Papers by Subhrangshu Sengupta
International journal of innovative research and development, 2013
Aim: To assess whether phacoemulsification or phacotrabeculectomy (with adjunctive Mitomycin C) i... more Aim: To assess whether phacoemulsification or phacotrabeculectomy (with adjunctive Mitomycin C) is the surgery of choice in eyes with chronic angle closure glaucoma (CACG) with concomitant cataract. Method: Patients with CACG and coexisting cataract were randomized into 2 groups, comparing phacoemulsification (Group A) versus combined phacotrabeculectomy with adjunctive Mitomycin C (Group B). Group A had 62 eyes of medically controlled CACG with Cataract and 56 eyes of medically uncontrolled CACG with cataract. Group B had 55 eyes of medically controlled CACG with Cataract and 59 eyes of medically uncontrolled CACG with cataract. The 2 groups had identical study designs. All patients were reviewed three-monthly for two years after surgery. The main outcome measure was the surgical complications of phacoemulsification versus phacotrabeculectomy in CACG eyes with cataract Result: In Group A, five(4.2%) of the 118 eyes reported four surgical complications while in Group B, eighteen(15....
Aim: To clinically analyse the various optic nerve head parameters in a rural and urban populatio... more Aim: To clinically analyse the various optic nerve head parameters in a rural and urban population in West Bengal aged over 40 years and with open angles. Materials and Methods: This research work has two arms, the rural arm is an eye care centre in Hooghly District of West Bengal (Village: Kuliapara, P.O. Dhobapara, P.S. Balagarh) and the urban arm is a tertiary eye hospital in Kolkata, West Bengal. People aged 40 years and above or those turning 40 in the calendar year and not on any topical or systemic medications underwent complete ophthalmological examination including clinical evaluation of optic nerve head with slit lamp biomicroscopy. Patients with history of intraocular surgery, ocular trauma, and corneal opacities preventing accurate applanation tonometry and media haze dense enough to preclude adequate fundal view were not enumerated. Results: The sample size analysed is 1641, making it one of the largest study of its kind in India. There is a positive correlation of VCDR...
Indian Journal of Ophthalmology, 2020
Purpose: Glaucoma is the leading cause of irreversible blindness in the world. The current study ... more Purpose: Glaucoma is the leading cause of irreversible blindness in the world. The current study aims to estimate prevalence, features, and associations of open angle glaucoma (OAG) in a rural and urban East Indian population. Methods: This is a population based cross sectional study with two arms, rural (28 contiguous villages from 13 Gram Panchayats in Balagarh Police Station, Hooghly district) and urban (Kolkata). Individuals residing in the study area aged 40 years and above were included using multistage random cluster sampling. All subjects underwent a detailed ophthalmic examination at our base hospitals including applanation tonometry, ultrasound pachymetry, gonioscopy, and frequency doubling technology perimetry. The primary outcome was the prevalence of POAG (95% CI). Age and gender specific prevalence estimates were calculated. Multiple logistic regressions were used to analyze the risk factors. Results: Data from 7128 and 6964 subjects aged 40 years or older from Kolkata city and Hooghly district, respectively were analyzed. In the urban population, 2.10% (95% CI: 1.99–2.21%) had POAG and 0.15% (95% CI: 0.13–0.17%) had secondary OAG. In the rural population, 1.45% (95% CI: 0.59–2.31%) had POAG and 0.10 ± 0.03% (95% CI: 0.07–0.13%) had secondary OAG. Conclusion: The study concludes that higher age, higher vertical cup disc ratio (VCDR), and lower central corneal thickness (CCT) are important independent predictors of OAG and emphasizes that increased intraocular pressure (IOP) is not POAG. Gonioscopy, disc evaluation, and screening perimetry need to be incorporated in the detection protocol for glaucoma if we intend to lighten the burden of blindness due to glaucoma.
Indian journal of ophthalmology, Sep 1, 2018
To estimate the prevalence, features, and associations of primary angle closure disease (PACD) in... more To estimate the prevalence, features, and associations of primary angle closure disease (PACD) in rural and urban populations from West Bengal in eastern India. This was a population-based cross-sectional study with two arms, rural and urban. The rural study area consisted of 28 contiguous villages from 13 gram panchayats in Balagarh Police Station, with rural base hospital at Dhobapara, Balagarh Police Station, in the village Kuliapara of Hooghly district. A tertiary eye hospital in central Kolkata was the urban study center. Individuals residing in the study area aged 40 years and above were included in this study using multistage random cluster sampling. All subjects underwent a detailed ophthalmic examination at our base hospitals including applanation tonometry, ultrasound pachymetry, gonioscopy, and frequency doubling technology perimetry. Data collected were analyzed using SPSS 13. Multiple logistic regressions were used to analyze risk factors for PACD. A total of 7,408 and ...
Indian Journal of Ophthalmology, 2016
Glaucoma, the leading cause of global irreversible blindness, is estimated to have affected over ... more Glaucoma, the leading cause of global irreversible blindness, is estimated to have affected over 60.5 million persons worldwide. The estimated prevalence for India was 11.9 million in a study conducted in the late 1990s; the number has only increased since. Urban and rural India differ in patient demographics, disease patterns, and access to ophthalmic care. The only glaucoma prevalence study from Eastern India examined 1269 subjects from a rural population. The purpose of the Hooghly River Glaucoma Study (HRGS) was to examine the prevalence of glaucoma in a larger rural and urban East Indian population to make the results comparable to other international landmark glaucoma prevalence studies. The HRGS was a population-based cross-sectional study. The Institutional Ethics Review Board approved the study that adhered to the tenets of the Declaration of Helsinki. The sample size required for a precise estimate of the prevalence of glaucoma was calculated based on the methodology of other prominent prevalence studies. Assuming a 3.5% prevalence of glaucoma based on the Andhra Pradesh Eye Diseases Study (APEDS), Vellore Eye Study, and Chennai Glaucoma Study (CGS) and a design effect of two, the required sample size (n) was calculated using Daniel's Formula. Kolkata city was our urban study area. The city is divided into 15 boroughs and 141 wards. [13] One division was randomly selected from each of these 15 boroughs and 8 divisions were randomly picked from those 15 divisions. The following areas of Kolkata constituted the eight randomly selected divisions: (i) Bidhan Sarani, (ii) C. R. Avenue, (iii) Rash Behari Avenue, (iv) Prince Anwar Shah Road, (v) Diamond Harbour Road, (vi) Circular Garden Reach Road, (vii) B. T. Road, and (viii) A. J. C. Bose Road. A simple random sample of 910 each from the above eight randomly selected divisions was enumerated to reach a sample size of 7248 for our urban population. The rural study area consisted of 28 contiguous villages from 13 Gram Panchayats in Balagarh Police Station of Hooghly district in West Bengal, which was within a 20 km radius surrounding the rural base hospital located at Dhobapara, Balagarh Police Station, in the village Kuliapara of this district.
Aim: Analysis of difference in Central Macular Thickness (CMT) by time domain Optical Coherence T... more Aim: Analysis of difference in Central Macular Thickness (CMT) by time domain Optical Coherence Tomography (OCT) in normal, glaucoma suspects and glaucomatous patients and establishing whether asymmetry in horizontal macular hemifield thickness (MHT) can detect early glaucoma. Methods: From a macular thickness map of OCT, difference of values vertically just beyond the centre (called DMT1) and the topmost-lowermost values of the macular thickness map (DMT2) were calculated for normal patients to establish a normative database. The number of glaucomatous patients and glaucoma suspects with either of the two DMT values outside 95% CI (+- 1.96 SD) was also calculated. Results: 200 healthy eyes, 105 eyes of glaucoma suspects and 65 glaucomatous eyes (45 early(EG) and 20 moderate-severe(M-SG)) were included in the study of whom 6.5%, 33.3%, 82.2% and 70% respectively had abnormal MHT(DMT values outside 95% CI). The M-SG group had the overall lowest macular thickness which was statistical...
Aim: To clinically analyse the various optic nerve head parameters in a rural and urban populatio... more Aim: To clinically analyse the various optic nerve head parameters in a rural and urban population in West Bengal aged over 40 years and with open angles. Materials and Methods: This research work has two arms, the rural arm is an eye care centre in Hooghly District of West Bengal (Village: Kuliapara, P.O. Dhobapara, P.S. Balagarh) and the urban arm is a tertiary eye hospital in Kolkata, West Bengal. People aged 40 years and above or those turning 40 in the calendar year and not on any topical or systemic medications underwent complete ophthalmological examination including clinical evaluation of optic nerve head with slit lamp biomicroscopy. Patients with history of intraocular surgery, ocular trauma, and corneal opacities preventing accurate applanation tonometry and media haze dense enough to preclude adequate fundal view were not enumerated. Results: The sample size analysed is 1641, making it one of the largest study of its kind in India. There is a positive correlation of VCDR...
IOSR Journal of Environmental Science, Toxicology and Food Technology, 2014
Dry eye represents a multifactorial, heterogeneous disorder of the preocular tear film, which res... more Dry eye represents a multifactorial, heterogeneous disorder of the preocular tear film, which results in ocular surface disease. The tear film and ocular surface form a complex and stable system that can lose its equilibrium through numerous disturbing factors. [1] Reduction in quality of life is inevitable when symptoms of dry eye occur. These symptoms range from mild transient irritation to persistent dryness, burning, itchiness, redness, pain, ocular fatigue and visual disturbance. In the United States alone, approximately 7-10 million Americans require artificial tear preparations, with consumers spending over $100 million/year. [2] Reported prevalence of dry eye is diverse, with questionnaire based surveys documenting rates ranging from 14.4% to 33% of the population sampled. 4, Studies which also involve tests of tear function including Schirmer's test, tear break up time, fluorescein staining, or rose bengal staining for determination of dry eye have found generally lower prevalence rates. Our study aims to study the prevalence of dry eye in a rural and urban population from West Bengal and analyse the role of air pollution as a causative agent of the same. This research work is a population based cross sectional study and has two arms, the rural arm and the urban arm. The urban arm has a tertiary eye hospital in Kolkata as the clinical examination centre, whereas an eye care centre in Kuliapara village (P.O. Dhobapara, P.S. Balagarh) of Hooghly district is the rural examination centre. Rural: The rural study area consists of 13 Gram Panchayats in the Balagarh Block of the Chinsurah Sub Division of Hugli district in West Bengal. [8] The total population of Balagarh sub district is 214,784 and this block has 46,022 households. 45,019 households having a population of 210,065 are classified as rural in the 2011 census. [9] The patients from the rural study area were transported to our rural Examination Centre which is located in village Kuliapara of Hooghly district. Social workers and volunteers belonging to Kuliapara village distributed leaflets throughout Balagarh regarding the Eye Check Up camps and also helped in word of mouth publicity with active participation of corresponding panchayats. Urban: Kolkata District under the Kolkata Metropolitan Area(KMA) in West Bengal is our urban study area. KMA is the largest urban agglomeration in eastern India, extends over 1851.41 sq. km. and envelopes three Municipal Corporations including Kolkata Municipal Corporation, Howrah Municipal Corporation and Chandannagore Municipal Corporation; and 38 Municipalities. [10] KMA has a population of 14,112,536, according to 2011 Census. [11] Kolkata District is bordered by Howrah District, North 24 Parganas District and South 24 Parganas District and has 11 Assembly Constituencies. [12] Kolkata District has a population of 4,572,876 and it has 929,586 households, all of whom are classified as urban in the 2011 Census. [13] Subjects residing in Kolkata District coming for ophthalmologic check up at the out patient department (OPD) of the tertiary eye hospital in Kolkata and fulfilling the laid down inclusion criteria were enrolled into the study. Institutional Ethics Committee approval was obtained before conducting this cross sectional research work. The clinical examination and data collection lasted from July to December 2013. All patients were examined by an ophthalmologist. The dry eye questionnaire was administered by a social scientist. The examinations, in brief, were as follows : (a) Ocular and medical history --A detailed history pertaining to medical and ophthalmic problems was elicited. History elicited includes use of glasses and its duration, history of previous trauma or surgery or laser in the eyes, family history of glaucoma, history of ocular and oral medication, significant systemic illness with special reference to diabetes or hypertension, significant family history and addiction history. (b) Refraction and recording of uncorrected and best-corrected visual acuity (c) Torch light external ocular examination including ocular movements and any other obvious strabismus / eyelid pathology.
IOSR Journal of Dental and Medical Sciences, 2013
Aim: To study the correlation between central corneal thickness (CCT) measured by ultrasound pach... more Aim: To study the correlation between central corneal thickness (CCT) measured by ultrasound pachymetry and Frequency Doubling Technology Perimetry (FDT) in patients aged more than or equal to 40 years with high IOP and normal discs. Materials and Methods: This research work has two arms, the rural arm is an eye care centre in Hooghly District of West Bengal (Village: Kuliapara, P.O. Dhobapara, P.S. Balagarh)and the urban arm is a tertiary eye hospital in Kolkata, West Bengal. People aged 40 years and above or those turning 40 in the calendar year with high IOP and normal discs and not on any topical or systemic medications underwent complete ophthalmological examination including CCT assessment by ultrasound pachymetry (Ocuscan RxP) and FDT (Humphrey, Carl Zeiss) . Patients with history of intraocular surgery, ocular trauma, corneal opacities preventing accurate applanation tonometry and media haze dense enough to preclude adequate fundal view were not enumerated. Results: One hundred and eighty subjects fulfilled the laid down study inclusion criteria. Average CCT for the right eye(RE) is 530.74 µ and that for the left eye(LE) is 531.32µ(p=0.61, not statistically significant). IOP in the RE varied from 18 to 32 mm Hg with an average value of 23 mm Hg and that in the LE varied from 14 to 32 mm Hg with an average value of 22 mm Hg. Abnormal FDT in either eye was present in eighteen subjects of whom nine subjects had bilateral abnormal FDT and eight subjects had only RE affection and one subject had only LE affection. Our study concludes that the included subjects with abnormal FDT had thinner CCTs as compared to those with a normal FDT. Extending this relation further, we conclude that among subjects with a higher IOP and normal discs or patients grouped as ocular hypertensives, thicker corneas lower the risk for development of early glaucomatous functional damage as picked up by FDT, as compared to patients with thinner corneas.
Indian Journal of Ophthalmology, 2011
Vascular endothelial growth factor-A (VEGF -A) has been proved to play a major role in the pathog... more Vascular endothelial growth factor-A (VEGF -A) has been proved to play a major role in the pathogenesis of neovascular age-related macular degeneration (AMD). The major anti-VEGFs in use today for the treatment of choroidal neovascular membrane (CNVM) secondary to AMD are pegaptanib sodium, ranibizumab and bevacizumab. The other drugs being evaluated for this purpose include VEGF Trap, combrestatin, sirolimus, squalamine (inhibits plasma membrane ion channels), vatalanib and pazopanib (receptor tyrosine kinase inhibitors) and bevasiranib (small interfering RNA).
Ophthalmology, 2011
Ophthalmology, Volume 118, Issue 3, Pages 600-600.e2, March 2011, Authors:Partha Biswas, MS; Subh... more Ophthalmology, Volume 118, Issue 3, Pages 600-600.e2, March 2011, Authors:Partha Biswas, MS; Subhrangshu Sengupta, DO; Ruby Choudhary, MBBS; Subhankar Home, MS; Ajoy Paul, MS; Sourav Sinha, MS. ...
Dry eye represents a multifactorial, heterogeneous disorder of the preocular tear film, which res... more Dry eye represents a multifactorial, heterogeneous disorder of the preocular tear film, which results in ocular surface disease. The tear film and ocular surface form a complex and stable system that can lose its equilibrium through numerous disturbing factors. [1] Reduction in quality of life is inevitable when symptoms of dry eye occur. These symptoms range from mild transient irritation to persistent dryness, burning, itchiness, redness, pain, ocular fatigue and visual disturbance. In the United States alone, approximately 7-10 million Americans require artificial tear preparations, with consumers spending over $100 million/year. [2] Reported prevalence of dry eye is diverse, with questionnaire based surveys documenting rates ranging from 14.4% to 33% of the population sampled. [3,4,5] Studies which also involve tests of tear function including Schirmer's test, tear break up time, fluorescein staining, or rose bengal staining for determination of dry eye have found generally lower prevalence rates. [6,7] Our study aims to study the prevalence of dry eye in a rural and urban population from West Bengal and analyse the role of air pollution as a causative agent of the same. II. Materials and Methods This research work is a population based cross sectional study and has two arms, the rural arm and the urban arm. The urban arm has a tertiary eye hospital in Kolkata as the clinical examination centre, whereas an eye care centre in Kuliapara village (P.O. Dhobapara, P.S. Balagarh) of Hooghly district is the rural examination centre. Study area: Rural: The rural study area consists of 13 Gram Panchayats in the Balagarh Block of the Chinsurah Sub Division of Hugli district in West Bengal. [8] The total population of Balagarh sub district is 214,784 and this block has 46,022 households. 45,019 households having a population of 210,065 are classified as rural in the 2011 census. [9] The patients from the rural study area were transported to our rural Examination Centre which is located in village Kuliapara of Hooghly district. Social workers and volunteers belonging to Kuliapara village distributed leaflets throughout Balagarh regarding the Eye Check Up camps and also helped in word of mouth publicity with active participation of corresponding panchayats. Urban: Kolkata District under the Kolkata Metropolitan Area(KMA) in West Bengal is our urban study area. KMA is the largest urban agglomeration in eastern India, extends over 1851.41 sq. km. and envelopes three Municipal Corporations including Kolkata Municipal Corporation, Howrah Municipal Corporation and Chandannagore Municipal Corporation; and 38 Municipalities. [10] KMA has a population of 14,112,536, according to 2011 Census. [11] Kolkata District is bordered by Howrah District, North 24 Parganas District and South 24 Parganas District and has 11 Assembly Constituencies. [12] Kolkata District has a population of 4,572,876 and it has 929,586 households, all of whom are classified as urban in the 2011 Census. [13] Subjects residing in Kolkata District coming for ophthalmologic check up at the out patient department (OPD) of the tertiary eye hospital in Kolkata and fulfilling the laid down inclusion criteria were enrolled into the study. Institutional Ethics Committee approval was obtained before conducting this cross sectional research work. The clinical examination and data collection lasted from July to December 2013. All patients were examined by an ophthalmologist. The dry eye questionnaire was administered by a social scientist. The examinations, in brief, were as follows : (a) Ocular and medical history-A detailed history pertaining to medical and ophthalmic problems was elicited. History elicited includes use of glasses and its duration, history of previous trauma or surgery or laser in the eyes, family history of glaucoma, history of ocular and oral medication, significant systemic illness with special reference to diabetes or hypertension, significant family history and addiction history. (b) Refraction and recording of uncorrected and best-corrected visual acuity (c) Torch light external ocular examination including ocular movements and any other obvious strabismus / eyelid pathology.
Journal of Clinical Ophthalmology and Research, 2013
ABSTRACT Context: Retinal nerve fibre layer (RNFL) being unmyelinated, RNFL thickness (RNFLT) pro... more ABSTRACT Context: Retinal nerve fibre layer (RNFL) being unmyelinated, RNFL thickness (RNFLT) provides direct evidence of axonal loss in optic neuritis (ON) and may prove to be a valuable diagnostic and prognostic tool in the development of multiple sclerosis (MS). Aims: Assessment of RNFLT by OCT3 in patients with recent onset retrobulbar ON, comparison of obtained values based on presence or absence of the periventricular white matter lesion (PVWML) on magnetic resonance imaging (MRI), comparison with the RNFLT of a control group, and analysis of the obtained results. Settings and Design: Cross-sectional study. Materials and Methods: Eighteen patients with <=3 weeks onset clinically diagnosed retrobulbar ON between 19 and 55 years were included. RNFLT was assessed on presentation by OCT3 for both the eyes. MRI of brain and spinal cord with gadolinium enhancement was also performed in all patients, after adequate medical clearance. Patients were divided into: group A (10 patients) with no MRI-proven PVWML and group B (8 patients) with one or more PVWML, operationally deemed to have MS. RNFLT analysis was also done in 18 age-matched controls who were assigned to group C. Statistical Analysis Used: ANOVA and Student's t test. Results: ON eyes in group B had thinnest RNFLT (average temporal = 39.75 μ), followed by group A (average temporal = 44.3 μ), and finally by group C (average temporal-OU = 80.78 μ). Conclusions: Our study shows that patients with ON, irrespective of detection of PVWML on MRI, have thinner RNFL compared to age-matched controls (P < 0.001). The average RNFLT values are lowest in patients with PVWML. The aspect of RNFL thinning in non-ON eyes should be further studied as a possible subclinical indicator of MS.
Journal of Clinical Ophthalmology and Research, 2014
Micron, 2012
Surface roughness parameters of various intraocular lenses (IOLs) biomaterials using atomic force... more Surface roughness parameters of various intraocular lenses (IOLs) biomaterials using atomic force microscopy (AFM) are compared. Variation, if any, in the micro-roughness properties of different IOLs made up of the same biomaterial is also explored. Retrospective analysis of posterior capsular opacification (PCO) incidence has been followed up for a period of four years post IOL implantation to evaluate the correlation of PCO formation with surface roughness of IOLs. Experimental materials study. MATERIALS AND PARTICIPANTS: Surface characteristics of 20 different IOL models were assessed using AFM. These IOL models were made up of PMMA or HEMA or acrylic hydrophobic or acrylic hydrophilic or silicone. Retrospective analysis of PCO incidence in 3629 eyes of 2656 patients implanted with the same IOL models was performed. Topological characteristics of 20 different IOLs made up of 5 different biomaterials including (i) PMMA, (ii) HEMA, (iii) acrylic hydrophobic, (iv) acrylic hydrophilic and (v) silicone were evaluated using AFM in the tapping mode. Images were acquired with a resolution of 256 × 256 data points per scan at a scan rate of 0.5 Hz per line and a scan size of 10 × 10μm. Rate of PCO formation in 3629 eyes of 2656 patients implanted with the five different IOL biomaterials was retrospectively analyzed. AFM images of IOL optic surfaces showed a collection of pores, grooves, ridges and surface irregularities. Surface roughness parameters of the IOL optics were significantly different on comparing lenses of different materials. Acrylic hydrophobic IOLs had minimum surface roughness while acrylic hydrophilic IOLs showed the highest surface roughness. Different IOL models of the same biomaterial showed varied topological roughness characteristics. Retrospective analyses of PCO formation rate after IOL implantation was carried out, which revealed that rate of PCO incidence, was directly proportional to the increase in surface micro-roughness of IOLs. AFM is a powerful technique for the topological characterization of IOLs. Acrylic hydrophobic IOLs showed minimum surface roughness properties as well as minimum PCO incidence over a period of four years post implantation. It is, therefore, tempting to consider acrylic hydrophobic IOLs over other IOL biomaterials as the ideal biocompatible material for lowering PCO incidence. These results suggest an urgent need for manufacturers to optimize the various steps involved in the fabrication of IOLs.
Indian Journal of Ophthalmology, 2012
Foldable intraocular lens (IOL) implantation using an injector system through 2.8-mm clear cornea... more Foldable intraocular lens (IOL) implantation using an injector system through 2.8-mm clear corneal incision following phacoemulsification provides excellent speedy postoperative recovery. In our reported case, a Sensar AR40e IOL (Abbott Medical Optics, USA) was loaded into Emerald C cartridge, outside the view of the operating microscope, by the first assistant. The surgeon proceeded with the IOL injection through a 2.8-mm clear corneal incision after uneventful phacoemulsification, immediately following which he noted a Descemet's tear with a rolled out flap of about 2 mm near the incision site. Gross downward beaking of the bevelled anterior end of the cartridge was subsequently noticed upon examination under the microscope. We suggest careful preoperative microscopic inspection of all instruments and devices entering the patient's eyes to ensure maximum safety to the patient.
Indian Journal of Ophthalmology, 2011
Ranibizumab and bevacizumab are used widely for treating patients with choroidal neovascular memb... more Ranibizumab and bevacizumab are used widely for treating patients with choroidal neovascular membrane (CNVM) secondary to age-related macular degeneration (AMD). To determine and compare the efficacy and safety of intravitreal ranibizumab and bevacizumab in treatment of CNVM due to AMD. Prospective comparative case series carried out in an eye institute and eye department of a hospital in Kolkata, India. One hundred and four eyes with CNVM due to AMD were randomized into two groups. Group A (n=54; 24 occult) received monthly intravitreal ranibizumab injections (0.5 mg in 0.05 ml) and Group B (n=50; 22 occult) received monthly bevacizumab injections (1.25 mg in 0.05 ml) for 3 consecutive months and then as per study criteria. Data analysis done using SPSS software. P-value of <0.05 was considered statistically significant. The mean best corrected visual acuity (BCVA) in the ranibizumab group increased from 58.19 Early Treatment Diabetic Retinopathy Study (ETDRS) letters at baseline to 64 ETDRS letters at month 3 (P<0.001). In bevacizumab group mean BCVA increased from 56.80 to 61.72 ETDRS letters at month 3 (P<0.001). At the end of 18 months, there was no statistically significant difference between groups A and B with respect to change in BCVA (P=0.563) or central macular thickness (CMT; P=0.281), as measured by optical coherence tomography (Stratus OCT 3000). No significant sight-threatening complications developed. Ranibizumab and bevacizumab are equally safe and efficacious in treating CNVM due to AMD.
Ophthalmology, Volume 118, Issue 3, Pages 600-600.e2, March 2011, Authors:Partha Biswas, MS; Subh... more Ophthalmology, Volume 118, Issue 3, Pages 600-600.e2, March 2011, Authors:Partha Biswas, MS; Subhrangshu Sengupta, DO; Ruby Choudhary, MBBS; Subhankar Home, MS; Ajoy Paul, MS; Sourav Sinha, MS. ...
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Papers by Subhrangshu Sengupta