Drug-resistant epilepsy in pediatric patients is associated with neuroinflammation and neurodegen... more Drug-resistant epilepsy in pediatric patients is associated with neuroinflammation and neurodegeneration. Vitamin D 25-OH exerts neuroprotective effects, while glial cell linederived neurotrophic factor (GDNF) and the proinflammatory cytokine interleukin-1β (IL-1β) are implicated in the mechanisms of neuroinflammation and epileptogenesis. The aim of this study was to investigate the relationship between vitamin D 25-OH, IL-1β, and GDNF levels with seizure severity and frequency in children with drug-resistant epilepsy. A cross-sectional study was conducted at Adam Malik Hospital, Medan, Indonesia, among children with drug-resistant epilepsy. Vitamin D 25-OH, IL-1β and GDNF levels were measured using enzyme-linked immunosorbent assay (ELISA). Epilepsy severity was assessed using the Hague Seizure Severity Scale (HASS), while seizure frequency was assessed using the Global Assessment of Severity of Epilepsy (GASE). The present study identified a significant correlation between GDNF levels and epilepsy severity, as measured by the HASS score (r=0.318; p=0.006). However, no significant correlation was observed between vitamin D 25-OH or IL-1β levels and epilepsy severity or seizure frequency (p>0.05). IL-1β levels correlated significantly with GDNF levels (r=0.525; p=0.001), but IL-1β did not directly correlate with seizure frequency or epilepsy severity. In conclusion, GDNF levels significantly correlated with epilepsy severity, suggesting that GDNF may serve as a potential biomarker for assessing epilepsy severity. However, further studies investigating the role of GDNF as a potential neurotrophic factor in the pathophysiology of epilepsy and its possible application as a therapeutic target are important.
Drug-resistant epilepsy in pediatric patients is associated with neuroinflammation and neurodegen... more Drug-resistant epilepsy in pediatric patients is associated with neuroinflammation and neurodegeneration. Vitamin D 25-OH exerts neuroprotective effects, while glial cell linederived neurotrophic factor (GDNF) and the proinflammatory cytokine interleukin-1β (IL-1β) are implicated in the mechanisms of neuroinflammation and epileptogenesis. The aim of this study was to investigate the relationship between vitamin D 25-OH, IL-1β, and GDNF levels with seizure severity and frequency in children with drug-resistant epilepsy. A cross-sectional study was conducted at Adam Malik Hospital, Medan, Indonesia, among children with drug-resistant epilepsy. Vitamin D 25-OH, IL-1β and GDNF levels were measured using enzyme-linked immunosorbent assay (ELISA). Epilepsy severity was assessed using the Hague Seizure Severity Scale (HASS), while seizure frequency was assessed using the Global Assessment of Severity of Epilepsy (GASE). The present study identified a significant correlation between GDNF levels and epilepsy severity, as measured by the HASS score (r=0.318; p=0.006). However, no significant correlation was observed between vitamin D 25-OH or IL-1β levels and epilepsy severity or seizure frequency (p>0.05). IL-1β levels correlated significantly with GDNF levels (r=0.525; p=0.001), but IL-1β did not directly correlate with seizure frequency or epilepsy severity. In conclusion, GDNF levels significantly correlated with epilepsy severity, suggesting that GDNF may serve as a potential biomarker for assessing epilepsy severity. However, further studies investigating the role of GDNF as a potential neurotrophic factor in the pathophysiology of epilepsy and its possible application as a therapeutic target are important.
Background: Epilepsy is highly prevalent among children worldwide, making it one of the most comm... more Background: Epilepsy is highly prevalent among children worldwide, making it one of the most common neurological disorders. Drug-Resistant Epilepsy (DRE) significantly impacts the quality of life (QoL) of affected children, attributed to factors such as seizure frequency and severity, low vitamin D levels, comorbidities, radiological abnormalities, and elevated IL-1β levels. Objective: This study aims to identify the factors most significantly affecting the QoL in children with DRE. Methods: This cross-sectional study at Adam Malik Hospital involved children with DRE. Participants' QoL was assessed with the QOLCE-55 score, while epilepsy severity was measured using the HASS score. Vitamin D status was quantified by serum 25-hydroxy vitamin D (25(OH)D) levels, and IL-1β levels were measured using the ELISA method. Multivariate logistic regression analysis using Pearson and Spearman test was conducted to evaluate risk factors that significantly impact the QoL of children with DRE. Results: The findings revealed several factors significantly influencing QoL in children with DRE. Comorbidities (OR = 24.98, p = 0.004, 95% CI) and high IL-1β levels (OR = 8.36, p = 0.022, 95% CI) were strongly correlated and significant factors in determining QoL, indicating 24.98-and 8.36-times higher likelihood of decreased QoL, respectively. Vitamin D levels had no statistically significant effect on QoL. Conclusion: Vitamin D levels have no substantial impact on QoL in children with DRE. IL-1β levels and comorbidities are crucial components affecting QoL in these patients. These findings highlight the importance of considering these factors in the management of children with DRE.
International journal of research publications, Mar 1, 2024
Cerebral palsy (CP) is a disorder of motor function and posture, due to impaired brain developmen... more Cerebral palsy (CP) is a disorder of motor function and posture, due to impaired brain development. Children with CP are at risk of experiencing vitamin D deficiency due to reduced mobility, low vitamin D intake, and use of anti-epileptic drugs. Vitamin D deficiency can cause hypocalcemia and reduce bone mineral density, osteopenia, and rickets so that it can result in pathological fractures even with only minor injuries. Monitoring vitamin D levels, early identification, and appropriate vitamin D supplementation are important in reducing the risk of injury and fracture in PS children. This study aims to determine the clinical profile of children with cerebral palsy and their vitamin D status. Methods: A descriptive study of children with cerebral palsy aged 2 to 6 years at the Neuro-pediatric outpatient clinic at H. Adam Malik Hospital, Medan from November 2022 to April 2023. Primary data was obtained from interviews and examination of serum vitamin D levels. Secondary data was obtained from medical records. Results: Eighty-five CP children were included in this study, 51.8% were boys and 48.2% were girls. The mean age of the subjects was 3.48 years, 34.1% of the subjects experienced malnutrition. The etiology of CP mainly occurs in the perinatal period (66.7%). Most subjects had spastic type (75.3%), with GMFCS grade V being the most common type (34.1%). Most of the subjects (57.6%) had epilepsy and were using anti-epileptic drugs. The majority of subjects had vitamin D deficiency status (56.5%). Conclusion: The clinical profile of cerebral palsy children at Haji Adam Malik Hospital Medan showed that most CP occurred during the perinatal period. Spastic type is the most common type of CP, most CP children experience epilepsy and vitamin D deficiency.
International journal of research publications, Mar 1, 2024
Cerebral palsy (CP) is a disorder of motor function and posture, due to impaired brain developmen... more Cerebral palsy (CP) is a disorder of motor function and posture, due to impaired brain development. Children with CP are at risk of experiencing vitamin D deficiency due to reduced mobility, low vitamin D intake, and use of anti-epileptic drugs. Vitamin D deficiency can cause hypocalcemia and reduce bone mineral density, osteopenia, and rickets so that it can result in pathological fractures even with only minor injuries. Monitoring vitamin D levels, early identification, and appropriate vitamin D supplementation are important in reducing the risk of injury and fracture in PS children. This study aims to determine the clinical profile of children with cerebral palsy and their vitamin D status. Methods: A descriptive study of children with cerebral palsy aged 2 to 6 years at the Neuro-pediatric outpatient clinic at H. Adam Malik Hospital, Medan from November 2022 to April 2023. Primary data was obtained from interviews and examination of serum vitamin D levels. Secondary data was obtained from medical records. Results: Eighty-five CP children were included in this study, 51.8% were boys and 48.2% were girls. The mean age of the subjects was 3.48 years, 34.1% of the subjects experienced malnutrition. The etiology of CP mainly occurs in the perinatal period (66.7%). Most subjects had spastic type (75.3%), with GMFCS grade V being the most common type (34.1%). Most of the subjects (57.6%) had epilepsy and were using anti-epileptic drugs. The majority of subjects had vitamin D deficiency status (56.5%). Conclusion: The clinical profile of cerebral palsy children at Haji Adam Malik Hospital Medan showed that most CP occurred during the perinatal period. Spastic type is the most common type of CP, most CP children experience epilepsy and vitamin D deficiency.
Cerebral palsy (CP) is the most common etiology of physical disability in children. Motoric distu... more Cerebral palsy (CP) is the most common etiology of physical disability in children. Motoric disturbance is mostly caused by central nervous system damage in the first 2 years of life. Chronic movement and postural disturbances in children will hamper their ability to conduct daily activities. Generally, there are 3 domains of management in CP: physical exercise, medications and surgery, and behavioral theraphy. Physiotheraphy is better be given in the first year of life or as soon as the diagnosis of CP established. Physiotheraphy in children with CP includes stretching, empowering, and positioning. Physiotheraphy given to children with CP significantly improve motoric function and increase their quality of life..
B lood pressure (BP) is important in physical examination in children and adolescents as are body... more B lood pressure (BP) is important in physical examination in children and adolescents as are body weight and height measurements, but almost never been done. BP measurement should be included in the physical examination as a part of the continuing care of the child, not as an isolated procedure. All physicians who care for children of 3 years of age through adolescence should be encouraged to measure BP at least once a year, when the child is well. The incorporation of BP measurement into the routine pediatric examination not only enable to detect significant asymptomatic hypertension secondary to a previously undetected disorder, but also confirm that mild elevations in BP during childhood are more common than previously recognized, particularly in adolescents. 1,2 BP in children and adolescents depends on multiple factors, both genetic and environmental such as gender, age, body weight and height, obesity, life style, socioeconomic status, etc. 1,3,4 Some studies about BP in infants, play group children, elementary and junior high schools in Medan have been done,
International journal of research publications, Dec 1, 2021
Background : The prevalence of obesity and overweight are increasing in adolescents. It can be ri... more Background : The prevalence of obesity and overweight are increasing in adolescents. It can be risk factor of obesity , chronic disease such as diabetes, cardiovascular disease in adulthood. The risk factor of obesity and overweight are high calorie intake and lack of physical activity. Dietary fiber can be an alternative because it is proven to be able to lose weight because it has fewer calories and have filling effect because it has a high viscosity. There are less study benefit of dietar y fiber intake in nutritional status in adolescent. Objective: The aim of this study was to investigate the correlation of dietary fibre and the other factors that caused overweight and obesity among adolescents of Junior high school. Methods: A cross sectional study with total of 102 subjects, including 42% boys and 58,8% girls aged 12-16 with normal weight, overweight and obesity. Dietary fiber information was reported using the food recall for a week and conversion it to self nutrition data. The nutritional status was assessed on the basis of body mass and height measurements with CDC 2000 curve. Data analysis used chi square and logistic regression. Results: There was correlation between dietary fiber intake and nutritional status (p < 0,001) (p < 0,001) with Rasio Prevalence 2,830 (CI 95% = 1,845-4,341). But snack consumption have more correlation with p < 0,001 with Rasio Prevalence 4,782 (IK 95% = 2,075-11,018). Conclusion: The intake of dietary fibre was associated with nutritional status in adolescent, but snack consumption have more correlation.
Background migraine is the most common cause of recurrent headaches in children and adolescents. ... more Background migraine is the most common cause of recurrent headaches in children and adolescents. Amitriptyline efficacy as a prophylactic treatment for migraine in adults has been widely studied, but there is limited data on its use in children and adolescents. Objective To determine the efficacy of amitriptyline for prophylactic treatment of migraine in adolescents. Methods We conducted a single-blind, randomized, clinical trial study in Medan, North Sumatra, from July to October 2009. All participants had migraines, according to the International Headache Society criteria. They were divided into two groups, receiving either 10 mg amitriptyline or a placebo daily for 3 months. Headache frequency (days per month), headache duration (hours) and information to assess functional disability according to the Pediatric Migraine Disability Assessment Scale (PedMIDAS) were recorded by subjects. Efficacy was measured before, during and after intervention. Results A total of 98 patients, aged 12-19 years (mean age 14.7 years) enrolled and were divided into the amitriptyline and placebo groups. Compared with baseline, there were significant differences in headache frequency and PedMIDAS score in the amitriptyline group (P=0.001, 95% CI 2.02 to 2.94 and P=0.001, 95% CI 7.64 to 9.76, respectively), but not in the placebo group (P >0.05) after 3 months of treatment. We also found that amitriptyline significantly decreased headache frequency, duration, and functional disability compared to the placebo, after 3 months of treatment (P < 0.05). Conclusion Amitriptyline was effective for prophylactic treatment of migraine in adolescents after 3 months of intervention.
Background migraine headaches are a common problem worldwide, especially in adolescents. They are... more Background migraine headaches are a common problem worldwide, especially in adolescents. They are usually chronic, with frequent relapses. Therefore, any dietary risk factor for headaches has important implications on migraineurs. However, the association between migraine and diet needs to be examined further. Objective To investigate the association between diet and migraine in adolescents. Methods We conducted a cross-sectional study in August to September 2009 on 13-18 year old adolescents in a senior high school in Medan, North Sumatera. We included subjects diagnosed with migraine, according to the International Headache Society (IHS) criteria. Ninety participants completed the questionnaire. Foods we observed for a link to migraine included milk, chocolate, ice cream, cheese, bread, instant noodles, meatballs, chili sauce, sweetener, yoghurt, pizza, and other foods and beverages. Results Of the 90 participants with migraines, there were more females (61.1%) than males. There were statistically significant associations between migraine and triggering foods (P = 0.045, 95% CI 0.59 to 0.79) as well as between migraine and family history of migraine (P = 0.043, 95% CI 0.46 to 0.66). Stress (P = 0.164), menstruation (P = 0.369), and sound or light (P= 0.577) had no significant association with migraine. A wide variety of foods and beverages were implicated as migraine precipitants. The most common were chili sauce (75.8%), ice cream (71.0%), milk (67.7%), instant noodles (67.7%), chocolate (61.3%), peanuts (59.7%), cheese (54.8%) and meatballs (54.8%). Conclusion Food and family history have a significant association with the occurrence of migraine in adolescents. [Paediatr Indones. 2011;51:223-6].
Background Cerebral palsy (CP) is the most common cause of severe physical disability in childhoo... more Background Cerebral palsy (CP) is the most common cause of severe physical disability in childhood. These limitations may cause lower level experience or quality of life (QoL). Physical therapy (PT) plays a central role in managing CP. Objective To compare QoL in CP children with PT more and less than 10 months and to compare gross motoric level before and after PT. 10 months PT have higher QoL than children with less than 10 months PT. There was significant gross motor improvement after PT in both groups. [Paediatr Indones. 2015;55:287-92].
International Journal of Research Publications, 2021
Background : The prevalence of obesity and overweight are increasing in adolescents. It can be ri... more Background : The prevalence of obesity and overweight are increasing in adolescents. It can be risk factor of obesity , chronic disease such as diabetes, cardiovascular disease in adulthood. The risk factor of obesity and overweight are high calorie intake and lack of physical activity. Dietary fiber can be an alternative because it is proven to be able to lose weight because it has fewer calories and have filling effect because it has a high viscosity. There are less study benefit of dietar y fiber intake in nutritional status in adolescent. Objective: The aim of this study was to investigate the correlation of dietary fibre and the other factors that caused overweight and obesity among adolescents of Junior high school. Methods: A cross sectional study with total of 102 subjects, including 42% boys and 58,8% girls aged 12-16 with normal weight, overweight and obesity. Dietary fiber information was reported using the food recall for a week and conversion it to self nutrition data. The nutritional status was assessed on the basis of body mass and height measurements with CDC 2000 curve. Data analysis used chi square and logistic regression. Results: There was correlation between dietary fiber intake and nutritional status (p < 0,001) (p < 0,001) with Rasio Prevalence 2,830 (CI 95% = 1,845-4,341). But snack consumption have more correlation with p < 0,001 with Rasio Prevalence 4,782 (IK 95% = 2,075-11,018). Conclusion: The intake of dietary fibre was associated with nutritional status in adolescent, but snack consumption have more correlation.
Drug-resistant epilepsy in pediatric patients is associated with neuroinflammation and neurodegen... more Drug-resistant epilepsy in pediatric patients is associated with neuroinflammation and neurodegeneration. Vitamin D 25-OH exerts neuroprotective effects, while glial cell linederived neurotrophic factor (GDNF) and the proinflammatory cytokine interleukin-1β (IL-1β) are implicated in the mechanisms of neuroinflammation and epileptogenesis. The aim of this study was to investigate the relationship between vitamin D 25-OH, IL-1β, and GDNF levels with seizure severity and frequency in children with drug-resistant epilepsy. A cross-sectional study was conducted at Adam Malik Hospital, Medan, Indonesia, among children with drug-resistant epilepsy. Vitamin D 25-OH, IL-1β and GDNF levels were measured using enzyme-linked immunosorbent assay (ELISA). Epilepsy severity was assessed using the Hague Seizure Severity Scale (HASS), while seizure frequency was assessed using the Global Assessment of Severity of Epilepsy (GASE). The present study identified a significant correlation between GDNF levels and epilepsy severity, as measured by the HASS score (r=0.318; p=0.006). However, no significant correlation was observed between vitamin D 25-OH or IL-1β levels and epilepsy severity or seizure frequency (p>0.05). IL-1β levels correlated significantly with GDNF levels (r=0.525; p=0.001), but IL-1β did not directly correlate with seizure frequency or epilepsy severity. In conclusion, GDNF levels significantly correlated with epilepsy severity, suggesting that GDNF may serve as a potential biomarker for assessing epilepsy severity. However, further studies investigating the role of GDNF as a potential neurotrophic factor in the pathophysiology of epilepsy and its possible application as a therapeutic target are important.
Drug-resistant epilepsy in pediatric patients is associated with neuroinflammation and neurodegen... more Drug-resistant epilepsy in pediatric patients is associated with neuroinflammation and neurodegeneration. Vitamin D 25-OH exerts neuroprotective effects, while glial cell linederived neurotrophic factor (GDNF) and the proinflammatory cytokine interleukin-1β (IL-1β) are implicated in the mechanisms of neuroinflammation and epileptogenesis. The aim of this study was to investigate the relationship between vitamin D 25-OH, IL-1β, and GDNF levels with seizure severity and frequency in children with drug-resistant epilepsy. A cross-sectional study was conducted at Adam Malik Hospital, Medan, Indonesia, among children with drug-resistant epilepsy. Vitamin D 25-OH, IL-1β and GDNF levels were measured using enzyme-linked immunosorbent assay (ELISA). Epilepsy severity was assessed using the Hague Seizure Severity Scale (HASS), while seizure frequency was assessed using the Global Assessment of Severity of Epilepsy (GASE). The present study identified a significant correlation between GDNF levels and epilepsy severity, as measured by the HASS score (r=0.318; p=0.006). However, no significant correlation was observed between vitamin D 25-OH or IL-1β levels and epilepsy severity or seizure frequency (p>0.05). IL-1β levels correlated significantly with GDNF levels (r=0.525; p=0.001), but IL-1β did not directly correlate with seizure frequency or epilepsy severity. In conclusion, GDNF levels significantly correlated with epilepsy severity, suggesting that GDNF may serve as a potential biomarker for assessing epilepsy severity. However, further studies investigating the role of GDNF as a potential neurotrophic factor in the pathophysiology of epilepsy and its possible application as a therapeutic target are important.
Background: Epilepsy is highly prevalent among children worldwide, making it one of the most comm... more Background: Epilepsy is highly prevalent among children worldwide, making it one of the most common neurological disorders. Drug-Resistant Epilepsy (DRE) significantly impacts the quality of life (QoL) of affected children, attributed to factors such as seizure frequency and severity, low vitamin D levels, comorbidities, radiological abnormalities, and elevated IL-1β levels. Objective: This study aims to identify the factors most significantly affecting the QoL in children with DRE. Methods: This cross-sectional study at Adam Malik Hospital involved children with DRE. Participants' QoL was assessed with the QOLCE-55 score, while epilepsy severity was measured using the HASS score. Vitamin D status was quantified by serum 25-hydroxy vitamin D (25(OH)D) levels, and IL-1β levels were measured using the ELISA method. Multivariate logistic regression analysis using Pearson and Spearman test was conducted to evaluate risk factors that significantly impact the QoL of children with DRE. Results: The findings revealed several factors significantly influencing QoL in children with DRE. Comorbidities (OR = 24.98, p = 0.004, 95% CI) and high IL-1β levels (OR = 8.36, p = 0.022, 95% CI) were strongly correlated and significant factors in determining QoL, indicating 24.98-and 8.36-times higher likelihood of decreased QoL, respectively. Vitamin D levels had no statistically significant effect on QoL. Conclusion: Vitamin D levels have no substantial impact on QoL in children with DRE. IL-1β levels and comorbidities are crucial components affecting QoL in these patients. These findings highlight the importance of considering these factors in the management of children with DRE.
International journal of research publications, Mar 1, 2024
Cerebral palsy (CP) is a disorder of motor function and posture, due to impaired brain developmen... more Cerebral palsy (CP) is a disorder of motor function and posture, due to impaired brain development. Children with CP are at risk of experiencing vitamin D deficiency due to reduced mobility, low vitamin D intake, and use of anti-epileptic drugs. Vitamin D deficiency can cause hypocalcemia and reduce bone mineral density, osteopenia, and rickets so that it can result in pathological fractures even with only minor injuries. Monitoring vitamin D levels, early identification, and appropriate vitamin D supplementation are important in reducing the risk of injury and fracture in PS children. This study aims to determine the clinical profile of children with cerebral palsy and their vitamin D status. Methods: A descriptive study of children with cerebral palsy aged 2 to 6 years at the Neuro-pediatric outpatient clinic at H. Adam Malik Hospital, Medan from November 2022 to April 2023. Primary data was obtained from interviews and examination of serum vitamin D levels. Secondary data was obtained from medical records. Results: Eighty-five CP children were included in this study, 51.8% were boys and 48.2% were girls. The mean age of the subjects was 3.48 years, 34.1% of the subjects experienced malnutrition. The etiology of CP mainly occurs in the perinatal period (66.7%). Most subjects had spastic type (75.3%), with GMFCS grade V being the most common type (34.1%). Most of the subjects (57.6%) had epilepsy and were using anti-epileptic drugs. The majority of subjects had vitamin D deficiency status (56.5%). Conclusion: The clinical profile of cerebral palsy children at Haji Adam Malik Hospital Medan showed that most CP occurred during the perinatal period. Spastic type is the most common type of CP, most CP children experience epilepsy and vitamin D deficiency.
International journal of research publications, Mar 1, 2024
Cerebral palsy (CP) is a disorder of motor function and posture, due to impaired brain developmen... more Cerebral palsy (CP) is a disorder of motor function and posture, due to impaired brain development. Children with CP are at risk of experiencing vitamin D deficiency due to reduced mobility, low vitamin D intake, and use of anti-epileptic drugs. Vitamin D deficiency can cause hypocalcemia and reduce bone mineral density, osteopenia, and rickets so that it can result in pathological fractures even with only minor injuries. Monitoring vitamin D levels, early identification, and appropriate vitamin D supplementation are important in reducing the risk of injury and fracture in PS children. This study aims to determine the clinical profile of children with cerebral palsy and their vitamin D status. Methods: A descriptive study of children with cerebral palsy aged 2 to 6 years at the Neuro-pediatric outpatient clinic at H. Adam Malik Hospital, Medan from November 2022 to April 2023. Primary data was obtained from interviews and examination of serum vitamin D levels. Secondary data was obtained from medical records. Results: Eighty-five CP children were included in this study, 51.8% were boys and 48.2% were girls. The mean age of the subjects was 3.48 years, 34.1% of the subjects experienced malnutrition. The etiology of CP mainly occurs in the perinatal period (66.7%). Most subjects had spastic type (75.3%), with GMFCS grade V being the most common type (34.1%). Most of the subjects (57.6%) had epilepsy and were using anti-epileptic drugs. The majority of subjects had vitamin D deficiency status (56.5%). Conclusion: The clinical profile of cerebral palsy children at Haji Adam Malik Hospital Medan showed that most CP occurred during the perinatal period. Spastic type is the most common type of CP, most CP children experience epilepsy and vitamin D deficiency.
Cerebral palsy (CP) is the most common etiology of physical disability in children. Motoric distu... more Cerebral palsy (CP) is the most common etiology of physical disability in children. Motoric disturbance is mostly caused by central nervous system damage in the first 2 years of life. Chronic movement and postural disturbances in children will hamper their ability to conduct daily activities. Generally, there are 3 domains of management in CP: physical exercise, medications and surgery, and behavioral theraphy. Physiotheraphy is better be given in the first year of life or as soon as the diagnosis of CP established. Physiotheraphy in children with CP includes stretching, empowering, and positioning. Physiotheraphy given to children with CP significantly improve motoric function and increase their quality of life..
B lood pressure (BP) is important in physical examination in children and adolescents as are body... more B lood pressure (BP) is important in physical examination in children and adolescents as are body weight and height measurements, but almost never been done. BP measurement should be included in the physical examination as a part of the continuing care of the child, not as an isolated procedure. All physicians who care for children of 3 years of age through adolescence should be encouraged to measure BP at least once a year, when the child is well. The incorporation of BP measurement into the routine pediatric examination not only enable to detect significant asymptomatic hypertension secondary to a previously undetected disorder, but also confirm that mild elevations in BP during childhood are more common than previously recognized, particularly in adolescents. 1,2 BP in children and adolescents depends on multiple factors, both genetic and environmental such as gender, age, body weight and height, obesity, life style, socioeconomic status, etc. 1,3,4 Some studies about BP in infants, play group children, elementary and junior high schools in Medan have been done,
International journal of research publications, Dec 1, 2021
Background : The prevalence of obesity and overweight are increasing in adolescents. It can be ri... more Background : The prevalence of obesity and overweight are increasing in adolescents. It can be risk factor of obesity , chronic disease such as diabetes, cardiovascular disease in adulthood. The risk factor of obesity and overweight are high calorie intake and lack of physical activity. Dietary fiber can be an alternative because it is proven to be able to lose weight because it has fewer calories and have filling effect because it has a high viscosity. There are less study benefit of dietar y fiber intake in nutritional status in adolescent. Objective: The aim of this study was to investigate the correlation of dietary fibre and the other factors that caused overweight and obesity among adolescents of Junior high school. Methods: A cross sectional study with total of 102 subjects, including 42% boys and 58,8% girls aged 12-16 with normal weight, overweight and obesity. Dietary fiber information was reported using the food recall for a week and conversion it to self nutrition data. The nutritional status was assessed on the basis of body mass and height measurements with CDC 2000 curve. Data analysis used chi square and logistic regression. Results: There was correlation between dietary fiber intake and nutritional status (p < 0,001) (p < 0,001) with Rasio Prevalence 2,830 (CI 95% = 1,845-4,341). But snack consumption have more correlation with p < 0,001 with Rasio Prevalence 4,782 (IK 95% = 2,075-11,018). Conclusion: The intake of dietary fibre was associated with nutritional status in adolescent, but snack consumption have more correlation.
Background migraine is the most common cause of recurrent headaches in children and adolescents. ... more Background migraine is the most common cause of recurrent headaches in children and adolescents. Amitriptyline efficacy as a prophylactic treatment for migraine in adults has been widely studied, but there is limited data on its use in children and adolescents. Objective To determine the efficacy of amitriptyline for prophylactic treatment of migraine in adolescents. Methods We conducted a single-blind, randomized, clinical trial study in Medan, North Sumatra, from July to October 2009. All participants had migraines, according to the International Headache Society criteria. They were divided into two groups, receiving either 10 mg amitriptyline or a placebo daily for 3 months. Headache frequency (days per month), headache duration (hours) and information to assess functional disability according to the Pediatric Migraine Disability Assessment Scale (PedMIDAS) were recorded by subjects. Efficacy was measured before, during and after intervention. Results A total of 98 patients, aged 12-19 years (mean age 14.7 years) enrolled and were divided into the amitriptyline and placebo groups. Compared with baseline, there were significant differences in headache frequency and PedMIDAS score in the amitriptyline group (P=0.001, 95% CI 2.02 to 2.94 and P=0.001, 95% CI 7.64 to 9.76, respectively), but not in the placebo group (P >0.05) after 3 months of treatment. We also found that amitriptyline significantly decreased headache frequency, duration, and functional disability compared to the placebo, after 3 months of treatment (P < 0.05). Conclusion Amitriptyline was effective for prophylactic treatment of migraine in adolescents after 3 months of intervention.
Background migraine headaches are a common problem worldwide, especially in adolescents. They are... more Background migraine headaches are a common problem worldwide, especially in adolescents. They are usually chronic, with frequent relapses. Therefore, any dietary risk factor for headaches has important implications on migraineurs. However, the association between migraine and diet needs to be examined further. Objective To investigate the association between diet and migraine in adolescents. Methods We conducted a cross-sectional study in August to September 2009 on 13-18 year old adolescents in a senior high school in Medan, North Sumatera. We included subjects diagnosed with migraine, according to the International Headache Society (IHS) criteria. Ninety participants completed the questionnaire. Foods we observed for a link to migraine included milk, chocolate, ice cream, cheese, bread, instant noodles, meatballs, chili sauce, sweetener, yoghurt, pizza, and other foods and beverages. Results Of the 90 participants with migraines, there were more females (61.1%) than males. There were statistically significant associations between migraine and triggering foods (P = 0.045, 95% CI 0.59 to 0.79) as well as between migraine and family history of migraine (P = 0.043, 95% CI 0.46 to 0.66). Stress (P = 0.164), menstruation (P = 0.369), and sound or light (P= 0.577) had no significant association with migraine. A wide variety of foods and beverages were implicated as migraine precipitants. The most common were chili sauce (75.8%), ice cream (71.0%), milk (67.7%), instant noodles (67.7%), chocolate (61.3%), peanuts (59.7%), cheese (54.8%) and meatballs (54.8%). Conclusion Food and family history have a significant association with the occurrence of migraine in adolescents. [Paediatr Indones. 2011;51:223-6].
Background Cerebral palsy (CP) is the most common cause of severe physical disability in childhoo... more Background Cerebral palsy (CP) is the most common cause of severe physical disability in childhood. These limitations may cause lower level experience or quality of life (QoL). Physical therapy (PT) plays a central role in managing CP. Objective To compare QoL in CP children with PT more and less than 10 months and to compare gross motoric level before and after PT. 10 months PT have higher QoL than children with less than 10 months PT. There was significant gross motor improvement after PT in both groups. [Paediatr Indones. 2015;55:287-92].
International Journal of Research Publications, 2021
Background : The prevalence of obesity and overweight are increasing in adolescents. It can be ri... more Background : The prevalence of obesity and overweight are increasing in adolescents. It can be risk factor of obesity , chronic disease such as diabetes, cardiovascular disease in adulthood. The risk factor of obesity and overweight are high calorie intake and lack of physical activity. Dietary fiber can be an alternative because it is proven to be able to lose weight because it has fewer calories and have filling effect because it has a high viscosity. There are less study benefit of dietar y fiber intake in nutritional status in adolescent. Objective: The aim of this study was to investigate the correlation of dietary fibre and the other factors that caused overweight and obesity among adolescents of Junior high school. Methods: A cross sectional study with total of 102 subjects, including 42% boys and 58,8% girls aged 12-16 with normal weight, overweight and obesity. Dietary fiber information was reported using the food recall for a week and conversion it to self nutrition data. The nutritional status was assessed on the basis of body mass and height measurements with CDC 2000 curve. Data analysis used chi square and logistic regression. Results: There was correlation between dietary fiber intake and nutritional status (p < 0,001) (p < 0,001) with Rasio Prevalence 2,830 (CI 95% = 1,845-4,341). But snack consumption have more correlation with p < 0,001 with Rasio Prevalence 4,782 (IK 95% = 2,075-11,018). Conclusion: The intake of dietary fibre was associated with nutritional status in adolescent, but snack consumption have more correlation.
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