Background Cash transfer (CT) programs are an important type of social protection meant to reduce... more Background Cash transfer (CT) programs are an important type of social protection meant to reduce poverty. Whether CT programs increase the risk of overweight and obesity is unclear. The objective was to characterize the relationship between CT programs and the risk of overweight and obesity in children and adults. Methods We searched articles in PubMed, Embase, Cochrane, EconLit, Global Health, CINAHL Plus, IBSS, Health & Medical Collection, Scopus, Web of Science, and WHO Global Index Medicus in August 2021. Studies involving CT as the intervention, a control group, body mass index, overweight, or obesity as an outcome, and sample size > 300 were included. The Newcastle–Ottawa Scale was used for quality assessment. Results Of 2355 articles identified, 20 met the inclusion criteria. Because of marked heterogeneity in methodology, a narrative synthesis was used to present results. Thirteen of the studies reported that CT programs were associated with a significantly lower risk of...
Abstract Although studies conducted over the last twenty-five years have demonstrated that vitami... more Abstract Although studies conducted over the last twenty-five years have demonstrated that vitamin A and related retinoids are immune enhancers, the use of vitamin A and related retinoids to enhance responses to immunization has been limited. Numerous animal studies have now demonstrated that vitamin A and related retinoids, when given at or prior to immunization, will enhance antibody responses and cell-mediated immune responses to protein antigens. Recent studies with humans show that vitamin A supplementation enhances the IgG response to tetanus toxoid, and that related retinoids can be used to enhance antibody responses to protein antigens. Vitamin A enhances immune responses to poor immunogens, and this may be relevant to vaccines which are characterized by low se-roconversion rates. Although most known adjuvants have too many side effects for human use, vitamin A and related retinoids appear to enhance antibody and cell-mediated immunity without severe side effects. Vitamin A, through its metabolite...
Selenium status, with important roles in oxidative stress and immunity, has a non-linear U-shaped... more Selenium status, with important roles in oxidative stress and immunity, has a non-linear U-shaped association with all-cause mortality in US populations; in HIV-infected persons, low selenium is associated with increased viral load. Factors associated with selenium deficiency and whether selenium is independently associated with HIV ART outcomes in HIV-infected persons is unknown. We performed a multi-country case-cohort where cases were HIV-1 infected adults with either clinical failure (incident WHO stage 3, 4 or death by 96 weeks) or virologic failure (HIV RNA levels 蠅 1000 copies/mL for 2 successive visits at 蠅16 weeks). Median baseline selenium levels were 82.04 µg/L (IQR: 57.28 - 99.89) and selenium deficiency prevalence was 53% varying widely by country from 0% (US) to 100% (Zimbabwe). Independent risk factors for baseline selenium deficiency (<85 µg/mL) were country, previous TB (adjusted odds ratio (aOR) 7.57, 95% CI 1.46-39.21), low albumin (aOR 3.61, CI 1.13-11.52), and log C-reactive protein (...
Table S1. Serum lipids species in adults without AMD and adults with geographic atrophy or neovas... more Table S1. Serum lipids species in adults without AMD and adults with geographic atrophy or neovascular AMD1. (DOCX 31 kb)
Assessing the capacity for newborn resuscitation and factors associated with providers ’ knowledg... more Assessing the capacity for newborn resuscitation and factors associated with providers ’ knowledge to build providers ’ capacity to perform newborn resuscitation. This kind of training could also help skilled birth Kim et al. BMC Pediatrics 2013, 13:140
Abstract Growth faltering under 5 years of age is unacceptably high worldwide, and even more chil... more Abstract Growth faltering under 5 years of age is unacceptably high worldwide, and even more children, while not stunted, fail to reach their growth potential. The time between conception and 2 years of age is critical for development. The period from 6 to 23 months, when complementary foods are introduced, coincides with a time when growth faltering and delayed neurocognitive developments are most common. Fortunately, this is also the period when diet exercises its greatest influence. Growing up in an adverse environment, with a deficient diet, as typically seen in low‐ and middle‐income countries (LMICs), hampers growth and development of children and prevents them from realising their full developmental and economic future potential. Sufficient nutrient availability and utilisation are paramount to a child's growth and development trajectory, especially in the period after breastfeeding. This review highlights the importance of essential amino acids (EAAs) in early life for linear growth and, likely, neurocognitive development. The paper further discusses signalling through mammalian target of rapamycin complex 1 (mTORC1) as one of the main amino acid (AA)‐sensing hubs and the master regulator of both growth and neurocognitive development. Children in LMICs, despite consuming sufficient total protein, do not meet their EAA requirements due to poor diet diversity and low‐quality dietary protein. AA deficiencies in early life can cause reductions in linear growth and cognition. Ensuring AA adequacy in diets, particularly through inclusion of nutrient‐dense animal source foods from 6 to 23 months, is strongly encouraged in LMICs in order to compensate for less than optimal growth during complementary feeding.
Resting metabolic rate (RMR) tends to decline with aging. The age-trajectory of decline in RMR is... more Resting metabolic rate (RMR) tends to decline with aging. The age-trajectory of decline in RMR is similar to changes that occur in muscle mass, muscle strength and fitness. However, while the decline in these phenotypes have been related to changes of mitochondrial function and oxidative capacity, whether lower RMR is associated with poorer mitochondrial oxidative capacity is unknown. In 619 participants of the Baltimore Longitudinal Study of Aging, we analyzed the cross-sectional association between RMR (kcal/day), assessed by indirect calorimetry, and skeletal muscle maximal oxidative phosphorylation capacity, assessed as post-exercise phosphocreatine recovery time constant (tau-PCr), by phosphorous magnetic resonance spectroscopy. Linear regression models were used to evaluate the relationship between tau-PCr and RMR, adjusting for potential confounders. We found that independent of age, sex, lean body mass, muscle density and fat mass, higher RMR was significantly associated wit...
Journal of Agriculture, Food Systems, and Community Development, 2020
The COVID-19 pandemic has increased food insecurity, especially among low-income Black and His¬pa... more The COVID-19 pandemic has increased food insecurity, especially among low-income Black and His¬panic families in the United States. Food insecurity is associated with poorer health and higher mortality in adults and greater risk of impaired cognitive development and behavioral problems in children. Pro-viding food for low-income families is an important priority of the COVID-19 response. Food That Connects Us All is a program that provides healthy meals to low-income Black and Hispanic families in Baltimore City. The meals follow guidelines for the planetary health diet, a reference diet developed by the EAT-Lancet Commission to optimize health and be sustainable within planetary boundaries. The planetary health diet consists largely of vegetables, fruit, whole grains, legumes, nuts, and unsaturated oils, with a low to moderate amount of seafood and poultry and with little or no red or processed meats, refined grains, starchy vegetables, and added sugar. In a food survey, participan...
Although hepcidin, a recently discovered peptide hormone, is considered a major regulator of iron... more Although hepcidin, a recently discovered peptide hormone, is considered a major regulator of iron metabolism and anemia in chronic inflammation, its role in anemia during pregnancy has not been characterized. Our objective was to characterize the role of hepcidin in anemia during pregnancy. We examined the relationships between urinary hepcidin, iron status indicators, hemoglobin, erythropoietin, alpha-1 acid glycoprotein, and C-reactive protein in a cross-sectional study conducted among 149 pregnant rural Bangladeshi women with biospecimens obtained during home visits. Urinary hepcidin was measured using surface-enhanced laser desorption/ ionization time-of-flight mass spectrometry. Urinary hepcidin, as log(intensity per mmol/L creatinine), was correlated with log ferritin (r = 0.33, p <0.001), the transferrin receptor index (r = -0.22, p = 0.007), and log alpha-1 acid glycoprotein (r = 0.20, p = 0.01), but not hemoglobin (r = 0.07, p= 0.40), log transferrin receptor (r = -0.07,...
Food insecurity is common in developing countries and related to the physical well being of famil... more Food insecurity is common in developing countries and related to the physical well being of families. Household food insecurity is intended to reflect a household's access, availability, and utilization of food. The relationship between paternal smoking and household food insecurity has not been well characterized. The objective of this study was to examine the relationship of paternal smoking with household food insecurity among poor families in rural Indonesia. In a cross-sectional study of 26,380 rural households in the Indonesian Nutrition Surveillance System in 2003, we examined the relationship between paternal smoking and household food insecurity score, as measured using a 9-item food security questionnaire. The prevalence of paternal smoking was 72.9%. In families with and without a father who smoked, the mean (standard error) household food insecurity score was 1.83 (0.01) and 1.48 (0.02), respectively (p<0.0001). Paternal smoking was associated with greater househo...
Background Dietary biomarkers may complement dietary intake assessment made by dietary questionna... more Background Dietary biomarkers may complement dietary intake assessment made by dietary questionnaires. We developed an a-posteriori dietary biomarkers score based on Mediterranean diet food groups and evaluated its association with mortality. Methods 642 participants (56% female), aged ≥65 years, with complete data on dietary biomarkers were followed during 20 years in the InCHIANTI cohort study (Tuscany, Italy). The main outcomes were all-cause, cardiovascular, and cancer mortality. Dietary biomarkers were selected from literature and from correlation analyses with dietary intakes of Mediterranean diet food groups in the study. The baseline levels of the following dietary biomarkers were chosen: urinary total polyphenols and resveratrol metabolites, and plasma carotenoids, selenium, vitamin B12, linolenic, eicosapentaenoic and docosahexaenoic acids, and the mono-unsaturated/saturated fatty acid ratio. Associations of the Mediterranean diet score using dietary biomarkers and a valid...
Journal of health, population, and nutrition, 2005
This prospective study was carried out during February 2000-April 2003 to characterize the relati... more This prospective study was carried out during February 2000-April 2003 to characterize the relationship between the status of carotenoids, vitamin E, and retinol and anthropometric status in apparently healthy infants and their mothers in Blantyre, Malawi. Anthropometric status of infants and concentrations of carotenoids (alpha-carotene, beta-carotene, beta-cryptoxanthin, lutein, zeaxanthin, and lycopene), retinol, and alpha-tocopherol in plasma were measured in 173 infants at 12 months of age, and concentrations of carotenoids, retinol, and a-tocopherol in plasma were measured in their mothers two weeks postpartum. In multivariate analyses, concentrations of retinol, total carotenoids, non-provitamin A carotenoids, and alpha-tocopherol in infants were associated with under-weight (p = 0.05). Concentrations of a-tocopherol were associated with wasting (p = 0.04). Concentrations in mothers and infants were all correlated (correlation coefficients from 0.230 to 0.502, p < 0.003). ...
Background Cash transfer (CT) programs are an important type of social protection meant to reduce... more Background Cash transfer (CT) programs are an important type of social protection meant to reduce poverty. Whether CT programs increase the risk of overweight and obesity is unclear. The objective was to characterize the relationship between CT programs and the risk of overweight and obesity in children and adults. Methods We searched articles in PubMed, Embase, Cochrane, EconLit, Global Health, CINAHL Plus, IBSS, Health & Medical Collection, Scopus, Web of Science, and WHO Global Index Medicus in August 2021. Studies involving CT as the intervention, a control group, body mass index, overweight, or obesity as an outcome, and sample size > 300 were included. The Newcastle–Ottawa Scale was used for quality assessment. Results Of 2355 articles identified, 20 met the inclusion criteria. Because of marked heterogeneity in methodology, a narrative synthesis was used to present results. Thirteen of the studies reported that CT programs were associated with a significantly lower risk of...
Abstract Although studies conducted over the last twenty-five years have demonstrated that vitami... more Abstract Although studies conducted over the last twenty-five years have demonstrated that vitamin A and related retinoids are immune enhancers, the use of vitamin A and related retinoids to enhance responses to immunization has been limited. Numerous animal studies have now demonstrated that vitamin A and related retinoids, when given at or prior to immunization, will enhance antibody responses and cell-mediated immune responses to protein antigens. Recent studies with humans show that vitamin A supplementation enhances the IgG response to tetanus toxoid, and that related retinoids can be used to enhance antibody responses to protein antigens. Vitamin A enhances immune responses to poor immunogens, and this may be relevant to vaccines which are characterized by low se-roconversion rates. Although most known adjuvants have too many side effects for human use, vitamin A and related retinoids appear to enhance antibody and cell-mediated immunity without severe side effects. Vitamin A, through its metabolite...
Selenium status, with important roles in oxidative stress and immunity, has a non-linear U-shaped... more Selenium status, with important roles in oxidative stress and immunity, has a non-linear U-shaped association with all-cause mortality in US populations; in HIV-infected persons, low selenium is associated with increased viral load. Factors associated with selenium deficiency and whether selenium is independently associated with HIV ART outcomes in HIV-infected persons is unknown. We performed a multi-country case-cohort where cases were HIV-1 infected adults with either clinical failure (incident WHO stage 3, 4 or death by 96 weeks) or virologic failure (HIV RNA levels 蠅 1000 copies/mL for 2 successive visits at 蠅16 weeks). Median baseline selenium levels were 82.04 µg/L (IQR: 57.28 - 99.89) and selenium deficiency prevalence was 53% varying widely by country from 0% (US) to 100% (Zimbabwe). Independent risk factors for baseline selenium deficiency (<85 µg/mL) were country, previous TB (adjusted odds ratio (aOR) 7.57, 95% CI 1.46-39.21), low albumin (aOR 3.61, CI 1.13-11.52), and log C-reactive protein (...
Table S1. Serum lipids species in adults without AMD and adults with geographic atrophy or neovas... more Table S1. Serum lipids species in adults without AMD and adults with geographic atrophy or neovascular AMD1. (DOCX 31 kb)
Assessing the capacity for newborn resuscitation and factors associated with providers ’ knowledg... more Assessing the capacity for newborn resuscitation and factors associated with providers ’ knowledge to build providers ’ capacity to perform newborn resuscitation. This kind of training could also help skilled birth Kim et al. BMC Pediatrics 2013, 13:140
Abstract Growth faltering under 5 years of age is unacceptably high worldwide, and even more chil... more Abstract Growth faltering under 5 years of age is unacceptably high worldwide, and even more children, while not stunted, fail to reach their growth potential. The time between conception and 2 years of age is critical for development. The period from 6 to 23 months, when complementary foods are introduced, coincides with a time when growth faltering and delayed neurocognitive developments are most common. Fortunately, this is also the period when diet exercises its greatest influence. Growing up in an adverse environment, with a deficient diet, as typically seen in low‐ and middle‐income countries (LMICs), hampers growth and development of children and prevents them from realising their full developmental and economic future potential. Sufficient nutrient availability and utilisation are paramount to a child's growth and development trajectory, especially in the period after breastfeeding. This review highlights the importance of essential amino acids (EAAs) in early life for linear growth and, likely, neurocognitive development. The paper further discusses signalling through mammalian target of rapamycin complex 1 (mTORC1) as one of the main amino acid (AA)‐sensing hubs and the master regulator of both growth and neurocognitive development. Children in LMICs, despite consuming sufficient total protein, do not meet their EAA requirements due to poor diet diversity and low‐quality dietary protein. AA deficiencies in early life can cause reductions in linear growth and cognition. Ensuring AA adequacy in diets, particularly through inclusion of nutrient‐dense animal source foods from 6 to 23 months, is strongly encouraged in LMICs in order to compensate for less than optimal growth during complementary feeding.
Resting metabolic rate (RMR) tends to decline with aging. The age-trajectory of decline in RMR is... more Resting metabolic rate (RMR) tends to decline with aging. The age-trajectory of decline in RMR is similar to changes that occur in muscle mass, muscle strength and fitness. However, while the decline in these phenotypes have been related to changes of mitochondrial function and oxidative capacity, whether lower RMR is associated with poorer mitochondrial oxidative capacity is unknown. In 619 participants of the Baltimore Longitudinal Study of Aging, we analyzed the cross-sectional association between RMR (kcal/day), assessed by indirect calorimetry, and skeletal muscle maximal oxidative phosphorylation capacity, assessed as post-exercise phosphocreatine recovery time constant (tau-PCr), by phosphorous magnetic resonance spectroscopy. Linear regression models were used to evaluate the relationship between tau-PCr and RMR, adjusting for potential confounders. We found that independent of age, sex, lean body mass, muscle density and fat mass, higher RMR was significantly associated wit...
Journal of Agriculture, Food Systems, and Community Development, 2020
The COVID-19 pandemic has increased food insecurity, especially among low-income Black and His¬pa... more The COVID-19 pandemic has increased food insecurity, especially among low-income Black and His¬panic families in the United States. Food insecurity is associated with poorer health and higher mortality in adults and greater risk of impaired cognitive development and behavioral problems in children. Pro-viding food for low-income families is an important priority of the COVID-19 response. Food That Connects Us All is a program that provides healthy meals to low-income Black and Hispanic families in Baltimore City. The meals follow guidelines for the planetary health diet, a reference diet developed by the EAT-Lancet Commission to optimize health and be sustainable within planetary boundaries. The planetary health diet consists largely of vegetables, fruit, whole grains, legumes, nuts, and unsaturated oils, with a low to moderate amount of seafood and poultry and with little or no red or processed meats, refined grains, starchy vegetables, and added sugar. In a food survey, participan...
Although hepcidin, a recently discovered peptide hormone, is considered a major regulator of iron... more Although hepcidin, a recently discovered peptide hormone, is considered a major regulator of iron metabolism and anemia in chronic inflammation, its role in anemia during pregnancy has not been characterized. Our objective was to characterize the role of hepcidin in anemia during pregnancy. We examined the relationships between urinary hepcidin, iron status indicators, hemoglobin, erythropoietin, alpha-1 acid glycoprotein, and C-reactive protein in a cross-sectional study conducted among 149 pregnant rural Bangladeshi women with biospecimens obtained during home visits. Urinary hepcidin was measured using surface-enhanced laser desorption/ ionization time-of-flight mass spectrometry. Urinary hepcidin, as log(intensity per mmol/L creatinine), was correlated with log ferritin (r = 0.33, p <0.001), the transferrin receptor index (r = -0.22, p = 0.007), and log alpha-1 acid glycoprotein (r = 0.20, p = 0.01), but not hemoglobin (r = 0.07, p= 0.40), log transferrin receptor (r = -0.07,...
Food insecurity is common in developing countries and related to the physical well being of famil... more Food insecurity is common in developing countries and related to the physical well being of families. Household food insecurity is intended to reflect a household's access, availability, and utilization of food. The relationship between paternal smoking and household food insecurity has not been well characterized. The objective of this study was to examine the relationship of paternal smoking with household food insecurity among poor families in rural Indonesia. In a cross-sectional study of 26,380 rural households in the Indonesian Nutrition Surveillance System in 2003, we examined the relationship between paternal smoking and household food insecurity score, as measured using a 9-item food security questionnaire. The prevalence of paternal smoking was 72.9%. In families with and without a father who smoked, the mean (standard error) household food insecurity score was 1.83 (0.01) and 1.48 (0.02), respectively (p<0.0001). Paternal smoking was associated with greater househo...
Background Dietary biomarkers may complement dietary intake assessment made by dietary questionna... more Background Dietary biomarkers may complement dietary intake assessment made by dietary questionnaires. We developed an a-posteriori dietary biomarkers score based on Mediterranean diet food groups and evaluated its association with mortality. Methods 642 participants (56% female), aged ≥65 years, with complete data on dietary biomarkers were followed during 20 years in the InCHIANTI cohort study (Tuscany, Italy). The main outcomes were all-cause, cardiovascular, and cancer mortality. Dietary biomarkers were selected from literature and from correlation analyses with dietary intakes of Mediterranean diet food groups in the study. The baseline levels of the following dietary biomarkers were chosen: urinary total polyphenols and resveratrol metabolites, and plasma carotenoids, selenium, vitamin B12, linolenic, eicosapentaenoic and docosahexaenoic acids, and the mono-unsaturated/saturated fatty acid ratio. Associations of the Mediterranean diet score using dietary biomarkers and a valid...
Journal of health, population, and nutrition, 2005
This prospective study was carried out during February 2000-April 2003 to characterize the relati... more This prospective study was carried out during February 2000-April 2003 to characterize the relationship between the status of carotenoids, vitamin E, and retinol and anthropometric status in apparently healthy infants and their mothers in Blantyre, Malawi. Anthropometric status of infants and concentrations of carotenoids (alpha-carotene, beta-carotene, beta-cryptoxanthin, lutein, zeaxanthin, and lycopene), retinol, and alpha-tocopherol in plasma were measured in 173 infants at 12 months of age, and concentrations of carotenoids, retinol, and a-tocopherol in plasma were measured in their mothers two weeks postpartum. In multivariate analyses, concentrations of retinol, total carotenoids, non-provitamin A carotenoids, and alpha-tocopherol in infants were associated with under-weight (p = 0.05). Concentrations of a-tocopherol were associated with wasting (p = 0.04). Concentrations in mothers and infants were all correlated (correlation coefficients from 0.230 to 0.502, p < 0.003). ...
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Papers by Richard Semba