Takeshi Todo

Followers

Following

Co-authors

Public Views

Jordi Vallverdú

Universitat Autònoma de Barcelona

Jayjit Majumdar

University of Kalyani

M.E. Hogan

Wells College

Estela Blaisten-Barojas

George Mason University

Miquel Solà

Universitat de Girona

Samit Chakrabarty

University of Leeds

Dipankar Chatterjee

Indian Institute of Science

Paul Kamweru

Leibniz Institute for Age Research - Fritz LipmannInstitute

Andras Lukacs

University of Pecs

shivani R pandya

Parul university

Interests

Uploads

Papers by Takeshi Todo

Author response: Unfolded protein response transducer IRE1-mediated signaling independent of XBP1 mRNA splicing is not required for growth and development of medaka fish

O-5 Accumulation characteristics of mutation in descendant mice after the every generational low dose-rate internal 137Cs radiation exposure, as the Fukushima simulation experiment(Platform Session 1)

Taikai Program Yoshisyu of the Environmental Mutagen Society of Japan, Oct 31, 2014

P-129 Genome Stress, Ecological Decrease and Biological Concentration of Radionuclides in Organisms after Chernobyl Catastrophe(Poster Session)

Taikai Program Yoshisyu of the Environmental Mutagen Society of Japan, Nov 20, 2008

Circasemidian, circadian, and longer-period activity rhythms in caffeine-treated molecular clock deficient cryptochrome (Cry) 1 and Cry 2 double knockout mice

Mammalian circadian rhythms are driven by the transcriptional-translational feedback loop of cloc... more Mammalian circadian rhythms are driven by the transcriptional-translational feedback loop of clock genes in the hypothalamic suprachiasmatic nucleus. However, chronic methamphetamine treatment induces circadian activity rhythms in arrhythmic animals with suprachiasmatic nucleus lesions or clock gene deletions. Activation of dopaminergic neurotransmission by methamphetamine is considered to induce activity rhythms. Adenosine antagonizes the actions of dopamine at heteromers of dopamine and adenosine receptors (dopamine D1 and adenosine A1 receptors, dopamine D2 and adenosine A2A receptors). In this study, we considered that adenosine inhibition acts similarly to methamphetamine, and administered an antagonist of adenosine A1 and A2A receptors, caffeine, in drinking water. Chronic caffeine treatment extended the circadian activity period of wild-type mice under constant darkness. The circadian period extension continued for three weeks after the replacement of caffeine with water. Chr...

Download

Isolation and characterization of Zebrafish (6-4)photolyase and CRY protein family

The mode of action of Trp-P-1 in DNA excision repair

Mutation Research/Environmental Mutagenesis and Related Subjects, 1996

Ovarian aromatase loss-of-function mutant medaka undergo ovary degeneration and partial female-to-male sex reversal after puberty

Molecular and cellular endocrinology, Jan 13, 2017

Although estrogens have been generally considered to play a critical role in ovarian differentiat... more Although estrogens have been generally considered to play a critical role in ovarian differentiation in non-mammalian vertebrates, the specific functions of estrogens during ovarian differentiation remain unclear. We isolated two mutants with premature stops in the ovarian aromatase (cyp19a1) gene from an N-ethyl-N-nitrosourea-based gene-driven mutagenesis library of the medaka, Oryzias latipes. In XX mutants, gonads first differentiated into normal ovaries containing many ovarian follicles that failed to accumulate yolk. Subsequently, ovarian tissues underwent extensive degeneration, followed by the appearance of testicular tissues on the dorsal side of ovaries. In the newly formed testicular tissue, strong expression of gsdf was detected in sox9a2-positive somatic cells surrounding germline stem cells suggesting that gsdf plays an important role in testicular differentiation during estrogen-depleted female-to-male sex reversal. We conclude that endogenous estrogens synthesized aft...

Download

Purification and characterization of Drosophila (6-4)photoproduct photoreactivating enzyme

Journal of Radiation Research, Dec 1, 1994

1P-267 光回復酵素およびクリプトクロムの光誘起構造変化の研究(光生物・視覚,光受容(1),第46回日本生物物理学会年会)

生物物理, Oct 25, 2008

Molecular cloning of the photolyase gene from marsupial

Journal of Radiation Research, Dec 1, 1993

Xenopus (6-4)photolyase is a Flavoprotein and repair (6-4)photoproduct to its undamaged original form

Journal of Radiation Research, Dec 1, 1997

3Q1434 (6-4)光回復酵素における活性化と修復過程の分光解析(光生物_視覚・光受容4,第49回年会講演予稿集)

生物物理, Aug 15, 2011

Regulation and Function of the p38 MAP Kinase Signaling in the Cellular Response to Ionizing Rdiation

Journal of Radiation Research, Dec 1, 1999

Binding Properties of Xenopus(6-4)photolyase

Journal of Radiation Research, Dec 1, 1997

nmeth.1278-S1

Expression of a mammalian DNA photolyase confers light-dependent repair activity and reduces mutations of UV-irradiated shuttle vectors in xeroderma pigmentosum cells

Mutation Research/DNA Repair, 1999

Photoreactivation is one of the DNA repair mechanisms to remove UV lesions from cellular DNA with... more Photoreactivation is one of the DNA repair mechanisms to remove UV lesions from cellular DNA with a function of the Ž. DNA photolyase and visible light. Two types of photolyase specific for cyclobutane pyrimidine dimers CPD and for Ž. Ž. pyrimidine 6-4 pyrimidones 6-4PD are found in nature, but neither is present in cells from placental mammals. To investigate the effect of the CPD-specific photolyase on killing and mutations induced by UV, we expressed a marsupial Ž. DNA photolyase in DNA repair-deficient group A xeroderma pigmentosum XP-A cells. Expression of the photolyase and visible light irradiation removed CPD from cellular DNA and elevated survival of the UV-irradiated XP-A cells, and also reduced mutation frequencies of UV-irradiated shuttle vector plasmids replicating in XP-A cells. The survival of UV-irradiated cells and mutation frequencies of UV-irradiated plasmids were not completely restored to the unirradiated levels by the removal of CPD. These results suggest that both CPD and other UV damage, probably 6-4PD, can lead to cell killing and mutations.

Download

A genetic effect of altered gravity: mutations induced by simulated hypogravity and hypergravity in microsatellite sequences of human tumor cells

Mutation Research/Fundamental and Molecular Mechanisms of Mutagenesis, 1999

To determine the possible genetic effects of gravity alterations, we analyzed mutation induction ... more To determine the possible genetic effects of gravity alterations, we analyzed mutation induction in microsatellite sequences of human tumor cells treated with simulated hypogravity provided by a clinostat or hypergravity by a centrifuge. Microsatellite mutations were detected as changes in the size of polymerase chain reaction (PCR)-amplified allelic markers. The frequencies of mutant clones in cultures treated with simulated hypogravity for 24 or 48 h were almost the same as those of controls, but after 72 h of treatment, the mutant frequencies had increased significantly in all three microsatellite loci examined. Significantly higher mutant frequencies were similarly detected in cultures treated for 72 h with a hypergravity condition as low as 18xg, but not detected in 24 or 48 h treated cultures. These findings clearly show that gravity alterations that last for 3 days can induce microsatellite mutations in human cells. A genetic effect of gravity change, therefore, is established for the first time. Moreover, high frequencies of microsatellite mutations were induced by 12-O-tetradecanoylphorbol-13-acetate (TPA) which activates protein kinase C-mediated signal transduction pathways and causes genetic instability. These findings suggest that gravity change induces microsatellite mutations by modulating the pattern of gene expression involved in signal transduction pathways.

High-level expression of the photorepair gene in Drosophila ovary and its evolutionary implications

Mutation Research/DNA Repair, 1994

DNA photolyase catalyzes light-dependent repair of cis,syn-cyclobutane dipyrimidines (pyrimidine ... more DNA photolyase catalyzes light-dependent repair of cis,syn-cyclobutane dipyrimidines (pyrimidine dimers); its apoenzyme is encoded by the photorepair (phr) gene. The phr cDNA was cloned from D. melanogaster; it has an open reading frame to encode a 61483-Da protein. The phr cDNA hybridized to band 44C-D of Drosophila polytene chromosome, equivalent to the locus of the phr-gene. Drosophila photolyase is made of an apoenzyme with a molecular weight of 62 kDa. Drosophila photolyase is extraordinarily abundant in the embryo and adult ovary, whereas mRNA of the phr gene is abundant only in the ovary. The action spectrum of Drosophila photolyase for photoreactivation has a maximum at 440 nm. The phr gene of Drosophila has about 60% identical amino acid sites with that of goldfish but only 13-18% with those of microorganisms. Implications of the unique characteristics of the Drosophila phr gene are discussed overviewing the diversified characteristics of phr genes in various organisms that have presumably evolved from a common ancestral gene.

Download

A positive role for PERIOD in mammalian circadian gene expression

Cell reports, Jan 22, 2014

In the current model of the mammalian circadian clock, PERIOD (PER) represses the activity of the... more In the current model of the mammalian circadian clock, PERIOD (PER) represses the activity of the circadian transcription factors BMAL1 and CLOCK, either independently or together with CRYPTOCHROME (CRY). Here, we provide evidence that PER has an entirely different function from that reported previously, namely, that PER inhibits CRY-mediated transcriptional repression through interference with CRY recruitment into the BMAL1-CLOCK complex. This indirect positive function of PER is consistent with previous data from genetic analyses using Per-deficient or mutant mice. Overall, our results support the hypothesis that PER plays different roles in different circadian phases: an early phase in which it suppresses CRY activity, and a later phase in which it acts as a transcriptional repressor with CRY. This buffering effect of PER on CRY might help to prolong the period of rhythmic gene expression. Additional studies are required to carefully examine the promoter- and phase-specific roles...

Download

Hypersensitivity to ultraviolet ligh and chemical mutagens of a cell line established from excisionless Drosophila strain mus201

Mutation Research/DNA Repair Reports, 1985

ABSTRACT A cell line was established from the homozygous strain mus201D1/mus201D1 of Drosophila m... more ABSTRACT A cell line was established from the homozygous strain mus201D1/mus201D1 of Drosophila melanogaster which completely lacks excision repair for pyrimidine dimers induced by ultraviolet light (UV). In comparison with an established cell line with wild-type DNA repair, the mus201 cell line showed hypersensitivity to inactivation of colony-forming ability by dose-modifying factors at 37% survival of 13, 7, 2 and 3, after treatment with UV, methyl nitrosourea, 4-nitroquinoline 1-oxide and mitomycin C, respectively, but a normal resistance to inactivation by X-rays. The results are discussed in comparison with responses of another excisionless cell-line mei-9a and with responses of mus201/mus201 and mes-9a larvae to inactivation by treatment with UV and chemical mutagens.

Author response: Unfolded protein response transducer IRE1-mediated signaling independent of XBP1 mRNA splicing is not required for growth and development of medaka fish

Taikai Program Yoshisyu of the Environmental Mutagen Society of Japan, Oct 31, 2014

P-129 Genome Stress, Ecological Decrease and Biological Concentration of Radionuclides in Organisms after Chernobyl Catastrophe(Poster Session)

Taikai Program Yoshisyu of the Environmental Mutagen Society of Japan, Nov 20, 2008

Circasemidian, circadian, and longer-period activity rhythms in caffeine-treated molecular clock deficient cryptochrome (Cry) 1 and Cry 2 double knockout mice

Download

Isolation and characterization of Zebrafish (6-4)photolyase and CRY protein family

The mode of action of Trp-P-1 in DNA excision repair

Mutation Research/Environmental Mutagenesis and Related Subjects, 1996

Ovarian aromatase loss-of-function mutant medaka undergo ovary degeneration and partial female-to-male sex reversal after puberty

Molecular and cellular endocrinology, Jan 13, 2017

Download

Purification and characterization of Drosophila (6-4)photoproduct photoreactivating enzyme

Journal of Radiation Research, Dec 1, 1994

1P-267 光回復酵素およびクリプトクロムの光誘起構造変化の研究(光生物・視覚,光受容(1),第46回日本生物物理学会年会)

生物物理, Oct 25, 2008

Molecular cloning of the photolyase gene from marsupial

Journal of Radiation Research, Dec 1, 1993

Xenopus (6-4)photolyase is a Flavoprotein and repair (6-4)photoproduct to its undamaged original form

Journal of Radiation Research, Dec 1, 1997

3Q1434 (6-4)光回復酵素における活性化と修復過程の分光解析(光生物_視覚・光受容4,第49回年会講演予稿集)

生物物理, Aug 15, 2011

Regulation and Function of the p38 MAP Kinase Signaling in the Cellular Response to Ionizing Rdiation

Journal of Radiation Research, Dec 1, 1999

Binding Properties of Xenopus(6-4)photolyase

Journal of Radiation Research, Dec 1, 1997

nmeth.1278-S1

Expression of a mammalian DNA photolyase confers light-dependent repair activity and reduces mutations of UV-irradiated shuttle vectors in xeroderma pigmentosum cells

Mutation Research/DNA Repair, 1999

Download

A genetic effect of altered gravity: mutations induced by simulated hypogravity and hypergravity in microsatellite sequences of human tumor cells

Mutation Research/Fundamental and Molecular Mechanisms of Mutagenesis, 1999

High-level expression of the photorepair gene in Drosophila ovary and its evolutionary implications

Mutation Research/DNA Repair, 1994

Download

A positive role for PERIOD in mammalian circadian gene expression

Cell reports, Jan 22, 2014

Download

Hypersensitivity to ultraviolet ligh and chemical mutagens of a cell line established from excisionless Drosophila strain mus201

Mutation Research/DNA Repair Reports, 1985

Takeshi Todo

Related Authors

Uploads

Papers by Takeshi Todo

Log In