Indian Research Journal of Pharmacy and Science, 2018
The objective of present study was to formulate directly compressible Oro improved solubility by ... more The objective of present study was to formulate directly compressible Oro improved solubility by using solid dispersion technique. Nitazoxanide treatment of giardiasis and crystopordiasis. Solid dispersion of nitazoxanide was prepared by Kneading method and physical mixture using polymer as a carrier and using three different drug:carrier ratios;1:0.5, 1:1 and 1:3.Saturation solubility of drug was determined in physical mixture and solid dispersion. Formulation batches of solid dispersion were characterized by drug content, FTIR Spectroscopy, DSC and nitazoxanideis converted into amorphous state during formulat nitazoxanide were designed using optimized solid dispersion and crospovidone dispersible tablet shows disintegration time 54seconds and dispersible tablet (-) shows disintegration time of60minutes. Thus solid dispersion based oro patient compliance and convenience.
For Correspondence: Department of Pharmaceutics, MET’s Institute of Pharmacy, Adgaon, Nashik, Mah... more For Correspondence: Department of Pharmaceutics, MET’s Institute of Pharmacy, Adgaon, Nashik, Maharashtra, India. ABSTRACT Slow dissolution rate of poorly water soluble drugs faces major challenge in the drug development and delivery processes. Improving aqueous solubility and slow dissolution of BCS Class II and Class IV drugs have been explored extensively. Of the available approaches, liquisolid compact technology is the most latest and novel approach for overcoming the trouble of inadequate solubility of the poorly soluble drugs. The liquisolid technology as described by Spireas is a liquid which is transformed into a free flowing, readily compressible and apparently dry powder by simple physical blending with selected excipients like the carrier and coating material. The liquid portion, which is a liquid drug, a drug suspension or a drug solution in suitable non-volatile liquid vehicles, is incorporated into the porous carrier material. Water-miscible organic solvent systems wi...
Microencapsulation is by far the most commonly exploited technique for the generation of multipar... more Microencapsulation is by far the most commonly exploited technique for the generation of multipartuculate drug delivery system. But serious drawbacks of this technique like non-uniform coating, nonreproducible release kinetics and more importantly, the use of more or less harsh conditions in the formulation process limits the encapsulation of the many substances such as proteins, enzymes and live cells etc. Besides this, the regulatory authorities, such as U.S.FDA are restricting to greater degrees the amount of additional components allowed such as organic solvents. The solution of this problem is presented by a technique, which involved neither the use of harsh chemicals nor elevated temperature and based on principle of ionotropic gelation (polyelectrolyte complexation). This review emphasizes the importance of ionotropic gelation and its cross linking potential to formulate hydrogel beads using different natural polymers.
Microencapsulation is by far the most commonly exploited technique for the generation of multipar... more Microencapsulation is by far the most commonly exploited technique for the generation of multipartuculate drug delivery system. But serious drawbacks of this technique like non-uniform coating, non-reproducible release kinetics and more importantly, the use of more or less harsh conditions in the formulation process limits the encapsulation of the many substances such as proteins, enzymes and live cells etc. Besides this, the regulatory authorities, such as U.S.FDA are restricting to greater degrees the amount of additional components allowed such as organic solvents. The solution of this problem is presented by a technique, which involved neither the use of harsh chemicals nor elevated temperature and based on principle of ionotropic gelation (polyelectrolyte complexation). This review emphasizes the importance of ionotropic gelation and its cross linking potential to formulate hydrogel beads using different natural polymers.
Objective: The objective of using natural polymer was to modify the release rate of Diclofenac so... more Objective: The objective of using natural polymer was to modify the release rate of Diclofenac sodium from matrix tablet. The matrix forming agent like Tamarind seed Polysaccharide show sustained release property in tablet which is obtained naturally from fruit of Tamarindus indica L. belonging to Family Leguminosae. Methods: The sustained release matrix tablet of Diclofenac sodium were prepared by wet granulation technique using varying concentration of hydrophilic polymer i.e. TSP. Results: OF1 and OF2 both are optimized batch. The in vitro dissolution study was carried out for optimized as well as marketed formulation (Voveran- SR). Both the optimized batchesat 10 h were found to be 90.27% and 90.18%, respectively. Conclusions: Tamarind seed polysaccharide can be employed in dosage form to sustain the drug release. Tablet formulated with various concentrations of Tamarind seed polysaccharide (TSP) gives release up to 10 h and more. OF1 and OF2 both formulations give comparable re...
There are various departments of medicine like cancer, pulmonary, cardiology, radiology and gynae... more There are various departments of medicine like cancer, pulmonary, cardiology, radiology and gynaecology etc, numerous drugs are used and they are delivered by various types of drug delivery system. Among them microspheric drug delivery system has gained enormous attention due to its wide range of application as it covers targeting the drug to particular site to imaging and helping the diagnostic features. In recent years scientific and technological advancements have been made in the research and development of rate-controlled oral drug delivery systems by overcoming physiological adversities, such as short gastric residence times (GRT) and unpredictable gastric emptying times (GET). Several approaches are currently utilized in the prolongation of the GRT, including floating drug delivery systems (FDDS), also known as hydrodynamically balanced systems, swelling and expanding systems, bioadhesive systems and high-density systems. The purpose of the review is to compile various types ...
Indian Research Journal of Pharmacy and Science, 2018
The objective of present study was to formulate directly compressible Oro improved solubility by ... more The objective of present study was to formulate directly compressible Oro improved solubility by using solid dispersion technique. Nitazoxanide treatment of giardiasis and crystopordiasis. Solid dispersion of nitazoxanide was prepared by Kneading method and physical mixture using polymer as a carrier and using three different drug:carrier ratios;1:0.5, 1:1 and 1:3.Saturation solubility of drug was determined in physical mixture and solid dispersion. Formulation batches of solid dispersion were characterized by drug content, FTIR Spectroscopy, DSC and nitazoxanideis converted into amorphous state during formulat nitazoxanide were designed using optimized solid dispersion and crospovidone dispersible tablet shows disintegration time 54seconds and dispersible tablet (-) shows disintegration time of60minutes. Thus solid dispersion based oro patient compliance and convenience.
For Correspondence: Department of Pharmaceutics, MET’s Institute of Pharmacy, Adgaon, Nashik, Mah... more For Correspondence: Department of Pharmaceutics, MET’s Institute of Pharmacy, Adgaon, Nashik, Maharashtra, India. ABSTRACT Slow dissolution rate of poorly water soluble drugs faces major challenge in the drug development and delivery processes. Improving aqueous solubility and slow dissolution of BCS Class II and Class IV drugs have been explored extensively. Of the available approaches, liquisolid compact technology is the most latest and novel approach for overcoming the trouble of inadequate solubility of the poorly soluble drugs. The liquisolid technology as described by Spireas is a liquid which is transformed into a free flowing, readily compressible and apparently dry powder by simple physical blending with selected excipients like the carrier and coating material. The liquid portion, which is a liquid drug, a drug suspension or a drug solution in suitable non-volatile liquid vehicles, is incorporated into the porous carrier material. Water-miscible organic solvent systems wi...
Microencapsulation is by far the most commonly exploited technique for the generation of multipar... more Microencapsulation is by far the most commonly exploited technique for the generation of multipartuculate drug delivery system. But serious drawbacks of this technique like non-uniform coating, nonreproducible release kinetics and more importantly, the use of more or less harsh conditions in the formulation process limits the encapsulation of the many substances such as proteins, enzymes and live cells etc. Besides this, the regulatory authorities, such as U.S.FDA are restricting to greater degrees the amount of additional components allowed such as organic solvents. The solution of this problem is presented by a technique, which involved neither the use of harsh chemicals nor elevated temperature and based on principle of ionotropic gelation (polyelectrolyte complexation). This review emphasizes the importance of ionotropic gelation and its cross linking potential to formulate hydrogel beads using different natural polymers.
Microencapsulation is by far the most commonly exploited technique for the generation of multipar... more Microencapsulation is by far the most commonly exploited technique for the generation of multipartuculate drug delivery system. But serious drawbacks of this technique like non-uniform coating, non-reproducible release kinetics and more importantly, the use of more or less harsh conditions in the formulation process limits the encapsulation of the many substances such as proteins, enzymes and live cells etc. Besides this, the regulatory authorities, such as U.S.FDA are restricting to greater degrees the amount of additional components allowed such as organic solvents. The solution of this problem is presented by a technique, which involved neither the use of harsh chemicals nor elevated temperature and based on principle of ionotropic gelation (polyelectrolyte complexation). This review emphasizes the importance of ionotropic gelation and its cross linking potential to formulate hydrogel beads using different natural polymers.
Objective: The objective of using natural polymer was to modify the release rate of Diclofenac so... more Objective: The objective of using natural polymer was to modify the release rate of Diclofenac sodium from matrix tablet. The matrix forming agent like Tamarind seed Polysaccharide show sustained release property in tablet which is obtained naturally from fruit of Tamarindus indica L. belonging to Family Leguminosae. Methods: The sustained release matrix tablet of Diclofenac sodium were prepared by wet granulation technique using varying concentration of hydrophilic polymer i.e. TSP. Results: OF1 and OF2 both are optimized batch. The in vitro dissolution study was carried out for optimized as well as marketed formulation (Voveran- SR). Both the optimized batchesat 10 h were found to be 90.27% and 90.18%, respectively. Conclusions: Tamarind seed polysaccharide can be employed in dosage form to sustain the drug release. Tablet formulated with various concentrations of Tamarind seed polysaccharide (TSP) gives release up to 10 h and more. OF1 and OF2 both formulations give comparable re...
There are various departments of medicine like cancer, pulmonary, cardiology, radiology and gynae... more There are various departments of medicine like cancer, pulmonary, cardiology, radiology and gynaecology etc, numerous drugs are used and they are delivered by various types of drug delivery system. Among them microspheric drug delivery system has gained enormous attention due to its wide range of application as it covers targeting the drug to particular site to imaging and helping the diagnostic features. In recent years scientific and technological advancements have been made in the research and development of rate-controlled oral drug delivery systems by overcoming physiological adversities, such as short gastric residence times (GRT) and unpredictable gastric emptying times (GET). Several approaches are currently utilized in the prolongation of the GRT, including floating drug delivery systems (FDDS), also known as hydrodynamically balanced systems, swelling and expanding systems, bioadhesive systems and high-density systems. The purpose of the review is to compile various types ...
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