Papers by Serkan Karadeniz
AMAC: Bu calismada poliklinigimize basvuran cocuk ve ergenlerden Tik bozuklugu (TB) olanlarin sos... more AMAC: Bu calismada poliklinigimize basvuran cocuk ve ergenlerden Tik bozuklugu (TB) olanlarin sosyodemografik ozelliklerini belirlemek ve DSM-IV’e gore TB’ndaki eshastanalim sikligini belirlemek amaclanmistir.YONTEMLER: : Arastirmanin orneklemi cocuk -ergen ruh sagligi ve hastaliklari poliklinigine basvuran, DSM-IV'e gore Tik Bozuklugu tanisi konmus ve zeka duzeyi normal saptanan, 7-16 yas arasi 48 cocuk – ergendendi. Kontrol grubu, tani grubu ile cinsiyet ve yas ozellikleri birebir eslesen ayni poliklinigine basvuran yaslari 7-16 yas arasinda bulunan Cocuk ve Ergenlere DSM-IV tani olcutlerine gore tik bozuklugu tanisi konmamis ve zeka duzeyi normal saptanan 48 cocuk-ergendendi. Calismadan dislanma olcutleri; eslik eden agir norolojik bir hastaliginin bulunmasi, klinik ve psikometrik olarak zeka geriliginin saptanmasi ve baska agir organik bozuklugun bulunmasi olarak belirlenmistir.Arastirmada cocuk ve ergenlerin depresyon belirtileri Cocuklar Icin Depresyon Envanteri (CDI) ile;...
The Journal of Clinical Psychiatry, 2021
Objective: In this study, we aimed to present the characteristics of juvenile pushed to crime who... more Objective: In this study, we aimed to present the characteristics of juvenile pushed to crime who were brought to a child psychiatry clinic in a two-year period, the forensic reports and the measure decisions for these children. Method: Sociodemographic, clinical and crime data of 67 children (59 boys and 8 girls) were entered into the SPSS 23.0 package program and required statistics were applied. Results: 22.4% of the children with an average age of 15.2 ± 1.3 had recurrent crime. At least one in the family of 20.9% and among friends of 43.3% were involved in crime before. The most common types of crime were theft, sexual abuse and property damage. A significant relationship was found between the recidivism and the disciplinary penalty, school drop-out, prior psychiatric diagnosis, smoking, self-injurious behavior, having peers pushed into crime, crimes as theft and property damage. In 25.4% of the judicial reports, “the child perceives the legal meaning of the act committed and c...
Entertain. Comput., 2021
Objective Gaming disorder is a serious public health problem; however, there is a limited number ... more Objective Gaming disorder is a serious public health problem; however, there is a limited number of studies on this issue in clinical settings. This study aimed to determine the prevalence of addicted and at-risk gamers among adolescents who applied to a child psychiatry clinic and to identify the differences in clinical characteristics and game preferences between addicted gamers and other gamers. Method A total of 320 adolescents participated in this study. The Digital Game Addiction Scale – Short Form (DGAS-7) was used to evaluate addiction, and the Strengths and Difficulties Questionnaire was used to evaluate emotional and behavioral problems. Game preferences and interest in those games were evaluated with a survey. Gamers were classified as “addicted gamers,” “regular gamers,” and “casual gamers” according to DGAS-7 scores and gaming frequency. Results One out of every five adolescents played digital games at least once a day; only 3.4% (n = 11) had not played digital games in...
Objective: Main objective was to address the issue by presenting the reasons of child and adolesc... more Objective: Main objective was to address the issue by presenting the reasons of child and adolescent psychiatry consultations, clinical and socio-demographic characteristics of the cases and the treatments suggested. Method: The records of patients hospitalized in Karadeniz Technical University Faculty of Medicine Hospital between the dates 01.01.2012 and 31.12.2012 that were consulted to the child and adolescent psychiatry unit during their inpatient stay were examined retrospecitvely. Results: In the past year, 240 child and adolescent psychiatry consultations were requested. 51.3% (n = 123) of the cases were male, 48.8% (n = 117) were female. While mean age was 11.3 years, most of the patients (50.4%) were between 13-16 years of age. Eighty nine point two percent of these consultations (n = 127) were requested from inpatient units of the paediatrics division. Patients who were consulted from surgery units made 0.6% of children and adolescents who were hospitalized in these units....
Minerva pediatrics, 2021
BACKGROUND Previous pandemics around the world have shown that negative emotions are intensified ... more BACKGROUND Previous pandemics around the world have shown that negative emotions are intensified in individuals when restrictions are imposed on human daily life activities. This study aims to draw attention to the pandemic-specific factors that might be associated with the severity of depression, anxiety, and COVID-19 phobia of high school students. METHODS A total of 1,431 high school students aged 14 to 18 years were invited to participate in thisstudy using online survey forms. They were asked to fill out a questionnaire about themselves and the changes in their lives during the pandemic. They completed the COVID-19 Phobia Scale (C19P-S) and the Revised Children's Anxiety and Depression Scale (RCADS). RESULTS Findings showed that being a girl is an increased risk factor for anxiety, depression, and COVID-19 phobia. In addition, following the official daily COVID-19 data and having a healthcare professional in the building of residence are significant risk factors for COVID-1...
Sleepwalking is a sleep disorder characterized by periods of waking up and travelling around duri... more Sleepwalking is a sleep disorder characterized by periods of waking up and travelling around during sleep, and its prevalence in general population is reported to be 1-5%. The pathophysiological mechanism of sleepwalking is not fully understood. However it is said that physiological problems such as fever, emotional stress (like child’s separation anxiety), underlying medical reasons (like obstructive sleep apnea, hyperthyroidism, migraine, stroke, encephalitis), drugs and substances that affect the central nervous system (like alcohol, sedatives-hypnotics, anticholinergics, lithium), physiological internal stimuli such as full bladder, perimenstruation and external stimuli such as light-noise may decrease the threshold for sleepwalking and trigger it. Information will be provided about the pathophysiology, triggers, diagnosis and treatment of the disease through our case of a 9-year-old girl with a sleepwalking history of one year and a severe increase in the frequency and severity...
Psychiatria Danubina, 2021
BACKGROUND Unipolar depression is common among adolescents and has high recurrence rates. Studies... more BACKGROUND Unipolar depression is common among adolescents and has high recurrence rates. Studies conducted with adults show that oxidative stress plays a role in etiology of depression but studies with adolescent patients are limited. In addition, baseline S100B level in adult patients with depression is considered as a marker of response to treatment. The purpose of this study was to measure the levels of serum S100B, Malondialdehyde (MDA), total oxidant status (TOS), and total antioxidant status (TAS), which have not been previously investigated in adolescent patients with first-episode, drug-naive unipolar depression, and to investigate the relationship of these parameters with disease severity and patient-specific variables. SUBJECTS AND METHODS This study was conducted with 37 adolescents diagnosed with unipolar depression and 37 healthy peers. Participants were asked to fill out the Beck Depression Scale, Screen for Child Anxiety Related Disorders, and suicide probability que...
Nordic Journal of Psychiatry
Abstract Background: Major depressive disorder (MDD) is a mental health and emotional disorder th... more Abstract Background: Major depressive disorder (MDD) is a mental health and emotional disorder that affects children and adolescents worldwide. This study aimed to evaluate serum nesfatin-1, ghrelin, and lipid levels as biological markers of adolescent MDD and their relationship with the severity of depression-anxiety and suicide risk in MDD. Methods:This study included 37 drug naïve adolescents between the ages of 12 and 18 who were diagnosed with a first episode MDD according to the Kiddie Schedule for Affective Disorders and Schizophrenia for School-Age Children-Present and Lifetime Version (K-SADS-PL) and DSM-V diagnostic criteria. Thirty-three healthy adolescents between the ages of 12 and 18 were included as the control group. The Children’s Depression Inventory (CDI), Screen for Child Anxiety Related Disorders (SCARED), and Suicide Probability Scale (SPS) were used to evaluate the subjects in the MDD and control groups. In the first stage, serum nesfatin-1, ghrelin, and lipid levels were compared between the adolescents diagnosed with MDD and the control group. Next, the correlations between these levels and the CDI, SCARED, and SPS scores were evaluated. Results: Nesfatin-1 levels were significantly lower in the MDD group than the control group (p < 0.001) A positive correlation was found between the nesfatin-1 levels and the SPS scores. Conclusions: This is the first study to evaluate nesfatin-1 levels in adolescent depression, suggesting that nesfatin-1, ghrelin, total cholesterol, and low-density lipoprotein cholesterol (LDL) levels can be used as biomarkers in child-adolescent MDD. However, it is evident that further studies with larger samples and post-treatment measurements are needed.
Turkish Journal of Pediatric Disease, Nov 21, 2017
Uyurgezerlik uyku sırasında yataktan kalkma ve gezinme dönemleri ile karakterize bir uyku bozuklu... more Uyurgezerlik uyku sırasında yataktan kalkma ve gezinme dönemleri ile karakterize bir uyku bozukluğu olup genel toplum yaygınlığı %1-5 arasında bildirilmektedir. Uyurgezerliğin tam olarak patofizyolojik mekanizması bilinmemektedir. Ancak ateş gibi fizyolojik sorunlar, emosyonel stres (çocukta ayrılık anksiyetesi gibi), altta yatan medikal sebepler (obstrüktif uyku apnesi, hipertiroidi, migren, inme, ensefalitler), santral sinir sistemini etkileyen ilaç-maddeler (alkol, sedatif-hipnotikler, antikolinerjikler, lityum gibi), dolu mesane, perimensturasyon gibi fizyolojik iç uyaranlar ve ışık-ses gibi dış uyaranların uyurgezerlik için eşiği düşürdüğü ve tetikleyici olabileceği söylenmektedir. Bu olgumuzda 1 yıldır uyurgezerlik öyküsü olan ve son 15 gündür atakların sıklığında ve şiddetinde ciddi artma olan 9 yaşında kız hasta üzerinden hastalığın patofizyolojisi, tetikleyicileri, tanısı ve tedavisinde izlenen yollara yönelik bilgiler sunulacaktır.
Asian Journal of Psychiatry
OBJECTIVE Electroconvulsive therapy (ECT) is a treatment modality in children that can be life-sa... more OBJECTIVE Electroconvulsive therapy (ECT) is a treatment modality in children that can be life-saving but is rarely preferred. In this study, we aimed to evaluate the knowledge, experience, and attitudes of child and adolescent psychiatrists (CAPs) in Turkey about pediatric ECT and to draw attention to possible gaps and needs regarding this treatment in the child and adolescent psychiatric policies of Turkey. METHOD An electronic survey was prepared and shared with child and adolescent psychiatric residents and specialists. The participants were asked about their residency training, clinical experience, and opinion about ECT. The obtained data were entered in SPSS Statistics 23.0. Descriptive analyses and chi-squared tests were applied. RESULTS One hundred and ninety-one CAPs filled in the questionnaire, 28.8% of whom assessed their knowledge level as "I have no knowledge." Only 34% of them stated that their patients, most of whom had mood disorders, schizophrenia, and catatonia, had received ECT before. Four of these patients were under 12 years old. Sixty-six percent of the participants suggested that ECT was safe in adolescents, whereas only 5.8% held this view for prepubertal children. The most common reason for physicians not to apply ECT was "lack of means to apply ECT," and 92.7% stated that opportunities should be provided for pediatric ECT treatment by the hospital administration. CONCLUSION This is the first data to present the knowledge and attitudes of CAPs in Turkey about ECT. The results suggest that physicians need to have more knowledge about ECT.
Anatolian Journal of Psychiatry
Ailevi Akdeniz ateşi (AAA) genellikle ateşle birlikte olan peritonit, plörit ve artrit nöbetleri ... more Ailevi Akdeniz ateşi (AAA) genellikle ateşle birlikte olan peritonit, plörit ve artrit nöbetleri ile giden, aile içinde ve sıklıkla Akdeniz çevresinde yaşayan etnik grupları (Türk, Arap, Ermeni, Yahudi) etkileyen, otozomal çekinik geçişli bir hastalıktır. AAA'nın etiyolojisinde genetik mutasyon oranı 1/8-16 olarak bildirilmiş, pyrin veya meranostrin olarak bilinen proteini kodlayan MEFV (MEditerranean FeVer) genindeki mutasyonlar olguların çoğunda hastalığın nedeni olarak görülmüştür. Obsesif kompulsif bozukluk (OKB), bireylerin sosyal, mesleksel işlevselliği ve toplumsal etkinlikleri üzerinde önemli ölçüde bozulmaya neden olan, obsesyon ve kompulsiyonlarla karakterize, kronik bir ruhsal bozukluk olup genetik çalışmalar etiyolojisinde ve belirtilerin ortaya çıkışında, hem genetik hem de çevresel ve kültürel etkenlerin rol oynadığını göstermektedir. OKB ve serotonerjik-dopaminerjik yolaklardaki genler arasında genetik bağlantı olduğunu ileri süren bazı çalışmalarda, 3q, 6q, 7p, 1q ve 15q non-parametrik kromozom bölgelerinde bağlantı noktaları bulunmuş, en kuvvetli bağlantı ise kromozom 3q27-28 üzerinde elde edilmiştir. Bu olgu sunumları ile ortaya çıkışında genetik etkenlerin rolünün bilindiği AAA ve OKB birlikteliğinin olası ortak etiyopatogenezleri ve tedavi yaklaşımları ele alınarak literatüre katkı sağlanması amaçlanmıştır.
Turkiye Cocuk Hastalıkları Dergisi, Nov 10, 2014
Attention deficit hyperactivity disorder (ADHD) is observed in approximately 5.9-7.1% of children... more Attention deficit hyperactivity disorder (ADHD) is observed in approximately 5.9-7.1% of children and adolescents. Atomoxetine is selective norepinephrine transporter inhibitor and an alternative to stimulants used to treat ADHD. An 11-year-old male patient was brought to the child psychiatry clinic with complaints of difficulty in sustaining attention, getting bored quickly, inability to complete tasks and activities, and forgetfulness. A diagnosis of “Attention Deficit and Hyperactivity Disorder, Predominantly Inattentive type’’ was made according to the diagnostic criteria of the Diagnostic and Statistical Manual of Mental Disorders IV (DSM IV) and long-acting methylphenidate treatment was started. Gastrointestinal side effects such as anorexia and nausea due to the drug occurred with 36 mg/day long-acting methylphenidate treatment and methylphenidate was discontinued. Atomoxetine treatment was started at 25 mg/day in the first week, 40 mg/day for 2 weeks and then 60 mg/day (1.2 mg/kg/day) maintenance. Obsessive-compulsive symptoms such as symmetry obsession, not being sure of having done something, and constant need for approval occurred after the use of 60 mg of atomoxetine per day. A diagnosis of ADHD + Obsessive-Compulsive Disorder (OCD) was made according to DSM IV-TR following a re-evaluation. We believe this case will contribute to the literature with the development of OCD following the use of atomoxetine.
Pamukkale Medical Journal, 2015
Bu çalışmada polikliniğimize başvuran çocuk ve ergenlerden Tik bozukluğu (TB) olanların sosyodemo... more Bu çalışmada polikliniğimize başvuran çocuk ve ergenlerden Tik bozukluğu (TB) olanların sosyodemografik özelliklerini belirlemek ve DSM-IV'e göre TB'ndaki eşhastanalım sıklığını belirlemek amaçlanmıştır. Gereç ve yöntem: Araştırmanın örneklemi çocuk-ergen ruh sağlığı ve hastalıkları polikliniğine başvuran, DSM-IV'e göre Tik Bozukluğu tanısı konmuş ve zeka düzeyi normal saptanan, 7-16 yaş arası 48 çocuk-ergendendi. Kontrol grubu, tanı grubu ile cinsiyet ve yaş özellikleri birebir eşleşen aynı polikliniğine başvuran yaşları 7-16 yaş arasında bulunan Çocuk ve Ergenlere DSM-IV tanı ölçütlerine göre tik bozukluğu tanısı konmamış ve zeka düzeyi normal saptanan 48 çocuk-ergendendi. Çalışmadan dışlanma ölçütleri; eşlik eden ağır nörolojik bir hastalığının bulunması, klinik ve psikometrik olarak zeka geriliğinin saptanması ve başka ağır organik bozukluğun bulunması olarak belirlenmiştir. Araştırmada çocuk ve ergenlerin depresyon belirtileri Çocuklar İçin Depresyon Envanteri (CDI) ile; anksiyete belirtileri Çocuklarda Anksiyete Bozukluklarını Tarama Ölçeği, obsesif-kompulsif belirtileri Maudsley Obsesif Kompulsif Bozukluk Ölçeği ile belirlenmiş, sosyodemografik özellikler "Yarı Yapılandırılmış Görüşme Formu" ile saptanmış, komorbid bozukluklar DSM-TV tanı ölçütlerine göre değerlendirilmiştir. Ayrıca her olguya EEG ve zeka testi yaptırılmıştır. İstatistiksel analizde; gruplar arasında değişkenlerin karşılaştırılmasında Student t testi, Mann Whitney-U testi ve Chi-Square testi kullanılmıştır. p<0.05 anlamlı kabul edilmiştir. Bulgular: Olguların ortalama yaşları 10.9±2.4 yaştı. Olguların %77.1'i erkek (n=37), %22.9'u kızdı (n=11). Olguların %18.8'inde obsesif-kompulsif bozukluk (OKB), %25'inde dikkat eksikliği ve hiperaktivite bozukluğu (DEHB), %14.5'inde enürezis nokturna eşhastanalım olarak bulunmaktaydı. En yaygın motor tik göz hareketleri (%81.2), en yaygın vokal tik boğaz temizlemeydi(%50). En yaygın karmaşık motor tik kendini ezim davranışı(%33), ve en yaygın karmaşık ses tiki heceler (%29.2) idi. Sonuç: TB erkeklerde kızlardan daha yüksek oranda bulunmaktaydı ve ergenlere göre çocuklarda daha fazla görülmekteydi. Tik bozukluğuna sıklıkla en az bir psikiyatrik bozukluk eşlik etmekteydi. DEHB ve OKB başta olmak üzere, dışa atım bozuklukları, depresif bozukluk, anksiyete bozukluklarının sıkça görülmekteydi. TB olan çocuklarda DEHB, ergenlerde ise OKB daha sık görülmekteydi.
Turkish Journal of Pediatric Disease, 2014
Dikkat eksikliği hiperaktivite bozukluğu (DEHB) çocuk ve ergenlerde yaklaşık olarak %5.9-7.1 oran... more Dikkat eksikliği hiperaktivite bozukluğu (DEHB) çocuk ve ergenlerde yaklaşık olarak %5.9-7.1 oranında görülen bir bozukluktur. Merkezi sinir sisteminde presinaptik nörepinefrin taşıyıcılarının seçici bir inhibitörü olan atomoksetin, psikostimülan dışı DEHB ilacı olarak yer almaktadır. Atomoksetin merkezi sinir sistemin-de presinaptik nörepinefrin taşıyıcılarının seçici inhibitörüdür. Özellikle frontal bölgede düşük oranda serotonin ve dopamin taşıyıcılarına da afinitesi bulunmaktadır (1). Prefrontal kortekste presinaptik norepinefrin taşıyıcılarının inhibisyonu ile dopamin ve noradrenalin düzeylerini arttırarak etki göstermektedir (2). Atomoksetinin, eştanılı durumlarda DEHB belirtilerinin yanı sıra depresyon, anksiyete ve tik belirti şiddetini de azalttığı, günde ÖzET Dikkat eksikliği hiperaktivite bozukluğu (DEHB) çocuk ve ergenlerde yaklaşık olarak %5,9-7.1 oranında görülmektedir. Atomoksetin, DEHB tedavisinde kullanılan psikostimülanlara alternatif norepinefrin taşıyıcılarının seçici inhibötürüdür. On bir yaşında erkek hasta dikkati sürdürmede güçlük, çabuk sıkılma, görev ve etkinliklerini tamamlayamama, unutkanlık şikâyetleriyle çocuk psikiyatri polikliniğine getirildi. Ruhsal Bozuklukların Tanısal ve Sayımsal Elkitabı IV (DSM IV) tanı kriterlerine göre "Dikkat Eksikliği Hiperaktivite Bozukluğu, Dikkatsizliğin Önde Olduğu Tip" tanısı alan olguda uzun etkili metilfenidat tedavisi planlandı. Otuz altı mg/gün uzun etkili metilfenidat tedavisinde iştahsızlık, bulantı gibi gastrointestinal yan etkiler ortaya çıkması ve buna bağlı gelişen ilaç uyumsuzluğu nedeniyle metilfenidat tedavisi kesilerek 1.hafta 25 mg/gün, 2.hafta 40 mg/gün ve idame olarak 60 mg/gün (1,2 mg/kg/gün) olacak şekilde atomoksetin tedavisi planlandı. Atomoksetin 60 mg/gün kullanımında olgumuzda düzen, simetri takıntısı, emin olamama, bir şey yaparken sürekli onaylanma ihtiyacı gibi yakınmalarının başlaması üzerine DSM IV tanı kriterleri dikkate alınarak yapılan klinik değerlendirme görüşmesi sonucunda DEHB ve OKB tanı kriterlerinin karşılandığı görülmüştür. Atomoksetin kullanımı ile OKB gelişen bu olgunun literatüre katkı sağlayacağı düşünülmüştür.
Turkish Journal of Child and Adolescent Mental Health
Objectives: It is aimed to present pediatric psychiatry consultations requested from children and... more Objectives: It is aimed to present pediatric psychiatry consultations requested from children and adolescents applying to the emergency departments of a university hospital and to evaluate the mental health services provided to these children. Materials and Methods: This study was carried out with 127 children and adolescents who applied to Child and Adult Emergency Departments of Karadeniz Technical University, Faculty of Medicine between 01.12.2017-31.12.2019 and asked for child psychiatry consultation. In addition to the sociodemographic data of the participants, data such as consultation reason, length of stay in the emergency room, psychiatric diagnoses, and treatment recommendations of children were collected. These data were recorded in SPSS 23.0 package program and the required statistics were applied Results: 61.4% of the participants were female (n=78) and 75.6% were between 13-18 years old. 10.6% of the children were not with their caregiver. Children between 0-12 years mostly applied for the drug side effects, and those between 13-18 years applied for suicide attempt. 25.2% of children had repeated emergency applications, and the rate of repeated applications was significantly higher due to somatic symptoms and panic attack. It was found that 10.6% of the children were offered hospitalization and those stayed in the emergency room for significantly longer time, but no one could be refered to a child psychiatry service. There was no child asked for consultation due to child maltreatment. 26% of the children were consulted due to suicide attempt, the rate of the children attempting suicide at least once was found to be significantly higher. Conclusion: It is thought that the results of this study would be beneficial in terms of reflecting the mental health services provided to children brought to the emergency room of a general hospital, defining the clinical features of these children, thus leading to cost effective mental health policies and emergency services policies.
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Papers by Serkan Karadeniz