This study presents Quantitative Structure Activity Relationships (QSAR) study on a pool of 18 bi... more This study presents Quantitative Structure Activity Relationships (QSAR) study on a pool of 18 bio-active sulfonamide compounds which includes five acetazolamide derivatives, eight sulfanilamide derivatives and five clinically used sulfonamides molecules as drugs namely acetazolamide, methazolamide, dichlorophenamide, ethoxolamide and dorzolamide. For all the compounds, initial geometry optimizations were carried out with a molecular mechanics (MM) method using the MM+ force fields. The lowest energy conformations of the compounds obtained by the MM method were further optimized by the Density Functional Theory (DFT) method by employing Becke's three-parameter hybrid functional (B3LYP) and 6-31G (d) basis set. Molecular descriptors, dipole moment, electronegativity, total energy at 0 K, entropy at 298 K, HOMO and LUMO energies obtained from DFT calculations provide valuable information and have a significant role in the assessment of carbonic anhydrase (CA-II) inhibitory activity of the compounds. By using the multiple linear regression technique several QSAR models have been drown up with the help these calculated descriptors and carbonic anhydrase (CA-II) inhibitory data of the molecules. Among the obtained QSAR models presented in the study, statistically the most significant one is a five parameters linear equation with the squared correlation coefficient R 2 values of ca. 0.94 and the squared cross-validated correlation coefficient R 2 CV values of ca. 0.85. The results were discussed in the light of the main factors that influence the inhibitory activity of the carbonic anhydrase (CA-II) isozyme.
Radiation enteritis occurs during the radiotherapy of many intraabdominal malignancies. Radiation... more Radiation enteritis occurs during the radiotherapy of many intraabdominal malignancies. Radiation induces cellular injury directly and through the generation of free radicals. In the present study we aimed to investigate the effect of octreotide (OCT) pretreatment in irradiation-induced enteritis. For this aim, rats were injected with 50 µg/kg OCT 4 days before irradiation and continued for 3 more days, until sacrifice. Then intestinal and pancreatic myeloperoxidase (MPO) activities and intestinal malondialdehyde (MDA) levels of the rats were measured. Irradiation significantly increased intestinal and pancreatic MPO activities and MDA levels of intestinal tissues in comparison to those of the sham group. OCT treatment improved this elevation. The histopathologic evaluation of the mucosal structure was also preserved in the OCT-treated group. Inflammation of pancreatic tissue was also confirmed with histopathological examinations. In the irradiation group, NFκ-B overexpression was detected. OCT treatment decreased the end organ damage and inflammation of the small intestine. In conclusion, OCT appears to have beneficial effects on intestinal and pancreatic damage in abdominal irradiation through the inflammatory process.
Hyperparathyroidism is nowadays diagnosed early and asymptomatically with the improvements in rou... more Hyperparathyroidism is nowadays diagnosed early and asymptomatically with the improvements in routine biochemical tests and radiological procedures. The late bony complications of the disease have therefore started to decline rapidly. Brown tumours are one of the bony complications of hyperparathyroidism. The mandible is the predominantly affected site in the maxillofacial area. Maxillary involvement is rare. Here, an extremely rare case of a 19-year-old male patient with brown tumours in his maxilla and mandible associated with tertiary hyperparathyroidism is presented. A thorough diagnostic work-up was carried out and treatment options for both hyperparathyroidism and brown tumours were discussed. The importance of different radiological evaluation methods and the consultation between the oral and maxillofacial surgeons, general practitioner dentists, endocrinologists and radiologists are emphasised.
Journal of Istanbul University Faculty of Dentistry, 2009
Bu çalışmada ağız mukozasında vc çene kemiklerinde yer alan çeşitli patolojik oluşumların tanısı ... more Bu çalışmada ağız mukozasında vc çene kemiklerinde yer alan çeşitli patolojik oluşumların tanısı için kullanılan ince iğne aspirasyon (İİA) yönteminin değerinin vc uygulanabilirliğinin araştırılması amaçlanmıştır. Bu amaç doğrultusunda İstanbul Üniversitesi Onkoloji Enstitüsü Onkolojik Sitoloji Bilim Dalfna ağız içinden alınarak tanı amacıyla gönderilen 108 İİA olgusu incelenmiştir. Olguların cinsiyet, yaş. lokalizasyon özellikleri, sitopatolojik vc histopatolojik tanıları karşılaştırmalı tablolar hazırlanarak elde edilen bulgular değerlendirilmiştir. Çalışmamız.daki olguların yaş, lokalizasyon vc cinsiyet bulguları genellikle kaynak bilgilerle uyum göstermektedir. Olguların %71'indc histopatolojik ve sitopatolojik tanı aynı bulunmuştur. Bir olguda (%2) iki tanı farklıdır. Olguların %28'inde ise sitopatolojik materyal tanı için yeterli değildir. Bu olguların %67'si fibröz yapıda lezyon, %14'ü ise kemik içinde yer alan sklcrotik lezyonlardır. Kemik dokusundaki sklerotik lezyonlar, fıbröz lezyonlar ve kistlerden alınan materyaldeki hücrelerin sayıca az oluşu yetersizlik oranını arttırmıştır. Çalışmamızdaki olguların %83'ünc klinik tanı konulmuş vc bu olguların %28'inin klinik, sitopatolojik vc histopatolojik tanısı uyumlu bulunmuştur. Ağız lezyonlarında İİA yönteminin benign vc malign olguların ayırımında yararlı olduğu vurgulanmaktadır. Çalışmamızda, sitopatolojik olarak benign düşünülen I olgunun histopatolojik incelemede malign olduğu anlaşılmış ve yöntemin duyarlılığı %9S olarak saptanmıştır. İİA yönteminin kolay uygulanması ve hızlı sonuç alınması nedeniyle oral lezyonların tanısında ilk basamak olarak kullanılabileceği kanısına varılmıştır.
This study presents Quantitative Structure Activity Relationships (QSAR) study on a pool of 18 bi... more This study presents Quantitative Structure Activity Relationships (QSAR) study on a pool of 18 bio-active sulfonamide compounds which includes five acetazolamide derivatives, eight sulfanilamide derivatives and five clinically used sulfonamides molecules as drugs namely acetazolamide, methazolamide, dichlorophenamide, ethoxolamide and dorzolamide. For all the compounds, initial geometry optimizations were carried out with a molecular mechanics (MM) method using the MM+ force fields. The lowest energy conformations of the compounds obtained by the MM method were further optimized by the Density Functional Theory (DFT) method by employing Becke's three-parameter hybrid functional (B3LYP) and 6-31G (d) basis set. Molecular descriptors, dipole moment, electronegativity, total energy at 0 K, entropy at 298 K, HOMO and LUMO energies obtained from DFT calculations provide valuable information and have a significant role in the assessment of carbonic anhydrase (CA-II) inhibitory activity of the compounds. By using the multiple linear regression technique several QSAR models have been drown up with the help these calculated descriptors and carbonic anhydrase (CA-II) inhibitory data of the molecules. Among the obtained QSAR models presented in the study, statistically the most significant one is a five parameters linear equation with the squared correlation coefficient R 2 values of ca. 0.94 and the squared cross-validated correlation coefficient R 2 CV values of ca. 0.85. The results were discussed in the light of the main factors that influence the inhibitory activity of the carbonic anhydrase (CA-II) isozyme.
Radiation enteritis occurs during the radiotherapy of many intraabdominal malignancies. Radiation... more Radiation enteritis occurs during the radiotherapy of many intraabdominal malignancies. Radiation induces cellular injury directly and through the generation of free radicals. In the present study we aimed to investigate the effect of octreotide (OCT) pretreatment in irradiation-induced enteritis. For this aim, rats were injected with 50 µg/kg OCT 4 days before irradiation and continued for 3 more days, until sacrifice. Then intestinal and pancreatic myeloperoxidase (MPO) activities and intestinal malondialdehyde (MDA) levels of the rats were measured. Irradiation significantly increased intestinal and pancreatic MPO activities and MDA levels of intestinal tissues in comparison to those of the sham group. OCT treatment improved this elevation. The histopathologic evaluation of the mucosal structure was also preserved in the OCT-treated group. Inflammation of pancreatic tissue was also confirmed with histopathological examinations. In the irradiation group, NFκ-B overexpression was detected. OCT treatment decreased the end organ damage and inflammation of the small intestine. In conclusion, OCT appears to have beneficial effects on intestinal and pancreatic damage in abdominal irradiation through the inflammatory process.
Hyperparathyroidism is nowadays diagnosed early and asymptomatically with the improvements in rou... more Hyperparathyroidism is nowadays diagnosed early and asymptomatically with the improvements in routine biochemical tests and radiological procedures. The late bony complications of the disease have therefore started to decline rapidly. Brown tumours are one of the bony complications of hyperparathyroidism. The mandible is the predominantly affected site in the maxillofacial area. Maxillary involvement is rare. Here, an extremely rare case of a 19-year-old male patient with brown tumours in his maxilla and mandible associated with tertiary hyperparathyroidism is presented. A thorough diagnostic work-up was carried out and treatment options for both hyperparathyroidism and brown tumours were discussed. The importance of different radiological evaluation methods and the consultation between the oral and maxillofacial surgeons, general practitioner dentists, endocrinologists and radiologists are emphasised.
Journal of Istanbul University Faculty of Dentistry, 2009
Bu çalışmada ağız mukozasında vc çene kemiklerinde yer alan çeşitli patolojik oluşumların tanısı ... more Bu çalışmada ağız mukozasında vc çene kemiklerinde yer alan çeşitli patolojik oluşumların tanısı için kullanılan ince iğne aspirasyon (İİA) yönteminin değerinin vc uygulanabilirliğinin araştırılması amaçlanmıştır. Bu amaç doğrultusunda İstanbul Üniversitesi Onkoloji Enstitüsü Onkolojik Sitoloji Bilim Dalfna ağız içinden alınarak tanı amacıyla gönderilen 108 İİA olgusu incelenmiştir. Olguların cinsiyet, yaş. lokalizasyon özellikleri, sitopatolojik vc histopatolojik tanıları karşılaştırmalı tablolar hazırlanarak elde edilen bulgular değerlendirilmiştir. Çalışmamız.daki olguların yaş, lokalizasyon vc cinsiyet bulguları genellikle kaynak bilgilerle uyum göstermektedir. Olguların %71'indc histopatolojik ve sitopatolojik tanı aynı bulunmuştur. Bir olguda (%2) iki tanı farklıdır. Olguların %28'inde ise sitopatolojik materyal tanı için yeterli değildir. Bu olguların %67'si fibröz yapıda lezyon, %14'ü ise kemik içinde yer alan sklcrotik lezyonlardır. Kemik dokusundaki sklerotik lezyonlar, fıbröz lezyonlar ve kistlerden alınan materyaldeki hücrelerin sayıca az oluşu yetersizlik oranını arttırmıştır. Çalışmamızdaki olguların %83'ünc klinik tanı konulmuş vc bu olguların %28'inin klinik, sitopatolojik vc histopatolojik tanısı uyumlu bulunmuştur. Ağız lezyonlarında İİA yönteminin benign vc malign olguların ayırımında yararlı olduğu vurgulanmaktadır. Çalışmamızda, sitopatolojik olarak benign düşünülen I olgunun histopatolojik incelemede malign olduğu anlaşılmış ve yöntemin duyarlılığı %9S olarak saptanmıştır. İİA yönteminin kolay uygulanması ve hızlı sonuç alınması nedeniyle oral lezyonların tanısında ilk basamak olarak kullanılabileceği kanısına varılmıştır.
Uploads
Papers by Semra Guler