Onion is not just an edible food compound but its seeds can also be an important source of valuab... more Onion is not just an edible food compound but its seeds can also be an important source of valuable oil with various sensitive applications mainly in pharmaceutical, cosmetic and food fields. This has encouraged the use of a sustainable extraction technique like the supercritical CO 2 extraction of oil from local onion seeds, as a clean and green alternative to organic solvent processes. To achieve this, the effects of four key operating parameters like pressure, temperature, particle size and CO 2 mass flowrate were investigated in ranges of [150, 250 bars], [35, 65 °C], [0.25, 0.85 mm] and [50, 100 g/min], respectively, using a Box-Behnken experimental design, for a constant extraction time of 3 h. This led to optimal operating conditions of 250 bar, 57 °C, 0.25 mm and 50 g CO 2 /min for the best oil extraction yield value of 24.36%. Furthermore, gas chromatography-mass spectrometry (GC-MS) was used to identify qualitatively and quantitatively the chemical composition of the onion seed oils. About ten components were identified in the extracts, but with four major ones, namely 9,12octadecadienoic acid, methyl ester, 9,12-octadecadienoic acid (Z,Z)-, methyl ester, 9-octadecadienoic acid (Z)-, methyl ester and hexadecanoic acid, methyl ester, present with significant percentages, depending on the operating parameters values. These fatty acids are well known for their benefits for human health. Finally this research showed ability of the supercritical CO 2 extraction to induce a sustainability character while being performing in producing bioactive substances, excluding the use of organic solvent and even replacing classical and traditional techniques like hydrodistillation.
A great variety of natural plants provide an important source of bioactive compounds having inter... more A great variety of natural plants provide an important source of bioactive compounds having interesting applications in sensitive fields like food, pharmaceutical and cosmetic industries, particularly with the development of the supercritical carbon dioxide extraction. Therefore the present study focused on the study of this technique to extract valuable bioactive substances from seeds of a local natural plant known as Peganum harmala. The properties of the extracts were also considered, particularly insisting on the antioxidant activity potential. The extraction yield was optimized and the corresponding operating conditions were determined. A Box-Behnken statistical design was used to investigate the effect of operating parameters like pressure, temperature and particle size at a fixed supercritical CO 2 flow rate of 50 g min − 1 for an extraction time of 180 min. Furthermore, the total antioxidant activity of the plant extracts was assessed using the 2, 2diphényl-1-picrylhydrazyl (DPPH) method whereas the Response surface methodology (RSM) combined with Box-Behnken design was used for the optimization of process key parameters. The highest extraction yield was achieved at a pressure of 300 bar, a temperature of 55 • C and a particle size of 0.3 mm. A maximum total phenolic content (TPC) and a 50% inhibition concentration (IC 50) of 79.04 mg GAE/g E and 172.199 μg/mL, respectively were obtained at 100 bar and 35 • C for a particle size of 0.9 mm, whereas a total flavonoid content of 7.10 mg QE/g E was obtained still at 35 • C and for a particle size of 0.9 mm but at a pressure of 170.7 bar. Finally supercritical CO 2 extraction showed to be an efficient technology, creating an added value through bioactive compounds with targeted properties like the antioxidant activity.
A great variety of natural plants provide an important source of bioactive compounds having inter... more A great variety of natural plants provide an important source of bioactive compounds having interesting applications in sensitive fields like food, pharmaceutical and cosmetic industries, particularly with the development of the supercritical carbon dioxide extraction. Therefore the present study focused on the study of this technique to extract valuable bioactive substances from seeds of a local natural plant known as Peganum harmala. The properties of the extracts were also considered, particularly insisting on the antioxidant activity potential. The extraction yield was optimized and the corresponding operating conditions were determined. A Box-Behnken statistical design was used to investigate the effect of operating parameters like pressure, temperature and particle size at a fixed supercritical CO 2 flow rate of 50 g min − 1 for an extraction time of 180 min. Furthermore, the total antioxidant activity of the plant extracts was assessed using the 2, 2diphényl-1-picrylhydrazyl (DPPH) method whereas the Response surface methodology (RSM) combined with Box-Behnken design was used for the optimization of process key parameters. The highest extraction yield was achieved at a pressure of 300 bar, a temperature of 55 • C and a particle size of 0.3 mm. A maximum total phenolic content (TPC) and a 50% inhibition concentration (IC 50) of 79.04 mg GAE/g E and 172.199 μg/mL, respectively were obtained at 100 bar and 35 • C for a particle size of 0.9 mm, whereas a total flavonoid content of 7.10 mg QE/g E was obtained still at 35 • C and for a particle size of 0.9 mm but at a pressure of 170.7 bar. Finally supercritical CO 2 extraction showed to be an efficient technology, creating an added value through bioactive compounds with targeted properties like the antioxidant activity.
Onion is not just an edible food but its seeds can also be an important source of valuable oil wi... more Onion is not just an edible food but its seeds can also be an important source of valuable oil with various sensitive applications mainly in pharmaceutical, cosmetic and food fields. This has encouraged the use of a supercritical fluid extraction in the present study to obtain oil from local onion seeds, hence avoiding even traces of organic solvents. For several advantages carbon dioxide at supercritical conditions was used as the fluid. The effects of four key operating parameters like pressure, temperature, particle size and CO2 mass flowrate were investigated in ranges of [150, 250 bars], [35, 65°C], [0.25, 0.85mm] and [50, 100g/min], respectively, using a Box-Behnken experimental design, for a constant extraction time of 3 hours. This led to optimal operating conditions of 250 bar, 57°C, 0.25mm and 50g CO2/min for the highest oil extraction yield value of 24.36%. Furthermore, gas chromatography-mass spectrometry (GC-MS) was used to identify qualitatively and quantitatively the ...
Functional Ingredients from Algae for Foods and Nutraceuticals, 2013
Highlights Supercritical fluid extracts optimization were done from radish leaves. The best r... more Highlights Supercritical fluid extracts optimization were done from radish leaves. The best results were obtained at 35 ºC/400 bar and 40 ºC/400 bar. Maturation of dendritic cells was not promoted being these extracts promising and interesting sources of antioxidative and anti-inflammatory agents.
Onion is not just an edible food compound but its seeds can also be an important source of valuab... more Onion is not just an edible food compound but its seeds can also be an important source of valuable oil with various sensitive applications mainly in pharmaceutical, cosmetic and food fields. This has encouraged the use of a sustainable extraction technique like the supercritical CO 2 extraction of oil from local onion seeds, as a clean and green alternative to organic solvent processes. To achieve this, the effects of four key operating parameters like pressure, temperature, particle size and CO 2 mass flowrate were investigated in ranges of [150, 250 bars], [35, 65 °C], [0.25, 0.85 mm] and [50, 100 g/min], respectively, using a Box-Behnken experimental design, for a constant extraction time of 3 h. This led to optimal operating conditions of 250 bar, 57 °C, 0.25 mm and 50 g CO 2 /min for the best oil extraction yield value of 24.36%. Furthermore, gas chromatography-mass spectrometry (GC-MS) was used to identify qualitatively and quantitatively the chemical composition of the onion seed oils. About ten components were identified in the extracts, but with four major ones, namely 9,12octadecadienoic acid, methyl ester, 9,12-octadecadienoic acid (Z,Z)-, methyl ester, 9-octadecadienoic acid (Z)-, methyl ester and hexadecanoic acid, methyl ester, present with significant percentages, depending on the operating parameters values. These fatty acids are well known for their benefits for human health. Finally this research showed ability of the supercritical CO 2 extraction to induce a sustainability character while being performing in producing bioactive substances, excluding the use of organic solvent and even replacing classical and traditional techniques like hydrodistillation.
A great variety of natural plants provide an important source of bioactive compounds having inter... more A great variety of natural plants provide an important source of bioactive compounds having interesting applications in sensitive fields like food, pharmaceutical and cosmetic industries, particularly with the development of the supercritical carbon dioxide extraction. Therefore the present study focused on the study of this technique to extract valuable bioactive substances from seeds of a local natural plant known as Peganum harmala. The properties of the extracts were also considered, particularly insisting on the antioxidant activity potential. The extraction yield was optimized and the corresponding operating conditions were determined. A Box-Behnken statistical design was used to investigate the effect of operating parameters like pressure, temperature and particle size at a fixed supercritical CO 2 flow rate of 50 g min − 1 for an extraction time of 180 min. Furthermore, the total antioxidant activity of the plant extracts was assessed using the 2, 2diphényl-1-picrylhydrazyl (DPPH) method whereas the Response surface methodology (RSM) combined with Box-Behnken design was used for the optimization of process key parameters. The highest extraction yield was achieved at a pressure of 300 bar, a temperature of 55 • C and a particle size of 0.3 mm. A maximum total phenolic content (TPC) and a 50% inhibition concentration (IC 50) of 79.04 mg GAE/g E and 172.199 μg/mL, respectively were obtained at 100 bar and 35 • C for a particle size of 0.9 mm, whereas a total flavonoid content of 7.10 mg QE/g E was obtained still at 35 • C and for a particle size of 0.9 mm but at a pressure of 170.7 bar. Finally supercritical CO 2 extraction showed to be an efficient technology, creating an added value through bioactive compounds with targeted properties like the antioxidant activity.
A great variety of natural plants provide an important source of bioactive compounds having inter... more A great variety of natural plants provide an important source of bioactive compounds having interesting applications in sensitive fields like food, pharmaceutical and cosmetic industries, particularly with the development of the supercritical carbon dioxide extraction. Therefore the present study focused on the study of this technique to extract valuable bioactive substances from seeds of a local natural plant known as Peganum harmala. The properties of the extracts were also considered, particularly insisting on the antioxidant activity potential. The extraction yield was optimized and the corresponding operating conditions were determined. A Box-Behnken statistical design was used to investigate the effect of operating parameters like pressure, temperature and particle size at a fixed supercritical CO 2 flow rate of 50 g min − 1 for an extraction time of 180 min. Furthermore, the total antioxidant activity of the plant extracts was assessed using the 2, 2diphényl-1-picrylhydrazyl (DPPH) method whereas the Response surface methodology (RSM) combined with Box-Behnken design was used for the optimization of process key parameters. The highest extraction yield was achieved at a pressure of 300 bar, a temperature of 55 • C and a particle size of 0.3 mm. A maximum total phenolic content (TPC) and a 50% inhibition concentration (IC 50) of 79.04 mg GAE/g E and 172.199 μg/mL, respectively were obtained at 100 bar and 35 • C for a particle size of 0.9 mm, whereas a total flavonoid content of 7.10 mg QE/g E was obtained still at 35 • C and for a particle size of 0.9 mm but at a pressure of 170.7 bar. Finally supercritical CO 2 extraction showed to be an efficient technology, creating an added value through bioactive compounds with targeted properties like the antioxidant activity.
Onion is not just an edible food but its seeds can also be an important source of valuable oil wi... more Onion is not just an edible food but its seeds can also be an important source of valuable oil with various sensitive applications mainly in pharmaceutical, cosmetic and food fields. This has encouraged the use of a supercritical fluid extraction in the present study to obtain oil from local onion seeds, hence avoiding even traces of organic solvents. For several advantages carbon dioxide at supercritical conditions was used as the fluid. The effects of four key operating parameters like pressure, temperature, particle size and CO2 mass flowrate were investigated in ranges of [150, 250 bars], [35, 65°C], [0.25, 0.85mm] and [50, 100g/min], respectively, using a Box-Behnken experimental design, for a constant extraction time of 3 hours. This led to optimal operating conditions of 250 bar, 57°C, 0.25mm and 50g CO2/min for the highest oil extraction yield value of 24.36%. Furthermore, gas chromatography-mass spectrometry (GC-MS) was used to identify qualitatively and quantitatively the ...
Functional Ingredients from Algae for Foods and Nutraceuticals, 2013
Highlights Supercritical fluid extracts optimization were done from radish leaves. The best r... more Highlights Supercritical fluid extracts optimization were done from radish leaves. The best results were obtained at 35 ºC/400 bar and 40 ºC/400 bar. Maturation of dendritic cells was not promoted being these extracts promising and interesting sources of antioxidative and anti-inflammatory agents.
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Papers by Sarra Melloul