Papers by Suggala Satyanarayana
Journal of Nutrition Research, 2015
Spirulina, is a simple extract of blue-green algae, which is now used worldwide as a food product... more Spirulina, is a simple extract of blue-green algae, which is now used worldwide as a food product and as a dietary supplement. It contains, essential amino acids, lipids, vitamins, minerals and anti-oxidants and can be considered as a wholesome food supplement. Spirulina contains, approximately, 65% to 71% protein by dry weight and is claimed to be non toxic nutritious food with exceptional properties. A large amount of scientific literature available about Spirulina and its usage in treatment of child malnutrition, nutrition rehabilitation of HIV-infected, cancer patients, hepato-protective effects etc. However, there is no specific review available which gives more emphasis on the protein and energy content and its effects. In the present work, we reviewed several papers and reports and paid more attention on protein content, which is the major constituent of Spirulina and its effect on various disease conditions and possibility of using Spirulina in combating against Protein Ener...
A simple, sensitive and economical UV spectrophotometric method has been developed for the determ... more A simple, sensitive and economical UV spectrophotometric method has been developed for the determination of Risperidone in bulk and tablet dosage forms. Risperidone is an anti-psychotic drug, which shows maximum absorbance at 238nm in 0.1N HCl. Beer's law was obeyed in the concentration range of 5–30 μg/ml with correlation coefficient of 0.9999. The standard plot clearly showed a straight line passing through the origin. The results of analysis were validated statistically and by recovery studies and found to be satisfactory. The proposed method was extended to pharmaceutical formulations and there was no interference of additives and excipients.
Alexandria Journal of Medicine, 2018
Objectives: To analyze and report adverse drug reactions (ADRs) in a tertiary care teaching hospi... more Objectives: To analyze and report adverse drug reactions (ADRs) in a tertiary care teaching hospital. Methods: This was an observational study, conducted to analyze and communicate the ADRs reported from July 2016 to June 2017 in a south Indian tertiary care teaching hospital. On daily basis, ADRs reported by healthcare professionals (HCPs) were analyzed and the reports that meet pharmacovigilance programme of India (PvPI) reporting criteria were communicated to PvPI through a specified updated Indian Pharmacopoeia Commission (IPC) suspected ADR reporting form. In this study, ADRs were summarised based on demographics, drug, incidence, type of reaction and its outcome. Causality, severity, seriousness, and predictability were assessed through WHO causality assessment scale, Hartwig and Siegel Severity Assessment Scale and PvPI criteria. Results: A total of 254 ADRs communicated to PvPI through specified, updated IPC suspected ADR reporting form. The incidence of ADRs in both males and females was identical. The occurrence of ADRs in adult patients (71.26%) was significantly higher than other age groups. Of total ADRs, most of them were with Antibiotics (24.01%) followed by antipsychotics (11.42%). In causality assessment, a majority of ADRs (48.82%) were considered possibly related to the drug or treatment and 55.12% were mild in severity. Overall, 36.22% patients were recovered from ADRs. Most of the reported ADRs (54.33%) were probably preventable. Conclusions: The results provided an insight to the HCPs on the importance of monitoring and reporting of ADRs. High-quality data gathered through a reporting system, most of the reported ADRs were probably preventable; the proper review of patient history and monitoring by HCPs can reduce the incidence of ADR. Our study results emphasize a need for establishing a pharmacovigilance centre to ensure the safe use of drugs.
Journal of Materials Science: Materials in Electronics, 2017
Express Polymer Letters, 2016
Cadmium sulfide (CdS) nanoparticles have been synthesized by hydrothermal method and dispersed in... more Cadmium sulfide (CdS) nanoparticles have been synthesized by hydrothermal method and dispersed in poly vinyl alcohol (PVA) matrix in varying amounts by weight. Subsequently, PVA/CdS nanocomposites have been synthesized with the objective of investigating the effect of CdS nanoparticles on structural and electrical properties of PVA films. Structural properties were analyzed by Fourier transform infrared spectroscopy (FTIR), X-ray diffraction (XRD) and scanning electron microscopy (SEM) techniques. Differential scanning calorimetry (DSC) was used to investigate thermal properties of PVA/CdS nanocomposites. Electrical properties were measured by using high frequency LCR meter and were found to be strongly dependent on frequency and nano CdS content. Dielectric constant decreased with increase in frequency and with increase in nanofiller concentration. AC conductivity and dielectric loss increased with frequency and decreased with increase in nano CdS content.
Journal of Bioremediation and Biodegradation, 2012
In the present paper, toxic effects and bioaccumulation of cadmium (II) ions by blue-green algae ... more In the present paper, toxic effects and bioaccumulation of cadmium (II) ions by blue-green algae Spirulina (Arthrospira) indica were discussed. Lab scale open race way ponds (0.5 m long, 0.4 m wide and 0.075 m deep) with Zarrouk medium and S. (Arthrospira) indica culture was loaded with various initial cadmium (II) ion concentrations (1-10 mg/L). The growth of S. (Arthrospira) indica was monitored for eight days. The growth of S. (Arthrospira) indica was adversely affected by Cd (II) at high concentrations (>1 mg/L), however at low concentrations upto 1 mg/L, Cd (II) could stimulate its growth slightly. The toxic effect of cadmium (II) ions was modeled by assuming Monod growth kinetics with competitive inhibition. The percentage decrease in the S. (Arthrospira) indica biomass was found to be 54.32% at 4 mg/L Cd (II) after 7 days. The lethal concentration and time (LCt50) of Cd (II) ions for seven days was measured as 3.61 mg/L. The organism was found tolerant up to 1 mg/L of Cd (II) and can have potential applications in removal of low concentration of Cd (II) ions from contaminated waters. The biosorption experiment was conducted at various initial Cd (II) concentrations (1-4 mg/L) with live S. (Arthrospira) indica . The biosorption equilibrium time was found to be 6 min. It had been observed that at the initial stage (0-5 min) the adsorption rate was so rapid that 80% of the metal had been biologically adsorbed. The experimental equilibrium data was verified using Langmuir and Freundlich adsorption isotherms. The maximum biosorption capacity of live S. (Arthrospira) indica was estimated to be 66.97 mg Cd (II) per gdw of S. (Arthrospira) indica . The study provides a new insight into the impact of cadmium (II) ions on S. (Arthrospira) indica , especially with regard to its toxicity, bioaccumulation and bioremediation potential.
Journal of Membrane Science, 2004
Anhydrous hydrazine, used as rocket propellant, is an important inorganic compound and is obtaine... more Anhydrous hydrazine, used as rocket propellant, is an important inorganic compound and is obtained by dehydrating hydrazine hydrate. However, hydrazine forms an azeotrope with water which makes conventional separation processes energy intensive. Pervaporation may act as an alternative process; however, because of the highly alkaline nature of hydrazine, proper selection of polymer plays a vital role. Several polymeric membranes (PERVAP ® 2200, 2201 and 2202, ethyl cellulose (EC), acrylonitrile butadiene styrene (ABS), polystyrene, and modified EC) were chosen to study separation characteristics. Reacting EC with phenyl isocyanate and varying its amount, modifications were carried out in order to alter the hydrophilic characteristics of the membrane to hydrophobic. 1 H NMR spectra estimated degree of substitution in terms of carbamate groups. Contact angle measurements were taken to observe hydrophilic/hydrophobic characteristics. The higher contact angles of water with modified EC membranes, compared to unmodified form, indicate increase of hydrophobicity of the membranes. Further, FT-IR, XRD and positron annihilation techniques were employed to observe characteristics of one such modified ethyl cellulose membrane. Sorption studies were also carried out and sorption of both water and hydrazine hydrate in modified EC membrane were observed to be lower compared to unmodified. Pervaporation studies with all chosen polymers revealed selective diffusion of water playing major role compared to sorption. Further, apolar materials exhibited higher separation factors than polar materials. Encouraging results, in terms of higher PSI, were obtained with modified EC (262.4) and ABS (395.9) membranes.
Asian Journal of Research in Chemistry, 2011
The present work describes a simple, precise and accurate HPLC method for estimation of darifenac... more The present work describes a simple, precise and accurate HPLC method for estimation of darifenacin hydrobomide in bulk and in tablet dosage form. The separation was achieved by using Waters Sunfire C 18 (4.6 X 250 mm) 5μm particle size column. The mobile phase consisted of 0.02M potassium dihydrogen phosphate buffer pH 7 adjusted with triethylamine: acetonitrile: methanol in the ratio of 40:30:30(v/v/v). Detection was carried out at 280 nm. The retention time of darifenacin hydrobromide was found to be 4.2 min respectively. The Limit of detection and limit of Quantification was found to be 2.112 μg/mL and 6.400 μg/mL respectively. The accuracy and reliability of the proposed method was ascertained by evaluating various validation parameters like linearity (10–100 μg/mL), precision, accuracy and specificity according to ICH guidelines. The proposed method provides an accurate and precise quality control tool for routine analysis of darifenacin hydrobromide in bulk and in tablet dosa...
Pharmacy Education, 2021
Introduction: Lack of awareness about pharmacovigilance (PV) is one of the most important causes ... more Introduction: Lack of awareness about pharmacovigilance (PV) is one of the most important causes of under-reporting, which is widespread and poses a daunting challenge in India. The aim of this study is to assess and to document the knowledge, attitude, and practices (KAP) of Doctor of Pharmacy (Pharm.D) interns who practicing in hospitals with regards to PV and adverse drug reaction (ADR) reporting and to identify the causes of under reporting. Methods: This cross-sectional descriptive study was conducted for a period of six months across ten hospitals in Andhra Pradesh, India. Results: Overall, 578 responses were analysed, 78% of the participants had good knowledge on reporting ADR, 82% were aware that patient will be benefited from the ADR reporting, and the majority of the participants had a positive attitude towards reporting ADR. Fifty-nine percentage of the participants had reported the ADRs through different ADR reporting procedures, 52% were advised the awareness programmes...
Crude extracts of Cuscuta reflexa (Cuscutaceae Convolvulaceae) were evaluated for in-vitro anthel... more Crude extracts of Cuscuta reflexa (Cuscutaceae Convolvulaceae) were evaluated for in-vitro anthelmintic activity on the Indian adult earthworms Pheritima posthuma. The extracts of Cuscuta reflexa have shown a dose dependant inhibition of spontaneous motility (Paralysis) of earthworms. It has been observed that all petroleum ether, chloroform and methanol extracts have shown anthelmintic activity, which was compared with albendazole as reference drug. The exact mode of action and the constituents responsible for the anthelmintic a ctivity needs to be investigated.
Journal of Advances in Medicine and Medical Research, 2020
Objectives: To analyse the adverse drug reactions (ADR) and related economic burden on the health... more Objectives: To analyse the adverse drug reactions (ADR) and related economic burden on the health care system and health seekers Methods: A prospective observational study was conducted in a South Indian tertiary care teaching hospital from July 2016 – December 2018.ADRs were analyzed for their causality, severity, predictability, and preventability through standard scales and were reported to the Pharmacovigilance Program of India (PvPI) through a specified updated Indian Pharmacopoeia Commission (IPC) suspected ADR reporting form. The total cost burden including both direct and indirect were calculated by assessing the ADR management including the clinical investigations done. The indirect cost was calculated based on the per capita analysis by using the Gross Domestic Product (GDP) of our study area. Results: Among 458 ADRs, 81.88% were reported in Adult population with an almost same incidence in both the genders, majority were probable (41.70%) and Antibiotics were most commonl...
International Journal of Applied Pharmaceutics, 2019
Objective: The current research was structured to achieve a maximum topical delivery for the drug... more Objective: The current research was structured to achieve a maximum topical delivery for the drug clobetasol-17-propionate (CP) and to predict the effects of various independent variables like lipid: drug ratio, surfactant, and homogenization time on particulate characters and performance solid lipid nanoparticles (SLNs). Methods: CP loaded SLNs were formulated by Emulsification–Homogenization method and optimized using 33 full factorial designs (Design-Expert software 11.0). Drug loaded SLNs were evaluated for various parameters like particle size, surface charge, polydispersity index, entrapment efficiency, surface morphology, thermal analysis, in vitro drug release through skin (Franz diffusion cell), drug deposition study and stability. Results: The optimized formulation (SLNs) attains a minimal Particle size of 133.3±3.66 nm, Poly dispersibility index of 0.179±0.081, % entrapment efficiency of 78.1±1.11 and Zeta potential of-36.2±0.11mV. Skin permeation study of CP loaded SLNs ...
International Journal of Research in Pharmaceutical Sciences, 2019
Stomach Specific Floating Tablets (SSFT) with a combination of Amoxicillin-Trihydrate (AT) and Ra... more Stomach Specific Floating Tablets (SSFT) with a combination of Amoxicillin-Trihydrate (AT) and Ranitidine Hydrochloride (RH) were developed by using different grades of Hydroxypropylmethylcellulose (HPMCK) (i.e.HPMCK 100M, HPMCK4M and HPMCK15M), to treat patients with H. pylori-infected duodenal ulcer. Floating tablets were prepared by direct compression method, developed formulations were evaluated for different pre-compression and post-compression parameters like angle of repose, compressibility index, hardness, weight variation, floating lag time, content uniformity, and in-vitro drug release. In-Vitro release of two drugs (Amoxicillin-Trihydrate and Ranitidine hydrochloride) from the developed formulation was estimated by the Simultaneous Estimation method (Vierordt's Method). The optimized formulation was subjected to Radio graphical evaluation by incorporating the BaSO4, a radio-opaque substance by replacing a part of the drug from the optimized formulation of into the for...
Asian Pacific Journal of Tropical Biomedicine, 2012
Abstract Objective Evaluation of preliminary antiinflammatory and cytotoxic activities of a paras... more Abstract Objective Evaluation of preliminary antiinflammatory and cytotoxic activities of a parasitic plant Cuscuta reflexa . Methods Human red blood stabilizing activity was used for the evaluation of in vitro antiinflammatory activity and Brine shrimp lethality assay was used to assess the cytotoxic potential of extract of stems of Cuscuta reflexa. Results Methanolic extract and Ethyl acetate fraction of methanolic extract of Cuscuta reflexa (MECR & EAMECR resp.) were found to have significant antiinflammatory and cytotoxic activity with inhibitory concentration IC50% values 277.83 μg/ml & 214.94 μg/ml in HRBC stabitlity assay[table 01], and lethal concentration LC50% 257.73 μg/ml 184.86 μg/ml in BSLA respectively[table 02]. Conclusions Amongst various extracts evaluated for cytotoxicity and antiinflammatory activities, methanolic extract of Cuscuta reflexa (MECR) and its ethyl acetate soluble fraction (EAMECR) show significant cytotoxic as well as antiinflammatory activities which may be due to the presence of phenols, polyphenols and flavonoids.
Separation and Purification Technology, 2013
Abstract Recovery of solvents from aqueous industrial effluents containing hazardous compounds is... more Abstract Recovery of solvents from aqueous industrial effluents containing hazardous compounds is not directly feasible by conventional methods due to the complex nature of such wastewaters. An effluent from a pharmaceutical industry contains 2–3 wt% explosive sodium azide + corrosive ammonium chloride salts, 15–20% dimethylsulfoxide (DMSO) solvent and water. The focus of this work is to establish a hybrid process to facilitate removal of salts by electrodialysis (ED) followed by distillation to recover DMSO. An indigenously constructed ED system of 1.05 m 2 membrane area was used to process 10 L batch size. Pure DMSO was recovered from desalted liquor by vacuum distillation in two stages to obtain DMSO concentration up to 60–70% in the first stage and subsequent recovery of pure DMSO in the second. Effect of operating parameters such as flow rate, limiting current density and voltage was evaluated. Distillation was carried out at 20–30 mmHg at reboiler temperature below 150 °C. Drug prepared using the recycled DMSO (>99.5%) was found to meet desired specifications. Detailed design of the ED–distillation process scheme to treat 7500 L/day of the effluent revealed that it was technically and economically feasible, since 30 Metric Tonnes of solvent has been recovered by the industry.
Journal of Pharmaceutical Research International
Direct compression was utilized to develop the floating tablets, because of moisture sensitivity ... more Direct compression was utilized to develop the floating tablets, because of moisture sensitivity of Felodipine(FD), formulation included polymers such as CARBOPOL 934 & HPMC K 15 M. FD Floating tablets were designed to enhance drug availability by prolonging gastric retention time (GRT). Physical properties of tablets, such as hardness, thickness, friability, and weight variation as well as drug content and floating behaviors, were evaluated. Further, tablets were studied for In vitro drug release tests for 12 hours, while floating in the dissolution medium, In- vivo imaging studies were conducted. According to FTIR studies, there is no interaction between the drug and polymer, In-vitro buoyancy of tablets was 12 hours, the in-vitro dissolution release studies exhibited sustained and prolonged drug release profiles. The release mechanism from these tablets has been confirmed to be non-Fickian diffusion, which also fits the zero order and higuchi models, GRT of floating tablets was o...
Uranium Corporation of India Limited (UCIL) has established a new uranium mining and milling faci... more Uranium Corporation of India Limited (UCIL) has established a new uranium mining and milling facility at Tummalapalle which is under geological region of Cuddapah basin, Andhra Pradesh, India. A study is carried out to measure the background concentration of natural uranium and other physicochemical parameters in drinking water around Tummalapalle uranium mining and milling site. Drinking water samples were collected from 24 locations in Post monsoon (March-May) and Pre monsoon (Oct-Dec) seasons during 2010-11. P H , EC, Salinity and TDS were analyzed in-situ using Systronics water analyzer kit and uranium concentration was estimated using Laser Flourimeter at Nuclear Fuel Complex, Hyderabad. The uranium concentration varied from 3±1 µg/l to 29±5 µg/l and was below the drinking water guideline value of 30 µg/l set by WHO. The correlation studies between the analyzed parameters were also carried out.
The present study was conducted to investigate the quality of hen eggs in respect of mineral cont... more The present study was conducted to investigate the quality of hen eggs in respect of mineral content and to elaborate the possibility of contamination of heavy metals and their distribution. The eggs were collected from surroundings of Tummalapalle Uranium mining site, India. The heavy metals (Al, Cr, Mn, Fe, Ni, Cu, Zn, Pb, V, Co, As, Cd and U) were estimated with the help of Inductively Coupled Plasma Mass Spectrometer (ICP – MS) by following open acid digestion technique. Concentration of essential elements like Fe, Al and Zn were in the range of 34.4 – 98.3 mg/kg, 2.5 – 71.1 mg/kg and 3.9 – 63.0 mg/kg, respectively. Elements like U and Cd were in the range of 1.3 – 12.6 µg/kg and 2.3 – 15.4 µg/kg, respectively. The mean concentration of hen egg samples for all the estimated heavy metals are found to be below the permissible limit and are in comparison with the literature reported values from various parts of the world. Further, the estimated heavy metal data were subjected to st...
Removal of dyes from polluted effluent is an essential task for environmental protection. The stu... more Removal of dyes from polluted effluent is an essential task for environmental protection. The studies carried through environmental biotechnology have shown that many sorbents present in the nature have great capacity for removal of dyes. Therefore, in the present work Syzygium cumini L is used for the removal of Methylene blue dye from aqueous solution. The effect of pH, initial dye concentration, biosorbent dosage, biosorbent average particle size and temperature are varied to study their effect on removal efficiency. It was found that a maximum amount of 93.45% dye was removed from the aqueous solution with 0.1 g of Syzygium cumini leaf powder from 30 ml of aqueous dye solution containing 20 mg/L of dye at room temperature and pH of 8 with Sorbent size 75 µm in 20 min. The experimental data were fitted with Freundlich, Langmuir and Redlich-Peterson isotherms and good fit was observed with Langmuir isotherm. Thermodynamic parameters like Gibbs free energy, enthalpy and entropy is ...
The present study is to carry out the baseline survey on evaluation of Aluminium (Al), Chromium (... more The present study is to carry out the baseline survey on evaluation of Aluminium (Al), Chromium (Cr), Manganese (Mn), Iron (Fe), Nickel (Ni), Copper (Cu), Zinc (Zn), Lead (Pb), Vanadium (V), Cobalt (Co), Arsenic (As), Cadmium (Cd) and Uranium (U) concentrations in chicken samples of the surrounding villages of the Tummalapalle uranium mining site, Andhra Pradesh, India. The trace metal concentrations were estimated using Inductively Coupled Plasma Mass Spectrometer (ICP – MS). As per the estimated data, the concentrations of trace metals are found in the range of 23.5 - 309.0 mg/kg for Al, 1.9 – 2.9 mg/kg for Cr, 0.8 – 2.3 mg/kg for Mn, 56.8 – 87.3 mg/kg for Fe, 0.2 – 0.6 mg/kg for Ni, 0.6 – 2.3 mg/kg for Cu, 16.8 – 31.6 mg/kg for Zn, 0.3 – 0.7 mg/kg for Pb, 88.2 – 160.6 µg/kg for V, 30.9 – 55.2 µg/kg for Co, 11.6 – 47.6 µg/kg for As, 7.2 -60.6 µg/kg for Cd and 4.9 – 35.2 µg/kg for U. The average trace metal concentrations of chicken samples are found to be below the permissible lim...
Uploads
Papers by Suggala Satyanarayana