Papers by Stefan Djordjevic
The objective of this study is to determine the effects of programs of physical exercise on visua... more The objective of this study is to determine the effects of programs of physical exercise on visually-impaired children and to provide guidelines for further research and practice with the population in question. Nine electronic databases were searched to identify relevant articles. The search included papers published between 1990 and 2013. The following keywords were used for the searches: visual impairments, blindness, disability, amblyopia, children, physical activity, and sports activity. The retrieved study titles, abstracts and whole papers were read and analyzed. In order for a study to be included in the final analysis, it had to satisfy the following criteria: first, the study had to include both an experimental and a control group, and second, the participants had to be aged between 7 and 18 years. The four studies satisfied the criteria set. The small number of studies collected for analysis point to an unfortunate deficit in terms of information resulting from focused sc...
Journal of Anthropology of Sport and Physical Education, 2021
The aim of this research is a systematic review of the available literature with the effects of p... more The aim of this research is a systematic review of the available literature with the effects of physical activity (aerobic training, strength endurance training, etc.) on the obesity of the population of different ages. For collection of previous research on the impact of physical activity on motor fitness, the following electronic databases were searched: PubMed, SCIndeks, PEDro, J-GATE, SCIndes, DOAJ and Google Scholar. The works in the period from 2000 to 2019 were searched. The following keywords were used in the database search: exercise, physical activity, children, adult, aerobic training, resistance training, walking. This systematic review was conducted in agreement with the PRISMA guidelines. The results of the analyzed works indicated that only 20 works met the set selection criteria. In the analyzed works were 845 respondents. In the most researches, the training program lasted 12 weeks, while the shortest program lasted only 5 weeks. Combining endurance training with ae...
Muscle & Nerve, 2020
It is unclear whether the heart is affected in pediatric patients with milder forms of spinal mus... more It is unclear whether the heart is affected in pediatric patients with milder forms of spinal muscular atrophy (SMA). Therefore, we aimed to determine the presence of any cardiac abnormalities in these patients.
American Journal of Hematology, 2021
Hereditary xerocytosis is a rare red blood cell disease related to gain‐of‐function mutations in ... more Hereditary xerocytosis is a rare red blood cell disease related to gain‐of‐function mutations in the FAM38A gene, encoding PIEZO1, in 90% of cases; PIEZO1 is a broadly expressed mechano‐transducer that plays a major role in many cell systems and tissues that respond to mechanical stress. In erythrocytes, PIEZO1 adapts the intracellular ionic content and cell hydration status to the mechanical constraints induced by the environment. Until recently, the pathophysiology of hereditary xerocytosis was mainly believed to be based on the “PIEZO1‐Gardos channel axis” in erythrocytes, according to which PIEZO1‐activating mutations induce a calcium influx that secondarily activates the Gardos channel, leading to potassium and water efflux and subsequently to red blood cell dehydration. However, recent studies have demonstrated additional roles for PIEZO1 during early erythropoiesis and reticulocyte maturation, as well as roles in other tissues and cells such as lymphatic vessels, hepatocytes, macrophages and platelets that may affect the pathophysiology of the disease. These findings, presented and discussed in this review, broaden our understanding of hereditary xerocytosis beyond that of primarily being a red blood cell disease and identify potential therapeutic targets.
Srpski Arhiv Za Celokupno Lekarstvo, 2017
Background: Methods of closing patent ductus arteriosus (PDA) have evolved over time. We review t... more Background: Methods of closing patent ductus arteriosus (PDA) have evolved over time. We review this development in our setting. Methods: This was a retrospective analysis of children who had transcatheter PDA closure at Chris Hani Baragwanath Hospital between 1993 and 2008. Results: Over 15 years, 1 254 PDAs were diagnosed, of which 293 required intervention; 139 patients had transcatheter closure, the median age was 1.8 years (interquartile range = 1-4.5 years) and 66% were female (92/139). Mean PDA diameter was 3.2 mm (standard deviation = 1.6 mm), with an average 2:1 shunt. Transcatheter closure was performed using COOK ® Flipper coils (n = 93) or Amplatzer™ devices (n = 46). Early occlusion rates for coils were 52% (39/75) and late occlusion occurred in 91% (68/75) of patients. For Amplatzer devices, early occlusion rates were 94% (33/35) and late occlusion was 100%. Amplatzer™ devices, available since 2003, were overwhelmingly used in the later years. Conclusion: Transcatheter PDA closure was safe and effective in this setting, with outcomes similar to reports elsewhere.
Facta universitatis. Series physical education and sport, 2016
The objective of this study was to determine the effects of dry-land strength training on swimmin... more The objective of this study was to determine the effects of dry-land strength training on swimming specific motor abilities for young swimmers aged 10-14 years. The participant sample comprised 60 swimmers, aged 10-12 and 13-14, divided into two experimental and two control groups. Measures included 16 variables for assessing specific motor abilities in disciplines 100m crawl and breaststroke. The experimental exercise program lasted 12 weeks. Compared to the control groups, the experimental groups had additional dry-land strength training targeting large muscle groups of the entire body. After the applied experimental program statistically significant effects were identified in the form of improvement of the following variables: start time 10m breaststroke, stroke length in breaststroke and turn length in breaststroke for swimmers aged 10-12, whereas for swimmers aged 13-14 there was improvement in the variable stroke efficiency in crawl. Based on the total analysis, we conclude th...
Facta universitatis. Series physical education and sport, 2016
The objective of this study is to determine the effects of programs of physical exercise on visua... more The objective of this study is to determine the effects of programs of physical exercise on visually-impaired children and to provide guidelines for further research and practice with the population in question. Nine electronic databases were searched to identify relevant articles. The search included papers published between 1990 and 2013. The following keywords were used for the searches: visual impairments, blindness, disability, amblyopia, children, physical activity, and sports activity. The retrieved study titles, abstracts and whole papers were read and analyzed. In order for a study to be included in the final analysis, it had to satisfy following criteria: first, the study had to include both an experimental and a control group, and second, the participants had to be aged between 7 and 18 years. The four studies satisfied the criteria set. The small number of studies collected for analysis points to an unfortunate deficit in terms of information resulting from focused sc...
Revista Portuguesa de Cardiologia, 2021
Neuromuscular Disorders, 2021
We aimed to estimate the prevalence of glucose and lipid metabolism disorders in children and ado... more We aimed to estimate the prevalence of glucose and lipid metabolism disorders in children and adolescents with spinal muscular atrophy (SMA) types 2 and 3. A cross-sectional study was conducted. Medical history, anthropometric measurements, pubertal status, blood chemistry (glucose and insulin levels, lipid profile, aminotransferases, and hemoglobin A1c [HbA1c]), and liver ultrasound were obtained in all patients. Oral glucose tolerance test was performed in those with body mass index (BMI) >25th percentile or glucose or HbA1c levels in the prediabetic range. A total of 37 patients with SMA (22 type 2, 15 type 3) with a median age of 8.5 years (range 2-18.9 years) were included. Eleven patients (29.7%) met the criteria for prediabetes, but none had overt type 2 diabetes. Dyslipidemia was detected in 11 patients (29.7%), and 4 (10.8%) had hepatic steatosis on ultrasound. Sixteen patients (43.2%) had at least one abnormal finding (prediabetes, dyslipidemia, or hepatic steatosis); all but one were non-ambulatory and 12 (75%) had BMI ≥85th percentile. One young child developed fasting hypoglycemia. Our results suggest that non-ambulatory overweight/obese SMA patients are particularly prone to abnormalities in glucose and lipid metabolism. Young underweight patients might develop fasting hypoglycemia.
TIMS. Acta, 2018
Goalball is one of the most popular ball sports for people with visual disability. Like other spo... more Goalball is one of the most popular ball sports for people with visual disability. Like other sports, goalball offers the benefit of developing one's physical abilities as well as affecting overall development; however, due to its specific characteristics, it can also have undesirable side effects. In view of this fact, the objective of this study was to determine the relationship between the parameters of body composition and postural status in goalball players. The study participants included 38 male goalball players with the mean age of 27.89 ± 8.4 competing at the international and national levels of goalball representation Group C. The measuring tool TANITA TBW 300 was used to assess body composition parameters, whereas the Spinal Mouse instrument was used for the assessment of postural status parameters among the goalball players. In order to assess the correlation between the two sets of variables (body composition and postural status), correlational analysis between two sets of variables was used. The obtained results reveal a correlation at the level of significance p=0.05 between the angle of the scoliotic curvature in the thoracic area of the spinal column on the one hand, and body mass index on the other, whereas the correlation of body fat percentage and the mass was at the level of p=0.01. No statistically significant correlation was found between the remaining variables. The results obtained indicate increased incidence of deformity both in the sagittal and in the frontal planes of the spinal column; furthermore, the testing of body composition parameters pertaining to fat returned very high results in this group of goalball players.
La Presse Médicale, 2019
The version in the Kent Academic Repository may differ from the final published version. Users ar... more The version in the Kent Academic Repository may differ from the final published version. Users are advised to check for the status of the paper. Users should always cite the published version of record.
Proceedings of the ISCIE International Symposium on Stochastic Systems Theory and its Applications, 2009
Srpski arhiv za celokupno lekarstvo, 2018
Introduction. Adult patients with pulmonary arterial hypertension (PAH) associated with congenita... more Introduction. Adult patients with pulmonary arterial hypertension (PAH) associated with congenital left-to-right shunting are often considered inoperable. Case outline. A 26-year-old man presented with effort intolerance and palpitations. The diagnosis of PAH in the presence of a large perimembranous ventricular septal defect (VSD) and patent ductus arteriosus (PDA) was established. The patient was managed with a two-stage surgical approach involving an initial ligation of PDA, followed by VSD closure using unidirectional valved patch. Treatment decisions were based on the results of both invasive and non-invasive investigations. At follow-up, the patient was asymptomatic with pulmonary arterial pressure and vascular resistance returning to normal levels. Conclusion. There is a possibility for an adult patient to have a congenital heart disease associated with marked pulmonary overcirculation that is still amenable to surgical repair. This implies that there is an individual respons...
Srpski arhiv za celokupno lekarstvo, 2017
Introduction/Objective. Transcatheter closure is a well-established procedure for treatment of pa... more Introduction/Objective. Transcatheter closure is a well-established procedure for treatment of patent ductus arteriosus (PDA). We aimed to make a comparison between transcatheter PDA occlusion with Flipper coil and Amplatzer Duct Occluder (ADO) and to determine the incidence and significance of procedural complications. Methods. Between November 2004 and October 2014, 148 patients were eligible for transcatheter PDA closure at the University Children?s Hospital in Belgrade, Serbia. The median age was 5.9 years (the range of 0.9 years to 17.3 years) and the median weight was 21 kg (the range of 8.8 kg to 94 kg). Follow-up evaluations with Doppler echocardiogram were performed at one day, three months, and one and two years after the PDA occlusion. Results. Median narrowest PDA diameter was 1.5 mm (the range of 0.5 mm to 5.6 mm). Flipper coil was used for PDA closure in 84 (59.2%) and ADO in 58 patients (40.8%). There was no significant difference in the rate of immediate complete clo...
Cardiology in the Young, 2017
Aorto-left ventricular tunnel is an exceedingly rare congenital cardiac defect. Early surgical cl... more Aorto-left ventricular tunnel is an exceedingly rare congenital cardiac defect. Early surgical closure is the treatment of choice. Residual or recurrent tunnel and aortic valve insufficiency are well-recognised complications after surgical repair. In this article, we report on successful transcatheter closure of a residual aorto-left ventricular tunnel using an Amplatzer duct occluder in a 7-year-old boy. The outcome after 6 years of follow-up is encouraging.
Aestimatio: Critical Reviews in the History of Science, 2015
Cardiology in the Young, 2017
Cardiac haemangiomas are exceedingly rare; however, they can cause significant haemodynamic impai... more Cardiac haemangiomas are exceedingly rare; however, they can cause significant haemodynamic impairment and disturbances in heart rhythm. Rarely, cardiac tumours may also coexist with congenital heart lesions. We present an extremely unusual case of a cardiac haemangioma in the setting of complex transposition of the great arteries that caused functional tricuspid atresia. To our knowledge, this is the first such case described in the literature.
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Papers by Stefan Djordjevic