Papers by Sharon Sandridge
The ASHA Leader, Sep 1, 2018
American Journal of Audiology, Mar 1, 1997
Page 1. Newman Jacobson Weinstein Sandridge 17 Clinical Focus s Grand Rounds American Journ... more Page 1. Newman Jacobson Weinstein Sandridge 17 Clinical Focus s Grand Rounds American Journal of Audiology Vol. 6 1059-0889/97/0601-0017 © American Speech-Language-Hearing Association Computer-Generated Hearing Disability/ Handicap Profiles ...

PubMed, Jul 1, 1991
A 48-item questionnaire was administered to 100 older adults to determine their expectations rega... more A 48-item questionnaire was administered to 100 older adults to determine their expectations regarding hearing aid use. The sample consisted of volunteers from a variety of senior citizen organizations and ranged in age from 55 to 92 years. Only individuals who reported no prior hearing aid usage were included in the sample. Expectations for the following factors were considered: cosmetics, acoustics, communication benefits, comfort, ease of use, cost and upkeep, and attitudes toward hearing aid use. In general, the older adults in this sample appeared to have very positive expectations regarding the use of hearing aids. Eighty-seven percent apparently have medium to high expectations for hearing aid use. Since the older adult's satisfaction with amplification may be influenced by original expectations and attitudes, the information provided in this study may be useful in improving the pre-fitting counseling of older hearing-impaired adults.

Journal of The American Academy of Audiology, 2014
Background: It has been estimated that as many as 50 million Americans do experience or have expe... more Background: It has been estimated that as many as 50 million Americans do experience or have experienced tinnitus. For approximately 12 million of these individuals, tinnitus makes it impossible for them to carry out normal everyday activities without limitation. These are the patients that present to audiology clinics for assessment and management. The tinnitus evaluation includes the measurement of acoustical characteristics of tinnitus and the impact that this impairment has on health-related quality of life (HRQoL). Tinnitus is a disorder that often occurs as a result of auditory system impairment. The impairment for some can impart an activity limitation and a participation restriction (i.e., tinnitus-related disability or handicap, respectively). The goal of tinnitus management is to reduce, or eliminate, activity limitations and participation restrictions by reducing or eliminating a patient’s perception of tinnitus or their reaction to tinnitus. Implicit in this statement is the assumption that there exist standardized measures for quantifying the patient’s tinnitus perception and their reaction to it. If there existed stable and responsive standardized tinnitus measures, then it would be possible to compare a patient’s tinnitus experience at different time points (e.g., before and after treatment) to assess, for example, treatment efficacy. Purpose: The purposes of the current review are to (1) describe psychometric standards used to select outcome measurement tools; (2) discuss available measurement techniques and their application to tinnitus evaluation and treatment-related assessment within the domains established by the World Health Organization’s International Classification of Functioning, Disability and Health; (3) list and briefly describe self-report tinnitus questionnaires; (4) describe how valuation of tinnitus treatment can be assessed using economic models of treatment effectiveness; and (5) provide future directions including the development of a tinnitus outcomes test battery and treatment-related study designs. Research Design: Retrospective literature review Conclusions: Although psychometrically robust measures of tinnitus HRQoL do exist, there is no unanimity in, for example, what tests should be included in the tinnitus assessment, and how studies of HRQoL should be conducted. The current authors suggest that future studies employ more rigorous designs and contain (minimally) the following characteristics: (1) utilization of randomized control groups and blinding; (2) appropriate statistical testing including “dropouts” that should be used in an “intention to treat” analysis rather than elimination from the final data set; (3) long-term follow-up assessment to evaluate responsiveness; (4) appropriate inclusion criteria to avoid “ceiling” and “floor” effects; and (5) suitable sample sizes based on the application of power analyses.

PubMed, 1997
Objective: To evaluate long-term hearing results and quality of life in patients with Ménière's d... more Objective: To evaluate long-term hearing results and quality of life in patients with Ménière's disease. Study design: Detailed audiometric evaluation and disease-specific as well as global health quality evaluation of patients with Ménière's disease. Setting: Ambulatory evaluation was conducted in a large multispecialty clinic. Patients: Ménière's disease in only one ear, were at least 1 year posttreatment, were < 65 years of age, had no neurologic or psychologic disorders, and lived within driving distance of the ambulatory clinic. Main outcome measures: Audiometry, the Hearing Handicap Inventory, Dizziness Handicap Inventory, Tinnitus Handicap Inventory, and SF-36 Health Survey. Results: No statistically significant differences in long-term hearing results were detected from natural history in medically or surgically treated patients with Ménière's disease. A significant disease-specific symptom handicap was detected. The global health handicap was greater for emotional disability than for physical disability. Conclusions: Medical and surgical treatment does not significantly influence hearing results in Ménière's disease. Patients with Ménière's disease have a greater emotional disability than a physical disability.

Otology & Neurotology, Apr 1, 2008
To develop a screening version of the Tinnitus Handicap Inventory (THI-S) and establish its psych... more To develop a screening version of the Tinnitus Handicap Inventory (THI-S) and establish its psychometric characteristics. Design: Prospective clinical study to analyze 1) the level of predictability between THI and THIS ; 2) test-retest reliability of the THIS ; 3) 95% confidence intervals (critical difference scores) for the THIS ; and 4) a THIS cutoff score used for referral purposes. Setting: Head and Neck Institute at the Cleveland Clinic, a tertiary care medical center. Patients: Thirty-three patients reporting tinnitus as their primary complaint. Interventions: There was, on average, a 16-day interval between test-retest administrations of the THIS. Main Outcome Measure: Comparability of scores between the THI and the THIS and test-retest reliability of the THIS was assessed using Pearson product-moment correlations. The level of agreement between the 2 administrations of the THIS was evaluated using Bland-Altman repeatability plots. Results: Comparability between the THI and THIS was high (r = 0.90). Test-retest reliability of the THIS was adequate (r = 0.81), as well as the level of agreement between administrations as demonstrated by the Bland-Altman plot. Based on 95% confidence intervals, pretreatment and posttreatment scores would have to differ by more than 10 points for intervention efforts to be considered significant. A 6-point cutoff score was analyzed as an appropriate fence for referral. Conclusion: The THIS is a psychometrically robust screening measure of activity limitation and participation restriction.

PubMed, Apr 1, 1998
This study assessed the test-retest reliability/repeatability and 95 percent confidence intervals... more This study assessed the test-retest reliability/repeatability and 95 percent confidence intervals (CIs) of the Tinnitus Handicap Inventory (THI) and developed categories for classifying self-perceived tinnitus handicap severity. Twenty-nine adults with tinnitus as their primary auditory complaint served as subjects. The THI was administered on two occasions (mean interval 20 days) using a paper-pencil format. Results support the contention that the THI is psychometrically robust. Specifically, the test-retest reliability/repeatability was high. Additionally, the 95 percent CI for the THI was 20-points, indicating that a 20-point or greater change had to occur from test to retest for a change to be considered statistically significant at the 5 percent confidence level. Quartiles calculated from raw scores were used to create a matrix of values representing tinnitus severity. We conclude that the THI is a brief, easily administered, and psychometrically robust measure that evaluates the impact of tinnitus on daily living.

Otology & Neurotology, 2002
To determine the surgical efficacy of a simplified retrosigmoid approach for vestibular nerve sec... more To determine the surgical efficacy of a simplified retrosigmoid approach for vestibular nerve sectioning. Study Design: A retrospective analysis. Setting: Tertiary academic referral center. Patients: Twenty-eight consecutive patients who underwent vestibular nerve sectioning for intractable peripheral vestibular disorders. Intervention: All patients had a simplified retrosigmoid approach for vestibular nerve sectioning. Main Outcome Measures: Functional outcome after vestibular nerve sectioning was analyzed with respect to improvement in patient disability from vertigo and reduction in the frequency of definitive vertigo attacks. Resolution of lightheadedness provided an additional outcome measure. The incidence of surgical complications, including postoperative headache, was determined, and the operative time was reviewed. Results: Twenty-six patients (92.9%) had an improved functional level postoperatively, 21 (75.
Cleveland Clinic Journal of Medicine, Mar 1, 2004
Screening for hearing loss should be part of the routine physical examination, but it is often no... more Screening for hearing loss should be part of the routine physical examination, but it is often not done because of time constraints. We present a quick and easy office screening test that measures the functional impact of hearing loss. We also review the steps of audiologic management that follow referral by the primary care physician.
Annals of Otology, Rhinology, and Laryngology, Mar 1, 1997
Using the Hearing Handicap Inventory for Adults (HHIA), we assessed self-perceived hearing handic... more Using the Hearing Handicap Inventory for Adults (HHIA), we assessed self-perceived hearing handicap in a sample of 63 patients having either unilaterally normal hearing or a mild hearing loss (pure tone average ≤40 dB hearing level). Large intersubject variability in responses to the HHIA confirmed observations that reactions to minimal hearing impairment vary greatly among patients. The individual differences in responses highlight the importance of quantifying the perceived communication and psychosocial handicap, which cannot be determined from the audiogram alone. An item examination of responses to the HHIA revealed a number of emotional and social-situational problems encountered by patients with minimal hearing loss.
The Hearing journal, May 1, 2011
AuD students are just that-students. They are pre-professionals, not independent practitioners.
Seminars in Hearing, Aug 1, 2008
Semin Hear 2008; 29(3): 300-309 DOI: 10.1055/s-0028-1082035. © Thieme Medical Publishers. Strateg... more Semin Hear 2008; 29(3): 300-309 DOI: 10.1055/s-0028-1082035. © Thieme Medical Publishers. Strategies for Managing Patients with Tinnitus: A Clinical Pathway Model. Craig W. Newman 1 , Sharon A. Sandridge 1 , Scott S. Meit 2 , Neil Cherian 3. ...

American Journal of Otolaryngology, May 1, 1987
In an effort to develop an adult animal model for acquired viral-induced hearing loss, three grou... more In an effort to develop an adult animal model for acquired viral-induced hearing loss, three groups of mature ferrets were inoculated intranasally with respiratory viruses (influenza A/Port Chalmers, influenza B/Mass, and parainfluenza I), which have been implicated as causative agents in idiopathic sudden hearing loss (ISHL). All ferrets challenged with influenza A/Port Chalmers (A/PC) exhibited clinical signs of infection, but neither of the other two groups exhibited such signs. Conductive and/or sensorineural hearing losses were demonstrated in eight of 15 ferrets challenged with influenza A/PC and four of 10 ferrets in the group challenged with influenza B/Mass by brainstem auditory-evoked responses (BAERs) and acoustic immittance. None of the four ferrets infected with parainfluenza I demonstrated auditory dysfunction. When auditory changes were observed, nasal washes were performed, and tissues of the middle and inner ears were collected for viral assay and morphologic examination. All ferrets demonstrating auditory changes were shown to be infected by isolation of virus from nasal tissues. Virus was isolated from eustachian tube tissue in six of the eight ferrets infected with influenza A/PC, which also demonstrated altered BAERs and one of the four infected with influenza B/Mass, which also had auditory changes. Virus was isolated from the middle ear of two ferrets infected with Influenza A/PC and from the inner ear of another two ferrets from the same group. These data suggest that influenza A/PC has a greater effect on auditory function in the ferret model than either influenza B/Mass or parainfluenza I and that the ferret may be an appropriate adult model to examine the etiologic role of viral upper respiratory tract infections in some acquired hearing impairments. Although it has been established that intrauterine infection with certain viruses (mumps, measles, rubella, and cytomegalovirus [CMV]) can directly cause profound congenital hearing loss,l-9 the role of viral infections in acquired hearing loss and vestibular dysfunction is an important unresolved problem in the field of otologic research. Controversy about the role of virus has resulted for the following reasons: 1) conflicting and/or inconsistent clinical findings; and 2) the

Elsevier eBooks, 2007
There is a wide range of assessment techniques for tinnitus, but no consensus has developed conce... more There is a wide range of assessment techniques for tinnitus, but no consensus has developed concerning how best to measure either the presenting features of tinnitus or the effects of tinnitus treatments. Standardization of reliable and valid tinnitus measures would provide many advantages including improving the uniformity of diagnostic and screening criteria between clinics and facilitating comparison of treatment outcomes obtained at different sites. This chapter attempts to clarify issues involved in developing self-report questionnaires for the assessment of tinnitus. While the tinnitus questionnaires that are currently available provide valuable information on which to base diagnostic and screening decisions, they were not originally developed in such a way as to maximize their sensitivity to treatment-related changes in tinnitus. As a result, their construct validity for measuring treatment benefit has not received appropriate attention. In this paper, special emphasis is devoted to the use of effect sizes as an estimate of the ability of questionnaires (and their individual items) to measure changes associated with treatment. We discuss the criteria relevant to evaluating the effectiveness of a questionnaire for diagnostic purposes vs. for treatment-evaluation purposes, and we present a detailed illustration of how the various criteria have been applied in a recent questionnaire development effort.
Journal of The American Academy of Audiology, Feb 1, 2012
This is an economic evaluation that meets the criteria for inclusion on NHS EED. Bibliographic de... more This is an economic evaluation that meets the criteria for inclusion on NHS EED. Bibliographic details Newman CW, Sandridge SA. A comparison of benefit and economic value between two sound therapy tinnitus management options.
The ASHA Leader, Sep 1, 2018
The Hearing journal, Jul 1, 2011
Advertisement. Close Window. Close Window. Thank you for choosing to subscribe to the eTOC for Th... more Advertisement. Close Window. Close Window. Thank you for choosing to subscribe to the eTOC for The Hearing Journal. Enter your Email address: Wolters Kluwer Health may email you for journal alerts and information, but is ...
The Hearing journal, Nov 1, 2011
Advertisement. Close Window. Close Window. Thank you for choosing to subscribe to the eTOC for Th... more Advertisement. Close Window. Close Window. Thank you for choosing to subscribe to the eTOC for The Hearing Journal. Enter your Email address: Wolters Kluwer Health may email you for journal alerts and information, but is ...

Hearing Research, Apr 1, 2018
The purpose of this study was to test whether a Kv3 potassium channel modulator, AUT00063, has th... more The purpose of this study was to test whether a Kv3 potassium channel modulator, AUT00063, has therapeutic potential for reversing noise-induced increases in spontaneous neural activity, a state that is widely believed to underlie noise-induced tinnitus. Recordings were conducted in noise exposed and control hamsters from dorsal cochlear nucleus (DCN) fusiform cells before and following intraperitoneal administration of AUT00063 (30 mg/kg). Fusiform cell spontaneous activity was increased in soundexposed animals, approximating levels that were nearly 50% above those of controls. Administration of AUT00063 resulted in a powerful suppression of this hyperactivity. The first signs of this suppression began 13 min after AUT00063 administration, but activity continued to decline gradually until reaching a floor level which was approximately 60% of pre-drug baseline by 25 min after drug treatment. A similar suppressive effect of AUT00063 was observed in control animals, with onset of suppression first apparent at 13 min post-treatment, but continuing to decline toward a floor level that was 54% of predrug baseline and was reached 28 min after drug treatment. In contrast, no suppression of spontaneous activity was observed in animals given similar injections of vehicle (control) solution. The suppressive effect of AUT00063 was achieved without significantly altering heart rate and with minimal effects on response thresholds, supporting the interpretation that the reductions of hyperactivity were not a secondary consequence of a more general physiological suppression of the brain or auditory system. These findings suggest that Kv3 channel modulation may be an effective approach to suppressing spontaneous activity in the auditory system and may provide a future avenue for treatment of tinnitus resulting from exposure to intense sound.
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Papers by Sharon Sandridge