process. Since miRNAs distributed with tissue specificity, the role of miRNAs in peritoneal fibrosis remains unknown. Our unpressed data showed that expression of miRNA589 was notably decreased in HPMCs isolated from patients undergoing long-term continuous ambulatory peritoneal dialysis (CAPD). Objective: To determine if miRNA589 regulates the EMT induced by TGFβ1 in human peritoneal mesothelial cell line (HMrSV5 cells). Methods: HMrSV5 cells were divided into three groups: control group (only FBS-free DMEM/F12), TGF-β1 group (treated with TGF-1 5 ng/ml for 24h) and pre-miR-5891 group (pre-treated with pre-miR-589 to up-regulate the level of miR-589, and treated with TGF-1 5 ng/ml for 24h). The level of miRNA589 was determined by realtime PCR. The expressions of ZO-1, vimentin, E-cadherinin HPMCs were determined by immunofluorescence, realtime PCR, and Western blot, respectively. Result: In vitro,TGF1 led to up-regulation of vimentin and downregulation of ZO-1 as well as E-cadherin in HMrSV5 cells, which suggested EMT was induced. The changes were accompanied with notably decreased level of miRNA589 in HMrSV5 cells treated by TGF1. Over-expression of miRNA589 by transfection with pre-miRNA589 partially reversed these EMT changes. Conclusion: miRNA589 mediates TGF1-induced EMT in human peritoneal mesothelial cells.
In essential hypertension, endothelial dysfunction has been documented many times and correlates ... more In essential hypertension, endothelial dysfunction has been documented many times and correlates with prognosis. The influence of the renin–angiotensin–aldosterone system (RAAS) on endothelial dysfunction has also been studied. The present study investigated the duration of the effects of RAAS-blocking drugs on endothelial function in 44 consecutive, never-treated, outpatients with mild to moderate hypertension. Patients (11 per group) received an angiotensin receptor blocker (ARB; irbesartan 300 mg/day or valsartan 160 mg/day) or an angiotensin-converting enzyme inhibitor (ACEi; fosinopril 10 mg/day or quinapril 20 mg/day). If target blood pressure (< 140/90 mmHg) was not achieved, 12.5 mg/day hydrochlorothiazide was added. Endothelial function, assessed by measuring brachial artery diameter, did not change significantly after 6 weeks, 1 year or 3 years of treatment in any group. Across all groups, endothelium-dependent and-independent vasodilation increased significantly after ...
Background and hypothesis: Genetic influence on cardiac remodeling is uncertain. The purpose of t... more Background and hypothesis: Genetic influence on cardiac remodeling is uncertain. The purpose of this study is to determine the effects of polymorphism of the angiotensin‐converting enzyme (ACE) gene on cardiac remodeling after myocardial infarction.
Catheterization and Cardiovascular Interventions, 2002
Forty-four consecutive pregnant patients with mitral stenosis were submitted to percutaneous mitr... more Forty-four consecutive pregnant patients with mitral stenosis were submitted to percutaneous mitral valvuloplasty (PMV) over a period of 12 years. The mean age was 28 +/- 6 years and the mean gestational age was 23 +/- 6 weeks. The mean mitral valve area had a significant increase from 1.17 +/- 0.26 to 2.06 +/- 0.41 cm(2) (P = 0.0000). The mean mitral valve gradient decreased from 16.22 +/- 5.55 to 7.94 +/- 3.75 mm Hg (P = 0.0001). The procedure was performed successfully in 95% of the patients and there were no major complications. Concerning labor and delivery, we evaluated 37 patients. Thirty patients (81%) reached term and delivered normal infants. Seven patients (18.9%) delivered prematurely, resulting in two fetal death; one patient delivered a stillborn. We concluded that PMV is a safe procedure for the treatment of mitral stenosis in pregnant patients, providing significant symptomatic relief and better clinical conditions for labor and delivery.
... (12:12) Alman doktorun Türkiye aşkı. ... Due To Clopidogrel: Case Report Seyit Mehmet KAYACAN... more ... (12:12) Alman doktorun Türkiye aşkı. ... Due To Clopidogrel: Case Report Seyit Mehmet KAYACAN, MD a , Sezai VATANSEVER, MD a , Mustafa YENEREL, MD b , Vakur AKKAYA, MD a , Dilek KAYACAN, MD c , Osman ERK, MD a , Aytaç KARADAĞ, MD a , İbrahim ALTUN, MD d ...
... In McGraw-Hill (ed). Harrison's Principles of Internal Medicine 15th ed., Braunwald E, F... more ... In McGraw-Hill (ed). Harrison's Principles of Internal Medicine 15th ed., Braunwald E, Fauci AS, Kasper DL, Hauser SL, Longo DL, Jameson JL: 2001; pp 1055-1058. 10. ... 13. Watt G, Padre LP, Tuazon ML, Calubaquib C, Santiago E, Ranoa CP, Laughlin LW. ...
Kliniğimizde 16'sı erkek, 20 hastada uygulanan 30 trans venöz endomiyokardiyal biyopsi (EMB) işle... more Kliniğimizde 16'sı erkek, 20 hastada uygulanan 30 trans venöz endomiyokardiyal biyopsi (EMB) işlemi literatür bilgisi ışığı altında değerlendirildi. Onbir hastaya dilate kardiyomiyopati, 3 hastaya restriktif-konstriktif kardiyak patolojinin ayırımı için, 3'üne amiloldoz, 2'sine akut Miyokardit, Tine hipertrofik kardiyomiyopati ön tanısı ile EMB uygulandı. Kalp transplantas yonu yapılan hastaya akut transplant rejeksiyonu izlenmesi için toplam 10 kez EMB yapıldı. Femoral venöz sheath tekniği kul lanılarak sağ ventrikülden biyopsi örnekleri alındı ve ışık mikroskobunda incelendi. Tüm hastalarda yeterli doku parçası alındı. Hastaların 4'ünde tanıya yardımcı bulgu saptanmadı ve yöntemin tanı değeri %86.6 olarak bulundu. EMB'nin iskemik ol mayan kalp hastalıklarında klinik olarak faydalı bilgiler sağlayan, güvenli bir invaz/f tanı yöntemi olduğu kanısına katilindi.
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