Papers by JAIME VALDERRAMA
Biochemical and biophysical research communications, Sep 23, 2016
The purpose of the study was to obtain further in vivo data of antitumor effects and mechanisms t... more The purpose of the study was to obtain further in vivo data of antitumor effects and mechanisms triggered by juglone and Q7 in combination with ascorbate. The study was done using Ehrlich ascites tumor-bearing mice. Treatments were intraperitoneal every 24 h for 9 days. Control group was treated with excipient. Previous tests selected the doses of juglone and Q7 plus ascorbate (1 and 100 mg/kg, respectively). Samples of ascitic fluid were collected to evaluate carbonyl proteins, GSH and activity of antioxidant enzymes such as catalase, superoxide dismutase, glutathione peroxidase and glutathione reductase. Hypoxia inducible factor HIF-1α, GLUT1, proteins driving cell cycle (p53, p16 and cyclin A) and apoptosis (poly-ADP-polymerase PARP, Bax and Bcl-xL) were assessed by western blot. Tumor cells were categorized by the phase of cell cycle using flow cytometry and type of cell death using acridine orange/ethidium bromide. A glucose uptake assessment was performed by liquid scintillati...
ABSTRACT El trabajo presenta la estructura y normas de manejo de una aplicación DSS (Sistema de S... more ABSTRACT El trabajo presenta la estructura y normas de manejo de una aplicación DSS (Sistema de Soporte a la Decisión) para utilizar un modelo de precios hedónicos del vino de calidad y otro del consumo de bebidas alcohólicas en España. El plan del artículo es el siguiente: en primer lugar se presentan, sucesivamente, sendos resúmenes de los trabajos que sirven de soporte a los dos modelos sobre los que se ha construido la aplicación DSS. A continuación, se ofrece la aplicación, mostrando, tanto su estructura como las normas de manejo, paro lo que se hará una secuencia ilustrada de las palancas de ambos modelos y sus principales outputs. Finalmente, se hará un resumen de las conclusiones extraídas del manejo de ambos modelos. En todo caso, debe quedar patente desde ahora que la finalidad de este trabajo es hacer ver que la investigación de base puede y debe ser puesto al alcance de los profesionales del campo de que se trate, en este caso el mercado de bebidas alcohólicas y en especial del de los vinos de calidad. Peer reviewed
En esta tesis doctoral se presenta un modelo de simulación dinámica, denominado DESPAS, cuyo fin ... more En esta tesis doctoral se presenta un modelo de simulación dinámica, denominado DESPAS, cuyo fin es contribuir al entendimiento de los sistemas ganado-pasto-suelo, en general, y de los procesos de desertificación por sobrepastoreo, en particular. Dos son ...
Acta Cancerol, Dec 1, 2006
... Autores: Basilio Sanz Carnero, Julián Rodríguez Ruiz, Pablo RAYEGO SERIÑÁN, Pedro A. Pérez Pa... more ... Autores: Basilio Sanz Carnero, Julián Rodríguez Ruiz, Pablo RAYEGO SERIÑÁN, Pedro A. Pérez Pascual, Mariano Matilla García, Jaime Martínez Valderrama, José V. GARCÍA SESTAFE, María del Carmen García Llamas, Nelson Alvarez Vázquez, Angel Alcaide Arenales; ...
European Journal of Biochemistry, 1999
Previous studies have shown that palmitoyl-carnitine is an anti-proliferative agent and a protein... more Previous studies have shown that palmitoyl-carnitine is an anti-proliferative agent and a protein kinase C inhibitor. Two new palmitoyl-carnitine analogs were synthesized by replacing the ester bond with a metabolically more stable ether bond. An LD50 value in the nM range was found in anti-proliferative assays using HL-60 cells and was dependent on the alkyl-chain length. The inhibitory action of these water-soluble compounds on protein kinase C in vitro was greatly increased with respect to palmitoyl-carnitine and was dependent on the length of the alkyl chain. Its effect was mediated by an increase in the enzyme's requirement for phosphatidylserine. Inhibition of the in situ phosphorylation of a physiological platelet protein kinase C substrate and of phorbol ester-induced differentiation of HL-60 cells was also observed. Finally, to test for isoenzyme selectivity, several human recombinant protein kinase C isoforms were used. Only the Ca2+-dependent classic protein kinase Cs (alpha, betaIota, betaIotaIota and gamma) were inhibited by these compounds, yet the activities of casein kinase I, Ca2+/calmodulin-dependent kinase and cAMP-dependent protein kinase were unaffected. Thus, these novel inhibitors appear to be both protein kinase C and isozyme selective. They may be useful in assessing the individual roles of protein kinase C isoforms in cell proliferation and tumor development and may be rational candidates for anti-neoplasic drug design.
Fluid Phase Equilibria, 1983
ABSTRACT The Peng-Robinson equation of state was used to treat and correlate experimental data of... more ABSTRACT The Peng-Robinson equation of state was used to treat and correlate experimental data of hydrogen-containing mixtures. The method of the equation of state was applied for reduction of data. Mixture parameters and pseudocritical constants were evaluated by regression of experimental data. The study was done by rigorous application of the fundamental equations of phase equilibria, and general correlations for the adjustable parameters were obtained. In this way, a better understanding of the behavior of the Peng-Robinson equation is obtained here. Also, a more complete comprehension of different factors involved in the behavior of hydrogen-containing mixtures is achieved.
Fluid Phase Equilibria, 1989
Synthetic Communications, 1994
ABSTRACT Ethyl 5-(1,4-cyclohexadiene-3,6-dione-1-yl)-3,5-dihydroxypentanoate (9) has been synthes... more ABSTRACT Ethyl 5-(1,4-cyclohexadiene-3,6-dione-1-yl)-3,5-dihydroxypentanoate (9) has been synthesized by using the reaction of 2,5-dimethoxybenzaldehyde(4) with β-ketoester dianions as the key step.
Fluid Phase Equilibria, Feb 1, 1994
Valderrama, J.O., de la Puente, H. and Ibrahim, A.A., 1994. Generalization of a polar-fluid Soave... more Valderrama, J.O., de la Puente, H. and Ibrahim, A.A., 1994. Generalization of a polar-fluid Soave-Redlich-Kwong equation of state. Fluid Phase Equilibria, 93: 377-383.
Cheminform, 2010
Synthesis of a Pyrrolo [1,4]benzodiazepinequinone.
J Heterocycl Chem, 1984
866 R. Cassis, R. Tapia and JA Valderrama Vol. 21 Table 1 Spectral Data of Cyclic Ketals 2a, 2b, ... more 866 R. Cassis, R. Tapia and JA Valderrama Vol. 21 Table 1 Spectral Data of Cyclic Ketals 2a, 2b, 7, 12, 13 Compound 2a 2b 7 12 13 IR v UV X max (log e) (nm) C=0 (cm"1) [ 245 sh (4.28), 250 (4.32), 1675 280 (4.12), 332 (3.48) 1650 245 sh (4.28), 250 (4.32), 1675 280 ( ...
J Org Chem, 1983
Page 1. 3026 J. Org. Chem. 1983,48, 3026-3029 were conducted at 75 "C in 2-propanol containi... more Page 1. 3026 J. Org. Chem. 1983,48, 3026-3029 were conducted at 75 "C in 2-propanol containing 0.2, 0.6, and 2.5 M MeOH, respectively. The procedures and analysis were as described above. Relevant data are as follows ...
Heterocycles, Sep 1, 1999
Http Dx Doi Org 10 1080 00397910008087260, Dec 4, 2007
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Papers by JAIME VALDERRAMA