Ion Torrent sequencing is one of the most frequently used platforms in healthcare research and in... more Ion Torrent sequencing is one of the most frequently used platforms in healthcare research and industry. Despite many advantages, platform-specific artifacts complicate efficient separation of true variants from errors, especially in variants with lower allele frequencies (<15%). Here, we developed a multi-step filtering toolbox AIRVF that works on flowgram, raw and mapped reads and called variants to reduce artifact-driven false variant calls. Tests on sequencing data of standard reference material showed up to ∼98% reduction of false variants when combined to conventional public pipelines and ∼48% to the in-house commercial solution, with a minimal loss of sensitivity. The program with detailed manual is available at https://sourceforge.net/projects/airvf/ . [email protected]. Supplementary data are available at Bioinformatics online.
This paper examines and interprets the images of the future in both the pre-modern and modern era... more This paper examines and interprets the images of the future in both the pre-modern and modern era in South Korea. Future images in pre-modern Korea depended on social and political status. The ruling class had a Confucian utopia based on remote places and the golden age of ancient Chinese regimes. On the other hand, the oppressed, denied the Confucian ideal society, sought a classless society without oppression. In modern Korean society, five alternative images of the future can be identified: (a) becoming a developed country, (b) apocalyptic discourse, (c) national unification, (d) advanced information society, and (e) feminist visions. Unlike the future images from pre-modern Korea, those in Korea’s modern era reject the ideal past, imaginary present, and radically different future. Instead, the images focus on a long-term, future-oriented vision and address the various dimensions of the feasible transformation of its current society.
This paper discusses South Korea’s five alternative future scenarios in 2030 to increase our unde... more This paper discusses South Korea’s five alternative future scenarios in 2030 to increase our understanding of its long-term future by exploring the key question of ‘what will South Korea look like in the year 2030’ in terms of society, economy, politics, class, and other pertinent issues. Following Jim Dator’s Alternative Futures method, the five alternative future scenarios include four alternative scenario archetypes (growth, discipline, collapse, and transformation) and one preferred future scenario. After reviewing South Korea's history and current situation as well as the existing forecasts of the possible futures, we address the uncertainty about the future in the five alternative scenarios: (a) the Republic of Samsung scenario, (b) the Great Han River Flood in a Warmer South Korea scenario, (c) the Big Global Family Phenomenon scenario, (d) the Age of Biotechnology scenario, (e) Peaceful Unification as a Dream Come True scenario. The purpose of this paper is to contribute to the enhancement of the vivid narratives and imagination characterizing each scenario to provide dramatic insights regarding the emotional and symbolic meanings, and to envision Korea’s preferred future that will transform Korea into a better society.
This paper examines the origin of the concept of alternative futures as developed by the West and... more This paper examines the origin of the concept of alternative futures as developed by the West and presents the main reasons for the necessity of alternative future discourses. Moreover, it proposes several countermeasures to improve Korea’s futures practice and posits that the current form-centered definition of alternative futures is unsound. To fully understand the comprehensive meaning of alternative futures, form-content integration should be considered. Korean society and its futures practices have been dominated by five tendencies: (a) poor methodological practice, (b) a high-uncertainty avoidance culture, (c) a modernization paradigm, (d) a unipolar worldview, and (e) Western futures studies. These current tendencies and their ensuing negative effects have caused Koreans to be strongly influenced by western views of future visions. Furthermore, this influence has undermined both the continuation of creative futures and the Korean way of seeing the future. Thus, Korea’s futures practice has experienced a lack of alternative approaches as well as a kind of identity crisis. In order to respond to those problems and create rigorous products of future practice, it is crucial for Korea’s futures community to concentrate on overcoming methodological challenges, building a low-uncertainty avoidance culture, inventing Korean models in a viable utopia, and adopting a more cosmopolitan worldview, as well as implementing indigenous futures studies.
Ion Torrent sequencing is one of the most frequently used platforms in healthcare research and in... more Ion Torrent sequencing is one of the most frequently used platforms in healthcare research and industry. Despite many advantages, platform-specific artifacts complicate efficient separation of true variants from errors, especially in variants with lower allele frequencies (<15%). Here, we developed a multi-step filtering toolbox AIRVF that works on flowgram, raw and mapped reads and called variants to reduce artifact-driven false variant calls. Tests on sequencing data of standard reference material showed up to ∼98% reduction of false variants when combined to conventional public pipelines and ∼48% to the in-house commercial solution, with a minimal loss of sensitivity. The program with detailed manual is available at https://sourceforge.net/projects/airvf/ . [email protected]. Supplementary data are available at Bioinformatics online.
This paper examines and interprets the images of the future in both the pre-modern and modern era... more This paper examines and interprets the images of the future in both the pre-modern and modern era in South Korea. Future images in pre-modern Korea depended on social and political status. The ruling class had a Confucian utopia based on remote places and the golden age of ancient Chinese regimes. On the other hand, the oppressed, denied the Confucian ideal society, sought a classless society without oppression. In modern Korean society, five alternative images of the future can be identified: (a) becoming a developed country, (b) apocalyptic discourse, (c) national unification, (d) advanced information society, and (e) feminist visions. Unlike the future images from pre-modern Korea, those in Korea’s modern era reject the ideal past, imaginary present, and radically different future. Instead, the images focus on a long-term, future-oriented vision and address the various dimensions of the feasible transformation of its current society.
This paper discusses South Korea’s five alternative future scenarios in 2030 to increase our unde... more This paper discusses South Korea’s five alternative future scenarios in 2030 to increase our understanding of its long-term future by exploring the key question of ‘what will South Korea look like in the year 2030’ in terms of society, economy, politics, class, and other pertinent issues. Following Jim Dator’s Alternative Futures method, the five alternative future scenarios include four alternative scenario archetypes (growth, discipline, collapse, and transformation) and one preferred future scenario. After reviewing South Korea's history and current situation as well as the existing forecasts of the possible futures, we address the uncertainty about the future in the five alternative scenarios: (a) the Republic of Samsung scenario, (b) the Great Han River Flood in a Warmer South Korea scenario, (c) the Big Global Family Phenomenon scenario, (d) the Age of Biotechnology scenario, (e) Peaceful Unification as a Dream Come True scenario. The purpose of this paper is to contribute to the enhancement of the vivid narratives and imagination characterizing each scenario to provide dramatic insights regarding the emotional and symbolic meanings, and to envision Korea’s preferred future that will transform Korea into a better society.
This paper examines the origin of the concept of alternative futures as developed by the West and... more This paper examines the origin of the concept of alternative futures as developed by the West and presents the main reasons for the necessity of alternative future discourses. Moreover, it proposes several countermeasures to improve Korea’s futures practice and posits that the current form-centered definition of alternative futures is unsound. To fully understand the comprehensive meaning of alternative futures, form-content integration should be considered. Korean society and its futures practices have been dominated by five tendencies: (a) poor methodological practice, (b) a high-uncertainty avoidance culture, (c) a modernization paradigm, (d) a unipolar worldview, and (e) Western futures studies. These current tendencies and their ensuing negative effects have caused Koreans to be strongly influenced by western views of future visions. Furthermore, this influence has undermined both the continuation of creative futures and the Korean way of seeing the future. Thus, Korea’s futures practice has experienced a lack of alternative approaches as well as a kind of identity crisis. In order to respond to those problems and create rigorous products of future practice, it is crucial for Korea’s futures community to concentrate on overcoming methodological challenges, building a low-uncertainty avoidance culture, inventing Korean models in a viable utopia, and adopting a more cosmopolitan worldview, as well as implementing indigenous futures studies.
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