Papers by Sujithra Srinivas
Heart Rate Variability of Healthcare Workers during Covid-19
2022 IEEE International Symposium on Medical Measurements and Applications (MeMeA)
Epilepsy is one of the most common neurological condition, which has drastic effects on an indivi... more Epilepsy is one of the most common neurological condition, which has drastic effects on an individual’s lifestyle .However we do not have a complete understanding of manifestation or pathophysiology of seizures or epileptic conditions. This case study aims to bring out the strong association between sleep and epileptic triggers. Sleep disorders, sleep disturbance or poor quality of sleep are some of the frequently observed comorbid conditions in epileptic populations. In addition sleep deprivation highly influences the seizure triggers. The strong relationship between sleep and circadian rhythm influences the frequencies of the epileptic trigger in an individual. Some of the sleep syndromes are categorized under sleep-related epilepsy. The effects of sleep on seizure occurrence is varied, with respect to different types of epilepsy. On the other hand, sleep quality is affected due to the antiepileptic drugs (AED) or other treatments administered to the patient or due to epilepsy whi...
Review on the mechanistic links between sleep characteristic changes and epileptogenesis
IP Indian Journal of Neurosciences
Sleep and epilepsy are known to have a bidirectional interaction. Although sleep is differentiate... more Sleep and epilepsy are known to have a bidirectional interaction. Although sleep is differentiated into Rapid eye movement and Non Rapid eye movement sleep, Further gets classified into different stages based on the electroencephalogram EEG traces. Sleep is popularly studied using a Polysomnogram (PSG) which is the golden standard in measuring sleep metrics. In 1929 using an intervention with electroencephalography (EEG) made better contributions to objective investigations and clinical observations for unravelling further reasoning. Although there is an increasing evidences of sleep disturbance in most cases of epileptic syndromes the sleep interaction methods are very poorly reasoned out. Using invasive intracranial EEG the evidences obtained on cortical activities of the deep and superficial brain structures are given evidences on the interaction mechanisms of sleep and epilepsy. The sleep spindles are phasic events seen in non –rapid eye movement sleep in mammals. The sleep spin...
Review on circadian rhythm the role of core clock gene expression during sleep in epileptic syndrome
IP Indian Journal of Neurosciences
Circadian rhythm is a 24 hour or a day’s rhythmic oscillations with physiological and behavioural... more Circadian rhythm is a 24 hour or a day’s rhythmic oscillations with physiological and behavioural changes that is internally governed by the brain. This activity is generally anticipated by the internal and external cues from the environment. In circadian rhythm of our body is regulated by a transcriptional –translational Auto-regulatory loop which leads to the molecular oscillations of our “core clock genes” at a specific cellular level. In the many mammalian and animal models, the master pacemaker is in the hypothalamus at the suprachiasmatic nucleus (SCN) that can regulate downstream oscillations in the peripheral tissues of the brain. The core clock genes are self- sustained and cell autonomous not only on the pace maker but also on the other dissociated cultured cells and peripheral tissues. Here we can review the general mechanisms involved in the clock genes that is responsible for the circadian rhythmicity in epileptic syndromes and these findings can elucidate the cell spec...
Review study on epileptiform discharge during sleep and circadian rhythm modulation during seizures
Indian journal of anatomy and surgery of head, neck and brain, Apr 15, 2022
Circadian rhythm in epilepsy: A brief note on clock gene expression
Indian journal of anatomy and surgery of head, neck and brain, Apr 15, 2022
IP Indian Journal of Neurosciences
Infantile spasm (IS) comprises of both an age dependent epileptic seizure and distinctive seizure... more Infantile spasm (IS) comprises of both an age dependent epileptic seizure and distinctive seizure Onset in infants. In the recent past the key observation in classification and standardization of infantile spasm has culminated many recommendations in distinguishing and recognizing the seizure type and the epileptic syndrome or the West syndrome. The Infantile spasm is an early onset epileptic encephalopathy which presents unique electrographic and clinical features, these features are found in children in the middle of the first year of their birth .However the pathophysiology and the heterogeneity of the infantile spasm remains partially or incompletely understood. In the neurobiological basis there are multiple aetiologies converge to form similar clinical interpretations. The description of the electroencephalographic features of the spasm and its hypsarrthythmia plays a pivot role in early diagnosis. The treatment options for infantile spasm are very limited and it is also calle...
The increased awareness of autism spectrum disorder (ASD) has raised many concerns for proper car... more The increased awareness of autism spectrum disorder (ASD) has raised many concerns for proper care and significant methodology of treatment and diagnosis of the condition which has been made a prevalent public health issue. The visual deficits cause loss in visual integration and processing that contributes to anxiety and uneasiness. However, these deficits in most cases causes hindrances in school going children. This case study brings in brief account of vision based behaviors and cognitive deficit which affect children at school primarily focusing on hypersensitivity ,hyposensitivity ,lack of eye contact ,lack of focus on objects ,poor recognition and impaired visual motor integration. The case study involves a group of children ranging from 10 to 12 years with clinical diagnosis of autism was referred for assessment of poor visual focus and insufficient response. There was a notable poor visual perception and developmental delays with concerns primarily on inability to comprehend, poor spatial organization and attention deficits. Majority of them had been previously in speech and language therapy in collation with occupational therapy. Although the current diagnosis yield poor tracking and accuracy when presented with objects, which could be possible diagnosis of ocular motility. The study revealed that poor performances in visualization task, poor gross motor coordination and fine motor coordination. Also an additional to the concurrent therapies vision therapy was recommend to improve the visual motor integrations, visualization, focus and tracking of objects. Vision therapy with strategic framework when inculcated and adapted techniques which is proven to enhance the visual processing and integration in class room for the children with ASD.
Attention deficit hyperactivity disorder (ADHD) is one of the mental disorder experienced by chil... more Attention deficit hyperactivity disorder (ADHD) is one of the mental disorder experienced by children worldwide. ADHD when not treated at the childhood it can also exacerbate through the adulthood. Some of the symptoms includes hyperactivity, poor attention and impulsivity typical in children with Attention deficit hyperactivity disorder (ADHD).Occupational therapy is one of the most focused interventions for children with ADHD, the therapy techniques focus on play skills, sensory integrations, cognitive skills and motor functions. Moreover the occupational therapy interventions yield progressive results but however there were few limitations that has to be considered in terms of study design, interventional techniques used and the desired outcome measures. In this study occupational multi-dimensional model of practice is used as the primary intervention, which uses a multi-dimensional analysis and understanding of Attention deficit hyperactivity disorder (ADHD) and efficient management technique. The framework of the study was altered according to the specific co conditions experienced by the children in the study .The clinical study was carried out with occupational therapists with proper clinical analysis and study date was collected based on previous neurological condition of the children involved in the study. The analysis was carried out in three particular levels that include neurological level, psychological level and behavioral level.
The increased awareness of autism spectrum disorder (ASD) has raised many concerns for proper car... more The increased awareness of autism spectrum disorder (ASD) has raised many concerns for proper care and significant methodology of treatment and diagnosis of the condition which has been made a prevalent public health issue. The visual deficits cause loss in visual integration and processing that contributes to anxiety and uneasiness. However, these deficits in most cases causes hindrances in school going children. This case study brings in brief account of vision based behaviors and cognitive deficit which affect children at school primarily focusing on hypersensitivity ,hyposensitivity ,lack of eye contact ,lack of focus on objects ,poor recognition and impaired visual motor integration. The case study involves a group of children ranging from 10 to 12 years with clinical diagnosis of autism was referred for assessment of poor visual focus and insufficient response. There was a notable poor visual perception and developmental delays with concerns primarily on inability to comprehend, poor spatial organization and attention deficits. Majority of them had been previously in speech and language therapy in collation with occupational therapy. Although the current diagnosis yield poor tracking and accuracy when presented with objects, which could be possible diagnosis of ocular motility. The study revealed that poor performances in visualization task, poor gross motor coordination and fine motor coordination. Also an additional to the concurrent therapies vision therapy was recommend to improve the visual motor integrations, visualization, focus and tracking of objects. Vision therapy with strategic framework when inculcated and adapted techniques which is proven to enhance the visual processing and integration in class room for the children with ASD.
Attention deficit hyperactivity disorder (ADHD) is one of the mental disorder experienced by chil... more Attention deficit hyperactivity disorder (ADHD) is one of the mental disorder experienced by children worldwide. ADHD when not treated at the childhood it can also exacerbate through the adulthood. Some of the symptoms includes hyperactivity, poor attention and impulsivity typical in children with Attention deficit hyperactivity disorder (ADHD).Occupational therapy is one of the most focused interventions for children with ADHD, the therapy techniques focus on play skills, sensory integrations, cognitive skills and motor functions. Moreover the occupational therapy interventions yield progressive results but however there were few limitations that has to be considered in terms of study design, interventional techniques used and the desired outcome measures. In this study occupational multi-dimensional model of practice is used as the primary intervention, which uses a multi-dimensional analysis and understanding of Attention deficit hyperactivity disorder (ADHD) and efficient management technique. The framework of the study was altered according to the specific co conditions experienced by the children in the study .The clinical study was carried out with occupational therapists with proper clinical analysis and study date was collected based on previous neurological condition of the children involved in the study. The analysis was carried out in three particular levels that include neurological level, psychological level and behavioral level.
IJCRT - Journal, 2020
Epilepsy is one of the most common neurological condition, which has drastic effects on an indivi... more Epilepsy is one of the most common neurological condition, which has drastic effects on an individual's lifestyle .However we do not have a complete understanding of manifestation or pathophysiology of seizures or epileptic conditions. This case study aims to bring out the strong association between sleep and epileptic triggers. Sleep disorders, sleep disturbance or poor quality of sleep are some of the frequently observed comorbid conditions in epileptic populations. In addition sleep deprivation highly influences the seizure triggers. The strong relationship between sleep and circadian rhythm influences the frequencies of the epileptic trigger in an individual. Some of the sleep syndromes are categorized under sleep-related epilepsy. The effects of sleep on seizure occurrence is varied, with respect to different types of epilepsy. On the other hand, sleep quality is affected due to the antiepileptic drugs (AED) or other treatments administered to the patient or due to epilepsy which occurs during sleep stages. The side effects of antiepileptic drugs (AED) may also alter sleep cycles. Sleep studies are proven important in treatments for epilepsy which can help in monitoring diagnosis, treatment and prognosis of the patients.
IJSER Journal ISSN (Online): 2347-3878, 2020
Sudden unexpected death in epilepsy (SUDEP) as considerable death rates, which is caused by a neu... more Sudden unexpected death in epilepsy (SUDEP) as considerable death rates, which is caused by a neurological disorder. However the recent advancement in technology and medicine has improved diagnosis and treatments in seizures and epilepsy cont rol .Commercial available Anti epilepsy drugs (AED) are proven to have control over the conditions at a higher rate. Although wi th more efficient AED and diagnosis the sudden unexpected death in epilepsy (SUDEP) causes still remain highly unpredictable. The mortality rate of SUDEP is reasonably scattered in a broader spectrum which accounts to most inconclusive deaths which is not found under autopsy or toxicology study. The inconclusive nature of sudden unexpected death in epilepsy (SUDEP) has led to investigation of occurrences of the event and preventive measures for this fatal scenario which can lead to declination of ea rly death in epilepsy. In this short review, we compile evidence from epidemiological research of 70 sudden unexpected death in epileps y (SUDEP) cases, which can help an individual assess the personal risk of SUDEP. Besides varying global practices and health ca re policy, health care providers are looking forward to promote routine SUDEP awareness in patient counselling. Detailed understanding of the risk may improve the patient adherence to the disease, treatments and optimization of the death .
International Journal of Engineering Research in Computer Science and Engineering (IJERCSE) , 2016
Accidents are very common in big cities as there are many modes of transport and roads are conges... more Accidents are very common in big cities as there are many modes of transport and roads are congested and overcrowded.. Accidents often result in tragic loss of life and material. A large no of accidents are caused by the carelessness of the drivers and their ignorance and negligence of the traffic rules. Drowsiness is one key factor for road accidents. Researchers are being done to detect drowsiness and many techniques have been introduced .In this paper, the authors analyze the issue of drowsiness, propose a method to detect drowsiness and elaborate on its advantages and limitations. The approach is based on a combination of Physiological and Vision based measures We conclude that by combining a unique non-intrusive physiological measures with other measures help accurately determine the drowsiness level of a driver. This contributes positively towards preventing accidents by alerting the driver.
Cerebral palsy is a widely discussed physical and mental dysfunction that leads to disturbances i... more Cerebral palsy is a widely discussed physical and mental dysfunction that leads to disturbances in growth, sensory integration, gross motor function and mobility .It is now a very common childhood physical disability that affects millions across the globe. There are other differential diagnosis of cerebral palsy that includes various aspects like genetic disorders and metabolic disorders. The main objective of the study is to understand etiology, assisted impairments and conditions for the individuals with cerebral palsy to establish baseline functioning and monitoring of the developmental prognosis contributed to an increase of the evidenced-based recommendation for patients with cerebral palsy. The prevalence's of congenital cerebral palsy (CP) is observed using data available and also cerebral palsy existed as an individual disability or was combined by other disabilities. There are many complications which are evident in patients with cerebral palsy some are contractures and spasticity, drooling, feeding difficulties, communication difficulties, pain, osteopenia, fractures, osteoporosis and gastrointestinal functional abnormalities contributing to reduced bowel movements ,vomiting ,constipation and obstruction. The aim of treatment is to improve the independent capabilities and functionality of the individual. The Multispecialty treatment teams with various first line medical aids and therapeutic must be developed in order to provide continuous medical updated treatments for each patients. Historical treatment methods for conditions like cerebral palsy are challenged and new treatment modalities are still questioned for their essential benefits for the patients. The mortality and morbidity in the patients with cerebral palsy is from cerebrovascular disease, heart disease, trauma and cancer.
Juvenile myoclonic epilepsy (JME) is called an idiopathic generalized epilepsy which can be ident... more Juvenile myoclonic epilepsy (JME) is called an idiopathic generalized epilepsy which can be identified by generalized tonic-clonic seizures (GTCS), myoclonic jerks, absence seizures and spasms which is common in majority of the cases. Although early diagnosis of Juvenile myoclonic epilepsy (JME) still a consideration due to its multiple epilepsy and also there requires a clinical profile of EEG and sleep data of the individual to support the diagnosis. There is high spike wave discharges in sleep study of EEG of the individuals under study which shows significant increase during the sleep to awakening stage or transition phase and this is to be a specific finding using sleep data in appropriate clinical setting. Since the discovery of the anticonvulsant drugs like Valproate, lamotrigine and levetiracetam are the most commonly and are established antiepileptic drugs that are effective in broad spectrum of epilepsy diagnosis and treatment. The case study which involves the retrospective analysis of epileptic patients with Juvenile myoclonic epilepsy (JME) had functional motor impairment and also went into secondary therapies such as occupational therapy, physical therapy and sensory integration to cope up to the initial dysfunction caused due to generalized tonic-clonic seizures (GTCS), myoclonic jerks, absences seizures and spasms. The routine EEGs was recorded under clinical settings with and without administration of drugs depending upon the individuals and it was found to be abnormal in 68% of cases only and the data was incorrect or misleading findings in 9%.The population under study showed significant improvement with antiepileptic drugs and secondary therapies..
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Papers by Sujithra Srinivas