Papers by Satya Jonnalagadda
OBM Geriatrics, 2020
Poor nutrition is linked to frailty and both poor nutrition and frailty are recognized risk facto... more Poor nutrition is linked to frailty and both poor nutrition and frailty are recognized risk factors for falls. This study examined the association between dietary protein intake and subsequent reported falls in community-dwelling older Americans with a history of falls. Other nutritional, functional, and sociodemographic-related variables were also considered in our model. This was a retrospective analysis using data from the U.S. Health and Retirement Study (HRS) and Health Care and Nutrition Study (HCNS), both funded by the U.S. National Institute on Aging. The study population (n=3,859) was community-dwelling older adults, aged >65 years, who reported ever experiencing a fall on the 2012 HRS and had also completed the 2013 HCNS and 2014 HRS. Univariable logistic models were created for all Keywords Very low protein intake; subsequent falls; community living older adults; HRS
The Gerontologist, 2004
Purpose: Using the life stress model of psychological well-being, in this study we examined risks... more Purpose: Using the life stress model of psychological well-being, in this study we examined risks and resources predicting the occurrence of both positive and negative affect among older Asian Indian immigrants who experienced stressful life events. Design and Methods: We collected data through a telephone survey of 226 respondents (aged 50 years and older) in the Southeastern United States. We used hierarchical, negative binomial regression analyses to examine correlates of positive and negative affect. Results: Different coping resources influenced positive and negative affect when stressful life events were controlled for. Being female was a common risk factor for poorer positive and increased negative affect. Satisfaction with friendships and a cultural or ethnic identity that is either bicultural or more American were predictive of greater positive affect. Greater religiosity and increased mastery were resources predicting less negative affect. Implications: Cognitive and structural interventions that increase opportunities for social integration, increasing mastery, and addressing spiritual concerns are discussed as ways of coping with stress to improve the well-being of individuals in this immigrant community.
Journal of Applied Gerontology, 2004
This study examines the validity of the short form (eight items) Center for Epidemiological Studi... more This study examines the validity of the short form (eight items) Center for Epidemiological Studies-Depression Scale (CES-D), as a screening tool for mental health problems among older immigrants who are minorities. The factor structure of the CES-D is examined empirically using two samples of older Asian Indian immigrants in the United States: the first sample of 226 English speakers, and the second sample of 114 Gujarati speakers residing in Atlanta, Georgia. The CES-D, administered via telephone interviews, showed high internal consistency. Exploratory and confirmatory factor analyses for the English speaking sample showed two factors indicating positive and negative affect, whereas the Gujarati-speaking sample yielded a unidimensional factor where depression was not differentiated, suggesting that depression may be conceptualized and manifested differently among diverse groups of older immigrants. Culturally competent practice with older adults should include an awareness of the...
Nutrients
The aims of the present study were to compare the adherence to dietary guidelines and evaluate po... more The aims of the present study were to compare the adherence to dietary guidelines and evaluate potential differences in nutrient profiles among adults by diabetes status. We used the Mexican Alternate Healthy Eating Index (MxAHEI) to evaluate adherence to dietary guidelines. We calculated the MxAHEI scores (total and by dietary component) with scales from 0 (non-adherence) to 100 (perfect adherence) based on a food frequency questionnaire. Mean daily intakes of macronutrients and micronutrients (g, mg, mcg/1000 kcal per day) were also estimated by diabetes status. Sex-specific, multivariable linear regression models were estimated to test whether MxAHEI scores as well as nutrient intakes were different by diabetes status. Mexican adults had low adherence to the dietary guidelines irrespective of their diabetes status (score < 50 points). Among men, the MxAHEI score was 2.6 points higher among those with diabetes than those without diabetes (46.9; 95% confidence intervals (CI): 44...
Nutrients, 2020
The aims of the present study were to compare the adherence to dietary guidelines and evaluate po... more The aims of the present study were to compare the adherence to dietary guidelines and evaluate potential differences in nutrient profiles among adults by diabetes status. We used the Mexican Alternate Healthy Eating Index (MxAHEI) to evaluate adherence to dietary guidelines. We calculated the MxAHEI scores (total and by dietary component) with scales from 0 (non-adherence) to 100 (perfect adherence) based on a food frequency questionnaire. Mean daily intakes of macronutrients and micronutrients (g, mg, mcg/1000 kcal per day) were also estimated by diabetes status. Sex-specific, multivariable linear regression models were estimated to test whether MxAHEI scores as well as nutrient intakes were different by diabetes status. Mexican adults had low adherence to the dietary guidelines irrespective of their diabetes status (score < 50 points). Among men, the MxAHEI score was 2.6 points higher among those with diabetes than those without diabetes (46.9; 95% confidence intervals (CI): 44...
Geriatrics
How different measures of adiposity are similarly or differentially related to mobility limitatio... more How different measures of adiposity are similarly or differentially related to mobility limitation and mortality is not clear. In total, 5849 community-dwelling men aged ≥65 years (mean age: 72 years) were followed mortality over 10 years and self-reported mobility limitations (any difficulty walking 2–3 blocks or with climbing 10 steps) at six contacts over 14 years. Baseline measures of adiposity included weight, BMI and percent fat by DXA. Appendicular lean mass (ALM, by DXA) was analyzed as ALM/ht2. Proportional hazards models estimated the risk of mortality, and repeated measures generalized estimating equations estimated the likelihood of mobility limitation. Over 10 years, 27.9% of men died; over 14 years, 48.0% of men reported at least one mobility limitation. We observed U-shaped relationships between weight, BMI, percent fat and ALM/ht2 with mortality. There was a clear log-linear relationship between weight, BMI and percent fat with incident mobility limitation, with high...
Journal of Parenteral and Enteral Nutrition
Parenteral and enteral nutrition support are key components of care for various medical and physi... more Parenteral and enteral nutrition support are key components of care for various medical and physiological conditions in infants, children, and adults. Nutrition support practices have advanced over time, driven by the goals of safe and sufficient delivery of needed nutrients and improved patient outcomes. These advances have been, and continue to be, dependent on research and development studies. Such studies address aspects of enteral and parenteral nutrition support: formulations, delivery devices, health outcomes, cost-effectiveness, and related metabolism. The studies are supported by public funding from the government and by private funding from foundations and from the nutrition support industry. To build public trust in nutrition support research findings, it is important to underscore ethical research conduct and reporting of results for all studies, including those with industry sponsors. In 2019, American Society for Parenteral and Enteral Nutrition's (ASPEN's) Board of Directors established a task force to ensure integrity in nutrition support research that is done as collaborative partnerships between the public (government and individuals) and private groups (foundations, academia, and industry). In this ASPEN Position Paper, the Task Force presents principles of ethical research to guide administrators, researchers, and funders. The Task Force identifies ways to curtail bias and to minimize actual or perceived conflict of interests, as related to funding sources and research conduct. Notably, this paper includes a Position Statement to describe the Task Force's guidance on Public-Private Partnerships for research and funding. This paper has been approved by the ASPEN Board of Directors.
Studies show rapid weight loss with short-term use of ready-to-eat (RTE) breakfast cereals as par... more Studies show rapid weight loss with short-term use of ready-to-eat (RTE) breakfast cereals as partial meal replacements. This study was designed to compare 2 wk weight loss from partial meal replacements of Special K® Original (Kellogg Company) vs. a calorie-matched whole grain control cereal (General Mills, Inc.). Overweight women (42±11 y; 31.7±4 kg/m2) were randomized to either Special K® (n=32) or control (n=32). All subjects were instructed to replace their usual breakfast and lunch or dinner with a 100 kcal serving of cereal, 2/3 c skim milk and fruit daily for 2 wks. Body weight, DEXA body composition, and circumference measurements were obtained at 0 and 2 weeks and were analyzed by repeated measures ANOVA. After 2 wks, women lost 2.9±2.6 lbs (p<0.001), with the control group losing significantly more weight than Special K® (-3.6±2.9 lbs vs.-2.2±2.0; p=0.026). Women reduced waist circumference (-0.4±1.0 in; p=0.003), with no significant difference between groups. No significant effects of time or group were observed for fat mass, % body fat or hip circumference. Results show that replacing two meals daily for 2 wks with a 100 kcal serving of either Special K® Original or a whole grain RTE cereal, served with skim milk and fruit, can help reduce body weight and waist circumference.
We found that a variety of cholecystokinin (CCK) receptor ligands bind to bovine serum albumin (B... more We found that a variety of cholecystokinin (CCK) receptor ligands bind to bovine serum albumin (BSA). This binding was rapid, fully reversible, temperature independent, of low affinity, and specific for BSA; it depended on the concentration of BSA, the chemical structure of the ligand, and the chemical composition of the incubation medium. BSA also decreased the binding of 1251-labeled CCK octapeptide (1251-CCK-8) to CCK receptors on pancreatic acini and membranes but increased the potency with which CCK-8 inhibited binding of 1251-CCK-8. These counterintuitive findings appeared to result from BSA altering the affinities of CCK-8 for different affinity states of the pancreatic CCK receptor. An alternate hypothesis is that BSA increased the efficacy of CCK-8 such that it bound to receptors and also caused biochemical changes in other receptors that reduced their ability to bind 1251-CCK-8. BSA enhanced the ability of CCK-8 to stimulate amylase secretion from pancreatic acini and to cause contraction of dispersed gastric smooth muscle cells. Thus, CCK can bind to BSA, and the BSA-CCK complex has substantially different activities from the free, uncomplexed hormone.
The Journal of Nutrition
Background Factor VIIc, fibrinogen, and plasminogen activator inhibitor 1 (PAI-1) are cardiovascu... more Background Factor VIIc, fibrinogen, and plasminogen activator inhibitor 1 (PAI-1) are cardiovascular disease (CVD) risk factors and are modulated, in part, by fat type and amount. Objective We evaluated fat type and amount on the primary outcomes: factor VIIc, fibrinogen, and PAI-1. Methods In the Dietary Effects on Lipoproteins and Thrombogenic Activity (DELTA) Trial, 2 controlled crossover feeding studies evaluated substituting carbohydrate or MUFAs for SFAs. Study 1: healthy participants (n = 103) were provided with (8 wk) an average American diet [AAD; designed to provide 37% of energy (%E) as fat, 16% SFA], a Step 1 diet (30%E fat, 9% SFA), and a diet low in SFA (Low-Sat; 26%E fat, 5% SFA). Study 2: participants (n = 85) at risk for CVD and metabolic syndrome (MetSyn) were provided with (7 wk) an AAD, a step 1 diet, and a high-MUFA diet (designed to provide 37%E fat, 8% SFA, 22% MUFA). Results Study 1: compared with AAD, the Step 1 and Low-Sat diets decreased mean factor VIIc b...
Current Developments in Nutrition
Objectives Diabetes and prediabetes are a major public health concern in the United States. It is... more Objectives Diabetes and prediabetes are a major public health concern in the United States. It is unknown how food-related behaviors are influenced by diabetes status. Therefore this study assessed the association between diabetes status and food behaviors (meal preparation, food procurement, and food spending) among U.S. adults. Methods Data from 8799 adults from the 2005–2016 National Health and Nutrition Examination Survey were categorized by glycated hemoglobin levels (A1c%): nondiabetes (<5.7%; n = 5455), prediabetes (5.7–6.4%; n = 2273), and diabetes (>6.5%; n = 1071). A1c levels were compared with meal preparation, food procurement, and spending data. Age-adjusted analyses for total and by sex (n = 4481 females and n = 4318 males) were performed. Results All adults (P = 0.002) and males (P = 0.001) with diabetes and prediabetes spent less money dining out than those without diabetes. Those with diabetes had a significantly further distance to grocery stores among the ad...
Current Developments in Nutrition
Objectives Adiposity is often approximated by body mass index (BMI), weight, and % fat from dual ... more Objectives Adiposity is often approximated by body mass index (BMI), weight, and % fat from dual energy x-ray absorptiometry (DXA). We aimed to describe how different measures of adiposity and body composition are similarly or differentially related to mobility limitation and mortality. Methods Older community-dwelling men aged ≥65 yrs were followed for 10 years for mortality (N = 5849) and at six study contacts over 14 year for self-reported mobility limitations (any difficulty walking 2–3 blocks or with climbing 10 steps, N = 5841). Baseline measures of adiposity included weight, BMI, % fat by DXA. Appendicular lean mass (ALM, by DXA) was analyzed as ALM/ht2. Proportional hazards models estimated the risk of mortality and repeated measures generalized estimating equations estimated the likelihood of mobility limitation. Adiposity and ALM/ht2 measures were analyzed as quintiles and with splines. Results Over 10 years, 27.9% of men died; over 14 years, 48.0% of men reported at least...
Current Developments in Nutrition
Objectives To compare the intake of macronutrients, micronutrients, and dietary patterns between ... more Objectives To compare the intake of macronutrients, micronutrients, and dietary patterns between Mexican adults with and without diabetes. Methods Design: We calculated the mean intakes and adequacies of energy, macronutrients and micronutrients, and factor analysis was used to identify dietary patterns. We computed sex-specific, age- and energy-adjusted and fully-adjusted linear regression models to test whether nutrient intakes and dietary patterns scores were different by diabetes status. Setting: Mexico Participants: Mexican men (n 1142) and women (n 1620) participating in the Mexican National Health and Nutrition Survey 2012. Results The energy intake from carbohydrates and added sugars was lower in men and women with diabetes than in men and women without diabetes, but slightly above the recommended among adults with diabetes. Men with diabetes consumed more protein, total, monounsaturated and saturated fatty acids, vitamin D, calcium, and potassium than men without diabetes. ...
Current Developments in Nutrition
Objectives Distribution of carbohydrate intakes (carb choices) throughout the day are an importan... more Objectives Distribution of carbohydrate intakes (carb choices) throughout the day are an important aspect to diabetes management and reducing blood glucose spikes. Skipping breakfast represents a behavior of concern, providing an extension of the overnight fast and may result in elevated sugar levels later in the day. Therefore, the purpose of this study was to evaluate dietary intake differences, including carbohydrates, based on consuming breakfast or not, and by diabetes status. Methods Adults over 30 years from NHANES 2005–2016 were classified into nondiabetes (HbA1c <5.7%, n = 14,701), prediabetes (HbA1c 5.7–6.4%, n = 5855) and diabetes (HbA1c (≥6.5%, n = 2881). Dietary intakes were assessed using a multiple pass 24-hour recall to estimate intakes from the foods and beverages reported as consumed on the day prior to the NHANES visit. Breakfast was self-defined by participants. Total population-based means (95% CI) of nutrient intakes, MyPlate equivalents, and Healthy Eating ...
Nutrients
Background: The prevalence of vascular dysfunction increases with advancing age, as does the loss... more Background: The prevalence of vascular dysfunction increases with advancing age, as does the loss of muscle mass, strength and function. This systematic review explores the association between vascular dysfunction and skeletal muscle health in healthy adults. Methods: EMBASE and MEDLINE were searched for cross-sectional and randomized controlled studies between January 2009 and April 2019, with 33 out of 1246 studies included based on predefined criteria. Assessments of muscular health included muscle mass, strength and function. Macrovascular function assessment included arterial stiffness (pulse wave velocity or augmentation index), carotid intima-media thickness, and flow-mediated dilation. Microvascular health assessment included capillary density or microvascular flow (contrast enhanced ultrasound). Results: All 33 studies demonstrated a significant association between vascular function and skeletal muscle health. Significant negative associations were reported between vascular...
Nutrients
The present study investigated the meal patterns across demographic characteristics in middle-age... more The present study investigated the meal patterns across demographic characteristics in middle-aged and older US adults. Study participants were noninstitutionalized participants from the 2005–2016 National Health and Nutrition Examination Survey, an observational cross-sectional study. Data from 17,361 adults were categorized into 45–59 years (n = 7366), 60–70 years (n = 5348), and 71+ years (n = 4647) to compare demographics, nutrient intakes, and meal patterns. Dietary recalls were collected using the multiple-pass method. Data analyses were weighted to create a nationally representative sample. Two-thirds of adults reported consuming three meals on the day of intake. Lunch was the most often skipped meal across all age groups. A greater proportion of adults over 70 years reported consuming breakfast, while a smaller proportion reported consuming snacks. Significant differences were observed in total energy and nutrient intakes and proportion of the day’s intakes by meal. Grain, m...
The American journal of clinical nutrition, Jan 16, 2017
Background: Emerging evidence suggests novel roles for bacterially derived vitamin K forms known ... more Background: Emerging evidence suggests novel roles for bacterially derived vitamin K forms known as menaquinones in health and disease, which may be attributable in part to anti-inflammatory effects. However, the relevance of menaquinones produced by gut bacteria to vitamin K requirements and inflammation is undetermined.Objective: This study aimed to quantify fecal menaquinone concentrations and identify associations between fecal menaquinone concentrations and serum vitamin K concentrations, gut microbiota composition, and inflammation.Design: Fecal and serum menaquinone concentrations, fecal microbiota composition, and plasma and fecal cytokine concentrations were measured in 80 men and postmenopausal women (48 men, 32 women, age 40-65 y) enrolled in a randomized, parallel-arm, provided-food trial. After consuming a run-in diet for 2 wk, participants were randomly assigned to consume a whole grain-rich (WG) or a refined grain-based (RG) diet for 6 wk. Outcomes were measured at we...
The American journal of clinical nutrition, Mar 8, 2017
Background: The effect of whole grains on the regulation of energy balance remains controversial.... more Background: The effect of whole grains on the regulation of energy balance remains controversial.Objective: We aimed to determine the effects of substituting whole grains for refined grains, independent of body weight changes, on energy-metabolism metrics and glycemic control.Design: The study was a randomized, controlled, parallel-arm controlled-feeding trial that was conducted in 81 men and postmenopausal women [49 men and 32 women; age range: 40-65 y; body mass index (in kg/m(2)): <35.0]. After a 2-wk run-in period, participants were randomly assigned to consume 1 of 2 weight-maintenance diets for 6 wk. Diets differed in whole-grain and fiber contents [mean ± SDs: whole grain-rich diet: 207 ± 39 g whole grains plus 40 ± 5 g dietary fiber/d; refined grain-based diet: 0 g whole grains plus 21 ± 3 g dietary fiber/d] but were otherwise similar. Energy metabolism and body-composition metrics, appetite, markers of glycemic control, and gut microbiota were measured at 2 and 8 wk.Resu...
The Faseb Journal, Apr 1, 2012
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Papers by Satya Jonnalagadda