Papers by Srinivas Munisekhar Manay
Scientific Reports
This meta-analysis aims to compare Apert syndrome (AS) patients with non-AS populations (not clin... more This meta-analysis aims to compare Apert syndrome (AS) patients with non-AS populations (not clinically or genetically diagnosed) on craniofacial cephalometric characteristics (CCC) to combine publicly available scientific information while also improving the validity of primary study findings. A comprehensive search was performed in the following databases: PubMed, Google Scholar, Scopus, Medline, and Web of Science, an article published between 1st January 2000 to October 17th, 2021. PRISMA (Preferred Reporting Items for Systematic Reviews and Meta-Analyses) guidelines were followed to carry out this systematic review. We used the PECO system to classify people with AS based on whether or not they had distinctive CCC compared to the non-AS population. Following are some examples of how PECO has been used: People with AS are labeled P; clinical or genetic diagnosis of AS is labeled E; individuals without AS are labeled C; CCC of AS are labeled O. Using the Newcastle–Ottawa Quality-...
Journal of Forensic Sciences, 2022
Age estimation of the dead and human remains has been challenging in forensic medicine, both in m... more Age estimation of the dead and human remains has been challenging in forensic medicine, both in mass disasters and criminal investigations. There are several approaches to accurately evaluate age, each with its own benefits and drawbacks. Dentine translucency (DT) and incremental cemental lines (ICL) have often been used for age estimation in living adults and unknown skeletal remains. We attempted to estimate age using both these parameters and compare accuracy of age estimated using these parameters in a larger sample. A total of 300 extracted single-rooted permanent teeth were collected from the patients aged between 15 and 75 years. Longitudinal ground sections in the buccolingual direction of 250 μm thickness were prepared, and the images obtained were subsequently analyzed to measure the length of DT using the ImageJ software program. In addition, the number of ICL were also counted in each tooth section. The age of the individuals was estimated using both methods individually, and the results have shown that both parameters have shown reliable age estimates in the middle age groups. However, there was overestimation of age up to 10.6 years in the younger age group using DT and an underestimation of age up to 13.4 years in the older age group with ICL. Pearson's correlation statistics revealed a strong positive and statistically significant correlation of both the parameters with the chronological age (0.973 and 0.917). To conclude, the method using the ICL should be preferred due to the relatively higher number of errors (<±3 years) which were considered excellent.
The orthodontic treatment brings numerous benefits and, in most cases, the benefits outweigh the ... more The orthodontic treatment brings numerous benefits and, in most cases, the benefits outweigh the possible disadvantages. Root resorption (RR) is a common adverse phenomenon associated with orthodontic treatment. This study evaluates the role of low-level laser emission / Photobiomodu-lation (LE/P) in quantitative measurements of root resorption (QRR). The application of LE/P was done after each orthodontic activation with 4 types of treatment intervention (TI) on the RR after fixed orthodontic treatment (FOT) of the upper arch with ectopic eye tooth/teeth [EET]. 32 Orthodontic patients scheduled for FOT were selected and assigned to the 4 groups. These were LE/P+Self ligating bracket (SLB), LE/P+Conventional bracket (CB), Non-Photobiomodulation (non-LE/P)+SLB, and non-LE/P+CB. Standard management stages of FOT were followed in the maxilla. Each patient received a single application of LE/P labially/buccally and palatally, a total of 5 different points during each activation or appoi...
BioMed Research International, 2021
Objective. To investigate the correlation of periodontal parameters and bite force in different s... more Objective. To investigate the correlation of periodontal parameters and bite force in different stages of periodontitis after phase I periodontal therapy. Methods. Periodontal clinical parameters such as mobility, attachment loss, gingival recession, and percentage of bone remaining were recorded at the mandibular first molar region after phase I therapy in subjects categorized according to the stage of periodontitis. Corresponding bite force was recorded at the first mandibular molar region using a bite force device after phase I therapy. ANOVA test was used to assess the significant difference among different groups. Pearson correlation coefficient was used to assess the correlation between measured variables. Results. The ANOVA test represents that there is no statistical significant difference between the bite force in stage I, stage II, and stage III type of periodontitis. A strong positive correlation was found ( r = 0.537 ) between bite force and percentage of remaining alveo...
Pesquisa Brasileira em Odontopediatria e Clínica Integrada, 2020
To evaluate the prevalence and gender-wise distribution of peg-shaped maxillary permanent lateral... more To evaluate the prevalence and gender-wise distribution of peg-shaped maxillary permanent lateral incisors among populations in Saudi Arabia representing different geographical locations (Saudi,
Journal of Oral Research, 2020
Objectives: A systematic review was conducted to evaluate effectiveness and safety of beta carote... more Objectives: A systematic review was conducted to evaluate effectiveness and safety of beta carotenes for the treatment of oral leukoplakia regarding clinical resolution and prevention of malignant transformation. Material and Methods: The systematic search was conducted in three electronic databases and the study's selection was performed according to pre-set eligibility criteria. Four studies evaluating the efficacy of beta carotenes in oral leukoplakia compared to placebo were included in the review; three of which were assigned for quantitative analysis. Data were extracted, tabulated, quality assessed and statistically analyzed. Results: The metaanalysis revealed that when comparing clinical resolution the beta carotene group favored was favored compared to placebo, with statistically significant difference. However, a meta-analysis comparing beta carotene and placebo groups regarding malignant transformation as a primary outcome failed to show any significant benefit. Furthermore, results showed evidence of beta carotene safety. Conclusion: the overall quality of evidence about efficacy of beta carotene in oral leukoplakia treatment was not high. However, given the obvious safety of this agent, data suggests it could have a promising effect in clinical improvement of oral leukoplakia lesions. However, no evidence supporting its benefits in reducing risk of malignant transformation in these lesions was found. Therefore, further long term, well designed randomized clinical trials are highly recommended.
Applied Sciences, 2021
Nanotechnology-based products containing antioxidants may be effective adjuvants in the treatment... more Nanotechnology-based products containing antioxidants may be effective adjuvants in the treatment of periodontal diseases. To assess the treatment effect of nano bio-fusion gel (NBFG) in pain perception (PP) in fixed orthodontic therapy-induced gingivitis (FOTIG). The gel contains propolis, vitamin C, and vitamin E in the form of nanoemulsion. Thirty-two patients were finally selected from the orthodontic clinic after assessments for FOTIG. Patients were allocated randomly into active and placebo-control groups. Patients were evaluated at three intervals (T1, T2, and T3). Pain perception using a numeric rating scale (NRS) was performed at baseline (T1), on the 7th day (T2) and on the 28th day (T3) on his/her visit to an orthodontic clinic. In the T1, T2, and T3 period, patients apply NBFG (active or placebo side) to their gingiva after brushing two times a day for 28 consecutive days. Results: The baseline data between the active or placebo group showed almost similar PP. From T1 to...
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Papers by Srinivas Munisekhar Manay