Manic Symptoms as a Symptom of Antidepressant Discontinuation Syndrome in a Child
Journal of Child and Adolescent Psychopharmacology, 2013
The antidepressant discontinuation syndrome is a withdrawal type of reaction that an individual t... more The antidepressant discontinuation syndrome is a withdrawal type of reaction that an individual taking an antidepressant over a period of time experiences whenever there is an abrupt cessation of the medication (Haddad and Anderson 2007). Although the discontinuation symptoms are best characterized with selective serotonin reuptake inhibitors (SSRIs), similar discontinuation symptoms are being reported with other classes of antidepressants (Narayan and Haddad 2011). Many features of the discontinuation syndrome are described as similar in children, adolescents, and adults, including time of onset, common symptoms, duration, and response to treatment (Diler and Avci 2002). The most common symptoms of discontinuation syndrome are dizziness, lightheadedness, drowsiness, poor concentration, nausea, headache, and fatigue in children and adults (Hosenbocus and Chahal 2011). However, in the adult literature, there are case reports reporting mania, hypomania, psychosis, delirium, and mood elevation in addition to classic symptoms (Haddad and Anderson 2007). The only antidepressant drug approved by the United States Food and Drug Administration (FDA) for use in children and adolesents is fluoxetine. Adolesents who have manic episode during fluoxetine use have been reported in previous case reports (Venkataraman et al. 1992; Go et al. 1998;). Here, we report the case of a child who experienced manic attack with the discontinuation of fluxetine.
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