Papers by Setyo G Pramudo
Journal of biomedicine and translational research, Aug 25, 2022
Background: Sepsis is a condition in systemic infection associated with organ dysfunction. Interl... more Background: Sepsis is a condition in systemic infection associated with organ dysfunction. Interleukin-17 is a pro-inflammatory cytokine produced by Th-17 cells. C-reactive protein and neutrophil-lymphocyte ratio (NLR) have been widely used as markers of inflammation. The relationship between IL-17 as a proinflammatory cytokine with CRP and NLR has not been reported. Objective: This study aims to prove the correlation between IL-17 with CRP and NLR in septic patients. Methods: Analytical observational study with a cross-sectional approach was carried out on 40 septic patients in July-December 2020. IL-17 levels were obtained by the ELISA method while CRP levels were obtained using the immunoturbidimetric method. NLR was the result of dividing the absolute number of neutrophils and lymphocytes from the automatic hematology analyzer. Correlation between variables was performed using Spearman correlation test. Results: The median levels of IL-17, CPR, and NLR were 363.55 (11.4-1695.80) pg/mL, 13.25 (0.43-53.87) mg/L, and 12.00 (2.26-48.5), respectively. The Spearman correlation test between IL-17 levels and CRP obtained p = 0.019, r = 0.37, and NLR p = 0.425, r = 0.13. Conclusion: There is a weak positive correlation between IL-17 levels and CRP in septic patients. There is no correlation between IL-17 levels and NLR in septic patients.
Medica Hospitalia : Journal of Clinical Medicine
Faktor Risiko Penyebab Kematian pada Kasus Terkonfirmasi COVID-19, Husain Junaedi, Jl. Prof. Suda... more Faktor Risiko Penyebab Kematian pada Kasus Terkonfirmasi COVID-19, Husain Junaedi, Jl. Prof. Sudarto, Tembalang, Kec. Tembalang, Kota Semarang, Jawa Tengah, 50275, Indonesia, Coronavirus Disease 2019 (COVID-19) merupakan penyakit infeksi yang disebabkan oleh Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2). Pada 11 Maret 2020, World Health Organization (WHO) mengumumkan bahwa COVID-19 telah menjadi pandemi dan jumlah kasus yang terus meningkat menyebabkan banyak kematian di lebih dari 150 negara. Indonesia melaporkan kasus COVID-19 pertamanya pada 2 Maret 2020 dan jumlah ini terus bertambah. Banyaknya kasus terkonfirmasi yang menyebabkan kematian maka hal ini mendorong dilaksanakannya penelitian untuk mengetahui faktor risiko yang menyebabkan kematian pada pasien terkonfirmasi COVID-19.
Bali Medical Journal, Jul 8, 2022
Background: Diabetes mellitus (DM) is a metabolic disorder characterized by hyperglycemia and ass... more Background: Diabetes mellitus (DM) is a metabolic disorder characterized by hyperglycemia and associated with several risk factors, such as an unhealthy and unbalanced diet. Porang tubers, known as healthy diet resources, contain glucomannan, a substance that has many positive effects, such as ameliorating blood glucose. Porang tubers are processed as many food products, one of which is porang-processed rice (PR). This study investigated the immediate effects of PR on the blood glucose levels compared to white rice (WR) in patients with diabetes mellitus (DM). Methods: This was a pilot study of a non-randomized clinical study with a pre-and post-test design held from July to August 2021 in Diponegoro National Hospital, Semarang, Indonesia, among 40 DM patients. Subjects who met the inclusion criteria were divided into two groups: subjects that consumed Porang-processed rice (PR group, n=20) for two days and those that consumed white rice (WR group, n=20). They were measured for fasting blood glucose (FBG) and 2 hours post-prandial glucose (2hPPG) at baseline (T0) and at day-3 after observation (T1). Data were analyzed using SPSS version 20 for Windows. Results: There were no significant differences in FBG and 2hPPG between the PR group and WR group at T0 and T1 (p>0.05). However, there were slightly larger decreases in FBG and 2hPPG in the PR group compared to the WR group, although they were insignificant (p>0.05). Conclusion: The immediate consumption of PR for only two days in patients with DM could not reduce FPG and 2hPPG. It is needed to be confirmed by further studies whether PR may have the role as adjunctive in inhibiting the dramatic rise of FBG or 2hPPG or stabilizing blood glucose in patients with DM in a more extended time of consumption.
PLOS Neglected Tropical Diseases
Background The immunopathogenesis of dengue virus (DENV) infection remains incompletely understoo... more Background The immunopathogenesis of dengue virus (DENV) infection remains incompletely understood. To increase our understanding of inflammatory response in non-severe dengue, we assessed longitudinal changes in the inflammatory proteome in patients with an acute DENV infection. Methods Using a multiplex proximity extension assay (PEA), we measured relative levels of 368 inflammatory markers in plasma samples from hospitalized patients with non-severe DENV infection in the acute (n = 43) and convalescence (n = 35) phase of the infection and samples of healthy controls (n = 10). Results We identified 203 upregulated and 39 downregulated proteins in acute versus convalescent plasma samples. The upregulated proteins had a strong representation of interferon (IFN) and IFN-inducible effector proteins, cytokines (e.g. IL-10, IL-33) and cytokine receptors, chemokines, pro-apoptotic proteins (e.g. granzymes) and endothelial markers. A number of differentially expressed proteins (DEPs) have...
Majalah Kedokteran Gigi Indonesia
Epidemiological studies have shown that several factors, such as age, gender, tooth loss, socioec... more Epidemiological studies have shown that several factors, such as age, gender, tooth loss, socioeconomic status, cultural background, psychological stress of dental visit, and smoking can influence OHRQoL. Oral health is strongly age dependent, therefore OHRQoL differences are predicted to exist in the elderly group according to WHO. This condition is especially true for Rembang Regency due to the high population of the elderly and the shared ignorance on oral health given an overemphasis on other priorities, which will have an impact on their quality of life. The objective of this study is to know the OHRQOL difference in the elderly group in Rembang Regency with cross-sectional design. The research subjects were selected by inclusion and exclusion criteria with online informed consent. The questionnaire related to age and GOHAI was distributed and filled out online. Data were processed and analyzed using the Kruskall Wallis followed by Mann-Whitney post-hoc analysis and multiple li...
Thrombosis and Haemostasis
Background Coronavirus disease 2019 (COVID-19) is often associated with mild thrombocytopenia and... more Background Coronavirus disease 2019 (COVID-19) is often associated with mild thrombocytopenia and increased platelet reactivity. Objective The aim of the current study was to investigate the adenosine triphosphate (ATP) release kinetics of platelets in hospitalized SARS-CoV-2-infected patients. Methods We studied time-dependent platelet activation in whole blood by monitoring the ATP release kinetics upon stimulation with a PAR1 receptor agonist in 41 hospitalized critically ill COVID-19 patients, 47 hospitalized noncritically ill COVID-19 patients, and 30 healthy controls. Results Our study demonstrated that platelets of critically ill COVID-19 patients were hyper-responsive with a shorter platelet response time (PRT) and a reduced platelet granule release capacity (GRC), probably due to chronic activation. The median PRT of COVID-19 patients admitted to the critical care unit was 10 and 7 seconds shorter than the median PRT in healthy controls and noncritical COVID-19 patients, re...
Patient Preference and Adherence
The Coronavirus disease (COVID-19) vaccination program has been rolled out to address the pandemi... more The Coronavirus disease (COVID-19) vaccination program has been rolled out to address the pandemic. However, the COVID-19 vaccination coverage rate in Indonesia, especially in Central Java, is low. The study aimed to identify COVID-19 vaccine acceptance and to determine the factors associated with COVID-19 vaccine hesitancy. Participants and Methods: A cross-sectional study was conducted from September to October 2021. A self-reported questionnaire was distributed to participants aged ≥ 18 years and living permanently in the area of study by the multistage sampling technique. Bivariate and multivariate analyses were performed to determine the association. All statistical tests were significantly considered if the p-value <0.05 at 95% confidence interval (CI). Results: A total of 500 participants were eligible, with the age ranging from 18 to 76 years old. COVID-19 vaccine acceptance rate was 93.6%. In the multivariate logistic regression analysis, we found that the elderly (aOR=5.231; 95% CI=1.891-14.468), having comorbidity (aOR=4.808; 95% CI=1.975-11.706), not being exposed to information (aOR=7.039; 95% CI=2.072-23.908), not believing in the vaccine halalness (OR=3.802; 95% CI=1.272-11.364), not believing that vaccines could prevent the COVID-19 infection (OR=4.964; 95% CI=1.970-12.507), and having vaccination-related mild-moderate anxiety (OR=14.169; 95% CI=2.405-83.474) were more likely to have vaccine hesitancy (p<0.05). Place of residence, education level, belief that the vaccine could prevent the severe symptoms of COVID-19, and knowledge were significantly related to the vaccine acceptance in the bivariate analysis (p<0.05), but they were no longer significant in the multivariate (p>0.05). Conclusion: A high acceptance rate of the COVID-19 vaccine was found in this study. However, vaccine hesitancy is a major public health concern for attaining herd immunity and reducing the risk of case mortality. These findings could be the strategic focus for the government to improve COVID-19 vaccination coverage.
DIPONEGORO MEDICAL JOURNAL (JURNAL KEDOKTERAN DIPONEGORO), 2017
DIPONEGORO MEDICAL JOURNAL (JURNAL KEDOKTERAN DIPONEGORO), 2016
Simpulan: Faktor risiko hipertensi usia, riwayat keluarga, merokok, obesitas, jenis kelamin, kons... more Simpulan: Faktor risiko hipertensi usia, riwayat keluarga, merokok, obesitas, jenis kelamin, konsumsi natrium, konsumsi lemak, aktivitas dan konsumsi alkohol tidak menunjukkan perbedaan yang bermakna terhadap kejadian hipertensi stage 1 dan stage 2. Kata Kunci: Hipertensi stage 1 dan stage 2, faktor risiko xvii ABSTRACT Background: Hypertension is not a disease that can be underestimated, for it states that the factual conditions of hypertension may increase the incidence of some complications of cerebrovascular disease, myocardial infarction, congestive heart failure and insufficiency renal. This will cause disability, limit daily activities, functions social, and psychological status. Objectives: For Knowing the relationship of hypertension risk factors on the incidence of hypertension grade 1 and grade 2 in patients seeking treatment at the polyclinic hospital RAA Soewondo Pati. Methods: This research type is analytic observational study with cross sectional approach. The subjects in this study amounted to 75 respondents, who suffers from hypertension. The study was conducted in the polyclinic Hospital RAA Soewondo Pati in March 2016. Samples were taken by consecutive sampling. Data were obtained through questionnaires and direct interviews and physical examinations of blood pressure, height, and weight measurement. Data analysis was carried out in stages include univariate analysis, bivariate analysis using Chi-square test, and multivariate analysis using multiple logistic regression test of Backward Stepwise method (Likelihood Ratio) on SPSS program. Results: The statistical test result with multiple logistic regression did not show any difference between the risk factors of hypertension stage 1 and stage 2 in patients who seek treatment at the polyclinic hospital RAA Soewondo Pati. This can be seen in the value of the significance that age (p = 0.83), family history (p = 0.615), smoking (p = 0.222), obesity (p = 0.25), gender (p = 0.713), the consumption of sodium (p = 0.653), fat intake (p = 1), activity (p = 0.673) and alcohol (p = 0.606). Conclusion: Age, family history, smoking, obesity, gender, sodium intake, fat consumption, activity and alcohol consumption as a risk factor for hypertension showed no significant difference in the incidence of hypertension stage 1 and stage 2.
DIPONEGORO MEDICAL JOURNAL (JURNAL KEDOKTERAN DIPONEGORO), 2016
Background: One non-communicable diseases are becoming an important health problem throughout the... more Background: One non-communicable diseases are becoming an important health problem throughout the world is hypertension, due to its prevalence is high and rising. hypertension associated with the incidence of cardiovascular disease, stroke, retinopathy, and kidney disease. Objective: For knowing the relationship of hypertension risk factors on the incidence of hypertension grade 1 and grade 2 in patients who seek treatment at health centers Kenduruan, Tuban, East Java. Methods: This research type is analytic observational study with cross sectional approach. The subjects in this study amounted to 75 respondents who suffer from hypertension. The research was conducted in the health centers Kenduruan, Tuban, East Java in March 2016. Samples were taken by consecutive sampling. Data were obtained through questionnaires and direct interviews and physical examinations of blood pressure, height, and weight measurement. Data analysis was carried out in stages include univariate analysis, bivariate analysis using Chi-square test, and multivariate analysis using multiple logistic regression test of Backward Stepwise method (Likelihood Ratio) on SPSS program.
Frontiers in Immunology, 2021
BackgroundEndothelial hyper-permeability with plasma leakage and thrombocytopenia are predominant... more BackgroundEndothelial hyper-permeability with plasma leakage and thrombocytopenia are predominant features of severe dengue virus infection. It is well established that heparanase, the endothelial glycocalyx degrading enzyme, plays a major role in various diseases with vascular leakage. It is yet to be elucidated whether heparanase activity plays a major role in dengue-associated plasma leakage. Moreover, the major source of heparanase secretion and activation in dengue remains elusive. Since a relatively high amount of heparanase is stored in platelets, we postulate that heparanase released by activated platelets contributes to the increased plasma heparanase activity during dengue virus infection.MethodsHeparanase activity (plasma and urine), and heparan sulfate and syndecan-1 (plasma levels) were measured in dengue patients with thrombocytopenia in acute phase (n=30), during course of disease (n=10) and in convalescent phase (n=25). Associations with clinical parameters and plasm...
Item does not contain fulltextThe dataset contains the results from a randomised controlled trial... more Item does not contain fulltextThe dataset contains the results from a randomised controlled trial assessing the effects of the sialidase inhibitor oseltamivir on the recovery of platelet counts and parameters of plasma leakage in Indonesian adult patients with acute dengue infection (TOTO trial). A total number of 70 patients with a platelet count <70 x 10^9/L and a duration of illness <7 days were randomized between oseltamivir phosphate 75mg BID or placebo for a maximum of five days. Primary outcomes were the time to platelet recovery (platelet count ≥ 100 x 109/l) or discharge from hospital and the course of measures of plasma leakage (measured by daily ultrasound, hematocrit, plasma albumin and syndecan-1 concentrations). A blood count was performed twice daily; maximum follow-up was five days. More details on the trial are given in https://doi.org/10.1186/ISRCTN3522771
Introduction . Populations with high BMI are at risk for cardiovascular disease because these pop... more Introduction . Populations with high BMI are at risk for cardiovascular disease because these populations usually have high levels of fat in the body. In contrast, there are several studies that prove that body weight below normal BMI also increases cardiovascular disease risk and death. The aim of this study was to determine the impact of BMI on mortality rates of in-hospital patients with acute myocardial infarction at dr. Kariadi Hospital. Methods . This research is a retrospective analytic observational study with cross sectional design. The sample of this study was acute myocardial infarction patients who were undergoing treatment at the RSUP dr. Kariadi between January 2013 - December 2018 complete data on body weight, height, and status of death or survival. Data comparisons were made using fisher exact test with statistical significant p value was less than 0.05. Results . Statistical analysis using fisher exact test showed association between body mass index and mortality r...
Background: Indonesia ranked seventh for the prevalence of diabetes mellitus in the world. Improv... more Background: Indonesia ranked seventh for the prevalence of diabetes mellitus in the world. Improved glycemic control has been shown to prevent the development and rate of occurrence of diabetes complications. Adherence to treatment, weight regulation with benchmarks for BMI indicators, activity or exercise habits, diet, and smoking history play an important role in glycemic control. Aim: Identifying factors that influence glycemic control in outpatient diabetes mellitus patients. Methods : A descriptive qualitative study with cross sectional approach in minimal 32 patients with diabetes mellitus This study was conducted from April 2019 to September 2019 in Rumah Sakit Nasional Diponegoro (RSND) Semarang. The glycemic control status are assesed by HbA1c and the factors are assesed with structured questionere that consist of question about medication adherence, diet adherence, smoking status, and physical activity and anthropmetric measurement. Data were analyzed with bivariat analysi...
Latar Belakang: Lupus Eritematosus Sistemik (LES) adalah penyakit inflamasi autoimun multisistem ... more Latar Belakang: Lupus Eritematosus Sistemik (LES) adalah penyakit inflamasi autoimun multisistem kronik yang menimbulkan manifestasi klinik dan prognosis penyakit yang beragam. Kejadian penyakit LES di Indonesia terus meningkat. Manifestasi klinik yang beragam sering menyebabkan terjadinya keterlembatan diagnosis. Tujuan: Mengetahui gambaran klinis pasien LES di RSUP Dr. Kariadi Semarang. Metode: Penelitian ini merupakan penelitian desktiptif dengan rancangan penelitian secara belah lintang. Sampel adalah catatan medik pasien LES rawat inap RSUP Dr. Kariadi Semarang periode Januari 2016 – Desember 2016 Hasil: Dari 103 pasien terdiagnosis LES periode Januari 2016 – Desember 2016 didapatkan 81 sampel yang terpilih sesuai kriteria inklusi dan ekslusi. Pasien dengan usia 21-30 tahun dan jenis kelamin perempuan paling banyak ditemukan dengan jumlah masing-masing 39 (48,75%) dan 78 (96%) pasien. Pekerjaan terbanyak adalah ibu rumah tangga pada 21 (25,92%) pasien. Lemas adalah keluhan utam...
Loss to follow-up (LTFU) of clients from antiretroviral therapy (ART) has a great negative impact... more Loss to follow-up (LTFU) of clients from antiretroviral therapy (ART) has a great negative impact on the immunological benefits of ART, and increased acquired immune deficiency syndrome related morbidity and mortality. The purpose of this study was to analyze socio-demographic characteristics related to LTFU among HIV and AIDS patients in Semarang City. A case-control study was carried out at Hospitals and Primary Health Centre. Patients who did not take anti-retroviral for 3 months were defined as LTFU while those regularly take anti retro viral for 3 months became the controls. The total sample of the research were 134 respondents obtained by purposive sampling technique. Chi square and logistic regression tests were performed to analyze factors associated with LTFU. The multivariate analyses showed the most dominant factors that influence with LTFU was education level (OR = 6.27. 95% CI: 2.29, 17.09). Intervention on literacy program should be emphasized to patients who are about to start and during the ART program.
Medica Hospitalia : Journal of Clinical Medicine, 2021
Latar Belakang: Penggunaan antibiotik yang tidak tepat dapat meningkatkan kejadian resistensi ant... more Latar Belakang: Penggunaan antibiotik yang tidak tepat dapat meningkatkan kejadian resistensi antibiotik yang pada akhirnya meningkatkan morbiditas, mortalitas, dan biaya kesehatan. WHO telah merekomendasikan untuk dilakukan kajian rasionalitas penggunaan antibiotik dalam rangka mengatasi masalah resistensi antibiotik. Tujuan: Menganalisis kualitas dan kuantitas penggunaan antibiotik di instalasi rawat inap Rumah Sakit Nasional Diponegoro (RSND). Metode: Penilaian kualitas dan kuantitas penggunaan antibiotik dilakukan berdasarkan DDD/100 pasien–hari dan kriteria van der Meer–Gyssens. Penelitian dilakukan secara retrospektif pada 86 rekam medis pasien yang didapatkan dengan metode consecutive sampling. Hasil: Terdapat 141 peresepan antibiotik dalam 86 rekam medis. Azithromycin, levofloxacin, dan ceftriaxone merupakan antibiotik terbanyak yang digunakan dengan nilai DDD/100 pasien–hari 48,12; 44,01; dan 21,13. Berdasarkan kriteria Gyssens, 35,4% penggunaan antibiotik dengan bijak, 51,...
BMC Health Services Research, 2017
Background: From 1990 to 2015, the number of maternal deaths globally has dropped by 43%. Despite... more Background: From 1990 to 2015, the number of maternal deaths globally has dropped by 43%. Despite this, progress in attaining MDG 5 is not remarkable in LMICs. Only 52% of pregnant women in LMICs obtain WHO recommended minimum of four antenatal consultations and the coverage of postnatal care is relatively poor. In recent years, the increased cellphone penetration has brought the potential for mHealth to improve preventive maternal healthcare services. The objective of this review is to assess the effectiveness of mHealth solutions on a range of maternal health outcomes by categorizing the interventions according to the types of mHealth applications. Methods: Three international online electronic databases were searched between January 1, 2000 and January 25, 2016 to identify studies exploring the role of mHealth solutions in improving preventive maternal healthcare services. Of 1262 titles screened after duplication, 69 potentially relevant abstracts were obtained. Out of 69 abstracts, 42 abstracts were shortlisted. Full text of 42 articles was reviewed using data extraction sheet. A total of 14 full text studies were included in the final analysis. Results: The 14 final studies were categorized in to five mHealth applications defined in the conceptual framework. Based on our analysis, the most reported use of mHealth was for client education and behavior change communication, such as SMS and voice reminders [n = 9, 65%]. The categorization provided the understanding that much work have been done on client education and behavior change communication. Most of the studies showed that mHealth interventions have proven to be effective to improve antenatal care and postnatal care services, especially those that are aimed at changing behavior of pregnant women and women in postnatal period. However, little evidence exists on other type of mHealth applications. Conclusion: This review suggests that mHealth solutions targeted at pregnant women and women in postnatal period can improve preventive maternal healthcare services. However, there is a need to conduct more controlled-trials and quasi-experimental studies to strengthen the literature in this research area. The review recommends that mHealth researchers, sponsors, and publishers should prioritize the transparent reporting of interventions to allow effective interpretation of extracted data.
Background : Pulmonary tuberculosis is a contagious infectious disease caused by the Mycobacteriu... more Background : Pulmonary tuberculosis is a contagious infectious disease caused by the Mycobacterium tuberculosis. Health workers have an increased risk of contracting tuberculosis, because they are exposed to TB in their workplaces. The absence of hospital control measures against TB infection makes the risk factor becomes high. Health workers often make contact with TB sufferers. In a good body condition, although infected by TB germs, it does not manifest as a disease or called latent TB. However, latent TB sufferers still have the risk of being active in certain conditions, which then becomes a source of new TB transmission. Objective: This study aims to look at the level of knowledge of health workers towards the incidence of Latent TB in the Hospital. Method : The research method is cross-sectional using a sample of health workers who work in hospitals. The sample size of this study was 46 people using purposive sampling. This study has a variable Health worker knowledge about T...
DIPONEGORO MEDICAL JOURNAL (JURNAL KEDOKTERAN DIPONEGORO), 2016
Lupus Eritematosus Sistemik (LES) adalah penyakit autoimun yang kompleks ditandai oleh adanya aut... more Lupus Eritematosus Sistemik (LES) adalah penyakit autoimun yang kompleks ditandai oleh adanya autoantibodi terhadap inti sel dan melibatkan banyak sistem organ dalam tubuh. Manifestasi klinik dari LES bergantung organ yang terlibat, dapat melibatkan banyak organ dalam tubuh manusia dengan perjalanan klinis yang kompleks, sangat bervariasi, dan dapat ditandai oleh serangan akut, periode aktif, terkendali ataupun remisi. Beberapa penelitian terdahulu menunjukkan prevalensi depresi pada pasien LES adalah antara lain 11,5%-47% dan menunjukkan kecenderungan depresi meningkat seiring dengan meningkatnya keparahan penyakit LES. Tujuan : Mengetahui gambaran mengenai kecenderungan kejadian depresi serta hubungannya dengan aktivitas penyakit LES di RSUP. dr. Kariadi, Semarang. Metode : Penelitian ini merupakan penelitian analitik observasional dengan jenis studi kasus belah lintang. Sampel penelitian adalah pasien LES yang berobat jalan di Rumah Sakit Dokter Kariadi periode Mei 2016. Pengambilan data dilakukan dengan menggunakan kuesioner. Uji statistik menggunakan uji korelasi Spearman Hasil : Hubungan antara aktivitas penyakit LES dengan kecenderungan kejadian depresi adalah positif dengan kekuatan korelasi sangat lemah. Selain itu ditemukannya lima komponen paling berpengaruh terhadap kecenderungan kejadian depresi pada pasien LES yang berobat jalan di RSUP dr. Kariadi, Semarang Simpulan : Sebagian besar pasien LES (67%) memiliki tingkat aktivitas penyakit sedang, pasien LES yang mengalami depresi dalam jumlah kecil (23,3%) serta terdapat hubungan positif antara tingkat aktivitas penyakit dengan kecenderungan kejadian depresi dengan kekuatan korelasi yang sangat lemah dan tidak bermakna. Kata kunci : Aktivitas penyakit, kecenderungan kejadian depresi, LES.
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Papers by Setyo G Pramudo