Papers by Sheila Veronese
Neurological sciences, Mar 5, 2024
A preserved sense of smell and taste allows us to understand many environmental "messages" and re... more A preserved sense of smell and taste allows us to understand many environmental "messages" and results in meaningfully improvements to quality of life. With the COVID-19 pandemic, it became clear how important these senses are for social and nutritional status and catapulted this niche chemosensory research area towards widespread interest. In the current exploratory work, we assessed two groups of post-COVID-19 patients who reported having had (Group 1) or not (Group 2) a smell/ taste impairment at the disease onset. The aim was to compare them using validated smell and taste tests as well as with brain magnetic resonance imaging volumetric analysis. Normative data were used for smell scores comparison and a pool of healthy subjects, recruited before the pandemic, served as controls for taste scores. The majority of patients in both groups showed an olfactory impairment, which was more severe in Group 1 (median UPSIT scores: 24.5 Group 1 vs 31.0 Group 2, p = 0.008), particularly among women (p = 0.014). No significant differences emerged comparing taste scores between Group 1 and Group 2, but dysgeusia was only present in Group 1 patients. However, for taste scores, a significant difference was found between Group 1 and controls (p = 0.005). No MRI anatomical abnormalities emerged in any patients while brain volumetric analysis suggested a significant difference among groups for the right caudate nucleus (p = 0.028), although this was not retained following Benjamini-Hochberg correction. This exploratory study could add new information in COVID-19 chemosensory long-lasting impairment and address future investigations on the post-COVID-19 patients' research.
Gluteal femoral subcutaneous and dermal adipose tissue in female
Journal of cosmetic dermatology, Apr 18, 2024
Journal of clinical medicine, Apr 19, 2024
This article is an open access article distributed under the terms and conditions of the Creative... more This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY
European journal of histochemistry, Apr 12, 2024
Knowledge of the structure of the face is of fundamental importance. In fact, the face is treated... more Knowledge of the structure of the face is of fundamental importance. In fact, the face is treated in many areas of medicine, from dermatology, to maxillofacial, to ENT, to ophthalmology, etc. and anti-aging aesthetic treatments, and those for the resolution of blemishes are on the increase. For ethical reasons it is not possible to take biopsy samples for facial analysis in the aesthetic field. The main aim of this study was to demonstrate that a high-resolution bimodal ultrasound examination, combined with elastosonography, could be a valid tool for pre-treatment morphological evaluation. To achieve this goal, skin samples were taken from the forehead, zygomatic area, nasolabial fold, upper and lower lip from cadavers to histologically characterize their structure. Subsequently, these same areas were evaluated in vivo using conventional B-mode ultrasound with a 24 MHz high-frequency probe, and elastosonography. The data obtained with the different techniques were compared, in order to state that modern ultrasound techniques can provide similar histological information. The analysis showed that the superficial hypodermis presented a different shape and structure in the different areas, with the exception of the areas of the upper and lower lip, which appeared similar. With aging, the forehead and zygomatic area showed a volumetric increase in the superficial hypodermic layer, while the lip showed non-structural changes. The morphology of the nasolabial fold remained unchanged. When it is not possible to perform histological investigations on the face, to understand its characteristics and dynamics, ultrasound with a 24 MHz probe would seem to be the most suitable method, while elastosonography could be a valid method for evaluating the stiffness of the structural components.
V‐EMF therapy: A new painless and completely non‐invasive treatment for striae gravidarum
Journal of cosmetic dermatology, Mar 28, 2024
Journal of clinical medicine, Feb 11, 2024
This article is an open access article distributed under the terms and conditions of the Creative... more This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY
Hyper- and Hypopigmentation in a Subject with Fitzpatrick VI Skin Phototype: A new Treatment Option
Journal of applied cosmetology, Jun 24, 2024
Compressive microvibration is a type of stimulation patented as Endospheres therapy. The stimulat... more Compressive microvibration is a type of stimulation patented as Endospheres therapy. The stimulation, through Endospheres, applied externally to the skin surface, causes changes in the physiological and functional structure of tissues underneath the epidermis, including adipose tissue. Cyclic mechanical stress, induced by this therapy with its particular compressive microvibration, modifies the normal cell cycle of adipose tissue and promotes tissue remodelling due to the activation of the abundantly present mesenchymal-derived stem cells. In this study, a literature revision was performed to elucidate the mechanisms through which the repetitive, cyclic, or modulated/ordered mechanical input of Endospheres, which results in harmonic compressive microvibrations, can have beneficial effects on the skin and all subcutaneous tissues up to the muscles, improving rejuvenation, tissue repair, vascularization, and macro-organization. It was possible to formulate the hypothesis that the ordered frequency and oscillatory dynamics can completely change the chaotic and oscillatory patterns of mitochondria alongside the endoplasmic reticulum membrane in a recently discovered complex known as mitochondria-associated endoplasmatic reticulum membrane complex or mitochondria-associated endoplasmatic reticulum membrane. Analyzing the biochemical and physical characteristics of these structures, it was assessed that the nature of the benefits of the Endospheres stimulation of tissues could include three different origins: mechanical, linked to the transfer of mechanical inputs; biophysical, related to the chaotic biology of mitochondria, the generation of sinusoidal waves, the generation of piezoelectric forces and the thermic effect; and biochemical, linked to the sensory function of adipose tissue. All these forces are discussed in detail.
Biomedicines, May 30, 2023
This article is an open access article distributed under the terms and conditions of the Creative... more This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY
This article is an open access article distributed under the terms and conditions of the Creative... more This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY
Intraoperative Electrically Auditory Brainstem Responses to Monitor Auditory Functionality Preservation During Auditory Brainstem Implant Application
Neuroscience and Neurological Surgery
Background: Perceptual outcomes of individuals with neurofibromatosis type II implanted with audi... more Background: Perceptual outcomes of individuals with neurofibromatosis type II implanted with auditory brainstem implant are poor, and many factors seem to be involved. Undoubtedly, the preservation of neural functionality is the crucial aspect. The aim of this study is to verify that the use of intraoperative electrically auditory brainstem responses can help to understand if there is neural damage related to the tumor, and / or surgery. Material and Methods: A retrospective case series analysis was performed to review data from 6 adult patients affected by neurofibromatosis type 2 who received an auditory brainstem implant. A correlation was sought between intraoperative electrophysiological data, auditory performance at 1 and 2.5 years of follow-up, and auditory brainstem implant stimulation levels. Results: Patients with a better perceptual outcomes were those with more intraoperative peaks and peaks with wider amplitudes in the electrically auditory brainstem response recordings...
Stretch marks: a visible expression of connective’s involvement in autism spectrum disorders
Frontiers in Psychiatry
In autism spectrum disorders (ASDs) in the pediatric population, skin manifestations are generall... more In autism spectrum disorders (ASDs) in the pediatric population, skin manifestations are generally attributable to the concomitance of allergic forms or to accidental, self-inflicted or abusive lesions. However, clinical evidence has highlighted the presence of an increasing number of abdominal stretch marks, probably caused by the increase in the number of obesity cases in the pediatric population, in general, and therefore also among children with ASD. Stretch marks are often attributed to obesity, as they have an incidence of more than 50% in obese individuals. In the first part of this article we hypothesized that in addition to obesity there are other factors, such as a structural alteration on the skin in people with ASD, which can contribute/aggravate the phenomenon of stretch marks. Despite the high frequency with which stretch marks are found in children with ASD, this aspect has never been studied, the structure of the skin of children with ASD is not known. Furthermore, i...
Vacuum and electromagnetic field in synergy for skin rejuvenation: A retrospective study on 217 patients
Journal of Cosmetic Dermatology
Proceedings of the National Academy of Sciences, 2011
The stochastic and elite models have been proposed for the mechanism of induced pluripotent stem ... more The stochastic and elite models have been proposed for the mechanism of induced pluripotent stem (iPS) cell generation. In this study we report a system that supports the elite model. We previously identified multilineage-differentiating stress-enduring (Muse) cells in human dermal fibroblasts that are characterized by stress tolerance, expression of pluripotency markers, self-renewal, and the ability to differentiate into endodermal-, mesodermal-, and ectodermal-lineage cells from a single cell. They can be isolated as stage-specific embryonic antigen-3/CD105 double-positive cells. When human fibroblasts were separated into Muse and non-Muse cells and transduced with Oct3/4 , Sox2 , Klf4 , and c-Myc , iPS cells were generated exclusively from Muse cells but not from non-Muse cells. Although some colonies were formed from non-Muse cells, they were unlike iPS cells. Furthermore, epigenetic alterations were not seen, and some of the major pluripotency markers were not expressed for th...
From the Classification of Stem Cells to the Release of Potential in Cell Therapies: Limits, Considerations and Future Aspects in Regenerative Medicine
Possibilities and limitations in current translational stem cell research [Working Title]
Regenerative medicine aims to repair organs or tissues that have congenital abnormalities, or tha... more Regenerative medicine aims to repair organs or tissues that have congenital abnormalities, or that have been damaged by disease, aging, or trauma, and to restore or at least improve their native function. One of the strategies used in regenerative medicine is stem cell therapy, due to the enormous regenerative potential of stem cells. A staminal cell line is a group of cells that can replicate for an extended period in vitro, that is outside the body. These cells are grown in incubators using a culture medium that should have a temperature and an oxygen/carbon dioxide composition that simulates the desired environment. This chapter describes the main characteristics of stem cells, the main fields of application, and outlines what could be the future developments of their use, also considering the ethical and technical problems that currently limit their use. There is still much to be done in the field of stem cell research, and researchers are working tirelessly to remain leaders an...
Otology Japan, 2009
INTRODUCTION Auditory restoration with implant technology has been a great success story in otolo... more INTRODUCTION Auditory restoration with implant technology has been a great success story in otology and the ultimate limits of the technology are still not known. Today there are a wide variety of approaches and auditory prostheses for restoration of hearing, each with a precise indication for specific degrees and sites of hearing loss (Figure 1). Modern auditory prostheses range from implants that impart mechanical energy to the cochlea (middle ear implants, MEIs) via the ossicular chain or bypass a damaged ossicular chain and vibrate the round window directly (round window implants, RWI). Cochlear implants (CIs) bypass damaged inner ear cells and electrically stimulate the auditory nerve within the cochlea. The auditory brainstem implant (ABI) bypasses a damaged cochlea and auditory nerve auditory and directly stimulate the brainstem nuclei. The inferior colliculus implant (ICI) or auditory midbrain implant (AMI) bypass damaged brainstem nuclei to stimulate the inferior colliculus...
Ten-year follow-up of auditory brainstem implants: From intra-operative electrical auditory brainstem responses to perceptual results
PLOS ONE
The auditory brainstem implant (ABI) can provide hearing sensation to individuals where the audit... more The auditory brainstem implant (ABI) can provide hearing sensation to individuals where the auditory nerve is damaged. However, patient outcomes with the ABI are typically much poorer than those for cochlear implant recipients. A major limitation to ABI outcomes is the number of implanted electrodes that can produce auditory responses to electric stimulation. One of the greatest challenges in ABI surgery is the intraoperative positioning of the electrode paddle, which must fit snugly within the cochlear nucleus complex. While there presently is no optimal procedure for intraoperative electrode positioning, intraoperative assessments may provide useful information regarding viable electrodes that may be included in patients’ clinical speech processors. Currently, there is limited knowledge regarding the relationship between intraoperative data and post-operative outcomes. Furthermore, the relationship between initial ABI stimulation with and long-term perceptual outcomes is unknown. ...
Bioengineering
Acid attacks are on the rise, and they cause extensive and deep burns, especially on the face. Th... more Acid attacks are on the rise, and they cause extensive and deep burns, especially on the face. The treatments used to improve the aesthetic, functional and social impact of non-acid scars do not always prove useful for acid scars. This article reports the case of a woman with an extended, mature, acid facial scar, caused by sulfuric acid assault, treated with a recent new procedure that combines the application of vacuum and electromagnetic fields. Before and after the treatment, the aesthetic appearance, and motor function of the face and neck were evaluated, as well as the level of hydration, the amount of sebum, the elasticity, and the pH of the skin. The improvements highlighted after the treatment of the aesthetic and functional characteristics of the face and neck, and of the physical parameters of the skin seemed to indicate that this particular treatment induces tissue regeneration, even in the nerve component. However, it is evident that the rehabilitation pathways of facia...
V-EMF treatment of facial scar: First results
Journal of Tissue Viability
Encyclopedia
An asymptomatic patient is someone who contracts a disease but shows no symptoms. An immune subje... more An asymptomatic patient is someone who contracts a disease but shows no symptoms. An immune subject is a person who is free from virus infection. Both of these categories of people experience the limitations of government imposed by a pandemic situation, with one important difference. Probably only the first subjects contribute, in spite of themselves, to the spread of the disease and to the contagion of the people most susceptible to the virus. This implies that their detection is essential to limit infections. Therefore, knowing the characteristics of these people and those immune to the virus can be extremely useful in mitigating the effects of the disease and/or defeating it.
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Papers by Sheila Veronese