Health promotion and chronic disease prevention in Canada : research, policy and practice, 2021
INTRODUCTION Arthritis is a leading cause of disability in First Nations communities and is often... more INTRODUCTION Arthritis is a leading cause of disability in First Nations communities and is often accompanied by other chronic diseases. Existing care models prioritize accessibility to specialty care for treatment, whereas patient-centred approaches support broader health goals. METHODS A patient care facilitator model of care, termed "arthritis liaison," was developed with the community to support culturally relevant patient-centred care plans. Following a one-year-long intervention, we report on the feasibility and acceptability of this care model from the perspectives of patients and health care providers. RESULTS The arthritis liaison served as a bridge between the clinicians and patients, and fostered continuity, helping patients receive coordinated care within the community.
Controlling the time point and site of the release of active ingredients within the gastrointesti... more Controlling the time point and site of the release of active ingredients within the gastrointestinal tract after administration of oral delivery systems is still a challenge. In this study, the effect of the combination of small capsules (size 3) and large capsules (size 00) on the disintegration site and time was investigated using magnetic resonance imaging (MRI) in combination with a salivary tracer technique. As capsule shells, Vcaps® HPMC capsules, Vcaps® Plus HPMC capsules, gelatin and DRcaps® designed release capsules were used. The three HPMC-based capsules (Vcaps®, Vcaps® Plus and DRcaps® capsules) were tested as single capsules; furthermore, seven DUOCAP® capsule-in-capsule combinations were tested in a 10-way crossover open-label study in six healthy volunteers. The capsules contained iron oxide and hibiscus tea powder as tracers for visualization in MRI, and two different caffeine species (natural caffeine and 13C3) to follow caffeine release and absorption as measured b...
The primary objective of this study was to investigate the potential synergy between low doses of... more The primary objective of this study was to investigate the potential synergy between low doses of L-carnitine tartrate and creatine monohydrate to induce muscle protein synthesis and anabolic pathway activation in primary human myoblasts. In addition, the effects of Lipid multi-particulates (LMP) formulation on creatine stability and bioavailability were assessed in rodents and healthy human subjects. When used individually, L-carnitine tartrate at 50 µM and creatine monohydrate at 0.5 µM did not affect myoblast protein synthesis and signaling. However, when combined, they led to a significant increase in protein synthesis. Increased AKT and RPS6 phosphorylation were observed with 50 µM L-carnitine tartrate 5 µM creatine in combination in primary human myoblasts. When Wistar rats were administered creatine with LMP formulation at either 21 or 51 mg/kg, bioavailability was increased by 27% based on the increase in the area under the curve (AUC) at a 51 mg/kg dose compared to without ...
Robots learn as they interact with humans. Consider a human teleoperating an assistive robot arm:... more Robots learn as they interact with humans. Consider a human teleoperating an assistive robot arm: as the human guides and corrects the arm's motion, the robot gathers information about the human's desired task. But how does the human know what their robot has inferred? Today's approaches often focus on conveying intent: for instance, using legible motions or gestures to indicate what the robot is planning. However, closing the loop on robot inference requires more than just revealing the robot's current policy: the robot should also display the alternatives it thinks are likely, and prompt the human teacher when additional guidance is necessary. In this paper we propose a multimodal approach for communicating robot inference that combines both passive and active feedback. Specifically, we leverage information-rich augmented reality to passively visualize what the robot has inferred, and attention-grabbing haptic wristbands to actively prompt and direct the human's teaching. We apply our system to shared autonomy tasks where the robot must infer the human's goal in real-time. Within this context, we integrate passive and active modalities into a single algorithmic framework that determines when and which type of feedback to provide. Combining both passive and active feedback experimentally outperforms single modality baselines; during an in-person user study, we demonstrate that our integrated approach increases how efficiently humans teach the robot while simultaneously decreasing the amount of time humans spend interacting with the robot. Videos here: https://youtu.be/swq_u4iIP-g
European Journal of Drug Metabolism and Pharmacokinetics, 2021
Background and Objective Because of the stomach-burning sensation it induces, capsaicin has been ... more Background and Objective Because of the stomach-burning sensation it induces, capsaicin has been used at relatively low doses as a nutritional supplement, which has limited its bioavailability. The objective of this study was to investigate the serum bioavailability of capsaicin supplementation with or without a lipid multi-particulate (LMP) formulation. Methods Thirty-five rats were divided into five groups and administered capsaicin at either 0.2 or 1 mg/kg with or without the LMP formulation. Capsaicin bioavailability was assessed based on the area under the concentation-time curve (AUC), the time to peak concentration (T max), and the peak serum concentration (C max). Results For each formulation, the capsaicin C max was reached at 90 min and decreased thereafter. Serum capsaicin concentrations were greater in rats administered the higher dose of capsaicin (1 mg/kg) in the LMP formulation at all measurement times (P ≤ 0.05). The AUC showed a significant increase, about 20%, when capsaicin was administered in the LMP formulation at the high dose (P = 0.002). The T max for oral capsaicin was similar whether or not administration was via the LMP formulation (P = 0.163). However, the C max of capsaicin increased in a dose-dependent manner (P < 0.05). Although the LMP formulation of the high dose of capsaicin resulted in a numerically higher C max , it was not statistically significantly higher (P = 0.068). Conclusions The present work demonstrated that administration of capsaicin via the LMP formulation significantly impacted the pharmacokinetic parameters and the serum bioavailability of orally administered 1 mg/kg capsaicin in rats. The bioavailability of capsaicin in humans may also be increased by using the LMP formulation.
Objectives In vitro dissolution tests are valuable first-step tools in the development of bioavai... more Objectives In vitro dissolution tests are valuable first-step tools in the development of bioavailable delivery systems, making it possible to assess the performance of novel technologies in releasing active ingredients through the amount dissolved in a dissolution medium. The objective of this study was to evaluate whether phosphatidyl choline-enriched lipid encapsulation releases the majority of vitamin C as ascorbic acid past the stomach in a standard in vitro dissolution procedure and to assess the release profile. Methods A novel phosphatidyl choline-enriched lipid encapsulation that is solid at room temperature was tested for dissolution in a standard dissolution apparatus according to compendial United States Pharmacopeia methods, as per Good Manufacturing Practices for dietary supplements. One serving (included 1000 mg ascorbic acid) was placed into vessels containing simulated gastric fluid (0.1 M HCl) for 120 minutes then changed to simulated intestinal fluid (buffered 2% ...
Background Arthritis is a highly prevalent disease and leading cause of disability in the Indigen... more Background Arthritis is a highly prevalent disease and leading cause of disability in the Indigenous population. A novel model of care consisting of a rheumatology outreach clinic in an on-reserve primary healthcare center has provided service to an Indigenous community in Southern Alberta since 2010. Despite quality assessments suggesting this model of care improves accessibility and is effective in meeting treatment targets, substantial improvements in patient-reported outcomes have not been realized. Therefore, the objective of this study was to explore the experiences of Indigenous persons with arthritis and healthcare providers involved in this model of care to inform the development of health service improvements that enhance patient outcomes.Methods This was a narrative-based qualitative study involving a purposeful sample of 32 individuals involved in the Indigenous rheumatology model of care. Semi-structured in-depth interviews were conducted to elicit experiences with the ...
Study Design:Narrative review.Objectives:The purpose of this article is to perform a review of th... more Study Design:Narrative review.Objectives:The purpose of this article is to perform a review of the literature assessing the efficacy of opioid alternatives, multimodal pain regimens, and rapid recovery in pediatric spine surgery.Methods:A literature search utilizing PubMed database was performed. Relevant studies from all the evidence levels have been included. Recommendations to decrease postoperative pain and expedite recovery after posterior spinal fusion in adolescent idiopathic scoliosis patients have been provided based on results of studies with the highest level of evidence.Results:Refining perioperative pain management to lessen opioid consumption with multimodal regimens may be useful to decrease recovery time, pain, and complications. Nonsteroidal anti-inflammatory drugs, acetaminophen, gabapentin, neuraxial blockades, and local anesthesia alone offer benefits for postoperative pain management, but their combination in multimodal regimens and rapid recovery pathways may c...
International Journal for Service Learning in Engineering, Humanitarian Engineering and Social Entrepreneurship, 2014
Lack of access to potable drinking water due to contamination from harmful metals is one of the m... more Lack of access to potable drinking water due to contamination from harmful metals is one of the most pressing public health issues globally. In areas close to mining and smelting operations, significant contamination from arsenic and other harmful metals can compound contamination from harmful microorganisms in drinking water. In response to this dual hazard, this study tests a prototype design of an improved point-of-use water filter for resource-poor areas and exposed populations. This project builds upon previous research that has demonstrated the effectiveness of clay pot filters impregnated with silver in reducing coliform bacteria. A compatible attachment comprised of activated charcoal in the form of bone char was added to the clay pot filter with the purpose of enabling the combined filter system to remove arsenic. The experiment tested the designed attachment with source water having an arsenic concentration of 500 parts per billion (ppb) to investigate the combined filter’...
longer term datasets, as well as estimates of annual production and food web flows. The latter an... more longer term datasets, as well as estimates of annual production and food web flows. The latter analyses are also required for the essential step of determining the extent to which fishes, native or nonnative, are food limited. The results of such analyses are forthcoming and, together with those presented here, will provide a thorough ecosystem-level assessment of this experiment and management actions being conducted by the Glen Canyon Dam Adaptive Management Program.
A model of care consisting of rheumatology specialty services embedded in the primary care system... more A model of care consisting of rheumatology specialty services embedded in the primary care system on a First Nations reserve was instituted to reduce barriers to care and improve inflammatory arthritis outcomes for patients. We assessed the effectiveness of this model of care on disease activity measures and patient-reported outcomes over 7 years. Patients were enrolled in a longitudinal cohort at the Siksika Nation in Alberta. Clinical characteristics, treatment recommendations and disease activity measures were systematically recorded over follow-up. Mixed-model regression was performed to determine rates of change for continuous measures. 59 participants (78% female; M = 47 years, SD = 13), predominantly with rheumatoid arthritis (RA; n = 36), were followed for an average of 29 months (SD = 23). Swollen and tender joint counts decreased significantly (change per month: -0.20, 95% CI -0.29 to -0.10, and -0.20, 95%CI -0.34 to -0.06, respectively) but pain, physician global and func...
To examine clinical effectiveness, treatment complications, and healthcare costs for indigenous a... more To examine clinical effectiveness, treatment complications, and healthcare costs for indigenous and non-indigenous Albertans with rheumatoid arthritis (RA) participating in the Alberta Biologics Pharmacosurveillance program. Patients initiating biologic therapy in Alberta (2004-2012) were characterized for disease severity and treatment response. Provincial hospitalization separations, physician claims, outpatient department data, and emergency department data were used to estimate treatment complication event rates and healthcare costs. Indigenous patients (n = 90) presented with higher disease activity [mean 28-joint count Disease Activity Score (DAS28) 6.11] than non-indigenous patients (n = 1400, mean DAS28 5.19, p < 0.0001). Improvements in DAS28, function, swollen joint count, CRP, and patient and physician global evaluation scores were comparable to non-indigenous patients, but indigenous patients did not have a significant improvement in erythrocyte sedimentation rate (-0...
To characterize patient-reported outcomes, resource use, and social participation during the cour... more To characterize patient-reported outcomes, resource use, and social participation during the course of biologic therapy for indigenous and non-indigenous patients with rheumatoid arthritis (RA). Patients initiating biologic therapy (2004 to 2012) were characterized longitudinally for patient-reported outcomes including physical function measured by the Health Assessment Questionnaire, EQ-5D, well-being [Medical Outcomes Study Short Form-36 (SF-36)], and visual analog scales for pain, fatigue, sleep, stiffness, and patient's global assessment. Resource use, participation in activities of daily living, and effect of RA on work productivity were also evaluated for change during therapy. Indigenous patients (n = 90) presented with significantly worse scores for global evaluation, pain, sleep, quality of life, well-being, and physical function compared to non-indigenous patients (n = 1400). All patient-reported outcomes improved significantly during treatment for patients in both gro...
The present study examined how interparental violence, neighborhood violence, behavioral regulati... more The present study examined how interparental violence, neighborhood violence, behavioral regulation during parental conflict, and age predicted beliefs about the acceptability of aggression and the acceptance of retaliation against an aggressive peer among youths. Participants were 110 families (mothers, fathers, and children) in which one or both parents met criteria for substance use disorder. Results of a bootstrapped path model revealed higher exposure to neighborhood violence predicted greater acceptability of general aggression, whereas higher father-to-mother violence perpetration predicted lower acceptability of general aggression. Higher exposure to neighborhood violence, behavioral dysregulation during parental conflict, and older child age predicted greater approval of retaliation toward an aggressive peer. Findings are interpreted as related to the cognitive-contextual framework.
Environment: Science and Policy for Sustainable Development, 2017
View related articles View Crossmark data Citing articles: 1 View citing articles 22 ENVIRONMENT ... more View related articles View Crossmark data Citing articles: 1 View citing articles 22 ENVIRONMENT WWW.ENVIRONMENTMAGAZINE.ORG VOLUME 59 NUMBER 4 NUCLEAR WEAPONS M any people tend to think that the outcome of any nuclear weapons use today will result in an escalatory situation with apocalyptic outcomes for the countries involved. 1 Yet many factors are increasing the probability of the limited use of nuclear weap-A nuclear-capable Trident D5 SLBM test over San Francisco on November 7, 2015.
Staphylococcus aureus(SA) is a commensal bacterium and opportunistic pathogen commonly associated... more Staphylococcus aureus(SA) is a commensal bacterium and opportunistic pathogen commonly associated with humans and is capable of causing serious disease and death including sepsis, pneumonia, and meningitis. Methicillin-resistant SA (MRSA) isolates are typically resistant to many available antibiotics with the common exception of vancomycin.
Health promotion and chronic disease prevention in Canada : research, policy and practice, 2021
INTRODUCTION Arthritis is a leading cause of disability in First Nations communities and is often... more INTRODUCTION Arthritis is a leading cause of disability in First Nations communities and is often accompanied by other chronic diseases. Existing care models prioritize accessibility to specialty care for treatment, whereas patient-centred approaches support broader health goals. METHODS A patient care facilitator model of care, termed "arthritis liaison," was developed with the community to support culturally relevant patient-centred care plans. Following a one-year-long intervention, we report on the feasibility and acceptability of this care model from the perspectives of patients and health care providers. RESULTS The arthritis liaison served as a bridge between the clinicians and patients, and fostered continuity, helping patients receive coordinated care within the community.
Controlling the time point and site of the release of active ingredients within the gastrointesti... more Controlling the time point and site of the release of active ingredients within the gastrointestinal tract after administration of oral delivery systems is still a challenge. In this study, the effect of the combination of small capsules (size 3) and large capsules (size 00) on the disintegration site and time was investigated using magnetic resonance imaging (MRI) in combination with a salivary tracer technique. As capsule shells, Vcaps® HPMC capsules, Vcaps® Plus HPMC capsules, gelatin and DRcaps® designed release capsules were used. The three HPMC-based capsules (Vcaps®, Vcaps® Plus and DRcaps® capsules) were tested as single capsules; furthermore, seven DUOCAP® capsule-in-capsule combinations were tested in a 10-way crossover open-label study in six healthy volunteers. The capsules contained iron oxide and hibiscus tea powder as tracers for visualization in MRI, and two different caffeine species (natural caffeine and 13C3) to follow caffeine release and absorption as measured b...
The primary objective of this study was to investigate the potential synergy between low doses of... more The primary objective of this study was to investigate the potential synergy between low doses of L-carnitine tartrate and creatine monohydrate to induce muscle protein synthesis and anabolic pathway activation in primary human myoblasts. In addition, the effects of Lipid multi-particulates (LMP) formulation on creatine stability and bioavailability were assessed in rodents and healthy human subjects. When used individually, L-carnitine tartrate at 50 µM and creatine monohydrate at 0.5 µM did not affect myoblast protein synthesis and signaling. However, when combined, they led to a significant increase in protein synthesis. Increased AKT and RPS6 phosphorylation were observed with 50 µM L-carnitine tartrate 5 µM creatine in combination in primary human myoblasts. When Wistar rats were administered creatine with LMP formulation at either 21 or 51 mg/kg, bioavailability was increased by 27% based on the increase in the area under the curve (AUC) at a 51 mg/kg dose compared to without ...
Robots learn as they interact with humans. Consider a human teleoperating an assistive robot arm:... more Robots learn as they interact with humans. Consider a human teleoperating an assistive robot arm: as the human guides and corrects the arm's motion, the robot gathers information about the human's desired task. But how does the human know what their robot has inferred? Today's approaches often focus on conveying intent: for instance, using legible motions or gestures to indicate what the robot is planning. However, closing the loop on robot inference requires more than just revealing the robot's current policy: the robot should also display the alternatives it thinks are likely, and prompt the human teacher when additional guidance is necessary. In this paper we propose a multimodal approach for communicating robot inference that combines both passive and active feedback. Specifically, we leverage information-rich augmented reality to passively visualize what the robot has inferred, and attention-grabbing haptic wristbands to actively prompt and direct the human's teaching. We apply our system to shared autonomy tasks where the robot must infer the human's goal in real-time. Within this context, we integrate passive and active modalities into a single algorithmic framework that determines when and which type of feedback to provide. Combining both passive and active feedback experimentally outperforms single modality baselines; during an in-person user study, we demonstrate that our integrated approach increases how efficiently humans teach the robot while simultaneously decreasing the amount of time humans spend interacting with the robot. Videos here: https://youtu.be/swq_u4iIP-g
European Journal of Drug Metabolism and Pharmacokinetics, 2021
Background and Objective Because of the stomach-burning sensation it induces, capsaicin has been ... more Background and Objective Because of the stomach-burning sensation it induces, capsaicin has been used at relatively low doses as a nutritional supplement, which has limited its bioavailability. The objective of this study was to investigate the serum bioavailability of capsaicin supplementation with or without a lipid multi-particulate (LMP) formulation. Methods Thirty-five rats were divided into five groups and administered capsaicin at either 0.2 or 1 mg/kg with or without the LMP formulation. Capsaicin bioavailability was assessed based on the area under the concentation-time curve (AUC), the time to peak concentration (T max), and the peak serum concentration (C max). Results For each formulation, the capsaicin C max was reached at 90 min and decreased thereafter. Serum capsaicin concentrations were greater in rats administered the higher dose of capsaicin (1 mg/kg) in the LMP formulation at all measurement times (P ≤ 0.05). The AUC showed a significant increase, about 20%, when capsaicin was administered in the LMP formulation at the high dose (P = 0.002). The T max for oral capsaicin was similar whether or not administration was via the LMP formulation (P = 0.163). However, the C max of capsaicin increased in a dose-dependent manner (P < 0.05). Although the LMP formulation of the high dose of capsaicin resulted in a numerically higher C max , it was not statistically significantly higher (P = 0.068). Conclusions The present work demonstrated that administration of capsaicin via the LMP formulation significantly impacted the pharmacokinetic parameters and the serum bioavailability of orally administered 1 mg/kg capsaicin in rats. The bioavailability of capsaicin in humans may also be increased by using the LMP formulation.
Objectives In vitro dissolution tests are valuable first-step tools in the development of bioavai... more Objectives In vitro dissolution tests are valuable first-step tools in the development of bioavailable delivery systems, making it possible to assess the performance of novel technologies in releasing active ingredients through the amount dissolved in a dissolution medium. The objective of this study was to evaluate whether phosphatidyl choline-enriched lipid encapsulation releases the majority of vitamin C as ascorbic acid past the stomach in a standard in vitro dissolution procedure and to assess the release profile. Methods A novel phosphatidyl choline-enriched lipid encapsulation that is solid at room temperature was tested for dissolution in a standard dissolution apparatus according to compendial United States Pharmacopeia methods, as per Good Manufacturing Practices for dietary supplements. One serving (included 1000 mg ascorbic acid) was placed into vessels containing simulated gastric fluid (0.1 M HCl) for 120 minutes then changed to simulated intestinal fluid (buffered 2% ...
Background Arthritis is a highly prevalent disease and leading cause of disability in the Indigen... more Background Arthritis is a highly prevalent disease and leading cause of disability in the Indigenous population. A novel model of care consisting of a rheumatology outreach clinic in an on-reserve primary healthcare center has provided service to an Indigenous community in Southern Alberta since 2010. Despite quality assessments suggesting this model of care improves accessibility and is effective in meeting treatment targets, substantial improvements in patient-reported outcomes have not been realized. Therefore, the objective of this study was to explore the experiences of Indigenous persons with arthritis and healthcare providers involved in this model of care to inform the development of health service improvements that enhance patient outcomes.Methods This was a narrative-based qualitative study involving a purposeful sample of 32 individuals involved in the Indigenous rheumatology model of care. Semi-structured in-depth interviews were conducted to elicit experiences with the ...
Study Design:Narrative review.Objectives:The purpose of this article is to perform a review of th... more Study Design:Narrative review.Objectives:The purpose of this article is to perform a review of the literature assessing the efficacy of opioid alternatives, multimodal pain regimens, and rapid recovery in pediatric spine surgery.Methods:A literature search utilizing PubMed database was performed. Relevant studies from all the evidence levels have been included. Recommendations to decrease postoperative pain and expedite recovery after posterior spinal fusion in adolescent idiopathic scoliosis patients have been provided based on results of studies with the highest level of evidence.Results:Refining perioperative pain management to lessen opioid consumption with multimodal regimens may be useful to decrease recovery time, pain, and complications. Nonsteroidal anti-inflammatory drugs, acetaminophen, gabapentin, neuraxial blockades, and local anesthesia alone offer benefits for postoperative pain management, but their combination in multimodal regimens and rapid recovery pathways may c...
International Journal for Service Learning in Engineering, Humanitarian Engineering and Social Entrepreneurship, 2014
Lack of access to potable drinking water due to contamination from harmful metals is one of the m... more Lack of access to potable drinking water due to contamination from harmful metals is one of the most pressing public health issues globally. In areas close to mining and smelting operations, significant contamination from arsenic and other harmful metals can compound contamination from harmful microorganisms in drinking water. In response to this dual hazard, this study tests a prototype design of an improved point-of-use water filter for resource-poor areas and exposed populations. This project builds upon previous research that has demonstrated the effectiveness of clay pot filters impregnated with silver in reducing coliform bacteria. A compatible attachment comprised of activated charcoal in the form of bone char was added to the clay pot filter with the purpose of enabling the combined filter system to remove arsenic. The experiment tested the designed attachment with source water having an arsenic concentration of 500 parts per billion (ppb) to investigate the combined filter’...
longer term datasets, as well as estimates of annual production and food web flows. The latter an... more longer term datasets, as well as estimates of annual production and food web flows. The latter analyses are also required for the essential step of determining the extent to which fishes, native or nonnative, are food limited. The results of such analyses are forthcoming and, together with those presented here, will provide a thorough ecosystem-level assessment of this experiment and management actions being conducted by the Glen Canyon Dam Adaptive Management Program.
A model of care consisting of rheumatology specialty services embedded in the primary care system... more A model of care consisting of rheumatology specialty services embedded in the primary care system on a First Nations reserve was instituted to reduce barriers to care and improve inflammatory arthritis outcomes for patients. We assessed the effectiveness of this model of care on disease activity measures and patient-reported outcomes over 7 years. Patients were enrolled in a longitudinal cohort at the Siksika Nation in Alberta. Clinical characteristics, treatment recommendations and disease activity measures were systematically recorded over follow-up. Mixed-model regression was performed to determine rates of change for continuous measures. 59 participants (78% female; M = 47 years, SD = 13), predominantly with rheumatoid arthritis (RA; n = 36), were followed for an average of 29 months (SD = 23). Swollen and tender joint counts decreased significantly (change per month: -0.20, 95% CI -0.29 to -0.10, and -0.20, 95%CI -0.34 to -0.06, respectively) but pain, physician global and func...
To examine clinical effectiveness, treatment complications, and healthcare costs for indigenous a... more To examine clinical effectiveness, treatment complications, and healthcare costs for indigenous and non-indigenous Albertans with rheumatoid arthritis (RA) participating in the Alberta Biologics Pharmacosurveillance program. Patients initiating biologic therapy in Alberta (2004-2012) were characterized for disease severity and treatment response. Provincial hospitalization separations, physician claims, outpatient department data, and emergency department data were used to estimate treatment complication event rates and healthcare costs. Indigenous patients (n = 90) presented with higher disease activity [mean 28-joint count Disease Activity Score (DAS28) 6.11] than non-indigenous patients (n = 1400, mean DAS28 5.19, p < 0.0001). Improvements in DAS28, function, swollen joint count, CRP, and patient and physician global evaluation scores were comparable to non-indigenous patients, but indigenous patients did not have a significant improvement in erythrocyte sedimentation rate (-0...
To characterize patient-reported outcomes, resource use, and social participation during the cour... more To characterize patient-reported outcomes, resource use, and social participation during the course of biologic therapy for indigenous and non-indigenous patients with rheumatoid arthritis (RA). Patients initiating biologic therapy (2004 to 2012) were characterized longitudinally for patient-reported outcomes including physical function measured by the Health Assessment Questionnaire, EQ-5D, well-being [Medical Outcomes Study Short Form-36 (SF-36)], and visual analog scales for pain, fatigue, sleep, stiffness, and patient's global assessment. Resource use, participation in activities of daily living, and effect of RA on work productivity were also evaluated for change during therapy. Indigenous patients (n = 90) presented with significantly worse scores for global evaluation, pain, sleep, quality of life, well-being, and physical function compared to non-indigenous patients (n = 1400). All patient-reported outcomes improved significantly during treatment for patients in both gro...
The present study examined how interparental violence, neighborhood violence, behavioral regulati... more The present study examined how interparental violence, neighborhood violence, behavioral regulation during parental conflict, and age predicted beliefs about the acceptability of aggression and the acceptance of retaliation against an aggressive peer among youths. Participants were 110 families (mothers, fathers, and children) in which one or both parents met criteria for substance use disorder. Results of a bootstrapped path model revealed higher exposure to neighborhood violence predicted greater acceptability of general aggression, whereas higher father-to-mother violence perpetration predicted lower acceptability of general aggression. Higher exposure to neighborhood violence, behavioral dysregulation during parental conflict, and older child age predicted greater approval of retaliation toward an aggressive peer. Findings are interpreted as related to the cognitive-contextual framework.
Environment: Science and Policy for Sustainable Development, 2017
View related articles View Crossmark data Citing articles: 1 View citing articles 22 ENVIRONMENT ... more View related articles View Crossmark data Citing articles: 1 View citing articles 22 ENVIRONMENT WWW.ENVIRONMENTMAGAZINE.ORG VOLUME 59 NUMBER 4 NUCLEAR WEAPONS M any people tend to think that the outcome of any nuclear weapons use today will result in an escalatory situation with apocalyptic outcomes for the countries involved. 1 Yet many factors are increasing the probability of the limited use of nuclear weap-A nuclear-capable Trident D5 SLBM test over San Francisco on November 7, 2015.
Staphylococcus aureus(SA) is a commensal bacterium and opportunistic pathogen commonly associated... more Staphylococcus aureus(SA) is a commensal bacterium and opportunistic pathogen commonly associated with humans and is capable of causing serious disease and death including sepsis, pneumonia, and meningitis. Methicillin-resistant SA (MRSA) isolates are typically resistant to many available antibiotics with the common exception of vancomycin.
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