Papers by Suthipong Soontrapa
DOAJ (DOAJ: Directory of Open Access Journals), Apr 1, 2015
The Southwest Respiratory and Critical Care Chronicles, 2015
ment (as-treated population). However, there was no significant difference in superiority analysi... more ment (as-treated population). However, there was no significant difference in superiority analysis in the intention-to-treat population. 1 Acute symptomatic DVT: 15 mg twice daily for 3 weeks, followed by 20 mg once daily for 3, 6, or 12 months. From the EINSTEIN-DVT trial, rivaroxaban had non-inferior efficacy with respect to the primary outcome (recurrent venous thromboembolism) compared to enoxaparin and vitamin K antagonist. There was no difference in the risk of major bleeding or in clinically relevant nonmajor bleeding. 2 Acute symptomatic PE: 15 mg twice daily for 3 weeks, followed by 20 mg once daily for 3, 6, or 12 months. From the EINSTEIN-PE trial, rivaroxaban was non-inferior to enoxaparin and vitamin K antagonist for the primary efficacy outcome of symptomatic recurrent venous thromboembolism. There was less major bleeding in the rivaroxaban group.
The American Journal of the Medical Sciences, Jun 26, 2012
A 52-year-old unvaccinated and splenectomized man presented with fever, altered sensorium, bilate... more A 52-year-old unvaccinated and splenectomized man presented with fever, altered sensorium, bilateral flank pain and chest discomfort accompanied with paroxysmal atrial fibrillation with a rapid ventricular response. An abdominal computed tomography scan was performed, which revealed a right renal infarct and splenosis. Transthoracic echocardiography was performed, which demonstrated an echodense structure on the mitral valve with mitral regurgitation and a vegetation on the aortic valve with aortic regurgitation. Subsequently, he was found to have pneumococcal infective endocarditis, pneumococcal pneumonia and bacterial meningitis, namely Austrian syndrome. He underwent an early aortic valve and mitral valve repair but still had a poor clinical outcome. Renal infarction has a mortality of approximately 13.2%, which is strongly influenced by the underlying diseases and infectious complications. Medical and surgical treatment initiated in a timely manner is often inadequate. The authors report the first case of Austrian syndrome presenting with renal infarction as a clue to an embolic event associated with infective endocarditis in this study.
Journal of controlled release : official journal of the Controlled Release Society, Jan 9, 2015
Current approaches to the diagnosis and therapy of atherosclerosis cannot target lesion-determina... more Current approaches to the diagnosis and therapy of atherosclerosis cannot target lesion-determinant cells in the artery wall. Intimal macrophage infiltration promotes atherosclerotic lesion development by facilitating the accumulation of oxidized low-density lipoproteins (oxLDL) and increasing inflammatory responses. The presence of these cells is positively associated with lesion progression, severity and destabilization. Hence, they are an important diagnostic and therapeutic target. The objective of this study was to noninvasively assess the distribution and accumulation of intimal macrophages using CD36-targeted nanovesicles. Soy phosphatidylcholine was used to synthesize liposome-like nanovesicles. 1-(Palmitoyl)-2-(5-keto-6-octene-dioyl) phosphatidylcholine was incorporated on their surface to target the CD36 receptor. All in vitro data demonstrate that these targeted nanovesicles had a high binding affinity for the oxLDL binding site of the CD36 receptor and participated in CD...
Journal of Controlled Release, 2015
Current approaches to the diagnosis and therapy of atherosclerosis cannot target lesion-determina... more Current approaches to the diagnosis and therapy of atherosclerosis cannot target lesion-determinant cells in the artery wall. Intimal macrophage infiltration promotes atherosclerotic lesion development by facilitating the accumulation of oxidized low-density lipoproteins (oxLDL) and increasing inflammatory responses. The presence of these cells is positively associated with lesion progression, severity and destabilization. Hence, they are an important diagnostic and therapeutic target. The objective of this study was to noninvasively assess the distribution and accumulation of intimal macrophages using CD36-targeted nanovesicles. Soy phosphatidylcholine was used to synthesize liposome-like nanovesicles. 1-(Palmitoyl)-2-(5-keto-6-octene-dioyl) phosphatidylcholine was incorporated on their surface to target the CD36 receptor. All in vitro data demonstrate that these targeted nanovesicles had a high binding affinity for the oxLDL binding site of the CD36 receptor and participated in CD36-mediated recognition and uptake of nanovesicles by macrophages. Intravenous administration into LDL receptor null mice of targeted compared to non-targeted nanovesicles resulted in higher uptake in aortic lesions. The nanovesicles co-localized with macrophages and their CD36 receptors in aortic lesions. This molecular target approach may facilitate the in vivo noninvasive imaging of atherosclerotic lesions in terms of intimal macrophage accumulation and distribution and disclose lesion features related to inflammation and possibly vulnerability thereby facilitate early lesion detection and targeted delivery of therapeutic compounds to intimal macrophages.
The American journal of tropical medicine and hygiene, 2008
In February 2005, we conducted a cross-sectional study to determine the prevalence and the risk f... more In February 2005, we conducted a cross-sectional study to determine the prevalence and the risk factors of giardiasis in 531 primary schoolchildren of a rural community, Chacheongsao province, Thailand. Using both sedimentation and flotation techniques to detect Giardia duodenalis, the prevalence of giardiasis was 6.2%. Assemblage A, subgenotype II and assemblage B, subgenotype IV were identified by PCR-RFLP of glutamate dehydrogenase gene. Our data might indicate that, in this population, only assemblage A, subgenotype II of G. duodenalis was transmitted via water. Using multivariate analysis, significant risk factors for giardiasis were children of age 5-9 years, households with > or = 3 children under the age of 12 years, low parental educational level, drinking bottled water, and living in close contact with dogs. Washing hands before meals had a protective effect. From these significant risk factors, multiple modes of transmission of G. duodenalis were suggested in this popu...
A 57-year-old man presented with sudden onset of leg pain, right-sided weakness, aphasia, confusi... more A 57-year-old man presented with sudden onset of leg pain, right-sided weakness, aphasia, confusion, drooling, and severe lactic acidosis (15 mmol/L). He had normal peripheral pulses and demonstrated no pain, pallor, poikilothermia, paresthesia, or paralysis. Empiric antibiotics, aspirin, full-dose enoxaparin, and intravenous fluid were initiated. Lactic acid level decreased to 2.5 mmol/L. The patient was subsequently extubated and was alert and oriented with no complaints of leg or abdominal pain. Unexpectedly, the patient developed cardiac arrest, rebound severe lactic acidosis (8.13 mmol/L), and signs of acute limb ischemia. Emergent computed tomography of the aorta confirmed infrarenal aortoiliac thrombosis. Transient leg pain and transient severe lactic acidosis can be unusual presentations of severe infrarenal aortoiliac stenosis. When in doubt, vascular studies should be implemented without delay to identify this catastrophic diagnosis.
Texas Heart Institute Journal, 2014
Journal of the American College of Cardiology, 2012
Background: There is evidence that platelet hyper-reactivity mediates peri-and post-procedural is... more Background: There is evidence that platelet hyper-reactivity mediates peri-and post-procedural ischemic events in patients undergoing percutaneous coronary intervention (PCI). The procedure itself has been shown to enhance platelet aggregation. Contemporary periprocedural dual antiplatelet therapy (DAPT) focuses primarily on the effects of arachidonic acid and adenosine-5'-diphosphate (ADP). PCI, however, leads to elevated levels of 8-isoprostane, an indicator of ischemia-induced oxidative stress, and also to the exposure of collagen, resulting from vascular endothelial injury that occurs during stent deployment. The purpose of this study was to investigate the role of other factors in the enhancement of platelet aggregability during PCI.
Clinical Nuclear Medicine, 2013
An 81-year-old man was incidentally found to have a large pericardial cyst on a chest computed to... more An 81-year-old man was incidentally found to have a large pericardial cyst on a chest computed tomography. Before surgical removal, an echocardiogram demonstrated that the cyst was more likely a large (7.5 cm) right coronary arterial aneurysm. A cardiac blood-pool study demonstrated a blood-filled structure adjacent to the heart, roughly the same size as the combined size of both the right and left ventricles. Coronary angiography confirmed the presence of a large right coronary artery aneurysm. A coronary aneurysm should be considered when a blood-filled structure is seen adjacent to the heart on a multigated acquisition scan.
The American Journal of the Medical Sciences, 2012
A 52-year-old unvaccinated and splenectomized man presented with fever, altered sensorium, bilate... more A 52-year-old unvaccinated and splenectomized man presented with fever, altered sensorium, bilateral flank pain and chest discomfort accompanied with paroxysmal atrial fibrillation with a rapid ventricular response. An abdominal computed tomography scan was performed, which revealed a right renal infarct and splenosis. Transthoracic echocardiography was performed, which demonstrated an echodense structure on the mitral valve with mitral regurgitation and a vegetation on the aortic valve with aortic regurgitation. Subsequently, he was found to have pneumococcal infective endocarditis, pneumococcal pneumonia and bacterial meningitis, namely Austrian syndrome. He underwent an early aortic valve and mitral valve repair but still had a poor clinical outcome. Renal infarction has a mortality of approximately 13.2%, which is strongly influenced by the underlying diseases and infectious complications. Medical and surgical treatment initiated in a timely manner is often inadequate. The authors report the first case of Austrian syndrome presenting with renal infarction as a clue to an embolic event associated with infective endocarditis in this study.
Proceedings, Apr 1, 2015
Takotsubo cardiomyopathy is an uncommon clinical entity, also called apical ballooning syndrome, ... more Takotsubo cardiomyopathy is an uncommon clinical entity, also called apical ballooning syndrome, characterized by transient systolic dysfunction of the apical and/or mid segments of the left ventricle. We report a case that highlights takotsubo syndrome in the setting of thyrotoxicosis that required thyroidectomy. The association of takotsubo syndrome and hyperthyroidism has been reported before. We found 13 previously reported cases of thyrotoxicosis-induced cardiomyopathy, most associated with Grave's disease and none treated with thyroidectomy. Awareness of this possible association is important in establishing the diagnosis and instituting proper management.
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Papers by Suthipong Soontrapa