Harmonization of Nematic's Filled with Esters Through Hydrogen Bonding
Anisotropic nature with fluidity and its inability to support shear is studied with harmonization... more Anisotropic nature with fluidity and its inability to support shear is studied with harmonization between nematics and esters in transformation to layered textures through intermolecular hydrogen bonding. The anisotropy include molecular properties of liquid crystalline materials such as its texture, phase transitions, structure, interactions and index with interrelationships responsible for supramolecular structures. The harmonization behavior is dependent on its chemical intuition that are characterized with numerous techniques like polarizing optical microscope, differential scanning calorimetry, Fourier transform infrared spectroscopy, proton Nuclear magnetic resonance spectroscopy and powdered X-ray diffraction. Interestingly the flexibility of nematics with higher energy when filled with esters transform to layered textures due to non covalent interaction with reduced energy on harmonization.
Integrated Rotor Performance Improvement and Vibration Reduction Using Active Camber Morphing
This paper discusses open-loop and closed-loop active control investigations of a full-scale Bo 1... more This paper discusses open-loop and closed-loop active control investigations of a full-scale Bo 105 helicopter rotor with active camber morphing. The potential of an active camber morphing concept to reduce non-rotating vibratory hub loads and rotor power using active control was investigated. The mechanism employed was a dynamically actuated airfoil camber morphing concept known as Fish Bone Active Camber (FishBAC) that smoothly deforms the camber over the aft section of the airfoil. A comprehensive rotorcraft aeromechanics analysis was used that modeled the blade elastic motion using one-dimensional finite beam elements combined with multibody dynamics. Aerodynamic forces were calculated with a free-vortex wake model together with lifting line theory for the blade aerodynamics. The open-loop investigation comprised of a parametric study of relevant control parameters that govern the active camber deflection cyclic actuation profile and their effects on rotor performance and hub vibration. It was found that active camber morphing using superimposed once-per-revolution (1P) and 2P control inputs was able to simultaneously reduce rotor power by 4.3% and overall vibratory hub loads by 27%. Additionally, a closed-loop adaptive multicyclic controller was used to identify the potential of this morphing concept for hub vibration reduction using multicyclic active control inputs. Active camber actuation using a sum of four control harmonic inputs, i.e. 1-4P, resulted in a maximum hub vibration reduction of 50%.
of-morphingblades-and-rotor-systems-12708.cfm Publisher's PDF, also known as Version of record Li... more of-morphingblades-and-rotor-systems-12708.cfm Publisher's PDF, also known as Version of record License (if available): Unspecified Link to publication record in Explore Bristol Research PDF-document This is the final published version of the article (version of record). It first appeared online via AHS International. Please refer to any applicable terms of use of the publisher.
A computational investigation of a helicopter main rotor with an active-camber morphing mechanism... more A computational investigation of a helicopter main rotor with an active-camber morphing mechanism was conducted to identify the capability to simultaneously save rotor power and reduce pitch-link loads using as low as possible camber deflection magnitudes. Comprehensive rotor aeromechanics analysis with elastic blade modeling and a free vortex wake for the aerodynamics model was used to ensure computational efficiency. The investigation was based on a full-scale Bo 105 helicopter main rotor in level flight condition at μ = 0.3 and C T /σ = 0.089. In addition to a variation of the radial position and length of the active-camber section, the capabilities and system behavior were investigated in an extensive parametric study using practical actuation inputs. The same computational framework was used to obtain optimal control inputs that led to best performance in terms of power savings using twoper-rev (2P) individual blade control (IBC) via pitch-link inputs and 2P active-twist control. The relative potential of the three active mechanisms and the aerodynamic phenomenology was compared. All of the investigated active-rotor mechanisms contributed to rotor power savings via a more uniform distribution of thrust over the rotor disk. Both IBC and active twist yielded maximum performance improvement of about 1.8% over the baseline in terms of power reduction. With active camber, simultaneous rotor power reduction of 3.8% and a peak-to-peak pitch-link load reduction of 20% were obtained using a nonharmonic camber deflection deployment schedule with a half-peak-to-peak magnitude of 2 •. The global maximum of power savings observed with active camber was 4.4%, which resulted in an increase of peak-to-peak pitch-link loads by 35% and a required half-peak-to-peak camber deflection magnitude of 3.6 • .
International Journal of Creative Research Thoughts (IJCRT), Apr 1, 2018
The revolution of ICT and Internet has transformed libraries from conventional to contemporary. T... more The revolution of ICT and Internet has transformed libraries from conventional to contemporary. This is the era of ICT where human beings are connected through ICT directlyor indirectly. Today, we cannot be imagine our life without Information and CommunicationTechnology (ICT). Internet and smart electronic devices such as Mobiles, Lap-Top, I-pad,etc. have became the significant parts of a student's life. Subsequently, we library professionals also adopted these technologies and modified our libraries in the form of 'Digital', 'Virtual', 'library 24x7', 'libraries without walls' and many more. There is no doubt that ICT and Internet have given the new life to the libraries and librarians as well as users have been taking optimum benefits through this technology. However, this is the one side of coin and definitely there is other side of coin, which shows the after effects of rapid use of Information and Technology that gradually students have been become impatient in order to collect superficial knowledge. Moreover, it has come into the notice very often the reading practices of the students have been declining. With these motives the present study has been taken place. Questionnaire tool has been used for data collection and simple statistical techniques have been used for analysis.100 students have randomly selected for survey and distributed questionnaire to them. In the users' response, 86 students have returned the filled questionnaire. Consequently, findings and suggestions are made.
Synthesis, characterization and evaluation of biosynthesized Cerium oxide nanoparticle for its anticancer activity on breast cancer cell (MCF 7)
Materials Today: Proceedings, 2021
Abstract Biosynthesis of metal oxide nanoparticles using plant attracted great interest recently,... more Abstract Biosynthesis of metal oxide nanoparticles using plant attracted great interest recently, due to its eco friendliness. Therefore, in the present study involves the synthesis of cerium oxide nanoparticle by using Brophyllamdaigremontianum plant ethanolic extract. The obtained powder was subsequently calcinated at 600 °C. Synthesized cerium oxide nanoparticles was confirmed by X-ray diffraction, Scanning electron microscopy, High resolution transmission electron microscopy, UV visible spectroscopy, Fourier transform infrared spectroscopy and Brunauer Emmett-teller (BET) measurement. To evaluate the anticancer activity of the spherical structured CeO2-Nps, it was tested towards the normal (L6) and breast cancer cell (MCF 7). It was found that Biosynthesized CeO2-Nps showed better cytotoxicity against cancerous MCF 7 cell line compared to normal L6 cell line due to its smaller size and high surface area.
The paper presents the modeling and also the numerical associate analysis over an optimisation of... more The paper presents the modeling and also the numerical associate analysis over an optimisation of camber position ever-changing for a small aerial vehicle application. This paper conferred the formed optimisation of cambered profile with 20% of chord length from edge, and during this study must be ascertained of mechanics performance over a wing. Firstly, the model was created by the planning software package and applying modularity and reconfigurability to a morphing wing system. A comparative analysis is conducted to explore the relationships between mechanics parameters and also the angle of attack. The results show that the morphing flap camber profiles considerably have an effect on mechanics performance. Associate analysis of the wind flow characteristics is enclosed as a supplementary validation; the pressure coefficients obtained through Ansys and thus lift, drag and lift-to-drag magnitude relation. When getting the results, each the results area unit compared before associated when morphing to prove an improvement within the lift, lift-to-drag, and reduction in drag simulation for many desired device shapes area unit compared. Hence forward when optimisation of the cambered profile in varied deflections in morphing edge because the given pure mathematics associated thus the results area unit showing for varied profiles when morphing there's an improvement in constant of lift from fifteen to thirty share of lift increasing when morphing edge.
Investigation of Active Rotor Design and Control for Performance Improvement
Proceedings of the Vertical Flight Society 75th Annual Forum
A computational investigation was conducted to identify the optimal performance of a rotor with a... more A computational investigation was conducted to identify the optimal performance of a rotor with an active camber morphing mechanism using up to twice-per-revolution (2P) control input. Using rotor comprehensive analysis with an elastic blade model and a free vortex wake for the aerodynamics model to ensure computational efficiency, a parametric study of design and control variables was carried out to identify their influence on rotor performance. The same computational framework was used to obtain optimal control inputs that led to best performance using 2P individual blade control (IBC) via pitch-link inputs and 2P active twist control. The relative potential of the three active mechanisms to improve rotor performance was studied and compared. A level flight condition at μ = 0.3 and CT /σ = 0.089 was used throughout this investigation. IBC or active twist both yielded maximum performance improvements of 1.8% in terms of power reduction. Optimal isolated 1P and 2P active camber actu...
A Proposal of FPGA-Based Low Cost and Power Efficient Autonomous Fruit Harvester
2020 6th International Conference on Control, Automation and Robotics (ICCAR)
In this paper, we present a power-efficient and low- cost prototype of a robotic harvester which ... more In this paper, we present a power-efficient and low- cost prototype of a robotic harvester which employs multiple subsystems such as fruit detection, odometry, localization, profi- cient manipulation through computer vision, deep learning and a novel end-effector design. Fruit Plucking is performed using an end effector, and 3-degree of freedom (DOF) arm (made out of the integration of two linear actuators and a rotating platform) consolidated with a 4-wheeled differential drive mobile platform. Effective implementation of the visual processing is executed on the FPGA Fabric of the Xilinx PYNQ-Z2 Board, which accelerates Deep Neural Networks (DNNs) with improved Latency and Energy Efficiency as compared to a CPU or GPU based implementation.
Conversations on social media (SM) are increasingly being used to investigate social issues on th... more Conversations on social media (SM) are increasingly being used to investigate social issues on the web, such as online harassment and rumor spread. For such issues, a common thread of research uses adversarial reactions, e.g., replies pointing out factual inaccuracies in rumors. Though adversarial reactions are prevalent in online conversations, inferring those adverse views (or stance) from the text in replies is difficult and requires complex natural language processing (NLP) models. Moreover, conventional NLP models for stance mining need labeled data for supervised learning. Getting labeled conversations can itself be challenging as conversations can be on any topic, and topics change over time. These challenges make learning the stance a difficult NLP problem. In this research, we first create a new stance dataset comprised of three different topics by labeling both users' opinions on the topics (as in pro/con) and users' stance while replying to others' posts (as in favor/oppose). As we find limitations with supervised approaches, we propose a weakly-supervised approach to predict the stance in Twitter replies. Our novel method allows using a smaller number of hashtags to generate weak labels for Twitter replies. Compared to supervised learning, our method improves the mean F1-macro by 8% on the hand-labeled dataset without using any hand-labeled examples in the training set. We further show the applicability of our proposed method on COVID 19 related conversations on Twitter.
Heterogeneous Activation Function Extraction for Training and Optimization of SNN Systems
2019 IEEE International Conference on Artificial Intelligence Circuits and Systems (AICAS)
Energy-efficiency and computation capability characteristics of analog/mixed-signal spiking neura... more Energy-efficiency and computation capability characteristics of analog/mixed-signal spiking neural networks offer capable platform for implementation of cognitive tasks on resource-limited embedded platforms. However, inherent mismatch in analog devices severely influence accuracy and reliability of the computing system. In this paper, we devise efficient algorithm for extracting of heterogeneous activation functions of analog hardware neurons as a set of constraints in an off-line training and optimization process, and examine how compensation of the mismatch effects influence synchronicity and information processing capabilities of the system.
In this paper, quasi-hemi-slant Riemannian maps from almost Hermitian manifolds onto Riemannian m... more In this paper, quasi-hemi-slant Riemannian maps from almost Hermitian manifolds onto Riemannian manifolds are introduced. The geometry of leaves of distributions that are involved in the definition of the submersion and quasi-hemi-slant Riemannian maps are studied. In addition, conditions for such distributions to be integrable and totally geodesic are obtained. Also, a necessary and sufficient condition for proper quasi-hemi-slant Riemannian maps to be totally geodesic is given. Moreover, structured concrete examples for this notion are given.
The Twelfth International Symposium on High-Performance Computer Architecture, 2006.
With reducing feature size, increasing chip capacity, and increasing clock speed, microprocessors... more With reducing feature size, increasing chip capacity, and increasing clock speed, microprocessors are becoming increasingly susceptible to transient (soft) errors. Redundant multi-threading (RMT) is an attractive approach for concurrent error detection and recovery. However, redundant threads significantly increase the pressure on the processor resources, resulting in dramatic performance impact. In this paper, we propose reducing resource redundancy as a means to mitigate the performance impact of redundancy. In this approach, all the instructions are redundantly executed, however, the redundant instructions do not use many of the resources used by an instruction. The approach taken to reduce resource redundancy is to exploit the runtime profile of the leading thread to optimally allocate resources to the trailing thread in a staggered RMT architecture. The key observation used in this approach is that, even with a small slack between the two threads, many instructions in the leading thread have already produced their results before their trailing counterparts are renamed. We investigate two techniques in this approach (i) register bits reuse technique that attempts to use the same register (but different bits) for both the copies of the same instruction, if the result produced by the instruction is of small size, and (ii) register value reuse technique that attempts to use the same register for a main instruction and a distinct redundant instruction, if both the instructions produce the same result. These techniques, along with some others, are used to reduce redundancy in register file, reorder buffer, and load/store buffer. The techniques are evaluated in terms of their performance, power, and vulnerability impact on an RMT processor. Our experiments show that the techniques achieve about 95% performance improvement and about 17% energy reduction. The vulnerability of the RMT remains the same with the techniques.
Compound heterozygous variants in Wiskott-Aldrich syndrome like (WASL) gene segregating in a family with early onset Parkinson's disease
Parkinsonism & Related Disorders, 2021
BACKGROUND Knowledge of genetic determinants in Parkinson's disease is still limited. Familia... more BACKGROUND Knowledge of genetic determinants in Parkinson's disease is still limited. Familial forms of the disease continue to provide a rich resource to capture the genetic spectrum in disease pathogenesis, and this approach is exploited in this study. METHODS Informative members from a three-generation family of Indian ethnicity manifesting a likely autosomal recessive mode of inheritance of Parkinson's disease were used for whole exome sequencing. Variant data analysis and in vitro functional characterisation of variant(s) segregating with the phenotype were carried out in HEK-293 and SH-SY5Y cells using gene constructs of interest. RESULTS Two compound heterozygous variants, a rare missense (c.1139C > T:p.P380L) and a novel splice variant (c.1456 + 2 delTAGA, intron10) in Wiskott-Aldrich syndrome like gene (WASL, 7q31), both predicted to be deleterious were shared among the proband and two affected siblings. WASL, a gene not previously linked to a human Mendelian disorder is known to regulate actin polymerisation via Arp2/3 complex. Based on exon trapping assay using pSPL3 vector in HEK-293 cells, the splice variant showed skipping of exon10. Characterisation of the missense variant in SH-SY5Y cells demonstrated: i) significant alterations in neurite length and number; ii) decreased reactive oxygen species tolerance in mutation carrying cells on Tetrabutylphosphonium hydroxide induction and iii) increase in alpha-synuclein protein. Screening for WASL variants in two independent PD cohorts identified four individuals with heterozygous but none with biallelic variants. CONCLUSION WASL, with demonstrated functional relevance in neurons may be yet another strong candidate gene for autosomal recessive PD encouraging assessment of its contribution across populations.
Harmonization of Nematic's Filled with Esters Through Hydrogen Bonding
Anisotropic nature with fluidity and its inability to support shear is studied with harmonization... more Anisotropic nature with fluidity and its inability to support shear is studied with harmonization between nematics and esters in transformation to layered textures through intermolecular hydrogen bonding. The anisotropy include molecular properties of liquid crystalline materials such as its texture, phase transitions, structure, interactions and index with interrelationships responsible for supramolecular structures. The harmonization behavior is dependent on its chemical intuition that are characterized with numerous techniques like polarizing optical microscope, differential scanning calorimetry, Fourier transform infrared spectroscopy, proton Nuclear magnetic resonance spectroscopy and powdered X-ray diffraction. Interestingly the flexibility of nematics with higher energy when filled with esters transform to layered textures due to non covalent interaction with reduced energy on harmonization.
Integrated Rotor Performance Improvement and Vibration Reduction Using Active Camber Morphing
This paper discusses open-loop and closed-loop active control investigations of a full-scale Bo 1... more This paper discusses open-loop and closed-loop active control investigations of a full-scale Bo 105 helicopter rotor with active camber morphing. The potential of an active camber morphing concept to reduce non-rotating vibratory hub loads and rotor power using active control was investigated. The mechanism employed was a dynamically actuated airfoil camber morphing concept known as Fish Bone Active Camber (FishBAC) that smoothly deforms the camber over the aft section of the airfoil. A comprehensive rotorcraft aeromechanics analysis was used that modeled the blade elastic motion using one-dimensional finite beam elements combined with multibody dynamics. Aerodynamic forces were calculated with a free-vortex wake model together with lifting line theory for the blade aerodynamics. The open-loop investigation comprised of a parametric study of relevant control parameters that govern the active camber deflection cyclic actuation profile and their effects on rotor performance and hub vibration. It was found that active camber morphing using superimposed once-per-revolution (1P) and 2P control inputs was able to simultaneously reduce rotor power by 4.3% and overall vibratory hub loads by 27%. Additionally, a closed-loop adaptive multicyclic controller was used to identify the potential of this morphing concept for hub vibration reduction using multicyclic active control inputs. Active camber actuation using a sum of four control harmonic inputs, i.e. 1-4P, resulted in a maximum hub vibration reduction of 50%.
of-morphingblades-and-rotor-systems-12708.cfm Publisher's PDF, also known as Version of record Li... more of-morphingblades-and-rotor-systems-12708.cfm Publisher's PDF, also known as Version of record License (if available): Unspecified Link to publication record in Explore Bristol Research PDF-document This is the final published version of the article (version of record). It first appeared online via AHS International. Please refer to any applicable terms of use of the publisher.
A computational investigation of a helicopter main rotor with an active-camber morphing mechanism... more A computational investigation of a helicopter main rotor with an active-camber morphing mechanism was conducted to identify the capability to simultaneously save rotor power and reduce pitch-link loads using as low as possible camber deflection magnitudes. Comprehensive rotor aeromechanics analysis with elastic blade modeling and a free vortex wake for the aerodynamics model was used to ensure computational efficiency. The investigation was based on a full-scale Bo 105 helicopter main rotor in level flight condition at μ = 0.3 and C T /σ = 0.089. In addition to a variation of the radial position and length of the active-camber section, the capabilities and system behavior were investigated in an extensive parametric study using practical actuation inputs. The same computational framework was used to obtain optimal control inputs that led to best performance in terms of power savings using twoper-rev (2P) individual blade control (IBC) via pitch-link inputs and 2P active-twist control. The relative potential of the three active mechanisms and the aerodynamic phenomenology was compared. All of the investigated active-rotor mechanisms contributed to rotor power savings via a more uniform distribution of thrust over the rotor disk. Both IBC and active twist yielded maximum performance improvement of about 1.8% over the baseline in terms of power reduction. With active camber, simultaneous rotor power reduction of 3.8% and a peak-to-peak pitch-link load reduction of 20% were obtained using a nonharmonic camber deflection deployment schedule with a half-peak-to-peak magnitude of 2 •. The global maximum of power savings observed with active camber was 4.4%, which resulted in an increase of peak-to-peak pitch-link loads by 35% and a required half-peak-to-peak camber deflection magnitude of 3.6 • .
International Journal of Creative Research Thoughts (IJCRT), Apr 1, 2018
The revolution of ICT and Internet has transformed libraries from conventional to contemporary. T... more The revolution of ICT and Internet has transformed libraries from conventional to contemporary. This is the era of ICT where human beings are connected through ICT directlyor indirectly. Today, we cannot be imagine our life without Information and CommunicationTechnology (ICT). Internet and smart electronic devices such as Mobiles, Lap-Top, I-pad,etc. have became the significant parts of a student's life. Subsequently, we library professionals also adopted these technologies and modified our libraries in the form of 'Digital', 'Virtual', 'library 24x7', 'libraries without walls' and many more. There is no doubt that ICT and Internet have given the new life to the libraries and librarians as well as users have been taking optimum benefits through this technology. However, this is the one side of coin and definitely there is other side of coin, which shows the after effects of rapid use of Information and Technology that gradually students have been become impatient in order to collect superficial knowledge. Moreover, it has come into the notice very often the reading practices of the students have been declining. With these motives the present study has been taken place. Questionnaire tool has been used for data collection and simple statistical techniques have been used for analysis.100 students have randomly selected for survey and distributed questionnaire to them. In the users' response, 86 students have returned the filled questionnaire. Consequently, findings and suggestions are made.
Synthesis, characterization and evaluation of biosynthesized Cerium oxide nanoparticle for its anticancer activity on breast cancer cell (MCF 7)
Materials Today: Proceedings, 2021
Abstract Biosynthesis of metal oxide nanoparticles using plant attracted great interest recently,... more Abstract Biosynthesis of metal oxide nanoparticles using plant attracted great interest recently, due to its eco friendliness. Therefore, in the present study involves the synthesis of cerium oxide nanoparticle by using Brophyllamdaigremontianum plant ethanolic extract. The obtained powder was subsequently calcinated at 600 °C. Synthesized cerium oxide nanoparticles was confirmed by X-ray diffraction, Scanning electron microscopy, High resolution transmission electron microscopy, UV visible spectroscopy, Fourier transform infrared spectroscopy and Brunauer Emmett-teller (BET) measurement. To evaluate the anticancer activity of the spherical structured CeO2-Nps, it was tested towards the normal (L6) and breast cancer cell (MCF 7). It was found that Biosynthesized CeO2-Nps showed better cytotoxicity against cancerous MCF 7 cell line compared to normal L6 cell line due to its smaller size and high surface area.
The paper presents the modeling and also the numerical associate analysis over an optimisation of... more The paper presents the modeling and also the numerical associate analysis over an optimisation of camber position ever-changing for a small aerial vehicle application. This paper conferred the formed optimisation of cambered profile with 20% of chord length from edge, and during this study must be ascertained of mechanics performance over a wing. Firstly, the model was created by the planning software package and applying modularity and reconfigurability to a morphing wing system. A comparative analysis is conducted to explore the relationships between mechanics parameters and also the angle of attack. The results show that the morphing flap camber profiles considerably have an effect on mechanics performance. Associate analysis of the wind flow characteristics is enclosed as a supplementary validation; the pressure coefficients obtained through Ansys and thus lift, drag and lift-to-drag magnitude relation. When getting the results, each the results area unit compared before associated when morphing to prove an improvement within the lift, lift-to-drag, and reduction in drag simulation for many desired device shapes area unit compared. Hence forward when optimisation of the cambered profile in varied deflections in morphing edge because the given pure mathematics associated thus the results area unit showing for varied profiles when morphing there's an improvement in constant of lift from fifteen to thirty share of lift increasing when morphing edge.
Investigation of Active Rotor Design and Control for Performance Improvement
Proceedings of the Vertical Flight Society 75th Annual Forum
A computational investigation was conducted to identify the optimal performance of a rotor with a... more A computational investigation was conducted to identify the optimal performance of a rotor with an active camber morphing mechanism using up to twice-per-revolution (2P) control input. Using rotor comprehensive analysis with an elastic blade model and a free vortex wake for the aerodynamics model to ensure computational efficiency, a parametric study of design and control variables was carried out to identify their influence on rotor performance. The same computational framework was used to obtain optimal control inputs that led to best performance using 2P individual blade control (IBC) via pitch-link inputs and 2P active twist control. The relative potential of the three active mechanisms to improve rotor performance was studied and compared. A level flight condition at μ = 0.3 and CT /σ = 0.089 was used throughout this investigation. IBC or active twist both yielded maximum performance improvements of 1.8% in terms of power reduction. Optimal isolated 1P and 2P active camber actu...
A Proposal of FPGA-Based Low Cost and Power Efficient Autonomous Fruit Harvester
2020 6th International Conference on Control, Automation and Robotics (ICCAR)
In this paper, we present a power-efficient and low- cost prototype of a robotic harvester which ... more In this paper, we present a power-efficient and low- cost prototype of a robotic harvester which employs multiple subsystems such as fruit detection, odometry, localization, profi- cient manipulation through computer vision, deep learning and a novel end-effector design. Fruit Plucking is performed using an end effector, and 3-degree of freedom (DOF) arm (made out of the integration of two linear actuators and a rotating platform) consolidated with a 4-wheeled differential drive mobile platform. Effective implementation of the visual processing is executed on the FPGA Fabric of the Xilinx PYNQ-Z2 Board, which accelerates Deep Neural Networks (DNNs) with improved Latency and Energy Efficiency as compared to a CPU or GPU based implementation.
Conversations on social media (SM) are increasingly being used to investigate social issues on th... more Conversations on social media (SM) are increasingly being used to investigate social issues on the web, such as online harassment and rumor spread. For such issues, a common thread of research uses adversarial reactions, e.g., replies pointing out factual inaccuracies in rumors. Though adversarial reactions are prevalent in online conversations, inferring those adverse views (or stance) from the text in replies is difficult and requires complex natural language processing (NLP) models. Moreover, conventional NLP models for stance mining need labeled data for supervised learning. Getting labeled conversations can itself be challenging as conversations can be on any topic, and topics change over time. These challenges make learning the stance a difficult NLP problem. In this research, we first create a new stance dataset comprised of three different topics by labeling both users' opinions on the topics (as in pro/con) and users' stance while replying to others' posts (as in favor/oppose). As we find limitations with supervised approaches, we propose a weakly-supervised approach to predict the stance in Twitter replies. Our novel method allows using a smaller number of hashtags to generate weak labels for Twitter replies. Compared to supervised learning, our method improves the mean F1-macro by 8% on the hand-labeled dataset without using any hand-labeled examples in the training set. We further show the applicability of our proposed method on COVID 19 related conversations on Twitter.
Heterogeneous Activation Function Extraction for Training and Optimization of SNN Systems
2019 IEEE International Conference on Artificial Intelligence Circuits and Systems (AICAS)
Energy-efficiency and computation capability characteristics of analog/mixed-signal spiking neura... more Energy-efficiency and computation capability characteristics of analog/mixed-signal spiking neural networks offer capable platform for implementation of cognitive tasks on resource-limited embedded platforms. However, inherent mismatch in analog devices severely influence accuracy and reliability of the computing system. In this paper, we devise efficient algorithm for extracting of heterogeneous activation functions of analog hardware neurons as a set of constraints in an off-line training and optimization process, and examine how compensation of the mismatch effects influence synchronicity and information processing capabilities of the system.
In this paper, quasi-hemi-slant Riemannian maps from almost Hermitian manifolds onto Riemannian m... more In this paper, quasi-hemi-slant Riemannian maps from almost Hermitian manifolds onto Riemannian manifolds are introduced. The geometry of leaves of distributions that are involved in the definition of the submersion and quasi-hemi-slant Riemannian maps are studied. In addition, conditions for such distributions to be integrable and totally geodesic are obtained. Also, a necessary and sufficient condition for proper quasi-hemi-slant Riemannian maps to be totally geodesic is given. Moreover, structured concrete examples for this notion are given.
The Twelfth International Symposium on High-Performance Computer Architecture, 2006.
With reducing feature size, increasing chip capacity, and increasing clock speed, microprocessors... more With reducing feature size, increasing chip capacity, and increasing clock speed, microprocessors are becoming increasingly susceptible to transient (soft) errors. Redundant multi-threading (RMT) is an attractive approach for concurrent error detection and recovery. However, redundant threads significantly increase the pressure on the processor resources, resulting in dramatic performance impact. In this paper, we propose reducing resource redundancy as a means to mitigate the performance impact of redundancy. In this approach, all the instructions are redundantly executed, however, the redundant instructions do not use many of the resources used by an instruction. The approach taken to reduce resource redundancy is to exploit the runtime profile of the leading thread to optimally allocate resources to the trailing thread in a staggered RMT architecture. The key observation used in this approach is that, even with a small slack between the two threads, many instructions in the leading thread have already produced their results before their trailing counterparts are renamed. We investigate two techniques in this approach (i) register bits reuse technique that attempts to use the same register (but different bits) for both the copies of the same instruction, if the result produced by the instruction is of small size, and (ii) register value reuse technique that attempts to use the same register for a main instruction and a distinct redundant instruction, if both the instructions produce the same result. These techniques, along with some others, are used to reduce redundancy in register file, reorder buffer, and load/store buffer. The techniques are evaluated in terms of their performance, power, and vulnerability impact on an RMT processor. Our experiments show that the techniques achieve about 95% performance improvement and about 17% energy reduction. The vulnerability of the RMT remains the same with the techniques.
Compound heterozygous variants in Wiskott-Aldrich syndrome like (WASL) gene segregating in a family with early onset Parkinson's disease
Parkinsonism & Related Disorders, 2021
BACKGROUND Knowledge of genetic determinants in Parkinson's disease is still limited. Familia... more BACKGROUND Knowledge of genetic determinants in Parkinson's disease is still limited. Familial forms of the disease continue to provide a rich resource to capture the genetic spectrum in disease pathogenesis, and this approach is exploited in this study. METHODS Informative members from a three-generation family of Indian ethnicity manifesting a likely autosomal recessive mode of inheritance of Parkinson's disease were used for whole exome sequencing. Variant data analysis and in vitro functional characterisation of variant(s) segregating with the phenotype were carried out in HEK-293 and SH-SY5Y cells using gene constructs of interest. RESULTS Two compound heterozygous variants, a rare missense (c.1139C > T:p.P380L) and a novel splice variant (c.1456 + 2 delTAGA, intron10) in Wiskott-Aldrich syndrome like gene (WASL, 7q31), both predicted to be deleterious were shared among the proband and two affected siblings. WASL, a gene not previously linked to a human Mendelian disorder is known to regulate actin polymerisation via Arp2/3 complex. Based on exon trapping assay using pSPL3 vector in HEK-293 cells, the splice variant showed skipping of exon10. Characterisation of the missense variant in SH-SY5Y cells demonstrated: i) significant alterations in neurite length and number; ii) decreased reactive oxygen species tolerance in mutation carrying cells on Tetrabutylphosphonium hydroxide induction and iii) increase in alpha-synuclein protein. Screening for WASL variants in two independent PD cohorts identified four individuals with heterozygous but none with biallelic variants. CONCLUSION WASL, with demonstrated functional relevance in neurons may be yet another strong candidate gene for autosomal recessive PD encouraging assessment of its contribution across populations.
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