Papers by Tsutomu Nakashima
Frontiers in Public Health, Apr 20, 2023
Results: After adjusting for age and sex, the presence of tinnitus was significantly associated w... more Results: After adjusting for age and sex, the presence of tinnitus was significantly associated with subjective olfactory dysfunction, poor olfactory test results, hearing deterioration, vertigo, and headache. Additionally, high serum calcium levels and a low albumin/globulin ratio were significantly associated with low physical activity and nutrition. Women scored higher than men in olfactory and hearing examinations, but there was no gender di erence in vision examinations. Subjective smell dysfunction and poor smell test results were significantly associated with tinnitus complaints. Hearing and vision were associated even after adjusting for age and sex. These findings suggest that evaluating the mutual relationships among sensory organs is important when evaluating the influence of sensory dysfunctions on cognitive function.
Equilibrium Research, 2005
Frontiers in Neurology
We evaluated the inner ear distribution of 17O-labeled saline administered to the human tympanic ... more We evaluated the inner ear distribution of 17O-labeled saline administered to the human tympanic cavity. Magnetic resonance imaging was performed after intratympanic administration in five healthy volunteers and one patient with cochlear endolymphatic hydrops. In all volunteers, 17O-labeled water permeated the cochlear basal turn and vestibule at 30 min and disappeared gradually within 2–4 h. All participants experienced positional vertigo lasting a few hours to a few days. Visualization of 17O-labeled water distribution in the endolymphatic space of the posterior ampulla showed indistinct separation of endolymph and perilymph in the cochlea and most of the vestibule in all participants. Intralabyrinthine distribution of 17O-labeled water differed from that in previous reports of intratympanically administered gadolinium-based contrast agent. 17O-labeled water in the endolymphatic space may cause heavier endolymph and positional vertigo. These results of this study may add new insig...
American Journal of Rhinology, 2007
Background The aim of this study was to investigate the effects of simple tonsillectomy on nasal ... more Background The aim of this study was to investigate the effects of simple tonsillectomy on nasal resistance in patients with obstructive sleep apnea syndrome (OSAS). Methods Conventional tonsillectomy was performed in 20 patients who were refractory to treatment with continuous positive airway pressure. The subjects consisted of 17 men and 3 women (mean age, 32.9 ± 6.3 years). The effects of tonsillectomy were evaluated with preoperative and postoperative polysomnography and nasal resistance. Results After tonsillectomy, nasal resistance decreased significantly from 0.39 ± 0.30 Pa/cm3 per second to 0.27 ± 0.16 Pa/cm3 per second (p < 0.05). Simultaneously, the apnea–hypopnea index decreased significantly from 55.7 ± 22.5 to 21.2 ± 14.2 (p < 0.05). There was no significant correlation between tonsillar weight and percentage of change in bilateral nasal resistance (p > 0.05). Conclusion The reduction in nasal resistance induced by simple tonsillectomy could play an important r...
Acta Oto-Laryngologica, 2007
Conclusions. The estimated annual number of patients with sudden deafness treated in Japan has in... more Conclusions. The estimated annual number of patients with sudden deafness treated in Japan has increased during the last 30 years, especially in the elderly population. Hypertension and diabetes mellitus could contribute to the etiology of this disorder. Objectives. To investigate the epidemiological trends of sudden deafness in Japan over the past 30 years by analyzing data from national surveys. Materials and methods. Nationwide epidemiological surveys on sudden deafness were conducted four times by the Research Committee of the Ministry of Health and Welfare in Japan.
Auris Nasus Larynx, 2008
All patients from both groups had ear fullness and tinnitus in association with the onset of SD. ... more All patients from both groups had ear fullness and tinnitus in association with the onset of SD. However, these symptoms improved only in Group A. showing a significant relationship between PTA recovery and the improvement of ear fullness annoyance (P < 0.05), presence of ...
European Archives of …, 2009
The objective of the present study was to investigate endolymphatic space images in patients with... more The objective of the present study was to investigate endolymphatic space images in patients with Xuctuating hearing loss without vertigo, and to elucidate its underlying pathophysiology. Eight patients with Xuctuating hearing loss without vertigo were included in this study. 3T MRI was taken, 24 h after intratympanic injection of gadolinium-diethylenetriamine pentaacetic acid (Gd-DTPA). Electrocochleography and VEMP tests were performed to evaluate cochlear and vestibular functions. Endolymphatic hydrops were observed both in the cochlea and in the vestibule of all eight patients. Three patients out of six whose summating potential/action potential (SP/AP) ratio was recordable showed an elevation of SP/AP ratio. In the two patients with remarkable endolymphatic hydrops in the vestibule, VEMP was absent from the aVected ear. In conclusion, 3T MRI after intratympanic injection of Gd-DTPA revealed endolymphatic hydrops both in the cochlea and in the vestibule in the patients with Xuctuating hearing loss without vertigo.
The …, 2007
This study was supported by research grants from the Ministry of Education, Culture, Sports, Scie... more This study was supported by research grants from the Ministry of Education, Culture, Sports, Science and Technology and the Acute Profound Deafness Committee of the Ministry of Health, Labor and Welfare, Japan. ... Objective: Recently, there have been many reports ...
Objecti6e: To examine our hypothesis that an unusual floating or tilting sensation claimed by pat... more Objecti6e: To examine our hypothesis that an unusual floating or tilting sensation claimed by patients with long-standing unilateral vestibular loss might be attributed to incomplete central compensation in the otolith system. Methods: Seven patients who were with or without symptoms for 6-101 months after intratympanic gentamicin therapy for unilateral endolymphatic hydrops were sinusoidally exposed to lateral linear acceleration, and their compensatory eye movements were compared with those of 18 normal controls, using electro-oculography (EOG). The subjects, secured firmly in the chair of a linear accelerator (sled), were oscillated at three different G-loadings of 0.1 (0.11 Hz), 0.2 (0.16 Hz) and 0.3 G (0.19 Hz), respectively. During displacement, they gazed at a real (visible) or imaginary target which was located on the wall (earth-fixed), or moved on the wall in sync with the sled (body-fixed). Results: Vertical EOG (V-EOG) with a frequency two-fold that of the stimulus frequency was characteristically evoked in all patients, but in none of the normal controls. One of the doubled V-EOG was larger in amplitude than the other, when the stimulus acceleration was directed from the affected ear to the intact ear in those patients whose symptoms still remained. Such a directional difference tended to be greater with the imaginary target than with the visible target. In the horizontal EOG, there was no marked difference between the patients and normal controls. Nobody reported tilt perception but only horizontal translation during the sled displacement, except one patient who was examined twice; a roll tilt was perceived in the first examination when she still had symptoms, but no tilt sensation in the second one when she no longer had symptoms. Conclusion: It was suggested that incomplete compensation in the otolith system could cause unusual sensations even after long-standing unilateral vestibular loss, and that V-EOG induced by a sled might be helpful in evaluating functional recovery.
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Papers by Tsutomu Nakashima