Alkylidene substituted)-5,5-dimethyl-δ-lactones have been synthesized in two steps. The stable ph... more Alkylidene substituted)-5,5-dimethyl-δ-lactones have been synthesized in two steps. The stable phosphorane carboethoxymethyledene (α-prenyl)-triphenylphosphorane is condensed with different carbonyl compounds to afford α,β-unsaturated esters which are cyclised using PPA to give title compounds.
ABSTRACT A convenient, general synthesis of 2-methyl-2,3-dihydrofuro [2,3-b] quinolines is descri... more ABSTRACT A convenient, general synthesis of 2-methyl-2,3-dihydrofuro [2,3-b] quinolines is described from o-nitrobenzaldehydes. The benzaldehydes (la-c) on reaction with phosphorane 2 provide (E)-ethyl-α-allylcinnamates (3a-c) in high yields. These esters 3a-c on reduction followed by acid catalysed cyclisation give 2,3-dihydrofuro [2,3-b] quinolines (5a-c).
A convenient method for the synthesis of phthalides (1–5), involving heteroatom directed lithiati... more A convenient method for the synthesis of phthalides (1–5), involving heteroatom directed lithiation reaction is described.
... Page 2. A Rapid Assembly of Furo [3,4-b] and Pyrrolo [3,4-b] carbazolones by Domino Wittig Di... more ... Page 2. A Rapid Assembly of Furo [3,4-b] and Pyrrolo [3,4-b] carbazolones by Domino Wittig Diels-Alder Reaction Prachi Torney, Rupesh Patre, Santosh Tilve* Department of Chemistry, Goa University, Goa 403 206, India E-mail: [email protected] Fax: +091-832-2452886 ...
ABSTRACT Condensation of indole with aromatic aldehydes has been carried out without using any ca... more ABSTRACT Condensation of indole with aromatic aldehydes has been carried out without using any catalyst and solvent to give bis(indolyl)methanes.
Http Dx Doi Org 10 1080 00397919908086477, Sep 25, 2007
ABSTRACT α,β-Unsaturated oximes of chalcones on treatment with 2,3-Dichloro-5,6-dicyano-l,4-benzo... more ABSTRACT α,β-Unsaturated oximes of chalcones on treatment with 2,3-Dichloro-5,6-dicyano-l,4-benzoquinone (DDQ) in methanol furnish 3,5-disubstituted isoxazoles in good yield.
An I2/TBHP-mediated intramolecular dehydrogenative coupling reaction is developed for the synthes... more An I2/TBHP-mediated intramolecular dehydrogenative coupling reaction is developed for the synthesis of a library of medicinally important 5,11-dialkylindolo[3,2-c]quinoline salts and 5,7-dimethylindolo[2,3-c]quinoline salts. The annulation reaction is followed by aromatization to yield tetracycles in good yield. This protocol is also demonstrated for the synthesis of the naturally occurring isocryptolepine in salt form.
An alternative synthesis of isoquinoline alkaloid (+/-) cherylline dimethyl ether is reported. Th... more An alternative synthesis of isoquinoline alkaloid (+/-) cherylline dimethyl ether is reported. The steps involved are acid-catalyzed Michael addition of veratrole to p-methoxycinnamic acid, Curtius rearrangement, reduction of isocyanate intermediate followed by Pictet-Spangler cyclization.
A synthesis of a series of novel 6H-indolo[2,3-b]quinolines with different substituents on the qu... more A synthesis of a series of novel 6H-indolo[2,3-b]quinolines with different substituents on the quinoline ring is described. The method involves reaction of indole-3-carboxyaldehyde with aryl amines in the presence of a catalytic amount of iodine in refluxing diphenyl ether to yield indolo[2,3-b]quinolines in one-pot. The present approach provides a new route for the synthesis of polycyclic structures related to an alkaloid cryptotackieine (neocryptolepine).
... Page 2. A Rapid Assembly of Furo [3,4-b] and Pyrrolo [3,4-b] carbazolones by Domino Wittig Di... more ... Page 2. A Rapid Assembly of Furo [3,4-b] and Pyrrolo [3,4-b] carbazolones by Domino Wittig Diels-Alder Reaction Prachi Torney, Rupesh Patre, Santosh Tilve* Department of Chemistry, Goa University, Goa 403 206, India E-mail: [email protected] Fax: +091-832-2452886 ...
Indian Journal of Chemistry Sect B Organic Chemistry Including Medical Chemistry, 2009
Abstract: 2-(-Alkylidene substituted)-5, 5-dimethyl--lactones have been synthesized in two steps.... more Abstract: 2-(-Alkylidene substituted)-5, 5-dimethyl--lactones have been synthesized in two steps. The stable phosphorane carboethoxymethyledene (-prenyl)-triphenylphosphorane is condensed with different carbonyl compounds to afford,-unsaturated esters which are ...
Alkylidene substituted)-5,5-dimethyl-δ-lactones have been synthesized in two steps. The stable ph... more Alkylidene substituted)-5,5-dimethyl-δ-lactones have been synthesized in two steps. The stable phosphorane carboethoxymethyledene (α-prenyl)-triphenylphosphorane is condensed with different carbonyl compounds to afford α,β-unsaturated esters which are cyclised using PPA to give title compounds.
ABSTRACT A convenient, general synthesis of 2-methyl-2,3-dihydrofuro [2,3-b] quinolines is descri... more ABSTRACT A convenient, general synthesis of 2-methyl-2,3-dihydrofuro [2,3-b] quinolines is described from o-nitrobenzaldehydes. The benzaldehydes (la-c) on reaction with phosphorane 2 provide (E)-ethyl-α-allylcinnamates (3a-c) in high yields. These esters 3a-c on reduction followed by acid catalysed cyclisation give 2,3-dihydrofuro [2,3-b] quinolines (5a-c).
A convenient method for the synthesis of phthalides (1–5), involving heteroatom directed lithiati... more A convenient method for the synthesis of phthalides (1–5), involving heteroatom directed lithiation reaction is described.
... Page 2. A Rapid Assembly of Furo [3,4-b] and Pyrrolo [3,4-b] carbazolones by Domino Wittig Di... more ... Page 2. A Rapid Assembly of Furo [3,4-b] and Pyrrolo [3,4-b] carbazolones by Domino Wittig Diels-Alder Reaction Prachi Torney, Rupesh Patre, Santosh Tilve* Department of Chemistry, Goa University, Goa 403 206, India E-mail: [email protected] Fax: +091-832-2452886 ...
ABSTRACT Condensation of indole with aromatic aldehydes has been carried out without using any ca... more ABSTRACT Condensation of indole with aromatic aldehydes has been carried out without using any catalyst and solvent to give bis(indolyl)methanes.
Http Dx Doi Org 10 1080 00397919908086477, Sep 25, 2007
ABSTRACT α,β-Unsaturated oximes of chalcones on treatment with 2,3-Dichloro-5,6-dicyano-l,4-benzo... more ABSTRACT α,β-Unsaturated oximes of chalcones on treatment with 2,3-Dichloro-5,6-dicyano-l,4-benzoquinone (DDQ) in methanol furnish 3,5-disubstituted isoxazoles in good yield.
An I2/TBHP-mediated intramolecular dehydrogenative coupling reaction is developed for the synthes... more An I2/TBHP-mediated intramolecular dehydrogenative coupling reaction is developed for the synthesis of a library of medicinally important 5,11-dialkylindolo[3,2-c]quinoline salts and 5,7-dimethylindolo[2,3-c]quinoline salts. The annulation reaction is followed by aromatization to yield tetracycles in good yield. This protocol is also demonstrated for the synthesis of the naturally occurring isocryptolepine in salt form.
An alternative synthesis of isoquinoline alkaloid (+/-) cherylline dimethyl ether is reported. Th... more An alternative synthesis of isoquinoline alkaloid (+/-) cherylline dimethyl ether is reported. The steps involved are acid-catalyzed Michael addition of veratrole to p-methoxycinnamic acid, Curtius rearrangement, reduction of isocyanate intermediate followed by Pictet-Spangler cyclization.
A synthesis of a series of novel 6H-indolo[2,3-b]quinolines with different substituents on the qu... more A synthesis of a series of novel 6H-indolo[2,3-b]quinolines with different substituents on the quinoline ring is described. The method involves reaction of indole-3-carboxyaldehyde with aryl amines in the presence of a catalytic amount of iodine in refluxing diphenyl ether to yield indolo[2,3-b]quinolines in one-pot. The present approach provides a new route for the synthesis of polycyclic structures related to an alkaloid cryptotackieine (neocryptolepine).
... Page 2. A Rapid Assembly of Furo [3,4-b] and Pyrrolo [3,4-b] carbazolones by Domino Wittig Di... more ... Page 2. A Rapid Assembly of Furo [3,4-b] and Pyrrolo [3,4-b] carbazolones by Domino Wittig Diels-Alder Reaction Prachi Torney, Rupesh Patre, Santosh Tilve* Department of Chemistry, Goa University, Goa 403 206, India E-mail: [email protected] Fax: +091-832-2452886 ...
Indian Journal of Chemistry Sect B Organic Chemistry Including Medical Chemistry, 2009
Abstract: 2-(-Alkylidene substituted)-5, 5-dimethyl--lactones have been synthesized in two steps.... more Abstract: 2-(-Alkylidene substituted)-5, 5-dimethyl--lactones have been synthesized in two steps. The stable phosphorane carboethoxymethyledene (-prenyl)-triphenylphosphorane is condensed with different carbonyl compounds to afford,-unsaturated esters which are ...
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