The development of a synchronized delivery and imaging system for small interfering RNA (siRNA) i... more The development of a synchronized delivery and imaging system for small interfering RNA (siRNA) is required for the clinical application of RNA interference(RNAi) in cancer treatment. In this paper, we propose a pH-responsive, magnetic nanoparticle-based siRNA delivery system that can facilitate the safe and efficient delivery and visualization of therapeutic siRNA by high-resolution magnetic resonance(MR) imaging.
The synthesized nano vectors were then complexed with siRNA targeting the CD44
gene via electrostatic interaction to verify the specific gene-silencing effect. The
imidazole magnetic nano vector (ImMNV) architectures developed here facilitated
improved cellular internalization and exhibited a high level of in vitro downregulation compared to non-imidazoline magnetic nano vectors in metastatic breast cancer cells.
The most difficult of implementation PACS is large amount of data. Therefore, PACS needs mass sto... more The most difficult of implementation PACS is large amount of data. Therefore, PACS needs mass storage, as well as rapid transmission time. Consequently, medical images needs compression when stored in PACS. WT(wavelet transform) was announced by Ingrid Daubechies and Stephane Mallat, WT was methods of signal analysis by a base functions set same as Fourie transform. This paper estimated an efficiency, that experimental medical images compressed by DWT. The result of estimated, we are knows effectiveness that display to remained signal in low frequency region after 4-level DWT form input images. Compression ratio of images by 4-level DWT was 1:16. It is a high compression ratio, the other side has a problem appears on staircase phenomenon.
Conference proceedings : ... Annual International Conference of the IEEE Engineering in Medicine and Biology Society. IEEE Engineering in Medicine and Biology Society. Annual Conference, 2008
Exercise is very important element for successful aging. Among many sports events, Korea is the s... more Exercise is very important element for successful aging. Among many sports events, Korea is the suzerain of Taekwondo. When competing (Taekwondo Free Fighting) after learning Poomse as basic movements and inuring them, people compete with movements depending on situation. Among Poomses of Taekwondo, Taegeuk Poomse consists of very basic movements from 1 Jang to 8 Jang and they are for inuring to body. In order to prescribe Taegeuk Jang, which is the basic movement of Taekwondo that Korea is the suzerain, as an exercise for successful aging, it is necessary to analyze physical activity level of each Taegeuk Jang (From 1 Jang through 8 Jang) and suggest the same. Therefore, in this study, I analyzed physical activity level of each Jang of Taegeuk Poomse by attaching Armband made by Body Media Company on brachia and legs below knee of Taekwondo trainees. The result of the analysis of the whole momentum from Taegeuk 1 Jang to 8 Jang is as follows: First, the average absolute value of ac...
The proposed context awareness system is composed of acceleration data acquisition part and fuzzy... more The proposed context awareness system is composed of acceleration data acquisition part and fuzzy inference system that processes acquired data, distinguishes user motion states and recognizes emergency situations. Two-axial accelerometer embedded in SenseWear PRO2 Armband (BodyMedia) on the right upper arm collects input data containing the longitudinal acceleration average (LAA), the transverse acceleration average (TAA), the longitudinal acceleration-mean of absolute difference (L-MAD), and transverse acceleration mean of absolute difference (T-MAD). Fuzzy inference system is a tool imitating the human ability of decision making. In our system, the fuzzy inference system was used to distinguish the user motion states and to recognize emergency situations. In an experiment using eight subjects, the recognition rates of lying, sitting, walking and running were 98.9%, 98.9%, 99.7% and 99.9%, respectively. Recognition rate for lying after walking and lying after running was 100%.
2009 year new execution of appointments for secondary school teachers was announced at 2004 year ... more 2009 year new execution of appointments for secondary school teachers was announced at 2004 year by Ministry of Education. The new school teacher appointment has been developed and studied in various aspects of appropriate qualification for good school teacher. In the results of the studies by Korea School Mathematics Education Association and pre-exams by Korea Institute for Curriculum and Evaluation, the Probability and Statistics chapters are less revaluated as 7.5-10%, but we argue those more than 15% as along with our recent Korean school texts reviews(Lee, et al., 2005). K e yword: Execution of 2009 Korea school teachers Appointment; Probability and Statistics chapters in School Mathematics.
As breast cancer shows the highest incidence among women's cancers, the use of mammography is... more As breast cancer shows the highest incidence among women's cancers, the use of mammography is also increasing as a screening test. Mammography should produce high-quality images for accurate diagnosis. For this, it is necessary to manage the performance and image quality of mammography. Thus, in order to investigate quality control, the present study conducted a questionnaire survey of 37 hospitals registered as breast cancer medical examination centers in Gwang-Ju, concerning their quality control of mammography. In the results of surveying the characteristics of apparatus use for mammography, many respondents did not know about the equipment that they were using. Of the hospitals, 19 (49%) were using film, 19 (49%) CR, and 1 DR. In the results of asking how to do quality control, only 38% answered that they inspected according to the manual. In addition, all the surveyed hospitals had specialized agencies do quality control for them. As to the reason for using agencies, 65% mentioned limitations in personnel, time, distance, etc, and 44% mentioned the absence of machines and materials. These results suggest that quality control is being performed perfunctorily, as well as passively and indifferently as it relies on specialized agencies. Accordingly, it is necessary to provide regular education for enhancing people's perception of quality control and to perform quality control adequately in the presence of Radiologist.
In this paper, we study to classify molecular imaging and applications to predict future. Molecul... more In this paper, we study to classify molecular imaging and applications to predict future. Molecular imaging in vivo at the cellular level and the molecular level changes taking place to be imaged, that is molecular cell biology and imaging technology combined with the development of the new field. Molecular imaging is used fluorescence, bioluminescence, SPECT, PET, MRI, Ultrasound and other imaging technologies. That is applied to monitoring of gene therapy, cell tracking and monitoring of cell therapy, antibody imaging, drug development, molecular interaction picture, the near-infrared fluorescence imaging of cancer using fluorescence, bacteria using tumor-targeting imaging, therapeutic early assessment, prediction and therapy. The future of molecular imaging would be developed through fused interdisciplinary research and mutual cooperation, which molecular cell biology, genetics, chemistry, physics, computer science, biomedical engineering, nuclear medicine, radiology, clinical medicine, etc. The advent of molecular imaging will be possible to early diagnosis and personalized treatment of disease in the future.
Journal of Vacuum Science & Technology B: Microelectronics and Nanometer Structures, 2003
We report on the fabrication of multiwalled carbon nanotube ͑MWCNT͒ bridges using poly-methylmeth... more We report on the fabrication of multiwalled carbon nanotube ͑MWCNT͒ bridges using poly-methylmethacrylate ͑PMMA͒ suspended dispersion. This method makes it possible to suspend nanotubes between metal electrodes, without any chemical etching of the substrate, and to remove unwanted nanotubes from the substrate. Using a spacer layer of PMMA with a known thickness, it is also possible to control the suspended height of the MWCNT bridges. The electrical measurement results on suspended MWCNT bridges reveals that the room temperature resistance ranges from under a k⍀ to a few M⍀, with the majority around 2-4 k⍀. It was shown that a plasma-enhanced chemical vapor deposition grown MWCNT with a diameter ϳ55 nm can sustain current densities of ϳ10 8 A/cm 2 , which will make them suitable for applications as integrated field emission cathodes.
Journal of the Korea Society of Computer and Information, 2016
In this study, an image processing algorithm was developed to increase readability of the images ... more In this study, an image processing algorithm was developed to increase readability of the images of specific parts of a KTX train acquired by using a mobile digital radiographic testing device in a situation where a running train is stopped. The image processing algorithm was realized by using a Visual C++ development tool.
To find how much radiation was exposed the patients who visit emergency room, a measurement study... more To find how much radiation was exposed the patients who visit emergency room, a measurement study was made for radiation amount toward 200 patients selected randomly among visitors to an emergency room in a university hospital from March 16 to 31st, 2006. The results are as follows ; 1. Among the subjects 50 person(25.0%) were transferred from other hospitals, 24 persons(8.3) come after traffic accident, 50 persons for other accident and 76 persons for general medical care. 2. The average frequency of X-ray taking was calculated as 6.4 time per person among transferred patients, 14.5 times per person among patients with traffic accident and 2.6 times per person among general medical care. 3. The radiation exposure amount by kind of X-ray showed 28.9mGyfor general X-ray diagnosis, 84.2mGy for CT scanning and 1.02mGy for other special radiation study. 4. Average radiation exposure amount was calculated as 24.6mGy by transferred patients, 55.2mGy by patients with traffic accident, 17.1mGy by patients with other accidents and 17.0mGy by general patients. 5. Through the comparison of radiation exposure amount among to subject with maximum allowance threshold by International Commission on X-ray Radium Protection, transferred patients exceeded 6 times than allowance in whole body except extremities and joints, blood forming organ, reproductive system, vitreous body of eye, bone, thyroid gland, skin and etc, Patient suffered from traffic accidents were exposed 10 times more than allowance. In conclusion, the radiation exposure amount during X-rat diagnosis re too much and exceeded allowance standard by International Commission on X-ray Radium Protection. So further study and preventive measure to decrease radiation exposure by patients who visit emergency room.
Myocardial imaging in SPECT (Single Photon Emission Computed tomography) scan of the gamma-ray em... more Myocardial imaging in SPECT (Single Photon Emission Computed tomography) scan of the gamma-ray emitting radiopharmaceuticals to patients after intravenous radiopharmaceuticals evenly spread in the heart region of interest by recording changes in the disease caused by a computer using the PSA test is to diagnose. Containing information on the functional myocardial perfusion imaging is a useful way to examine non-invasive heart disease, but the argument by noise and low resolution of the physical landscape that is difficult to give. For this paper, the level of myocardial imaging by using the three algorithms to split the video into 3-D implementation of the partitioned area to help you read the proposed plan. To solve the difficulty of reading level, interest in using the sheet set, partitioned area of the left ventricle was ranked the partitioned area was modeled as a 3-D images.
In this paper has proposed to the recognition of the disease on medical images using neural netwo... more In this paper has proposed to the recognition of the disease on medical images using neural network. The neural network is constructed as three-layers of the input-layer, the hidden-layer and the output-layer. The training method applied for the recognition of disease region is adaptive error back-propagation. The low-frequency region analyzed by DWT are expressed by matrix. The coefficient-values of the characteristic polynomial applied are n+1. The normalized maximum value +1 and minimum value-1 in the range of tangent-sigmoid transfer function are applied to be use as the input vector of the neural network. To prove the validity of the proposed methods used in the experiment with a simulation experiment, the
The development of a synchronized delivery and imaging system for small interfering RNA (siRNA) i... more The development of a synchronized delivery and imaging system for small interfering RNA (siRNA) is required for the clinical application of RNA interference(RNAi) in cancer treatment. In this paper, we propose a pH-responsive, magnetic nanoparticle-based siRNA delivery system that can facilitate the safe and efficient delivery and visualization of therapeutic siRNA by high-resolution magnetic resonance(MR) imaging.
The synthesized nano vectors were then complexed with siRNA targeting the CD44
gene via electrostatic interaction to verify the specific gene-silencing effect. The
imidazole magnetic nano vector (ImMNV) architectures developed here facilitated
improved cellular internalization and exhibited a high level of in vitro downregulation compared to non-imidazoline magnetic nano vectors in metastatic breast cancer cells.
The most difficult of implementation PACS is large amount of data. Therefore, PACS needs mass sto... more The most difficult of implementation PACS is large amount of data. Therefore, PACS needs mass storage, as well as rapid transmission time. Consequently, medical images needs compression when stored in PACS. WT(wavelet transform) was announced by Ingrid Daubechies and Stephane Mallat, WT was methods of signal analysis by a base functions set same as Fourie transform. This paper estimated an efficiency, that experimental medical images compressed by DWT. The result of estimated, we are knows effectiveness that display to remained signal in low frequency region after 4-level DWT form input images. Compression ratio of images by 4-level DWT was 1:16. It is a high compression ratio, the other side has a problem appears on staircase phenomenon.
Conference proceedings : ... Annual International Conference of the IEEE Engineering in Medicine and Biology Society. IEEE Engineering in Medicine and Biology Society. Annual Conference, 2008
Exercise is very important element for successful aging. Among many sports events, Korea is the s... more Exercise is very important element for successful aging. Among many sports events, Korea is the suzerain of Taekwondo. When competing (Taekwondo Free Fighting) after learning Poomse as basic movements and inuring them, people compete with movements depending on situation. Among Poomses of Taekwondo, Taegeuk Poomse consists of very basic movements from 1 Jang to 8 Jang and they are for inuring to body. In order to prescribe Taegeuk Jang, which is the basic movement of Taekwondo that Korea is the suzerain, as an exercise for successful aging, it is necessary to analyze physical activity level of each Taegeuk Jang (From 1 Jang through 8 Jang) and suggest the same. Therefore, in this study, I analyzed physical activity level of each Jang of Taegeuk Poomse by attaching Armband made by Body Media Company on brachia and legs below knee of Taekwondo trainees. The result of the analysis of the whole momentum from Taegeuk 1 Jang to 8 Jang is as follows: First, the average absolute value of ac...
The proposed context awareness system is composed of acceleration data acquisition part and fuzzy... more The proposed context awareness system is composed of acceleration data acquisition part and fuzzy inference system that processes acquired data, distinguishes user motion states and recognizes emergency situations. Two-axial accelerometer embedded in SenseWear PRO2 Armband (BodyMedia) on the right upper arm collects input data containing the longitudinal acceleration average (LAA), the transverse acceleration average (TAA), the longitudinal acceleration-mean of absolute difference (L-MAD), and transverse acceleration mean of absolute difference (T-MAD). Fuzzy inference system is a tool imitating the human ability of decision making. In our system, the fuzzy inference system was used to distinguish the user motion states and to recognize emergency situations. In an experiment using eight subjects, the recognition rates of lying, sitting, walking and running were 98.9%, 98.9%, 99.7% and 99.9%, respectively. Recognition rate for lying after walking and lying after running was 100%.
2009 year new execution of appointments for secondary school teachers was announced at 2004 year ... more 2009 year new execution of appointments for secondary school teachers was announced at 2004 year by Ministry of Education. The new school teacher appointment has been developed and studied in various aspects of appropriate qualification for good school teacher. In the results of the studies by Korea School Mathematics Education Association and pre-exams by Korea Institute for Curriculum and Evaluation, the Probability and Statistics chapters are less revaluated as 7.5-10%, but we argue those more than 15% as along with our recent Korean school texts reviews(Lee, et al., 2005). K e yword: Execution of 2009 Korea school teachers Appointment; Probability and Statistics chapters in School Mathematics.
As breast cancer shows the highest incidence among women's cancers, the use of mammography is... more As breast cancer shows the highest incidence among women's cancers, the use of mammography is also increasing as a screening test. Mammography should produce high-quality images for accurate diagnosis. For this, it is necessary to manage the performance and image quality of mammography. Thus, in order to investigate quality control, the present study conducted a questionnaire survey of 37 hospitals registered as breast cancer medical examination centers in Gwang-Ju, concerning their quality control of mammography. In the results of surveying the characteristics of apparatus use for mammography, many respondents did not know about the equipment that they were using. Of the hospitals, 19 (49%) were using film, 19 (49%) CR, and 1 DR. In the results of asking how to do quality control, only 38% answered that they inspected according to the manual. In addition, all the surveyed hospitals had specialized agencies do quality control for them. As to the reason for using agencies, 65% mentioned limitations in personnel, time, distance, etc, and 44% mentioned the absence of machines and materials. These results suggest that quality control is being performed perfunctorily, as well as passively and indifferently as it relies on specialized agencies. Accordingly, it is necessary to provide regular education for enhancing people's perception of quality control and to perform quality control adequately in the presence of Radiologist.
In this paper, we study to classify molecular imaging and applications to predict future. Molecul... more In this paper, we study to classify molecular imaging and applications to predict future. Molecular imaging in vivo at the cellular level and the molecular level changes taking place to be imaged, that is molecular cell biology and imaging technology combined with the development of the new field. Molecular imaging is used fluorescence, bioluminescence, SPECT, PET, MRI, Ultrasound and other imaging technologies. That is applied to monitoring of gene therapy, cell tracking and monitoring of cell therapy, antibody imaging, drug development, molecular interaction picture, the near-infrared fluorescence imaging of cancer using fluorescence, bacteria using tumor-targeting imaging, therapeutic early assessment, prediction and therapy. The future of molecular imaging would be developed through fused interdisciplinary research and mutual cooperation, which molecular cell biology, genetics, chemistry, physics, computer science, biomedical engineering, nuclear medicine, radiology, clinical medicine, etc. The advent of molecular imaging will be possible to early diagnosis and personalized treatment of disease in the future.
Journal of Vacuum Science & Technology B: Microelectronics and Nanometer Structures, 2003
We report on the fabrication of multiwalled carbon nanotube ͑MWCNT͒ bridges using poly-methylmeth... more We report on the fabrication of multiwalled carbon nanotube ͑MWCNT͒ bridges using poly-methylmethacrylate ͑PMMA͒ suspended dispersion. This method makes it possible to suspend nanotubes between metal electrodes, without any chemical etching of the substrate, and to remove unwanted nanotubes from the substrate. Using a spacer layer of PMMA with a known thickness, it is also possible to control the suspended height of the MWCNT bridges. The electrical measurement results on suspended MWCNT bridges reveals that the room temperature resistance ranges from under a k⍀ to a few M⍀, with the majority around 2-4 k⍀. It was shown that a plasma-enhanced chemical vapor deposition grown MWCNT with a diameter ϳ55 nm can sustain current densities of ϳ10 8 A/cm 2 , which will make them suitable for applications as integrated field emission cathodes.
Journal of the Korea Society of Computer and Information, 2016
In this study, an image processing algorithm was developed to increase readability of the images ... more In this study, an image processing algorithm was developed to increase readability of the images of specific parts of a KTX train acquired by using a mobile digital radiographic testing device in a situation where a running train is stopped. The image processing algorithm was realized by using a Visual C++ development tool.
To find how much radiation was exposed the patients who visit emergency room, a measurement study... more To find how much radiation was exposed the patients who visit emergency room, a measurement study was made for radiation amount toward 200 patients selected randomly among visitors to an emergency room in a university hospital from March 16 to 31st, 2006. The results are as follows ; 1. Among the subjects 50 person(25.0%) were transferred from other hospitals, 24 persons(8.3) come after traffic accident, 50 persons for other accident and 76 persons for general medical care. 2. The average frequency of X-ray taking was calculated as 6.4 time per person among transferred patients, 14.5 times per person among patients with traffic accident and 2.6 times per person among general medical care. 3. The radiation exposure amount by kind of X-ray showed 28.9mGyfor general X-ray diagnosis, 84.2mGy for CT scanning and 1.02mGy for other special radiation study. 4. Average radiation exposure amount was calculated as 24.6mGy by transferred patients, 55.2mGy by patients with traffic accident, 17.1mGy by patients with other accidents and 17.0mGy by general patients. 5. Through the comparison of radiation exposure amount among to subject with maximum allowance threshold by International Commission on X-ray Radium Protection, transferred patients exceeded 6 times than allowance in whole body except extremities and joints, blood forming organ, reproductive system, vitreous body of eye, bone, thyroid gland, skin and etc, Patient suffered from traffic accidents were exposed 10 times more than allowance. In conclusion, the radiation exposure amount during X-rat diagnosis re too much and exceeded allowance standard by International Commission on X-ray Radium Protection. So further study and preventive measure to decrease radiation exposure by patients who visit emergency room.
Myocardial imaging in SPECT (Single Photon Emission Computed tomography) scan of the gamma-ray em... more Myocardial imaging in SPECT (Single Photon Emission Computed tomography) scan of the gamma-ray emitting radiopharmaceuticals to patients after intravenous radiopharmaceuticals evenly spread in the heart region of interest by recording changes in the disease caused by a computer using the PSA test is to diagnose. Containing information on the functional myocardial perfusion imaging is a useful way to examine non-invasive heart disease, but the argument by noise and low resolution of the physical landscape that is difficult to give. For this paper, the level of myocardial imaging by using the three algorithms to split the video into 3-D implementation of the partitioned area to help you read the proposed plan. To solve the difficulty of reading level, interest in using the sheet set, partitioned area of the left ventricle was ranked the partitioned area was modeled as a 3-D images.
In this paper has proposed to the recognition of the disease on medical images using neural netwo... more In this paper has proposed to the recognition of the disease on medical images using neural network. The neural network is constructed as three-layers of the input-layer, the hidden-layer and the output-layer. The training method applied for the recognition of disease region is adaptive error back-propagation. The low-frequency region analyzed by DWT are expressed by matrix. The coefficient-values of the characteristic polynomial applied are n+1. The normalized maximum value +1 and minimum value-1 in the range of tangent-sigmoid transfer function are applied to be use as the input vector of the neural network. To prove the validity of the proposed methods used in the experiment with a simulation experiment, the
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Papers by Sangbock Lee
The synthesized nano vectors were then complexed with siRNA targeting the CD44
gene via electrostatic interaction to verify the specific gene-silencing effect. The
imidazole magnetic nano vector (ImMNV) architectures developed here facilitated
improved cellular internalization and exhibited a high level of in vitro downregulation compared to non-imidazoline magnetic nano vectors in metastatic breast cancer cells.
The synthesized nano vectors were then complexed with siRNA targeting the CD44
gene via electrostatic interaction to verify the specific gene-silencing effect. The
imidazole magnetic nano vector (ImMNV) architectures developed here facilitated
improved cellular internalization and exhibited a high level of in vitro downregulation compared to non-imidazoline magnetic nano vectors in metastatic breast cancer cells.